DK137451B - Analogifremgangsmåde til fremstilling af derivater af 2-oxo-pyrrolidin. - Google Patents

Analogifremgangsmåde til fremstilling af derivater af 2-oxo-pyrrolidin.

Info

Publication number
DK137451B
DK137451B DK59571AA DK59571A DK137451B DK 137451 B DK137451 B DK 137451B DK 59571A A DK59571A A DK 59571AA DK 59571 A DK59571 A DK 59571A DK 137451 B DK137451 B DK 137451B
Authority
DK
Denmark
Prior art keywords
pyrrolidine
oxo
derivatives
preparation
analogous process
Prior art date
Application number
DK59571AA
Other languages
Danish (da)
English (en)
Other versions
DK137451C (cs
Inventor
Joseph Honore Lucien M Strubbe
Raymond Armand Linz
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of DK137451B publication Critical patent/DK137451B/da
Application granted granted Critical
Publication of DK137451C publication Critical patent/DK137451C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK59571AA 1970-02-13 1971-02-10 Analogifremgangsmåde til fremstilling af derivater af 2-oxo-pyrrolidin. DK137451B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB697870A GB1309692A (en) 1970-02-13 1970-02-13 N-substituted lactams

Publications (2)

Publication Number Publication Date
DK137451B true DK137451B (da) 1978-03-06
DK137451C DK137451C (cs) 1978-07-24

Family

ID=9824325

Family Applications (1)

Application Number Title Priority Date Filing Date
DK59571AA DK137451B (da) 1970-02-13 1971-02-10 Analogifremgangsmåde til fremstilling af derivater af 2-oxo-pyrrolidin.

Country Status (15)

Country Link
JP (2) JPS535301B1 (cs)
BE (1) BE762728R (cs)
CH (1) CH530395A (cs)
CS (2) CS167911B2 (cs)
DE (1) DE2106418C2 (cs)
DK (1) DK137451B (cs)
ES (1) ES388135A2 (cs)
FI (1) FI54916C (cs)
FR (1) FR2081508B2 (cs)
GB (1) GB1309692A (cs)
MY (1) MY7400072A (cs)
NL (1) NL168830C (cs)
SU (2) SU508186A3 (cs)
YU (2) YU34876B (cs)
ZA (1) ZA71877B (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK151010B (da) * 1977-03-03 1987-10-12 Parke Davis & Co Analogifremgangsmaade til fremstilling af n-(substitueret aminoalkyl)-2-oxo-1-pyrrolidinacetamider eller farmaceutisk acceptable syreadditionssalte deraf
DK156055B (da) * 1975-08-13 1989-06-19 Isf Spa Analogifremgangsmaade til fremstilling af pyrrolidin-2-onderivater

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1583871A (en) * 1976-10-19 1981-02-04 Ucb Sa Anti-aggregants
ATE27T1 (de) * 1978-05-08 1981-04-15 Ucb Sa Lactam-n-essigsaeuren und ihre amide, verfahren zu ihrer herstellung und heilmittel, die sie enthalten
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
EP0089900B1 (en) * 1982-03-24 1985-12-27 Prodes S.A. New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
DE3420193A1 (de) * 1984-05-30 1985-12-05 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
US4804400A (en) * 1986-09-12 1989-02-14 Ciba-Geigy Corporation N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof
GB8827389D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
TW544311B (en) * 1998-08-06 2003-08-01 Daiichi Seiyaku Co Therapeutic or preventive agent for intractable epilepsies
GB0004297D0 (en) * 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
WO2002094787A1 (en) * 2001-05-23 2002-11-28 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
DE60229267D1 (de) 2001-08-10 2008-11-20 Ucb Pharma Sa Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen
ES2281545T3 (es) * 2001-10-08 2007-10-01 Ucb, S.A. Uso de derivados de 2-oxo-1-pirrolidina para la preparacion de un farmaco para tratar la discinesia.
WO2004069796A2 (en) 2003-02-03 2004-08-19 Teva Pharmaceutical Industries Ltd. Process for producing levetiracetam
ES2214147B1 (es) * 2003-02-28 2005-10-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.
CA2497062A1 (en) 2004-02-18 2005-08-18 Dr. Reddy's Laboratories Limited Preparation of amino acid amides
CA2488325C (en) 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
US20080146819A1 (en) * 2005-03-10 2008-06-19 Rubamin Limited Process for Preparing Levetiracetam
EP1912966A2 (en) 2005-06-01 2008-04-23 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
US20100099735A1 (en) 2008-10-16 2010-04-22 Michela Gallagher Methods and compositions for improving cognitive function
US8785661B2 (en) 2009-05-13 2014-07-22 Nektar Therapeutics Oligome-containing pyrrolidine compounds
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
CA2904767C (en) 2013-03-15 2022-06-21 Agenebio, Inc. Methods and compositions for improving cognitive function
AU2015208233B2 (en) 2014-01-21 2019-08-29 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
LT3431106T (lt) 2014-01-21 2021-02-10 Janssen Pharmaceutica Nv Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
CN104059010A (zh) * 2014-06-12 2014-09-24 浙江华海药业股份有限公司 一种制备2-(2-氧代吡咯烷-1-基)-丁酸酯的方法
CN106591179B (zh) * 2016-12-05 2018-07-03 长兴制药股份有限公司 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用
RU2663899C1 (ru) * 2017-07-19 2018-08-13 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Способ получения 1-карбамоилметил-4-фенил-2-пирролидона
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
CN113979911A (zh) * 2021-11-12 2022-01-28 汤斌 一种从大鲵肽中提取乙拉西坦的方法
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK156055B (da) * 1975-08-13 1989-06-19 Isf Spa Analogifremgangsmaade til fremstilling af pyrrolidin-2-onderivater
DK151010B (da) * 1977-03-03 1987-10-12 Parke Davis & Co Analogifremgangsmaade til fremstilling af n-(substitueret aminoalkyl)-2-oxo-1-pyrrolidinacetamider eller farmaceutisk acceptable syreadditionssalte deraf

Also Published As

Publication number Publication date
SU508186A3 (ru) 1976-03-25
DE2106418C2 (de) 1983-12-22
JPS535301B1 (cs) 1978-02-25
NL7101697A (cs) 1971-08-17
BE762728R (fr) 1971-08-10
ES388135A2 (es) 1973-05-01
CS167912B2 (cs) 1976-05-28
NL168830C (nl) 1982-05-17
FI54916B (fi) 1978-12-29
FR2081508B2 (cs) 1975-06-06
YU30671A (en) 1979-10-31
JPS53130656A (en) 1978-11-14
YU34876B (en) 1980-04-30
CS167911B2 (cs) 1976-05-28
MY7400072A (en) 1974-12-31
ZA71877B (en) 1971-10-27
YU144578A (en) 1982-10-31
DE2106418A1 (de) 1971-08-19
GB1309692A (en) 1973-03-14
FR2081508A2 (cs) 1971-12-03
NL168830B (nl) 1981-12-16
CH530395A (fr) 1972-11-15
DK137451C (cs) 1978-07-24
SU508185A3 (ru) 1976-03-25
FI54916C (fi) 1979-04-10
JPS5420491B2 (cs) 1979-07-23

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