CS167912B2 - - Google Patents
Info
- Publication number
- CS167912B2 CS167912B2 CS140674A CS140674A CS167912B2 CS 167912 B2 CS167912 B2 CS 167912B2 CS 140674 A CS140674 A CS 140674A CS 140674 A CS140674 A CS 140674A CS 167912 B2 CS167912 B2 CS 167912B2
- Authority
- CS
- Czechoslovakia
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB697870A GB1309692A (en) | 1970-02-13 | 1970-02-13 | N-substituted lactams |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS167912B2 true CS167912B2 (en) | 1976-05-28 |
Family
ID=9824325
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS987A CS167911B2 (en) | 1970-02-13 | 1971-02-10 | |
| CS140674A CS167912B2 (en) | 1970-02-13 | 1971-12-10 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS987A CS167911B2 (en) | 1970-02-13 | 1971-02-10 |
Country Status (15)
| Country | Link |
|---|---|
| JP (2) | JPS535301B1 (en) |
| BE (1) | BE762728R (en) |
| CH (1) | CH530395A (en) |
| CS (2) | CS167911B2 (en) |
| DE (1) | DE2106418C2 (en) |
| DK (1) | DK137451B (en) |
| ES (1) | ES388135A2 (en) |
| FI (1) | FI54916C (en) |
| FR (1) | FR2081508B2 (en) |
| GB (1) | GB1309692A (en) |
| MY (1) | MY7400072A (en) |
| NL (1) | NL168830C (en) |
| SU (2) | SU508186A3 (en) |
| YU (2) | YU34876B (en) |
| ZA (1) | ZA71877B (en) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1045043B (en) * | 1975-08-13 | 1980-04-21 | Isf Spa | PYROLIDINE DERIVATIVES |
| GB1583871A (en) | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
| BE864269A (en) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | NEW N- (AMINOALKYL SUBSTITUTE) -2-OXO-1-PYRROLIDINE-ACETAMIDES AND METHODS FOR PRODUCING THEM |
| EP0005689B1 (en) * | 1978-05-08 | 1981-03-18 | U C B, S.A. | Lactam-n-acetic acids, their amides, process for their preparation and therapeutic compositions containing them |
| IT1141287B (en) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | PYROLIDIN ACIDS AMIDS- (2) -ON- (1) -ILALKYL-CARBOXYLS, PROCEDURE FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM |
| FR2515179A1 (en) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | PYRROLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES FOR THEIR SYNTHESIS AND THEIR THERAPEUTIC APPLICATION |
| DE3361609D1 (en) * | 1982-03-24 | 1986-02-06 | Prodes Sa | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| DE3420193A1 (en) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | NEW SUBSTITUTED PYRROLIDINONES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
| US4804400A (en) * | 1986-09-12 | 1989-02-14 | Ciba-Geigy Corporation | N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof |
| GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| TW544311B (en) * | 1998-08-06 | 2003-08-01 | Daiichi Seiyaku Co | Therapeutic or preventive agent for intractable epilepsies |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6686477B2 (en) | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
| WO2002094787A1 (en) | 2001-05-23 | 2002-11-28 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
| US7122682B2 (en) * | 2001-08-10 | 2006-10-17 | Ucb, S.A. | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
| DE60218193T2 (en) * | 2001-10-08 | 2007-11-22 | Ucb S.A. | USE OF 2-OXO-1-PYRROLIDINE DERIVATIVES FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF DYSKINESIA |
| CA2515090A1 (en) | 2003-02-03 | 2004-08-19 | Teva Pharmaceutical Industries Ltd | Process for producing levetiracetam |
| ES2214147B1 (en) | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT. |
| CA2497062A1 (en) | 2004-02-18 | 2005-08-18 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
| CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| US20080146819A1 (en) * | 2005-03-10 | 2008-06-19 | Rubamin Limited | Process for Preparing Levetiracetam |
| AU2006254335A1 (en) | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system |
| EP2147911A1 (en) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Process for the preparation of levetiracetam |
| DK3260118T3 (en) | 2008-10-16 | 2021-04-19 | Univ Johns Hopkins | PROCEDURES AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| WO2010132693A2 (en) | 2009-05-13 | 2010-11-18 | Nektar Therapeutics | Oligomer-containing pyrrolidine compounds |
| US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
| CN109662964A (en) | 2010-02-09 | 2019-04-23 | 约翰斯.霍普金斯大学 | For improving the method and composition of cognitive function |
| JP6440625B2 (en) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | Methods and compositions for treating schizophrenia |
| JP6433482B2 (en) | 2013-03-15 | 2018-12-05 | エージンバイオ， インコーポレイテッド | Methods and compositions for improving cognitive function |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| PT3096790T (en) | 2014-01-21 | 2019-10-15 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| DK3431106T3 (en) | 2014-01-21 | 2021-03-15 | Janssen Pharmaceutica Nv | COMBINATIONS INCLUDING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROP GLUTAMATERG SUBTYPE 2 RECEPTOR AND USE OF THESE |
| CN104059010A (en) * | 2014-06-12 | 2014-09-24 | 浙江华海药业股份有限公司 | Preparation method of 2-(2-oxopyrrolidine-1-yl)-butyrate |
| CN106591179B (en) * | 2016-12-05 | 2018-07-03 | 长兴制药股份有限公司 | Methyl packing bacterium and its prepare the application on (S)-α-ethyl -2- oxygen -1- pyrrolidine acetic acid salt in selective fractionation |
| RU2663899C1 (en) * | 2017-07-19 | 2018-08-13 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Process for the preparation of 1-carbamoylmethyl-4-phenyl-2-pyrrolidone |
| US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
| CN113979911A (en) * | 2021-11-12 | 2022-01-28 | 汤斌 | Method for extracting etiracetam from giant salamander peptide |
| JP2025529834A (en) | 2022-08-19 | 2025-09-09 | エージンバイオ， インコーポレイテッド | Benzazepine derivatives, compositions and methods for treating cognitive disorders |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1039113A (en) * | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
-
1970
- 1970-02-13 GB GB697870A patent/GB1309692A/en not_active Expired
-
1971
- 1971-02-08 FR FR7104195A patent/FR2081508B2/fr not_active Expired
- 1971-02-09 NL NLAANVRAGE7101697,A patent/NL168830C/en not_active IP Right Cessation
- 1971-02-10 ES ES388135A patent/ES388135A2/en not_active Expired
- 1971-02-10 DK DK59571AA patent/DK137451B/en not_active IP Right Cessation
- 1971-02-10 YU YU306/71A patent/YU34876B/en unknown
- 1971-02-10 BE BE762728A patent/BE762728R/en active
- 1971-02-10 CS CS987A patent/CS167911B2/cs unknown
- 1971-02-10 FI FI383/71A patent/FI54916C/en active
- 1971-02-11 DE DE2106418A patent/DE2106418C2/en not_active Expired
- 1971-02-11 CH CH200171A patent/CH530395A/en not_active IP Right Cessation
- 1971-02-11 ZA ZA710877A patent/ZA71877B/en unknown
- 1971-02-12 JP JP612471A patent/JPS535301B1/ja active Pending
- 1971-02-12 SU SU1893858A patent/SU508186A3/en active
- 1971-02-12 SU SU1621307A patent/SU508185A3/en active
- 1971-12-10 CS CS140674A patent/CS167912B2/cs unknown
-
1974
- 1974-12-31 MY MY197472A patent/MY7400072A/en unknown
-
1977
- 1977-11-07 JP JP13335277A patent/JPS53130656A/en active Granted
-
1978
- 1978-06-19 YU YU01445/78A patent/YU144578A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU30671A (en) | 1979-10-31 |
| ZA71877B (en) | 1971-10-27 |
| JPS5420491B2 (en) | 1979-07-23 |
| GB1309692A (en) | 1973-03-14 |
| NL7101697A (en) | 1971-08-17 |
| FR2081508B2 (en) | 1975-06-06 |
| CS167911B2 (en) | 1976-05-28 |
| NL168830C (en) | 1982-05-17 |
| JPS53130656A (en) | 1978-11-14 |
| YU34876B (en) | 1980-04-30 |
| FI54916C (en) | 1979-04-10 |
| CH530395A (en) | 1972-11-15 |
| NL168830B (en) | 1981-12-16 |
| FI54916B (en) | 1978-12-29 |
| YU144578A (en) | 1982-10-31 |
| DK137451B (en) | 1978-03-06 |
| ES388135A2 (en) | 1973-05-01 |
| FR2081508A2 (en) | 1971-12-03 |
| JPS535301B1 (en) | 1978-02-25 |
| DE2106418C2 (en) | 1983-12-22 |
| BE762728R (en) | 1971-08-10 |
| DE2106418A1 (en) | 1971-08-19 |
| SU508185A3 (en) | 1976-03-25 |
| SU508186A3 (en) | 1976-03-25 |
| DK137451C (en) | 1978-07-24 |
| MY7400072A (en) | 1974-12-31 |