YU34876B - Process for obtaining novel n-substituted pyrrolidines - Google Patents
Process for obtaining novel n-substituted pyrrolidinesInfo
- Publication number
- YU34876B YU34876B YU306/71A YU30671A YU34876B YU 34876 B YU34876 B YU 34876B YU 306/71 A YU306/71 A YU 306/71A YU 30671 A YU30671 A YU 30671A YU 34876 B YU34876 B YU 34876B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- obtaining novel
- substituted pyrrolidines
- pyrrolidines
- substituted
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB697870A GB1309692A (en) | 1970-02-13 | 1970-02-13 | N-substituted lactams |
Publications (2)
Publication Number | Publication Date |
---|---|
YU30671A YU30671A (en) | 1979-10-31 |
YU34876B true YU34876B (en) | 1980-04-30 |
Family
ID=9824325
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU306/71A YU34876B (en) | 1970-02-13 | 1971-02-10 | Process for obtaining novel n-substituted pyrrolidines |
YU01445/78A YU144578A (en) | 1970-02-13 | 1978-06-19 | Process for obtaining new n-substituted pyrrolidones |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU01445/78A YU144578A (en) | 1970-02-13 | 1978-06-19 | Process for obtaining new n-substituted pyrrolidones |
Country Status (15)
Country | Link |
---|---|
JP (2) | JPS535301B1 (en) |
BE (1) | BE762728R (en) |
CH (1) | CH530395A (en) |
CS (2) | CS167911B2 (en) |
DE (1) | DE2106418C2 (en) |
DK (1) | DK137451B (en) |
ES (1) | ES388135A2 (en) |
FI (1) | FI54916C (en) |
FR (1) | FR2081508B2 (en) |
GB (1) | GB1309692A (en) |
MY (1) | MY7400072A (en) |
NL (1) | NL168830C (en) |
SU (2) | SU508186A3 (en) |
YU (2) | YU34876B (en) |
ZA (1) | ZA71877B (en) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1045043B (en) * | 1975-08-13 | 1980-04-21 | Isf Spa | PYROLIDINE DERIVATIVES |
GB1583871A (en) | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
BE864269A (en) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | NEW N- (AMINOALKYL SUBSTITUTE) -2-OXO-1-PYRROLIDINE-ACETAMIDES AND METHODS FOR PRODUCING THEM |
EP0005689B1 (en) * | 1978-05-08 | 1981-03-18 | U C B, S.A. | Lactam-n-acetic acids, their amides, process for their preparation and therapeutic compositions containing them |
IT1141287B (en) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | PYROLIDIN ACIDS AMIDS- (2) -ON- (1) -ILALKYL-CARBOXYLS, PROCEDURE FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM |
FR2515179A1 (en) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | PYRROLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES FOR THEIR SYNTHESIS AND THEIR THERAPEUTIC APPLICATION |
DE3361609D1 (en) * | 1982-03-24 | 1986-02-06 | Prodes Sa | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
DE3420193A1 (en) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | NEW SUBSTITUTED PYRROLIDINONES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
US4804400A (en) * | 1986-09-12 | 1989-02-14 | Ciba-Geigy Corporation | N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof |
GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
TW544311B (en) * | 1998-08-06 | 2003-08-01 | Daiichi Seiyaku Co | Therapeutic or preventive agent for intractable epilepsies |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
US6686477B2 (en) | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
EP1395560A1 (en) * | 2001-05-23 | 2004-03-10 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
AU2002329233B2 (en) | 2001-08-10 | 2007-08-16 | Ucb Pharma | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
MXPA04002714A (en) * | 2001-10-08 | 2004-07-05 | Ucb Sa | Use of 2-oxo-1-pyrrolidine derivatives for the preparation of a drug. |
CN1802352A (en) | 2003-02-03 | 2006-07-12 | 特瓦制药工业有限公司 | Process for producing levetiracetam |
ES2214147B1 (en) | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT. |
US7531673B2 (en) | 2004-02-18 | 2009-05-12 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
EP1863761A1 (en) * | 2005-03-10 | 2007-12-12 | Rubamin Limited | Process for preparing levetiracetam |
WO2006128692A2 (en) | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system |
EP2147911A1 (en) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Process for the preparation of levetiracetam |
EA033130B1 (en) | 2008-10-16 | 2019-08-30 | Дзе Джонс Хопкинс Юниверсити | Methods and compositions for improving cognitive function |
WO2010132693A2 (en) | 2009-05-13 | 2010-11-18 | Nektar Therapeutics | Oligomer-containing pyrrolidine compounds |
US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
US20110212928A1 (en) | 2010-02-09 | 2011-09-01 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | Methods and compositions for treating schizophrenia |
ES2881081T3 (en) | 2013-03-15 | 2021-11-26 | Agenebio Inc | Procedures and compositions to improve cognitive function |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
KR20200036063A (en) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
JP6629740B2 (en) | 2014-01-21 | 2020-01-15 | ヤンセン ファーマシューティカ エヌ.ベー. | Combinations comprising metabolic glutamatergic receptor subtype 2 positive allosteric modulators or orthosteric agonists and uses thereof |
CN104059010A (en) * | 2014-06-12 | 2014-09-24 | 浙江华海药业股份有限公司 | Preparation method of 2-(2-oxopyrrolidine-1-yl)-butyrate |
CN106591179B (en) * | 2016-12-05 | 2018-07-03 | 长兴制药股份有限公司 | Methyl packing bacterium and its prepare the application on (S)-α-ethyl -2- oxygen -1- pyrrolidine acetic acid salt in selective fractionation |
RU2663899C1 (en) * | 2017-07-19 | 2018-08-13 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Process for the preparation of 1-carbamoylmethyl-4-phenyl-2-pyrrolidone |
US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
US20240132513A1 (en) | 2022-08-19 | 2024-04-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1039113A (en) * | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
-
1970
- 1970-02-13 GB GB697870A patent/GB1309692A/en not_active Expired
-
1971
- 1971-02-08 FR FR7104195A patent/FR2081508B2/fr not_active Expired
- 1971-02-09 NL NLAANVRAGE7101697,A patent/NL168830C/en not_active IP Right Cessation
- 1971-02-10 DK DK59571AA patent/DK137451B/en not_active IP Right Cessation
- 1971-02-10 YU YU306/71A patent/YU34876B/en unknown
- 1971-02-10 CS CS987A patent/CS167911B2/cs unknown
- 1971-02-10 FI FI383/71A patent/FI54916C/en active
- 1971-02-10 BE BE762728A patent/BE762728R/en active
- 1971-02-10 ES ES388135A patent/ES388135A2/en not_active Expired
- 1971-02-11 ZA ZA710877A patent/ZA71877B/en unknown
- 1971-02-11 DE DE2106418A patent/DE2106418C2/en not_active Expired
- 1971-02-11 CH CH200171A patent/CH530395A/en not_active IP Right Cessation
- 1971-02-12 SU SU1893858A patent/SU508186A3/en active
- 1971-02-12 JP JP612471A patent/JPS535301B1/ja active Pending
- 1971-02-12 SU SU1621307A patent/SU508185A3/en active
- 1971-12-10 CS CS140674A patent/CS167912B2/cs unknown
-
1974
- 1974-12-31 MY MY197472A patent/MY7400072A/en unknown
-
1977
- 1977-11-07 JP JP13335277A patent/JPS53130656A/en active Granted
-
1978
- 1978-06-19 YU YU01445/78A patent/YU144578A/en unknown
Also Published As
Publication number | Publication date |
---|---|
YU30671A (en) | 1979-10-31 |
JPS535301B1 (en) | 1978-02-25 |
SU508185A3 (en) | 1976-03-25 |
NL168830B (en) | 1981-12-16 |
SU508186A3 (en) | 1976-03-25 |
YU144578A (en) | 1982-10-31 |
BE762728R (en) | 1971-08-10 |
FI54916B (en) | 1978-12-29 |
FR2081508B2 (en) | 1975-06-06 |
NL7101697A (en) | 1971-08-17 |
CS167911B2 (en) | 1976-05-28 |
FI54916C (en) | 1979-04-10 |
DK137451C (en) | 1978-07-24 |
DE2106418A1 (en) | 1971-08-19 |
ES388135A2 (en) | 1973-05-01 |
DK137451B (en) | 1978-03-06 |
JPS5420491B2 (en) | 1979-07-23 |
CS167912B2 (en) | 1976-05-28 |
ZA71877B (en) | 1971-10-27 |
MY7400072A (en) | 1974-12-31 |
NL168830C (en) | 1982-05-17 |
JPS53130656A (en) | 1978-11-14 |
GB1309692A (en) | 1973-03-14 |
DE2106418C2 (en) | 1983-12-22 |
FR2081508A2 (en) | 1971-12-03 |
CH530395A (en) | 1972-11-15 |
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