US4069316A
(en)
*
|
1976-11-01 |
1978-01-17 |
Takeda Chemical Industries, Ltd. |
Method for producing antibiotic T-42082 and antibiotic T-42082
|
US4230692A
(en)
*
|
1978-11-03 |
1980-10-28 |
Ayerst Mckenna & Harrison, Inc. |
Ravidomycin and process of preparation
|
US5206018A
(en)
*
|
1978-11-03 |
1993-04-27 |
Ayerst, Mckenna & Harrison, Inc. |
Use of rapamycin in treatment of tumors
|
US5066493A
(en)
*
|
1978-11-03 |
1991-11-19 |
American Home Products Corporation |
Rapamycin in treatment of tumors
|
AU543727B2
(en)
|
1980-06-02 |
1985-05-02 |
Ayerst Mckenna & Harrison Inc. |
Injectable composition of rapamycin
|
US4316885A
(en)
*
|
1980-08-25 |
1982-02-23 |
Ayerst, Mckenna And Harrison, Inc. |
Acyl derivatives of rapamycin
|
US4401653A
(en)
*
|
1981-03-09 |
1983-08-30 |
Ayerst, Mckenna & Harrison Inc. |
Combination of rapamycin and picibanil for the treatment of tumors
|
US4375464A
(en)
*
|
1981-11-19 |
1983-03-01 |
Ayerst, Mckenna & Harrison Inc. |
Antibiotic AY24,668 and process of preparation
|
AR240943A1
(es)
*
|
1985-02-05 |
1991-03-27 |
Sankio Company Limited |
Nuevo compuesto agroquimico denominado "sustancia n*51262" procedimiento para prepararlo y composicion que lo comprende"
|
US5100899A
(en)
*
|
1989-06-06 |
1992-03-31 |
Roy Calne |
Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
|
US5023264A
(en)
*
|
1990-07-16 |
1991-06-11 |
American Home Products Corporation |
Rapamycin oximes
|
US5120726A
(en)
*
|
1991-03-08 |
1992-06-09 |
American Home Products Corporation |
Rapamycin hydrazones
|
US5023263A
(en)
*
|
1990-08-09 |
1991-06-11 |
American Home Products Corporation |
42-oxorapamycin
|
US5023262A
(en)
*
|
1990-08-14 |
1991-06-11 |
American Home Products Corporation |
Hydrogenated rapamycin derivatives
|
US5358944A
(en)
*
|
1990-09-19 |
1994-10-25 |
American Home Products Corporation |
Rapamycin esters for treating transplantation rejection
|
US5378696A
(en)
*
|
1990-09-19 |
1995-01-03 |
American Home Products Corporation |
Rapamycin esters
|
US5130307A
(en)
*
|
1990-09-28 |
1992-07-14 |
American Home Products Corporation |
Aminoesters of rapamycin
|
US5221670A
(en)
*
|
1990-09-19 |
1993-06-22 |
American Home Products Corporation |
Rapamycin esters
|
US5233036A
(en)
*
|
1990-10-16 |
1993-08-03 |
American Home Products Corporation |
Rapamycin alkoxyesters
|
US5080899A
(en)
*
|
1991-02-22 |
1992-01-14 |
American Home Products Corporation |
Method of treating pulmonary inflammation
|
US5078999A
(en)
*
|
1991-02-22 |
1992-01-07 |
American Home Products Corporation |
Method of treating systemic lupus erythematosus
|
US5120842A
(en)
*
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
US5321009A
(en)
*
|
1991-04-03 |
1994-06-14 |
American Home Products Corporation |
Method of treating diabetes
|
US5100883A
(en)
*
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
US5118678A
(en)
*
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5147877A
(en)
*
|
1991-04-18 |
1992-09-15 |
Merck & Co. Inc. |
Semi-synthetic immunosuppressive macrolides
|
US5091389A
(en)
*
|
1991-04-23 |
1992-02-25 |
Merck & Co., Inc. |
Lipophilic macrolide useful as an immunosuppressant
|
US5102876A
(en)
*
|
1991-05-07 |
1992-04-07 |
American Home Products Corporation |
Reduction products of rapamycin
|
US5138051A
(en)
*
|
1991-08-07 |
1992-08-11 |
American Home Products Corporation |
Rapamycin analogs as immunosuppressants and antifungals
|
US5776943A
(en)
*
|
1991-05-14 |
1998-07-07 |
American Home Products Corporation |
Rapamycin metabolites
|
US5118677A
(en)
*
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
US5120727A
(en)
*
|
1991-05-29 |
1992-06-09 |
American Home Products Corporation |
Rapamycin dimers
|
US5120725A
(en)
*
|
1991-05-29 |
1992-06-09 |
American Home Products Corporation |
Bicyclic rapamycins
|
DE69209183T2
(de)
|
1991-06-18 |
1996-08-08 |
American Home Prod |
Verwendung von Rapamycin zur Behandlung von T-Zellen Lymphom/Leukämie bei Erwachsenen
|
ZA924953B
(en)
*
|
1991-07-25 |
1993-04-28 |
Univ Louisville Res Found |
Method of treating ocular inflammation
|
US5162333A
(en)
*
|
1991-09-11 |
1992-11-10 |
American Home Products Corporation |
Aminodiesters of rapamycin
|
US5286731A
(en)
*
|
1991-09-17 |
1994-02-15 |
American Home Products Corporation |
Method of treating immunoinflammatory bowel disease
|
US5286730A
(en)
*
|
1991-09-17 |
1994-02-15 |
American Home Products Corporation |
Method of treating immunoinflammatory disease
|
US5151413A
(en)
*
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
US5164399A
(en)
*
|
1991-11-18 |
1992-11-17 |
American Home Products Corporation |
Rapamycin pyrazoles
|
US5516781A
(en)
*
|
1992-01-09 |
1996-05-14 |
American Home Products Corporation |
Method of treating restenosis with rapamycin
|
US5221740A
(en)
*
|
1992-01-16 |
1993-06-22 |
American Home Products Corporation |
Oxepane isomers of rapamycin useful as immunosuppressive agents
|
US5262424A
(en)
*
|
1992-02-18 |
1993-11-16 |
American Home Products Corporation |
Composition of sulfonylcarbamates of rapamycin and method of treating diseases requiring immunosuppression therewith
|
US5177203A
(en)
*
|
1992-03-05 |
1993-01-05 |
American Home Products Corporation |
Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
|
ATE138807T1
(de)
|
1992-03-27 |
1996-06-15 |
American Home Prod |
29-demethoxyrapamycin zur induktion der immunosuppression
|
NZ251628A
(en)
*
|
1992-03-30 |
1996-07-26 |
American Home Prod |
Aqueous insectable rapamycin solution; product containing concentrate and diluent solutions
|
US5288711A
(en)
*
|
1992-04-28 |
1994-02-22 |
American Home Products Corporation |
Method of treating hyperproliferative vascular disease
|
US5256790A
(en)
*
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
CA2106034A1
(en)
*
|
1992-09-24 |
1994-03-25 |
Ralph J. Russo |
21-norrapamycin
|
US5318895A
(en)
*
|
1992-10-05 |
1994-06-07 |
Merck & Co., Inc. |
Aspergillus niger mutants
|
US5480988A
(en)
*
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5489680A
(en)
*
|
1992-10-13 |
1996-02-06 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5434260A
(en)
*
|
1992-10-13 |
1995-07-18 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5480989A
(en)
*
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5302584A
(en)
*
|
1992-10-13 |
1994-04-12 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5262423A
(en)
*
|
1992-10-29 |
1993-11-16 |
American Home Products Corporation |
Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents
|
US5258389A
(en)
*
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
US5260300A
(en)
*
|
1992-11-19 |
1993-11-09 |
American Home Products Corporation |
Rapamycin carbonate esters as immuno-suppressant agents
|
US5482945A
(en)
*
|
1992-12-22 |
1996-01-09 |
American Home Products Corporation |
Innovative technique for immunosuppression involving administration of rapamycin loaded formed blood elements
|
US5349060A
(en)
*
|
1993-01-07 |
1994-09-20 |
American Home Products Corporation |
Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents
|
GB9302569D0
(en)
*
|
1993-02-10 |
1993-03-24 |
Smithkline Beecham Plc |
Novel compound
|
US5252579A
(en)
*
|
1993-02-16 |
1993-10-12 |
American Home Products Corporation |
Macrocyclic immunomodulators
|
US5310903A
(en)
*
|
1993-03-05 |
1994-05-10 |
Merck & Co., Inc. |
Imidazolidyl rapamycin derivatives
|
US5310901A
(en)
*
|
1993-03-05 |
1994-05-10 |
Merck & Co., Inc. |
O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
|
US5504091A
(en)
*
|
1993-04-23 |
1996-04-02 |
American Home Products Corporation |
Biotin esters of rapamycin
|
ES2176245T3
(es)
|
1993-04-23 |
2002-12-01 |
Wyeth Corp |
Anticuerpos de ramapicinas de ciclo abierto.
|
US7279561B1
(en)
*
|
1993-04-23 |
2007-10-09 |
Wyeth |
Anti-rapamycin monoclonal antibodies
|
AT408520B
(de)
*
|
1993-05-27 |
2001-12-27 |
Novartis Erfind Verwalt Gmbh |
Galenische formulierungen
|
CH686761A5
(de)
*
|
1993-05-27 |
1996-06-28 |
Sandoz Ag |
Galenische Formulierungen.
|
GB9315914D0
(en)
*
|
1993-07-31 |
1993-09-15 |
Smithkline Beecham Plc |
Novel compound
|
US5387680A
(en)
*
|
1993-08-10 |
1995-02-07 |
American Home Products Corporation |
C-22 ring stabilized rapamycin derivatives
|
US5516770A
(en)
*
|
1993-09-30 |
1996-05-14 |
American Home Products Corporation |
Rapamycin formulation for IV injection
|
US5616588A
(en)
*
|
1993-09-30 |
1997-04-01 |
American Home Products Corporation |
Rapamycin formulation for IV injection
|
IL111004A
(en)
*
|
1993-09-30 |
1998-06-15 |
American Home Prod |
Oral formulations of rapamycin
|
US5536729A
(en)
*
|
1993-09-30 |
1996-07-16 |
American Home Products Corporation |
Rapamycin formulations for oral administration
|
US5391730A
(en)
*
|
1993-10-08 |
1995-02-21 |
American Home Products Corporation |
Phosphorylcarbamates of rapamycin and oxime derivatives thereof
|
US5373014A
(en)
*
|
1993-10-08 |
1994-12-13 |
American Home Products Corporation |
Rapamycin oximes
|
US5378836A
(en)
*
|
1993-10-08 |
1995-01-03 |
American Home Products Corporation |
Rapamycin oximes and hydrazones
|
US5527907A
(en)
*
|
1993-11-19 |
1996-06-18 |
Abbott Laboratories |
Macrolide immunomodulators
|
CA2175215C
(en)
*
|
1993-11-19 |
2008-06-03 |
Yat Sun Or |
Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
|
US5385908A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Hindered esters of rapamycin
|
US5385909A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Heterocyclic esters of rapamycin
|
US5385910A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Gem-distributed esters of rapamycin
|
US5389639A
(en)
*
|
1993-12-29 |
1995-02-14 |
American Home Products Company |
Amino alkanoic esters of rapamycin
|
US5525610A
(en)
*
|
1994-03-31 |
1996-06-11 |
American Home Products Corporation |
42-Epi-rapamycin and pharmaceutical compositions thereof
|
US5362718A
(en)
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
US6150137A
(en)
|
1994-05-27 |
2000-11-21 |
Ariad Pharmaceuticals, Inc. |
Immunosuppressant target proteins
|
US5463048A
(en)
*
|
1994-06-14 |
1995-10-31 |
American Home Products Corporation |
Rapamycin amidino carbamates
|
US5849730A
(en)
*
|
1994-08-31 |
1998-12-15 |
Pfizer Inc. |
Process for preparing demethylrapamycins
|
PE52896A1
(es)
|
1994-10-26 |
1996-12-12 |
Novartis Ag |
Composicion farmaceutica
|
US5491231A
(en)
*
|
1994-11-28 |
1996-02-13 |
American Home Products Corporation |
Hindered N-oxide esters of rapamycin
|
US5563145A
(en)
*
|
1994-12-07 |
1996-10-08 |
American Home Products Corporation |
Rapamycin 42-oximes and hydroxylamines
|
US5561138A
(en)
*
|
1994-12-13 |
1996-10-01 |
American Home Products Corporation |
Method of treating anemia
|
US5606222A
(en)
*
|
1994-12-29 |
1997-02-25 |
Philips Electronics North America Corporation |
Lighting system with a device for reducing system wattage
|
US5496832A
(en)
*
|
1995-03-09 |
1996-03-05 |
American Home Products Corporation |
Method of treating cardiac inflammatory disease
|
FR2736550B1
(fr)
*
|
1995-07-14 |
1998-07-24 |
Sandoz Sa |
Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
|
US5780462A
(en)
*
|
1995-12-27 |
1998-07-14 |
American Home Products Corporation |
Water soluble rapamycin esters
|
US5922730A
(en)
*
|
1996-09-09 |
1999-07-13 |
American Home Products Corporation |
Alkylated rapamycin derivatives
|
US7282220B1
(en)
|
1996-11-05 |
2007-10-16 |
Hsing-Wen Sung |
Genipin-crosslinked gelatin microspheres as drug carrier
|
US5989591A
(en)
*
|
1997-03-14 |
1999-11-23 |
American Home Products Corporation |
Rapamycin formulations for oral administration
|
US6273913B1
(en)
|
1997-04-18 |
2001-08-14 |
Cordis Corporation |
Modified stent useful for delivery of drugs along stent strut
|
US5985325A
(en)
*
|
1997-06-13 |
1999-11-16 |
American Home Products Corporation |
Rapamycin formulations for oral administration
|
US6890546B2
(en)
|
1998-09-24 |
2005-05-10 |
Abbott Laboratories |
Medical devices containing rapamycin analogs
|
US20030129215A1
(en)
*
|
1998-09-24 |
2003-07-10 |
T-Ram, Inc. |
Medical devices containing rapamycin analogs
|
US20060198867A1
(en)
*
|
1997-09-25 |
2006-09-07 |
Abbott Laboratories, Inc. |
Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
|
US6015815A
(en)
|
1997-09-26 |
2000-01-18 |
Abbott Laboratories |
Tetrazole-containing rapamycin analogs with shortened half-lives
|
US7399480B2
(en)
|
1997-09-26 |
2008-07-15 |
Abbott Laboratories |
Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices
|
US7378105B2
(en)
*
|
1997-09-26 |
2008-05-27 |
Abbott Laboratories |
Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens
|
US8057816B2
(en)
*
|
1997-09-26 |
2011-11-15 |
Abbott Laboratories |
Compositions and methods of administering paclitaxel with other drugs using medical devices
|
US8257726B2
(en)
*
|
1997-09-26 |
2012-09-04 |
Abbott Laboratories |
Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
|
US8394398B2
(en)
*
|
1997-09-26 |
2013-03-12 |
Abbott Laboratories |
Methods of administering rapamycin analogs with anti-inflammatories using medical devices
|
US7357942B2
(en)
*
|
1997-09-26 |
2008-04-15 |
Abbott Laboratories |
Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens
|
US8257725B2
(en)
*
|
1997-09-26 |
2012-09-04 |
Abbott Laboratories |
Delivery of highly lipophilic agents via medical devices
|
PL340606A1
(en)
*
|
1997-10-22 |
2001-02-12 |
Jens Ponikau |
Methods of and materials for treating and preventing mucositis
|
US20030216303A1
(en)
*
|
1998-03-06 |
2003-11-20 |
Michael Ambuhl |
Emulsion preconcentrates containing cyclosporin or a macrolide
|
US6015809A
(en)
*
|
1998-08-17 |
2000-01-18 |
American Home Products Corporation |
Photocyclized rapamycin
|
US8257724B2
(en)
*
|
1998-09-24 |
2012-09-04 |
Abbott Laboratories |
Delivery of highly lipophilic agents via medical devices
|
US20060240070A1
(en)
*
|
1998-09-24 |
2006-10-26 |
Cromack Keith R |
Delivery of highly lipophilic agents via medical devices
|
US7960405B2
(en)
*
|
1998-09-24 |
2011-06-14 |
Abbott Laboratories |
Compounds and methods for treatment and prevention of diseases
|
US7455853B2
(en)
*
|
1998-09-24 |
2008-11-25 |
Abbott Cardiovascular Systems Inc. |
Medical devices containing rapamycin analogs
|
GB9826882D0
(en)
|
1998-12-07 |
1999-01-27 |
Novartis Ag |
Organic compounds
|
US6331547B1
(en)
|
1999-08-18 |
2001-12-18 |
American Home Products Corporation |
Water soluble SDZ RAD esters
|
US6790228B2
(en)
*
|
1999-12-23 |
2004-09-14 |
Advanced Cardiovascular Systems, Inc. |
Coating for implantable devices and a method of forming the same
|
US7807211B2
(en)
|
1999-09-03 |
2010-10-05 |
Advanced Cardiovascular Systems, Inc. |
Thermal treatment of an implantable medical device
|
US20070032853A1
(en)
*
|
2002-03-27 |
2007-02-08 |
Hossainy Syed F |
40-O-(2-hydroxy)ethyl-rapamycin coated stent
|
GB0008785D0
(en)
|
2000-04-10 |
2000-05-31 |
Novartis Ag |
Organic compounds
|
US6573074B2
(en)
|
2000-04-12 |
2003-06-03 |
Smithkline Beecham Plc |
Methods for ansamitocin production
|
US8236048B2
(en)
|
2000-05-12 |
2012-08-07 |
Cordis Corporation |
Drug/drug delivery systems for the prevention and treatment of vascular disease
|
US7300662B2
(en)
|
2000-05-12 |
2007-11-27 |
Cordis Corporation |
Drug/drug delivery systems for the prevention and treatment of vascular disease
|
US7419678B2
(en)
*
|
2000-05-12 |
2008-09-02 |
Cordis Corporation |
Coated medical devices for the prevention and treatment of vascular disease
|
US6670355B2
(en)
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
ES2313983T3
(es)
|
2000-09-19 |
2009-03-16 |
Wyeth |
Esteres hidrosolubles de rapamicina.
|
US6399625B1
(en)
|
2000-09-27 |
2002-06-04 |
Wyeth |
1-oxorapamycins
|
US20060222756A1
(en)
*
|
2000-09-29 |
2006-10-05 |
Cordis Corporation |
Medical devices, drug coatings and methods of maintaining the drug coatings thereon
|
US7261735B2
(en)
*
|
2001-05-07 |
2007-08-28 |
Cordis Corporation |
Local drug delivery devices and methods for maintaining the drug coatings thereon
|
AU9486901A
(en)
|
2000-09-29 |
2002-04-08 |
Cordis Corp |
Coated medical devices
|
US6399626B1
(en)
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
US6440991B1
(en)
|
2000-10-02 |
2002-08-27 |
Wyeth |
Ethers of 7-desmethlrapamycin
|
TWI286074B
(en)
|
2000-11-15 |
2007-09-01 |
Wyeth Corp |
Pharmaceutical composition containing CCI-779 as an antineoplastic agent
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
TWI296196B
(en)
*
|
2001-04-06 |
2008-05-01 |
Wyeth Corp |
Antineoplastic combinations
|
TWI233359B
(en)
*
|
2001-04-06 |
2005-06-01 |
Wyeth Corp |
Pharmaceutical composition for treating neoplasm
|
US8182527B2
(en)
|
2001-05-07 |
2012-05-22 |
Cordis Corporation |
Heparin barrier coating for controlled drug release
|
ZA200603888B
(en)
*
|
2001-06-01 |
2007-05-30 |
Wyeth Corp |
Antineoplastic combinations
|
UA77200C2
(en)
|
2001-08-07 |
2006-11-15 |
Wyeth Corp |
Antineoplastic combination of cci-779 and bkb-569
|
ES2246409T3
(es)
|
2001-08-22 |
2006-02-16 |
Wyeth |
29-enoles de rapamicina.
|
BR0211905A
(pt)
|
2001-08-22 |
2004-09-21 |
Wyeth Corp |
Dialdeìdos de rapamicina
|
US20080145402A1
(en)
*
|
2001-09-10 |
2008-06-19 |
Abbott Cardiovascular Systems Inc. |
Medical Devices Containing Rapamycin Analogs
|
US7195640B2
(en)
|
2001-09-25 |
2007-03-27 |
Cordis Corporation |
Coated medical devices for the treatment of vulnerable plaque
|
US20030065377A1
(en)
|
2001-09-28 |
2003-04-03 |
Davila Luis A. |
Coated medical devices
|
US6939376B2
(en)
*
|
2001-11-05 |
2005-09-06 |
Sun Biomedical, Ltd. |
Drug-delivery endovascular stent and method for treating restenosis
|
US7682387B2
(en)
|
2002-04-24 |
2010-03-23 |
Biosensors International Group, Ltd. |
Drug-delivery endovascular stent and method for treating restenosis
|
WO2003057218A1
(en)
*
|
2002-01-10 |
2003-07-17 |
Novartis Ag |
Drug delivery systems for the prevention and treatment of vascular diseases comprising rapamycin and derivatives thereof
|
US20040024450A1
(en)
*
|
2002-04-24 |
2004-02-05 |
Sun Biomedical, Ltd. |
Drug-delivery endovascular stent and method for treating restenosis
|
US20030204168A1
(en)
*
|
2002-04-30 |
2003-10-30 |
Gjalt Bosma |
Coated vascular devices
|
US20070083258A1
(en)
|
2005-10-06 |
2007-04-12 |
Robert Falotico |
Intraluminal device and therapeutic agent combination for treating aneurysmal disease
|
DK1589031T3
(da)
|
2002-07-16 |
2007-12-10 |
Biotica Tech Ltd |
Fremstillingaf polyketider og andre naturlige produkter
|
CA2493878C
(en)
|
2002-07-30 |
2013-07-23 |
Wyeth |
Parenteral formulations containing a rapamycin hydroxyester
|
MXPA05002539A
(es)
|
2002-09-06 |
2005-06-17 |
Abbott Lab |
Dispositivo medico que tiene inhibidor de hidratacion.
|
AU2002330737A1
(en)
*
|
2002-09-09 |
2004-03-29 |
Biocon Limited |
Solid state fermentation and fed batch for the production of an immunosuppressant
|
CA2496332A1
(en)
*
|
2002-09-17 |
2004-04-01 |
Wyeth |
Oral formulations
|
US8318235B2
(en)
*
|
2003-01-22 |
2012-11-27 |
Cordis Corporation |
Method for applying drug coating to a medical device in surgeon room
|
US6919100B2
(en)
*
|
2003-01-22 |
2005-07-19 |
Cordis Corporation |
Method for coating medical devices
|
US20050038504A1
(en)
|
2003-01-22 |
2005-02-17 |
Harry Halleriet |
Kit for applying drug coating to a medical device in surgeon room
|
AR042938A1
(es)
*
|
2003-02-06 |
2005-07-06 |
Wyeth Corp |
Uso del cci-779 en el tratamiento de la fibrosis hepatica
|
US20040167572A1
(en)
*
|
2003-02-20 |
2004-08-26 |
Roth Noah M. |
Coated medical devices
|
UA83484C2
(uk)
*
|
2003-03-05 |
2008-07-25 |
Уайт |
Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
|
US7527632B2
(en)
*
|
2003-03-31 |
2009-05-05 |
Cordis Corporation |
Modified delivery device for coated medical devices
|
DE602004004520T2
(de)
*
|
2003-04-22 |
2007-11-08 |
Wyeth |
Antineoplastische zusammensetzungen
|
WO2004100868A2
(en)
*
|
2003-04-23 |
2004-11-25 |
Abbott Laboratories |
Method of treating transplant rejection
|
US7160867B2
(en)
|
2003-05-16 |
2007-01-09 |
Isotechnika, Inc. |
Rapamycin carbohydrate derivatives
|
US20040236416A1
(en)
*
|
2003-05-20 |
2004-11-25 |
Robert Falotico |
Increased biocompatibility of implantable medical devices
|
US20050118344A1
(en)
|
2003-12-01 |
2005-06-02 |
Pacetti Stephen D. |
Temperature controlled crimping
|
US20050033417A1
(en)
*
|
2003-07-31 |
2005-02-10 |
John Borges |
Coating for controlled release of a therapeutic agent
|
US20050137677A1
(en)
*
|
2003-12-17 |
2005-06-23 |
Rush Scott L. |
Endovascular graft with differentiable porosity along its length
|
US8652502B2
(en)
*
|
2003-12-19 |
2014-02-18 |
Cordis Corporation |
Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury
|
US20050249776A1
(en)
*
|
2003-12-19 |
2005-11-10 |
Chen Chao C |
Coated aneurysmal repair device
|
US8747881B2
(en)
|
2003-12-19 |
2014-06-10 |
Cordis Corporation |
Intraluminal medical devices in combination with therapeutic agents
|
AU2004314213A1
(en)
*
|
2004-01-08 |
2005-08-04 |
Wyeth |
Directly compressible pharmaceutical composition for the oral admimistration of CCI-779
|
US7303758B2
(en)
*
|
2004-01-20 |
2007-12-04 |
Cordis Corporation |
Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury
|
US7806924B2
(en)
|
2004-02-18 |
2010-10-05 |
Cordis Corporation |
Implantable structures for local vascular delivery of cladribine in combination with rapamycin for restenosis
|
US20050187608A1
(en)
*
|
2004-02-24 |
2005-08-25 |
O'hara Michael D. |
Radioprotective compound coating for medical devices
|
EP1568394A1
(en)
|
2004-02-26 |
2005-08-31 |
Muijs van de Moer, Wouter Matthijs |
Coated electrode
|
US8828416B2
(en)
|
2004-03-09 |
2014-09-09 |
Cordis Corporation |
Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury
|
EP2301619B1
(en)
*
|
2004-03-19 |
2017-05-10 |
Abbott Laboratories |
Multiple drug delivery from a balloon and a prosthesis
|
US8431145B2
(en)
|
2004-03-19 |
2013-04-30 |
Abbott Laboratories |
Multiple drug delivery from a balloon and a prosthesis
|
US7875282B2
(en)
*
|
2004-03-22 |
2011-01-25 |
Cordis Corporation |
Coated medical device for local vascular delivery of Panzem® in combination with rapamycin to prevent restenosis following vascular injury
|
US7695731B2
(en)
|
2004-03-22 |
2010-04-13 |
Cordis Corporation |
Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury
|
US8003122B2
(en)
*
|
2004-03-31 |
2011-08-23 |
Cordis Corporation |
Device for local and/or regional delivery employing liquid formulations of therapeutic agents
|
US7989490B2
(en)
*
|
2004-06-02 |
2011-08-02 |
Cordis Corporation |
Injectable formulations of taxanes for cad treatment
|
US7846940B2
(en)
*
|
2004-03-31 |
2010-12-07 |
Cordis Corporation |
Solution formulations of sirolimus and its analogs for CAD treatment
|
WO2005098011A1
(en)
*
|
2004-04-12 |
2005-10-20 |
Biocon Limited |
Process for the production of macrolides using a novel strain, streptomyces sp. bicc 7522
|
WO2005105811A1
(en)
|
2004-04-14 |
2005-11-10 |
Wyeth |
Regiospecific synthesis of rapamycin 42-ester derivatives
|
EP1751168A1
(en)
|
2004-04-14 |
2007-02-14 |
Wyeth |
Proline cci-779 (proline-rapamycin 42-ester with 2,2-bis (hydroxymethyl) propionic acid) and two-step enzymatic synthesis of proline cci-779 and cci-779 using microbial lipase
|
US8007737B2
(en)
|
2004-04-14 |
2011-08-30 |
Wyeth |
Use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices
|
WO2005105812A1
(en)
|
2004-04-14 |
2005-11-10 |
Wyeth |
Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
|
US20050232965A1
(en)
*
|
2004-04-15 |
2005-10-20 |
Robert Falotico |
Local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque
|
CA2562164A1
(en)
*
|
2004-04-27 |
2005-11-10 |
Wyeth |
Labeling of rapamycin using rapamycin-specific methylases
|
GB0417852D0
(en)
|
2004-08-11 |
2004-09-15 |
Biotica Tech Ltd |
Production of polyketides and other natural products
|
AR050374A1
(es)
*
|
2004-08-20 |
2006-10-18 |
Wyeth Corp |
Forma polimorfica de rafampicina
|
US7393952B2
(en)
*
|
2004-08-27 |
2008-07-01 |
Cordis Corporation |
Solvent free amorphous rapamycin
|
WO2006031661A2
(en)
*
|
2004-09-10 |
2006-03-23 |
Ivax Pharmaceuticals S.R.O. |
Process for isolation of macrolide compounds
|
WO2006031664A1
(en)
*
|
2004-09-10 |
2006-03-23 |
Ivax Pharmaceuticals S.R.O. |
Process for isolation of crystalline tacrolimus
|
WO2006029726A1
(en)
*
|
2004-09-16 |
2006-03-23 |
Bayer Healthcare Ag |
Dermally applicable formulations for treating skin diseases in animals
|
US7901451B2
(en)
|
2004-09-24 |
2011-03-08 |
Biosensors International Group, Ltd. |
Drug-delivery endovascular stent and method for treating restenosis
|
EP1809247A1
(en)
*
|
2004-09-29 |
2007-07-25 |
Cordis Corporation |
Pharmaceutical dosage forms of stable amorphous rapamycin like compounds
|
US20060129225A1
(en)
*
|
2004-12-15 |
2006-06-15 |
Kopia Gregory A |
Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium
|
GB0503936D0
(en)
*
|
2005-02-25 |
2005-04-06 |
San Raffaele Centro Fond |
Method
|
GB0504994D0
(en)
|
2005-03-11 |
2005-04-20 |
Biotica Tech Ltd |
Novel compounds
|
US20100061994A1
(en)
*
|
2005-03-11 |
2010-03-11 |
Rose Mary Sheridan |
Medical uses of 39-desmethoxyrapamycin and analogues thereof
|
EP2327429B1
(en)
|
2005-03-23 |
2014-09-17 |
Abbott Laboratories |
Delivery of highly lipophilic agents via medical devices
|
EP3138531A1
(en)
|
2005-03-23 |
2017-03-08 |
Abbott Laboratories |
Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
|
KR101492545B1
(ko)
*
|
2005-07-15 |
2015-02-12 |
미셀 테크놀로지즈, 인코포레이티드 |
제어된 형태의 약물 분말을 함유하는 중합체 코팅
|
WO2007011708A2
(en)
|
2005-07-15 |
2007-01-25 |
Micell Technologies, Inc. |
Stent with polymer coating containing amorphous rapamycin
|
JP5756588B2
(ja)
|
2005-07-15 |
2015-07-29 |
ミセル テクノロジーズ、インコーポレイテッド |
制御されたモルホロジーの薬剤粉末を含むポリマーコーティング
|
US10307481B2
(en)
|
2005-07-25 |
2019-06-04 |
Aptevo Research And Development Llc |
CD37 immunotherapeutics and uses thereof
|
US20070026042A1
(en)
*
|
2005-07-29 |
2007-02-01 |
Narayanan Pallasssana V |
System for treating aneurysmal disease
|
US20070048350A1
(en)
*
|
2005-08-31 |
2007-03-01 |
Robert Falotico |
Antithrombotic coating for drug eluting medical devices
|
US20090246212A1
(en)
*
|
2005-09-30 |
2009-10-01 |
Kyoto University |
Development of method for screening for drug capable of improving production of regulatory t cells and method for producing regulatory t cells using immunosuppressive macrolide antibiotic
|
US8784860B2
(en)
*
|
2005-10-27 |
2014-07-22 |
Cordis Corporation |
Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease
|
US20070173787A1
(en)
*
|
2005-11-01 |
2007-07-26 |
Huang Mark C T |
Thin-film nitinol based drug eluting stent
|
US20070116736A1
(en)
*
|
2005-11-23 |
2007-05-24 |
Argentieri Dennis C |
Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
|
US20070128242A1
(en)
*
|
2005-12-01 |
2007-06-07 |
Zhao Jonathan Z |
Polymeric compositions for controlled release or delivery of pharmacologically active agents
|
AU2006322030A1
(en)
*
|
2005-12-07 |
2007-06-14 |
Wyeth |
Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
|
US7700614B2
(en)
|
2005-12-14 |
2010-04-20 |
Abbott Laboratories |
One pot synthesis of tetrazole derivatives of rapamycin
|
US7842312B2
(en)
*
|
2005-12-29 |
2010-11-30 |
Cordis Corporation |
Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
|
US7622477B2
(en)
*
|
2006-02-28 |
2009-11-24 |
Cordis Corporation |
Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same
|
US20070203169A1
(en)
*
|
2006-02-28 |
2007-08-30 |
Zhao Jonathon Z |
Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same
|
US7678901B2
(en)
|
2006-02-28 |
2010-03-16 |
Wyeth |
Rapamycin analogs containing an antioxidant moiety
|
CA2650590C
(en)
|
2006-04-26 |
2018-04-03 |
Micell Technologies, Inc. |
Coatings containing multiple drugs
|
GB0609962D0
(en)
*
|
2006-05-19 |
2006-06-28 |
Biotica Tech Ltd |
Novel compounds
|
GB0609963D0
(en)
*
|
2006-05-19 |
2006-06-28 |
Biotica Tech Ltd |
Novel compounds
|
CA2656112A1
(en)
*
|
2006-06-30 |
2008-05-08 |
Hanje Chen |
Bioresponsive polymers
|
US8506984B2
(en)
*
|
2006-07-26 |
2013-08-13 |
Cordis Corporation |
Therapeutic agent elution control process
|
US20100081681A1
(en)
*
|
2006-08-16 |
2010-04-01 |
Blagosklonny Mikhail V |
Methods and compositions for preventing or treating age-related diseases
|
WO2008033956A2
(en)
|
2006-09-13 |
2008-03-20 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
US10695327B2
(en)
|
2006-09-13 |
2020-06-30 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
US8088789B2
(en)
|
2006-09-13 |
2012-01-03 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
US8636767B2
(en)
|
2006-10-02 |
2014-01-28 |
Micell Technologies, Inc. |
Surgical sutures having increased strength
|
US20080097591A1
(en)
*
|
2006-10-20 |
2008-04-24 |
Biosensors International Group |
Drug-delivery endovascular stent and method of use
|
US8067055B2
(en)
|
2006-10-20 |
2011-11-29 |
Biosensors International Group, Ltd. |
Drug-delivery endovascular stent and method of use
|
CA2667228C
(en)
|
2006-10-23 |
2015-07-14 |
Micell Technologies, Inc. |
Holder for electrically charging a substrate during coating
|
US9737640B2
(en)
|
2006-11-20 |
2017-08-22 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
US8414910B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
US20080276935A1
(en)
|
2006-11-20 |
2008-11-13 |
Lixiao Wang |
Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
|
US8414525B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
US9700704B2
(en)
|
2006-11-20 |
2017-07-11 |
Lutonix, Inc. |
Drug releasing coatings for balloon catheters
|
US8998846B2
(en)
|
2006-11-20 |
2015-04-07 |
Lutonix, Inc. |
Drug releasing coatings for balloon catheters
|
US20080175887A1
(en)
|
2006-11-20 |
2008-07-24 |
Lixiao Wang |
Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
|
US8414526B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
|
US8425459B2
(en)
|
2006-11-20 |
2013-04-23 |
Lutonix, Inc. |
Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
|
US20080138405A1
(en)
*
|
2006-12-06 |
2008-06-12 |
Raheja Praveen |
Sirolimus nanodispersion
|
CN101711137B
(zh)
|
2007-01-08 |
2014-10-22 |
米歇尔技术公司 |
具有可生物降解层的支架
|
US11426494B2
(en)
|
2007-01-08 |
2022-08-30 |
MT Acquisition Holdings LLC |
Stents having biodegradable layers
|
EP1952807A1
(en)
*
|
2007-01-24 |
2008-08-06 |
LEK Pharmaceuticals D.D. |
Sirolimus formulation
|
US20090281059A1
(en)
|
2007-02-21 |
2009-11-12 |
Robert Falotico |
Coating for a medical device having an anti-thrombotic conjugate
|
US20080241215A1
(en)
|
2007-03-28 |
2008-10-02 |
Robert Falotico |
Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke
|
TW200845960A
(en)
*
|
2007-04-05 |
2008-12-01 |
Wyeth Corp |
Wortmannin-rapalog conjugate and uses thereof
|
AU2008256684B2
(en)
|
2007-05-25 |
2012-06-14 |
Micell Technologies, Inc. |
Polymer films for medical device coating
|
US20090068266A1
(en)
*
|
2007-09-11 |
2009-03-12 |
Raheja Praveen |
Sirolimus having specific particle size and pharmaceutical compositions thereof
|
US20090130210A1
(en)
*
|
2007-09-11 |
2009-05-21 |
Raheja Praveen |
Pharmaceutical compositions of sirolimus
|
US20090074831A1
(en)
*
|
2007-09-18 |
2009-03-19 |
Robert Falotico |
LOCAL VASCULAR DELIVERY OF mTOR INHIBITORS IN COMBINATION WITH PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR STIMULATORS
|
KR100930167B1
(ko)
*
|
2007-09-19 |
2009-12-07 |
삼성전기주식회사 |
초광각 광학계
|
US20110091508A1
(en)
|
2007-10-05 |
2011-04-21 |
Interface Biologics ,Inc. |
Oligofluorinated cross-linked polymers and uses thereof
|
US20110104228A1
(en)
|
2007-10-19 |
2011-05-05 |
Interface Biologics, Inc |
Self-eliminating coatings
|
CA2703956C
(en)
*
|
2007-10-31 |
2016-07-12 |
Cordis Corporation |
Method of making a vascular closure device
|
US9603980B2
(en)
|
2008-02-26 |
2017-03-28 |
CARDINAL HEALTH SWITZERLAND 515 GmbH |
Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices
|
US8420110B2
(en)
|
2008-03-31 |
2013-04-16 |
Cordis Corporation |
Drug coated expandable devices
|
US8409601B2
(en)
|
2008-03-31 |
2013-04-02 |
Cordis Corporation |
Rapamycin coated expandable devices
|
WO2009126944A1
(en)
|
2008-04-11 |
2009-10-15 |
Trubion Pharmaceuticals, Inc. |
Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
|
SG192523A1
(en)
|
2008-04-17 |
2013-08-30 |
Micell Technologies Inc |
Stents having bioabsorbable layers
|
US8273404B2
(en)
|
2008-05-19 |
2012-09-25 |
Cordis Corporation |
Extraction of solvents from drug containing polymer reservoirs
|
EP3031324A3
(en)
|
2008-06-10 |
2016-09-07 |
AbbVie Inc. |
Tricyclic kinase inhibitors
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
JP2011528275A
(ja)
|
2008-07-17 |
2011-11-17 |
ミセル テクノロジーズ,インク. |
薬物送達医療デバイス
|
US9510856B2
(en)
|
2008-07-17 |
2016-12-06 |
Micell Technologies, Inc. |
Drug delivery medical device
|
WO2010024898A2
(en)
|
2008-08-29 |
2010-03-04 |
Lutonix, Inc. |
Methods and apparatuses for coating balloon catheters
|
EP2352459A4
(en)
*
|
2008-10-03 |
2013-09-25 |
Elixir Medical Corp |
MACROCYCLIC LACTONE COMPOUNDS AND METHODS OF USE
|
US20100098770A1
(en)
*
|
2008-10-16 |
2010-04-22 |
Manikandan Ramalingam |
Sirolimus pharmaceutical formulations
|
DK2365802T3
(da)
|
2008-11-11 |
2017-11-13 |
Univ Texas |
Mikrokapsler af rapamycin og anvendelse til behandling af cancer
|
SG172361A1
(en)
*
|
2008-12-23 |
2011-07-28 |
Pharmasset Inc |
Nucleoside analogs
|
AR074897A1
(es)
|
2008-12-23 |
2011-02-23 |
Pharmasset Inc |
Fosforamidatos de nucleosidos
|
EP2376515A1
(en)
|
2008-12-23 |
2011-10-19 |
Pharmasset, Inc. |
Synthesis of purine nucleosides
|
US8834913B2
(en)
|
2008-12-26 |
2014-09-16 |
Battelle Memorial Institute |
Medical implants and methods of making medical implants
|
EP2391401A2
(en)
*
|
2009-02-02 |
2011-12-07 |
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. |
Crystalline drug-containing coatings
|
US20100233733A1
(en)
*
|
2009-02-10 |
2010-09-16 |
Nodality, Inc., A Delaware Corporation |
Multiple mechanisms for modulation of the pi3 kinase pathway
|
FR2943539B1
(fr)
|
2009-03-31 |
2011-07-22 |
Ethypharm Sa |
Composition pharmaceutique comprenant un macrolide immunosuppresseur de la famille des limus.
|
WO2010120552A2
(en)
|
2009-04-01 |
2010-10-21 |
Micell Technologies, Inc. |
Coated stents
|
EA023244B1
(ru)
|
2009-04-10 |
2016-05-31 |
Хаян Ки |
Способ предотвращения старения клеток
|
WO2010121187A2
(en)
|
2009-04-17 |
2010-10-21 |
Micell Techologies, Inc. |
Stents having controlled elution
|
US20100268187A1
(en)
*
|
2009-04-17 |
2010-10-21 |
Ranbaxy Laboratories Limited |
Packaging for sirolimus and composition thereof
|
US20100280600A1
(en)
*
|
2009-04-30 |
2010-11-04 |
Vipul Bhupendra Dave |
Dual drug stent
|
US20110137407A1
(en)
|
2009-07-09 |
2011-06-09 |
Thai Minh Nguyen |
Bare metal stent with drug eluting reservoirs
|
US9327060B2
(en)
|
2009-07-09 |
2016-05-03 |
CARDINAL HEALTH SWITZERLAND 515 GmbH |
Rapamycin reservoir eluting stent
|
MX2012005023A
(es)
|
2009-10-30 |
2012-06-19 |
Ariad Pharma Inc |
Metodos y composiciones para tratar cancer.
|
US9283211B1
(en)
|
2009-11-11 |
2016-03-15 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
DK2506716T3
(en)
|
2009-12-01 |
2017-09-04 |
Abbvie Inc |
HIS UNKNOWN TRICYCLIC RELATIONS
|
CN102711470A
(zh)
*
|
2009-12-01 |
2012-10-03 |
雅培制药有限公司 |
新的三环化合物
|
US8951595B2
(en)
|
2009-12-11 |
2015-02-10 |
Abbott Cardiovascular Systems Inc. |
Coatings with tunable molecular architecture for drug-coated balloon
|
US8480620B2
(en)
|
2009-12-11 |
2013-07-09 |
Abbott Cardiovascular Systems Inc. |
Coatings with tunable solubility profile for drug-coated balloon
|
EP2531140B1
(en)
|
2010-02-02 |
2017-11-01 |
Micell Technologies, Inc. |
Stent and stent delivery system with improved deliverability
|
WO2011128910A2
(en)
|
2010-03-02 |
2011-10-20 |
Rpg Life Sciences Limited |
A drug delivery solid dosage formulation of sirolimus
|
US8795762B2
(en)
|
2010-03-26 |
2014-08-05 |
Battelle Memorial Institute |
System and method for enhanced electrostatic deposition and surface coatings
|
PT3290428T
(pt)
|
2010-03-31 |
2021-12-27 |
Gilead Pharmasset Llc |
Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
|
EP2560576B1
(en)
|
2010-04-22 |
2018-07-18 |
Micell Technologies, Inc. |
Stents and other devices having extracellular matrix coating
|
WO2012009684A2
(en)
|
2010-07-16 |
2012-01-19 |
Micell Technologies, Inc. |
Drug delivery medical device
|
US20120130481A1
(en)
|
2010-11-18 |
2012-05-24 |
Robert Falotico |
Local vascular delivery of adenosine a2a receptor agonists in combination with other agents to reduce myocardial injury
|
US20120302954A1
(en)
|
2011-05-25 |
2012-11-29 |
Zhao Jonathon Z |
Expandable devices coated with a paclitaxel composition
|
US20120303115A1
(en)
|
2011-05-25 |
2012-11-29 |
Dadino Ronald C |
Expandable devices coated with a rapamycin composition
|
WO2012166819A1
(en)
|
2011-05-31 |
2012-12-06 |
Micell Technologies, Inc. |
System and process for formation of a time-released, drug-eluting transferable coating
|
EP2532740A1
(en)
|
2011-06-11 |
2012-12-12 |
Michael Schmück |
Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
|
WO2013012689A1
(en)
|
2011-07-15 |
2013-01-24 |
Micell Technologies, Inc. |
Drug delivery medical device
|
US10188772B2
(en)
|
2011-10-18 |
2019-01-29 |
Micell Technologies, Inc. |
Drug delivery medical device
|
CN102372726B
(zh)
*
|
2011-11-08 |
2014-02-19 |
福建省微生物研究所 |
西罗莫司粗晶的制备方法
|
CN102433364B
(zh)
*
|
2011-11-10 |
2013-10-23 |
中科医药行业生产力促进中心有限公司 |
一种微生物发酵法制取雷帕霉素的工艺
|
EP2594260A1
(en)
|
2011-11-18 |
2013-05-22 |
LEK Pharmaceuticals d.d. |
Solid preparations comprising sirolimus with desired bioavailability and method for its preparation
|
KR20140107413A
(ko)
|
2011-12-16 |
2014-09-04 |
화이자 인코포레이티드 |
암의 처치를 위한 이노투즈맙 오조가미신 및 토리셀의 조합
|
GB201122305D0
(en)
|
2011-12-23 |
2012-02-01 |
Biotica Tech Ltd |
Novel compound
|
US9365880B2
(en)
|
2012-04-12 |
2016-06-14 |
Natco Pharma Limited |
Fermentation process for the production of rapamycin
|
CN104203959B
(zh)
|
2012-06-08 |
2017-09-15 |
百多力股份公司 |
雷帕霉素40‑o‑环状烃酯、组合物和方法
|
US9278090B2
(en)
|
2012-09-05 |
2016-03-08 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods of preventing the development of mucositis and related disorders
|
US20150258127A1
(en)
|
2012-10-31 |
2015-09-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for preventing antiphospholipid syndrome (aps)
|
WO2014072984A1
(en)
|
2012-11-06 |
2014-05-15 |
Natco Pharma Limited |
Improved process for isolation and purification of rapamycin from fermentation broth
|
EP2919759A4
(en)
|
2012-11-14 |
2016-07-20 |
Ohio State Innovation Foundation |
MATERIALS AND METHODS FOR THE TREATMENT OF GLIOBLASTOMES
|
EP2967803B1
(en)
|
2013-03-12 |
2023-12-27 |
Micell Technologies, Inc. |
Bioabsorbable biomedical implants
|
DK2968281T3
(da)
|
2013-03-13 |
2020-11-02 |
Univ Texas |
Mtor-hæmmere til forebyggelse af vækst af tarmpolyp
|
EP2996629B1
(en)
|
2013-05-15 |
2021-09-22 |
Micell Technologies, Inc. |
Bioabsorbable biomedical implants
|
JP6529012B2
(ja)
|
2013-10-08 |
2019-06-12 |
エイアイ・セラピューティクス・インコーポレーテッド |
リンパ脈管筋腫症の処置のためのラパマイシン
|
CN105899232A
(zh)
|
2013-11-13 |
2016-08-24 |
诺华股份有限公司 |
用于增强免疫应答的mTOR抑制剂
|
CA2931684C
(en)
|
2013-12-19 |
2024-02-20 |
Novartis Ag |
Human mesothelin chimeric antigen receptors and uses thereof
|
EP3087101B1
(en)
|
2013-12-20 |
2024-06-05 |
Novartis AG |
Regulatable chimeric antigen receptor
|
CA2933908C
(en)
|
2013-12-31 |
2024-01-30 |
Rapamycin Holdings, Llc |
Oral rapamycin nanoparticle preparations and use
|
US9700544B2
(en)
|
2013-12-31 |
2017-07-11 |
Neal K Vail |
Oral rapamycin nanoparticle preparations
|
AU2015217349A1
(en)
|
2014-02-11 |
2016-09-08 |
AI Therapeutics, Inc. |
Rapamycin for the treatment of lymphangioleiomyomatosis
|
US10307371B2
(en)
|
2014-02-11 |
2019-06-04 |
AI Therapeutics, Inc. |
Rapamycin for the treatment of lymphangioleiomyomatosis
|
US20170335281A1
(en)
|
2014-03-15 |
2017-11-23 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor
|
ES2857226T3
(es)
|
2014-03-15 |
2021-09-28 |
Novartis Ag |
Receptor de antígeno quimérico regulable
|
US20170014341A1
(en)
|
2014-04-04 |
2017-01-19 |
Lam Therapeutics, Inc. |
An Inhalable Rapamycin Formulation for Treating Age-Related Conditions
|
IL307423A
(en)
|
2014-04-07 |
2023-12-01 |
Novartis Ag |
Cancer treatment using chimeric antigen receptor (CAR) against CD19
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
WO2016014565A2
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Treatment of cancer using humanized anti-bcma chimeric antigen receptor
|
EP3722316A1
(en)
|
2014-07-21 |
2020-10-14 |
Novartis AG |
Treatment of cancer using a cd33 chimeric antigen receptor
|
EP4205749A1
(en)
|
2014-07-31 |
2023-07-05 |
Novartis AG |
Subset-optimized chimeric antigen receptor-containing cells
|
WO2016025880A1
(en)
|
2014-08-14 |
2016-02-18 |
Novartis Ag |
Treatment of cancer using gfr alpha-4 chimeric antigen receptor
|
CN112410363A
(zh)
|
2014-08-19 |
2021-02-26 |
诺华股份有限公司 |
抗cd123嵌合抗原受体(car)用于癌症治疗
|
CN113620978A
(zh)
|
2014-09-11 |
2021-11-09 |
加利福尼亚大学董事会 |
mTORC1抑制剂
|
US10577417B2
(en)
|
2014-09-17 |
2020-03-03 |
Novartis Ag |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
CN107249576A
(zh)
|
2014-10-07 |
2017-10-13 |
拉姆医疗公司 |
用于治疗肺高压的可吸入雷帕霉素制剂
|
RU2743657C2
(ru)
|
2014-10-08 |
2021-02-20 |
Новартис Аг |
Биомаркеры, прогнозирующие способность к терапевтическому ответу на терапию химерным рецептором антигена, и их применение
|
WO2016069556A2
(en)
|
2014-10-29 |
2016-05-06 |
University Of Maryland |
Methods of treating age-related symptoms in mammals and compositions therefor
|
MA40910A
(fr)
|
2014-11-07 |
2017-09-12 |
Civitas Therapeutics Inc |
Poudres de rapamycine pour administration pulmonaire
|
WO2016098078A2
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Dimerization switches and uses thereof
|
WO2016130645A1
(en)
|
2015-02-10 |
2016-08-18 |
Lam Therapeutics, Inc. |
Rapamycin for the treatment of lymphangioleiomyomatosis
|
ES2876974T3
(es)
|
2015-04-07 |
2021-11-15 |
Novartis Ag |
Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina
|
CN104844620B
(zh)
*
|
2015-04-10 |
2018-06-19 |
鲁南新时代生物技术有限公司 |
一种雷帕霉素的分离纯化方法
|
US11896614B2
(en)
|
2015-04-17 |
2024-02-13 |
Novartis Ag |
Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
|
WO2016172583A1
(en)
|
2015-04-23 |
2016-10-27 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
KR20180058659A
(ko)
|
2015-05-20 |
2018-06-01 |
노파르티스 아게 |
에베롤리무스와 닥톨리십의 약제학적 병용물
|
WO2017029391A1
(en)
|
2015-08-20 |
2017-02-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New method for treating cancer
|
AU2016315653A1
(en)
*
|
2015-08-28 |
2018-03-15 |
Buck Institute For Research On Aging |
Rapamycin analogs showing improved mTORC1 specificity
|
US10550126B2
(en)
|
2015-10-16 |
2020-02-04 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
US11365198B2
(en)
|
2015-10-16 |
2022-06-21 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
US11524964B2
(en)
|
2015-10-16 |
2022-12-13 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
KR20180081523A
(ko)
|
2015-10-16 |
2018-07-16 |
애브비 인코포레이티드 |
(3S,4R)-3-에틸-4-(3H-이미다조[1,2-a]피롤로[2,3-e]-피라진-8-일)-N-(2,2,2-트리플루오로에틸)피롤리딘-1-카복스아미드 및 이의 고체상 형태의 제조 방법
|
US11512092B2
(en)
|
2015-10-16 |
2022-11-29 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
US11773106B2
(en)
|
2015-10-16 |
2023-10-03 |
Abbvie Inc. |
Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
|
EP3373927A1
(en)
|
2015-11-11 |
2018-09-19 |
Novartis AG |
Uses of myostatin antagonists, combinations containing them and uses thereof
|
CA3031542A1
(en)
|
2016-07-20 |
2018-01-25 |
University Of Utah Research Foundation |
Cd229 car t cells and methods of use thereof
|
CN117866991A
(zh)
|
2016-10-07 |
2024-04-12 |
诺华股份有限公司 |
用于治疗癌症的嵌合抗原受体
|
MX2019006090A
(es)
|
2016-11-23 |
2019-08-21 |
Novartis Ag |
Metodos para mejorar la respuesta inmune con everolimus, dactolisib o ambos.
|
JP2020507632A
(ja)
|
2017-02-10 |
2020-03-12 |
マウント タム セラピューティクス, インコーポレイテッドMount Tam Therapeutics, Inc. |
ラパマイシン類似体
|
US20200055948A1
(en)
|
2017-04-28 |
2020-02-20 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
US20200129486A1
(en)
|
2017-06-26 |
2020-04-30 |
Inserm (Institut National De La Santé Et De La Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of olmsted syndrome
|
AR112834A1
(es)
|
2017-09-26 |
2019-12-18 |
Novartis Ag |
Derivados de rapamicina
|
WO2019157516A1
(en)
|
2018-02-12 |
2019-08-15 |
resTORbio, Inc. |
Combination therapies
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
US20210396739A1
(en)
|
2018-05-01 |
2021-12-23 |
Novartis Ag |
Biomarkers for evaluating car-t cells to predict clinical outcome
|
JP7381492B2
(ja)
|
2018-05-01 |
2023-11-15 |
レヴォリューション・メディスンズ,インコーポレイテッド |
Mtor阻害剤としてのc26-連結ラパマイシン類似体
|
BR112020022201A2
(pt)
|
2018-05-01 |
2021-02-02 |
Revolution Medicines, Inc. |
análogos de rapamicina ligada a c40, c28, e c-32 como inibidores de mtor
|
JP7438988B2
(ja)
|
2018-06-13 |
2024-02-27 |
ノバルティス アーゲー |
Bcmaキメラ抗原受容体及びその使用
|
EP3826649A4
(en)
|
2018-07-23 |
2022-07-20 |
Enclear Therapies, Inc. |
METHODS OF TREATMENT OF NEUROLOGICAL DISORDERS
|
WO2020023418A1
(en)
|
2018-07-23 |
2020-01-30 |
Enclear Therapies, Inc. |
Methods of treating neurological disorders
|
US20220047567A1
(en)
|
2018-09-10 |
2022-02-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of neurofibromatosis
|
MX2021007247A
(es)
|
2018-12-18 |
2021-07-15 |
Novartis Ag |
Derivados de rapamicina.
|
JP7461369B2
(ja)
|
2019-03-26 |
2024-04-03 |
ノバルティス アーゲー |
イソチアゾリジン1,1-ジオキシド及び1,4-ブタンスルトン含有ラパマイシン誘導体並びにその使用
|
JP2022526671A
(ja)
|
2019-04-11 |
2022-05-25 |
エンクリアー セラピーズ, インク. |
脳脊髄液の改善の方法ならびにそのためのデバイスおよびシステム
|
US20220409567A1
(en)
*
|
2021-06-23 |
2022-12-29 |
Thomas Winston |
Adjuvant and complementary therapies for the treatment of cancer
|
TW202402277A
(zh)
|
2022-05-25 |
2024-01-16 |
美商銳新醫藥公司 |
以mtor抑制劑治療癌症之方法
|
WO2024008799A1
(en)
|
2022-07-06 |
2024-01-11 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of proliferative glomerulonephritis
|
WO2024028433A1
(en)
|
2022-08-04 |
2024-02-08 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of lymphoproliferative disorders
|
US20240360153A1
(en)
|
2023-04-07 |
2024-10-31 |
Regeneron Pharmaceuticals, Inc. |
Selective rapamycin analogs and uses thereof
|