FI54916C - Foerfarande foer framstaellning av terapeutiskt verksamma n-substituerade 2-pyrrolidoner - Google Patents
Foerfarande foer framstaellning av terapeutiskt verksamma n-substituerade 2-pyrrolidonerInfo
- Publication number
- FI54916C FI54916C FI383/71A FI38371A FI54916C FI 54916 C FI54916 C FI 54916C FI 383/71 A FI383/71 A FI 383/71A FI 38371 A FI38371 A FI 38371A FI 54916 C FI54916 C FI 54916C
- Authority
- FI
- Finland
- Prior art keywords
- pyrrolidoner
- nutritional
- substitute
- framework
- therapeutic treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB697870A GB1309692A (en) | 1970-02-13 | 1970-02-13 | N-substituted lactams |
Publications (2)
Publication Number | Publication Date |
---|---|
FI54916B FI54916B (fi) | 1978-12-29 |
FI54916C true FI54916C (fi) | 1979-04-10 |
Family
ID=9824325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI383/71A FI54916C (fi) | 1970-02-13 | 1971-02-10 | Foerfarande foer framstaellning av terapeutiskt verksamma n-substituerade 2-pyrrolidoner |
Country Status (15)
Country | Link |
---|---|
JP (2) | JPS535301B1 (fi) |
BE (1) | BE762728R (fi) |
CH (1) | CH530395A (fi) |
CS (2) | CS167911B2 (fi) |
DE (1) | DE2106418C2 (fi) |
DK (1) | DK137451B (fi) |
ES (1) | ES388135A2 (fi) |
FI (1) | FI54916C (fi) |
FR (1) | FR2081508B2 (fi) |
GB (1) | GB1309692A (fi) |
MY (1) | MY7400072A (fi) |
NL (1) | NL168830C (fi) |
SU (2) | SU508186A3 (fi) |
YU (2) | YU34876B (fi) |
ZA (1) | ZA71877B (fi) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
GB1583871A (en) | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
EP0005689B1 (fr) * | 1978-05-08 | 1981-03-18 | U C B, S.A. | Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques |
IT1141287B (it) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
DE3361609D1 (en) * | 1982-03-24 | 1986-02-06 | Prodes Sa | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
US4804400A (en) * | 1986-09-12 | 1989-02-14 | Ciba-Geigy Corporation | N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof |
GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
AR020115A1 (es) * | 1998-08-06 | 2002-04-10 | Daiichi Seiyaku Co | Agente terapeutico o preventivo para epilepsias rebeldes y uso del compuesto para la produccion de los mismos |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
US6686477B2 (en) * | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
WO2002094787A1 (en) | 2001-05-23 | 2002-11-28 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
EP1419144B1 (en) * | 2001-08-10 | 2008-10-08 | UCB Pharma S.A. | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
US20040242671A1 (en) * | 2001-10-08 | 2004-12-02 | Renee Grimee | Use of 2-oxo-1-pyrrolidine derivatives for the preparation of a drug |
WO2004069796A2 (en) | 2003-02-03 | 2004-08-19 | Teva Pharmaceutical Industries Ltd. | Process for producing levetiracetam |
ES2214147B1 (es) * | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | Procedimiento de obtencion de un agente antiepileptico. |
US7531673B2 (en) | 2004-02-18 | 2009-05-12 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
EP1863761A1 (en) * | 2005-03-10 | 2007-12-12 | Rubamin Limited | Process for preparing levetiracetam |
WO2006128693A2 (en) | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2 -oxo-i -pyrrolidine derivatives/ processes for preparing them and their therapeutic use on the central nervous system |
EP2147911A1 (en) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Process for the preparation of levetiracetam |
CN107243007A (zh) | 2008-10-16 | 2017-10-13 | 约翰斯.霍普金斯大学 | 改善认知功能的方法和组合物 |
US8785661B2 (en) | 2009-05-13 | 2014-07-22 | Nektar Therapeutics | Oligome-containing pyrrolidine compounds |
US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
BR112012019923A2 (pt) | 2010-02-09 | 2016-08-09 | Univ Johns Hopkins | métodos e composições para melhorar a função cognitiva |
CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
EP2968220B1 (en) | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
KR20200036063A (ko) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
CN104059010A (zh) * | 2014-06-12 | 2014-09-24 | 浙江华海药业股份有限公司 | 一种制备2-(2-氧代吡咯烷-1-基)-丁酸酯的方法 |
CN106591179B (zh) * | 2016-12-05 | 2018-07-03 | 长兴制药股份有限公司 | 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用 |
RU2663899C1 (ru) * | 2017-07-19 | 2018-08-13 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Способ получения 1-карбамоилметил-4-фенил-2-пирролидона |
US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1039113A (en) * | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
-
1970
- 1970-02-13 GB GB697870A patent/GB1309692A/en not_active Expired
-
1971
- 1971-02-08 FR FR7104195A patent/FR2081508B2/fr not_active Expired
- 1971-02-09 NL NLAANVRAGE7101697,A patent/NL168830C/xx not_active IP Right Cessation
- 1971-02-10 ES ES388135A patent/ES388135A2/es not_active Expired
- 1971-02-10 DK DK59571AA patent/DK137451B/da not_active IP Right Cessation
- 1971-02-10 CS CS987A patent/CS167911B2/cs unknown
- 1971-02-10 BE BE762728A patent/BE762728R/xx active
- 1971-02-10 FI FI383/71A patent/FI54916C/fi active
- 1971-02-10 YU YU306/71A patent/YU34876B/xx unknown
- 1971-02-11 ZA ZA710877A patent/ZA71877B/xx unknown
- 1971-02-11 CH CH200171A patent/CH530395A/fr not_active IP Right Cessation
- 1971-02-11 DE DE2106418A patent/DE2106418C2/de not_active Expired
- 1971-02-12 SU SU1893858A patent/SU508186A3/ru active
- 1971-02-12 JP JP612471A patent/JPS535301B1/ja active Pending
- 1971-02-12 SU SU1621307A patent/SU508185A3/ru active
- 1971-12-10 CS CS140674A patent/CS167912B2/cs unknown
-
1974
- 1974-12-31 MY MY197472A patent/MY7400072A/xx unknown
-
1977
- 1977-11-07 JP JP13335277A patent/JPS53130656A/ja active Granted
-
1978
- 1978-06-19 YU YU01445/78A patent/YU144578A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JPS5420491B2 (fi) | 1979-07-23 |
CH530395A (fr) | 1972-11-15 |
GB1309692A (en) | 1973-03-14 |
SU508185A3 (ru) | 1976-03-25 |
YU30671A (en) | 1979-10-31 |
CS167911B2 (fi) | 1976-05-28 |
BE762728R (fr) | 1971-08-10 |
NL168830B (nl) | 1981-12-16 |
JPS535301B1 (fi) | 1978-02-25 |
CS167912B2 (fi) | 1976-05-28 |
FR2081508B2 (fi) | 1975-06-06 |
DK137451C (fi) | 1978-07-24 |
FI54916B (fi) | 1978-12-29 |
JPS53130656A (en) | 1978-11-14 |
DE2106418C2 (de) | 1983-12-22 |
NL168830C (nl) | 1982-05-17 |
DE2106418A1 (de) | 1971-08-19 |
YU34876B (en) | 1980-04-30 |
ES388135A2 (es) | 1973-05-01 |
DK137451B (da) | 1978-03-06 |
SU508186A3 (ru) | 1976-03-25 |
NL7101697A (fi) | 1971-08-17 |
MY7400072A (en) | 1974-12-31 |
YU144578A (en) | 1982-10-31 |
ZA71877B (en) | 1971-10-27 |
FR2081508A2 (fi) | 1971-12-03 |
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