YU34876B - Process for obtaining novel n-substituted pyrrolidines - Google Patents

Process for obtaining novel n-substituted pyrrolidines

Info

Publication number
YU34876B
YU34876B YU306/71A YU30671A YU34876B YU 34876 B YU34876 B YU 34876B YU 306/71 A YU306/71 A YU 306/71A YU 30671 A YU30671 A YU 30671A YU 34876 B YU34876 B YU 34876B
Authority
YU
Yugoslavia
Prior art keywords
obtaining novel
substituted pyrrolidines
pyrrolidines
substituted
novel
Prior art date
Application number
YU306/71A
Other versions
YU30671A (en
Inventor
Lucien Honore Joseph
Honore Joseph Lucien
Raymond Dilbeek
Dilbeek Raymond
Original Assignee
Ucb Union Chimique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Union Chimique filed Critical Ucb Union Chimique
Publication of YU30671A publication Critical patent/YU30671A/en
Publication of YU34876B publication Critical patent/YU34876B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
YU306/71A 1970-02-13 1971-02-10 Process for obtaining novel n-substituted pyrrolidines YU34876B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB697870A GB1309692A (en) 1970-02-13 1970-02-13 N-substituted lactams

Publications (2)

Publication Number Publication Date
YU30671A YU30671A (en) 1979-10-31
YU34876B true YU34876B (en) 1980-04-30

Family

ID=9824325

Family Applications (2)

Application Number Title Priority Date Filing Date
YU306/71A YU34876B (en) 1970-02-13 1971-02-10 Process for obtaining novel n-substituted pyrrolidines
YU01445/78A YU144578A (en) 1970-02-13 1978-06-19 Process for obtaining new n-substituted pyrrolidones

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU01445/78A YU144578A (en) 1970-02-13 1978-06-19 Process for obtaining new n-substituted pyrrolidones

Country Status (15)

Country Link
JP (2) JPS535301B1 (en)
BE (1) BE762728R (en)
CH (1) CH530395A (en)
CS (2) CS167911B2 (en)
DE (1) DE2106418C2 (en)
DK (1) DK137451B (en)
ES (1) ES388135A2 (en)
FI (1) FI54916C (en)
FR (1) FR2081508B2 (en)
GB (1) GB1309692A (en)
MY (1) MY7400072A (en)
NL (1) NL168830C (en)
SU (2) SU508186A3 (en)
YU (2) YU34876B (en)
ZA (1) ZA71877B (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1045043B (en) * 1975-08-13 1980-04-21 Isf Spa PYROLIDINE DERIVATIVES
GB1583871A (en) * 1976-10-19 1981-02-04 Ucb Sa Anti-aggregants
BE864269A (en) * 1977-03-03 1978-06-16 Parke Davis & Co NEW N- (AMINOALKYL SUBSTITUTE) -2-OXO-1-PYRROLIDINE-ACETAMIDES AND METHODS FOR PRODUCING THEM
DE2960194D1 (en) 1978-05-08 1981-04-16 Ucb Sa Lactam-n-acetic acids, their amides, process for their preparation and therapeutic compositions containing them
IT1141287B (en) * 1979-06-13 1986-10-01 Nattermann A & Cie PYROLIDIN ACIDS AMIDS- (2) -ON- (1) -ILALKYL-CARBOXYLS, PROCEDURE FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM
FR2515179A1 (en) * 1981-07-24 1983-04-29 Hoffmann La Roche PYRROLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES FOR THEIR SYNTHESIS AND THEIR THERAPEUTIC APPLICATION
EP0089900B1 (en) * 1982-03-24 1985-12-27 Prodes S.A. New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
DE3420193A1 (en) * 1984-05-30 1985-12-05 Boehringer Ingelheim KG, 6507 Ingelheim NEW SUBSTITUTED PYRROLIDINONES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
US4804400A (en) * 1986-09-12 1989-02-14 Ciba-Geigy Corporation N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof
GB8827389D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
TW544311B (en) * 1998-08-06 2003-08-01 Daiichi Seiyaku Co Therapeutic or preventive agent for intractable epilepsies
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
EP1395560A1 (en) 2001-05-23 2004-03-10 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
ATE410412T1 (en) 2001-08-10 2008-10-15 Ucb Pharma Sa OXOPYRROLIDINE COMPOUNDS, METHOD FOR PREPARING THESE COMPOUNDS AND THEIR USE FOR PRODUCING LEVETIRACETAM AND ANALOGUES
CA2461961A1 (en) * 2001-10-08 2003-04-17 Ucb, S.A. Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders
EP1517893A2 (en) 2003-02-03 2005-03-30 Teva Pharmaceutical Industries Limited Process for producing levetiracetam
ES2214147B1 (en) 2003-02-28 2005-10-01 Farma-Lepori S.A. PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT.
US7531673B2 (en) 2004-02-18 2009-05-12 Dr. Reddy's Laboratories Limited Preparation of amino acid amides
CA2488325C (en) 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
US20080146819A1 (en) * 2005-03-10 2008-06-19 Rubamin Limited Process for Preparing Levetiracetam
CA2610695A1 (en) 2005-06-01 2006-12-07 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
CN102227217A (en) 2008-10-16 2011-10-26 约翰斯.霍普金斯大学 Methods and compositions for improving cognitive function
US8785661B2 (en) 2009-05-13 2014-07-22 Nektar Therapeutics Oligome-containing pyrrolidine compounds
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
EP2533645B1 (en) 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins Methods and compositions for treating schizophrenia
DK2968220T3 (en) 2013-03-15 2021-06-14 Agenebio Inc PROCEDURES AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins Methods and compositions for improving cognitive function
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
ME03518B (en) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
CN104059010A (en) * 2014-06-12 2014-09-24 浙江华海药业股份有限公司 Preparation method of 2-(2-oxopyrrolidine-1-yl)-butyrate
CN106591179B (en) * 2016-12-05 2018-07-03 长兴制药股份有限公司 Methyl packing bacterium and its prepare the application on (S)-α-ethyl -2- oxygen -1- pyrrolidine acetic acid salt in selective fractionation
RU2663899C1 (en) * 2017-07-19 2018-08-13 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Process for the preparation of 1-carbamoylmethyl-4-phenyl-2-pyrrolidone
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams

Also Published As

Publication number Publication date
ES388135A2 (en) 1973-05-01
JPS53130656A (en) 1978-11-14
DK137451B (en) 1978-03-06
FI54916B (en) 1978-12-29
DE2106418C2 (en) 1983-12-22
DE2106418A1 (en) 1971-08-19
FR2081508B2 (en) 1975-06-06
CS167911B2 (en) 1976-05-28
DK137451C (en) 1978-07-24
SU508186A3 (en) 1976-03-25
NL7101697A (en) 1971-08-17
CH530395A (en) 1972-11-15
JPS535301B1 (en) 1978-02-25
SU508185A3 (en) 1976-03-25
ZA71877B (en) 1971-10-27
NL168830B (en) 1981-12-16
GB1309692A (en) 1973-03-14
BE762728R (en) 1971-08-10
JPS5420491B2 (en) 1979-07-23
NL168830C (en) 1982-05-17
FI54916C (en) 1979-04-10
YU30671A (en) 1979-10-31
YU144578A (en) 1982-10-31
MY7400072A (en) 1974-12-31
FR2081508A2 (en) 1971-12-03
CS167912B2 (en) 1976-05-28

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