CH530395A - Process for the preparation of new N-substituted lactams - Google Patents
Process for the preparation of new N-substituted lactamsInfo
- Publication number
- CH530395A CH530395A CH200171A CH200171A CH530395A CH 530395 A CH530395 A CH 530395A CH 200171 A CH200171 A CH 200171A CH 200171 A CH200171 A CH 200171A CH 530395 A CH530395 A CH 530395A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- new
- substituted lactams
- lactams
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB697870A GB1309692A (en) | 1970-02-13 | 1970-02-13 | N-substituted lactams |
Publications (1)
Publication Number | Publication Date |
---|---|
CH530395A true CH530395A (en) | 1972-11-15 |
Family
ID=9824325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH200171A CH530395A (en) | 1970-02-13 | 1971-02-11 | Process for the preparation of new N-substituted lactams |
Country Status (15)
Country | Link |
---|---|
JP (2) | JPS535301B1 (en) |
BE (1) | BE762728R (en) |
CH (1) | CH530395A (en) |
CS (2) | CS167911B2 (en) |
DE (1) | DE2106418C2 (en) |
DK (1) | DK137451B (en) |
ES (1) | ES388135A2 (en) |
FI (1) | FI54916C (en) |
FR (1) | FR2081508B2 (en) |
GB (1) | GB1309692A (en) |
MY (1) | MY7400072A (en) |
NL (1) | NL168830C (en) |
SU (2) | SU508186A3 (en) |
YU (2) | YU34876B (en) |
ZA (1) | ZA71877B (en) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1045043B (en) * | 1975-08-13 | 1980-04-21 | Isf Spa | PYROLIDINE DERIVATIVES |
GB1583871A (en) | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
BE864269A (en) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | NEW N- (AMINOALKYL SUBSTITUTE) -2-OXO-1-PYRROLIDINE-ACETAMIDES AND METHODS FOR PRODUCING THEM |
EP0005689B1 (en) * | 1978-05-08 | 1981-03-18 | U C B, S.A. | Lactam-n-acetic acids, their amides, process for their preparation and therapeutic compositions containing them |
IT1141287B (en) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | PYROLIDIN ACIDS AMIDS- (2) -ON- (1) -ILALKYL-CARBOXYLS, PROCEDURE FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM |
FR2515179A1 (en) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | PYRROLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES FOR THEIR SYNTHESIS AND THEIR THERAPEUTIC APPLICATION |
DE3361609D1 (en) * | 1982-03-24 | 1986-02-06 | Prodes Sa | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
DE3420193A1 (en) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | NEW SUBSTITUTED PYRROLIDINONES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
US4804400A (en) * | 1986-09-12 | 1989-02-14 | Ciba-Geigy Corporation | N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof |
GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
TW544311B (en) * | 1998-08-06 | 2003-08-01 | Daiichi Seiyaku Co | Therapeutic or preventive agent for intractable epilepsies |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
US6686477B2 (en) | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
EP1395560A1 (en) | 2001-05-23 | 2004-03-10 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
DE60229267D1 (en) * | 2001-08-10 | 2008-11-20 | Ucb Pharma Sa | OXOPYRROLIDINE COMPOUNDS, METHOD FOR PRODUCING THESE COMPOUNDS AND THEIR USE FOR THE PRODUCTION OF LEVETIRACETAM AND ANALOGUE |
WO2003030899A2 (en) * | 2001-10-08 | 2003-04-17 | Ucb, S.A. | Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders |
US7132552B2 (en) | 2003-02-03 | 2006-11-07 | Teva Pharmaceutical Industries, Ltd. | Process for producing levetiracetam |
ES2214147B1 (en) * | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT. |
US7531673B2 (en) | 2004-02-18 | 2009-05-12 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
US20080146819A1 (en) * | 2005-03-10 | 2008-06-19 | Rubamin Limited | Process for Preparing Levetiracetam |
CA2610695A1 (en) | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system |
EP2147911A1 (en) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Process for the preparation of levetiracetam |
ES2637497T3 (en) | 2008-10-16 | 2017-10-13 | The Johns Hopkins University | Procedures and compositions for the improvement of cognitive function |
WO2010132693A2 (en) | 2009-05-13 | 2010-11-18 | Nektar Therapeutics | Oligomer-containing pyrrolidine compounds |
US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
CN102905532A (en) | 2010-02-09 | 2013-01-30 | 约翰斯.霍普金斯大学 | Methods and compositions for improving cognitive function |
US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
ES2881081T3 (en) | 2013-03-15 | 2021-11-26 | Agenebio Inc | Procedures and compositions to improve cognitive function |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
IL279202B2 (en) | 2014-01-21 | 2023-09-01 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
PL3431106T3 (en) | 2014-01-21 | 2021-06-28 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use |
CN104059010A (en) * | 2014-06-12 | 2014-09-24 | 浙江华海药业股份有限公司 | Preparation method of 2-(2-oxopyrrolidine-1-yl)-butyrate |
CN106591179B (en) * | 2016-12-05 | 2018-07-03 | 长兴制药股份有限公司 | Methyl packing bacterium and its prepare the application on (S)-α-ethyl -2- oxygen -1- pyrrolidine acetic acid salt in selective fractionation |
RU2663899C1 (en) * | 2017-07-19 | 2018-08-13 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Process for the preparation of 1-carbamoylmethyl-4-phenyl-2-pyrrolidone |
US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1039113A (en) * | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
-
1970
- 1970-02-13 GB GB697870A patent/GB1309692A/en not_active Expired
-
1971
- 1971-02-08 FR FR7104195A patent/FR2081508B2/fr not_active Expired
- 1971-02-09 NL NLAANVRAGE7101697,A patent/NL168830C/en not_active IP Right Cessation
- 1971-02-10 CS CS987A patent/CS167911B2/cs unknown
- 1971-02-10 BE BE762728A patent/BE762728R/en active
- 1971-02-10 DK DK59571AA patent/DK137451B/en not_active IP Right Cessation
- 1971-02-10 FI FI383/71A patent/FI54916C/en active
- 1971-02-10 YU YU306/71A patent/YU34876B/en unknown
- 1971-02-10 ES ES388135A patent/ES388135A2/en not_active Expired
- 1971-02-11 DE DE2106418A patent/DE2106418C2/en not_active Expired
- 1971-02-11 ZA ZA710877A patent/ZA71877B/en unknown
- 1971-02-11 CH CH200171A patent/CH530395A/en not_active IP Right Cessation
- 1971-02-12 SU SU1893858A patent/SU508186A3/en active
- 1971-02-12 JP JP612471A patent/JPS535301B1/ja active Pending
- 1971-02-12 SU SU1621307A patent/SU508185A3/en active
- 1971-12-10 CS CS140674A patent/CS167912B2/cs unknown
-
1974
- 1974-12-31 MY MY197472A patent/MY7400072A/en unknown
-
1977
- 1977-11-07 JP JP13335277A patent/JPS53130656A/en active Granted
-
1978
- 1978-06-19 YU YU01445/78A patent/YU144578A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPS5420491B2 (en) | 1979-07-23 |
YU30671A (en) | 1979-10-31 |
MY7400072A (en) | 1974-12-31 |
CS167912B2 (en) | 1976-05-28 |
NL168830C (en) | 1982-05-17 |
GB1309692A (en) | 1973-03-14 |
YU34876B (en) | 1980-04-30 |
ES388135A2 (en) | 1973-05-01 |
DE2106418C2 (en) | 1983-12-22 |
DK137451B (en) | 1978-03-06 |
DE2106418A1 (en) | 1971-08-19 |
FR2081508B2 (en) | 1975-06-06 |
FI54916B (en) | 1978-12-29 |
NL7101697A (en) | 1971-08-17 |
FR2081508A2 (en) | 1971-12-03 |
BE762728R (en) | 1971-08-10 |
CS167911B2 (en) | 1976-05-28 |
SU508185A3 (en) | 1976-03-25 |
SU508186A3 (en) | 1976-03-25 |
YU144578A (en) | 1982-10-31 |
DK137451C (en) | 1978-07-24 |
ZA71877B (en) | 1971-10-27 |
FI54916C (en) | 1979-04-10 |
JPS53130656A (en) | 1978-11-14 |
NL168830B (en) | 1981-12-16 |
JPS535301B1 (en) | 1978-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PL | Patent ceased |