DK1366018T3 - Omega-aminoalkylamid r af (r)-2-aryl-propionsyrer som inhibitorer af kemotaksien af polymorphonukleat og mononukleatceller - Google Patents
Omega-aminoalkylamid r af (r)-2-aryl-propionsyrer som inhibitorer af kemotaksien af polymorphonukleat og mononukleatceller Download PDFInfo
- Publication number
- DK1366018T3 DK1366018T3 DK02744900.8T DK02744900T DK1366018T3 DK 1366018 T3 DK1366018 T3 DK 1366018T3 DK 02744900 T DK02744900 T DK 02744900T DK 1366018 T3 DK1366018 T3 DK 1366018T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenyl
- propionamide
- isobutyl
- propyl
- dimethylamino
- Prior art date
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- -1 4-isobutyl-phenyl Chemical group 0.000 claims description 46
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Classifications
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- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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IT2001MI000395A ITMI20010395A1 (it) | 2001-02-27 | 2001-02-27 | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
PCT/EP2002/001974 WO2002068377A1 (en) | 2001-02-27 | 2002-02-25 | Omega-aminoalkylamides of r-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells |
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ITMI20010395A1 (it) * | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
SI1590314T1 (sl) * | 2003-02-06 | 2015-12-31 | Dompe Farmaceutici S.P.A. | 2-aril-ocetne kisline, njihovi derivati in farmacevtski sestavki, ki jih vsebujejo |
EP1457485A1 (en) * | 2003-03-14 | 2004-09-15 | Dompé S.P.A. | Sulfonic acids, their derivatives and pharmaceutical compositions containing them |
CA2530075C (en) * | 2003-06-27 | 2012-08-21 | Harvey Pollard | Amphiphilic pyridinium compounds, method of making and use thereof |
EP1776336B1 (en) * | 2004-03-23 | 2009-09-30 | DOMPE' pha.r.ma s.p.a. | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them |
CA2589495C (en) | 2004-12-15 | 2013-10-01 | Dompe Pha.R.Ma. S.P.A. | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them |
CA2592608A1 (en) * | 2005-01-25 | 2006-08-03 | Dompe Pha.R.Ma. S.P.A. | Metabolites of 2-arylpropionic acid derivatives and pharmaceutical compositions containing them |
EP1739078A1 (de) | 2005-05-30 | 2007-01-03 | Jerini AG | C5a-Rezeptor-Antagonisten |
ES2597843T3 (es) * | 2005-11-24 | 2017-01-23 | Dompé Farmaceutici S.P.A. | Derivados de (R)-arilalquilamino y composiciones farmacéuticas que los contienen |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
CN103948571A (zh) * | 2006-07-18 | 2014-07-30 | 天津昕晨泰飞尔医药科技有限公司 | 具有快速皮肤穿透率的带正电荷的水溶性布洛芬前药 |
EP3210964A1 (en) * | 2006-07-18 | 2017-08-30 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
CN108250090B (zh) * | 2006-07-27 | 2021-08-20 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
CN103772259B (zh) * | 2006-08-08 | 2016-08-31 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药 |
CN103772258B (zh) * | 2006-08-08 | 2016-09-28 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药 |
HUE028425T2 (en) * | 2006-08-08 | 2016-12-28 | Techfields Biochem Co Ltd | Positive charged water-soluble prodrugs of aryl and heteroarylacetic acids with very fast skin penetration rate |
AU2006347391B2 (en) * | 2006-08-15 | 2013-03-07 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
WO2008110351A2 (en) * | 2007-03-15 | 2008-09-18 | Dompe' Pha.R.Ma S.P.A. | Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents |
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