DK1341774T3 - Kondenserede heteroaromatiske glucokinase-aktivatorer - Google Patents

Kondenserede heteroaromatiske glucokinase-aktivatorer

Info

Publication number
DK1341774T3
DK1341774T3 DK01999565T DK01999565T DK1341774T3 DK 1341774 T3 DK1341774 T3 DK 1341774T3 DK 01999565 T DK01999565 T DK 01999565T DK 01999565 T DK01999565 T DK 01999565T DK 1341774 T3 DK1341774 T3 DK 1341774T3
Authority
DK
Denmark
Prior art keywords
glucokinase activators
condensed heteroaromatic
heteroaromatic glucokinase
condensed
activators
Prior art date
Application number
DK01999565T
Other languages
Danish (da)
English (en)
Inventor
Wendy Lea Corbett
Nancy-Ellen Haynes
Robert Francis Kester
Paige Erin Mahaney
Ramakanth Sarabu
Joseph Samuel Grimbsy
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1341774T3 publication Critical patent/DK1341774T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK01999565T 2000-12-06 2001-11-28 Kondenserede heteroaromatiske glucokinase-aktivatorer DK1341774T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25163700P 2000-12-06 2000-12-06

Publications (1)

Publication Number Publication Date
DK1341774T3 true DK1341774T3 (da) 2006-06-12

Family

ID=22952803

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01999565T DK1341774T3 (da) 2000-12-06 2001-11-28 Kondenserede heteroaromatiske glucokinase-aktivatorer

Country Status (21)

Country Link
US (3) US6448399B1 (uk)
EP (1) EP1341774B1 (uk)
JP (1) JP4109111B2 (uk)
KR (1) KR100545431B1 (uk)
CN (1) CN1226294C (uk)
AR (1) AR031627A1 (uk)
AT (1) ATE316965T1 (uk)
AU (2) AU2002221902B2 (uk)
BR (1) BR0115999A (uk)
CA (1) CA2429642C (uk)
DE (1) DE60117059T2 (uk)
DK (1) DK1341774T3 (uk)
ES (1) ES2256340T3 (uk)
GT (1) GT200100243A (uk)
MX (1) MXPA03005119A (uk)
PA (1) PA8534301A1 (uk)
PE (1) PE20020753A1 (uk)
PT (1) PT1341774E (uk)
UY (1) UY27055A1 (uk)
WO (1) WO2002046173A1 (uk)
ZA (1) ZA200303748B (uk)

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ATE374768T1 (de) 2002-10-03 2007-10-15 Hoffmann La Roche Indole-3-carbonsaüreamide als glucokinase (gk) aktivatoren
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CA2581619A1 (en) 2004-10-16 2006-04-20 Astrazeneca Ab Process for making phenoxy benzamide compounds
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US20110059941A1 (en) * 2005-05-24 2011-03-10 Peter William Rodney Caulkett 2-phenyl substituted imidazol [4,5b] pyridine/pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
BRPI0622262A2 (pt) * 2005-07-09 2011-08-09 Astrazeneca Ab composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
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Also Published As

Publication number Publication date
CA2429642C (en) 2007-11-20
MXPA03005119A (es) 2004-10-15
PE20020753A1 (es) 2002-08-27
EP1341774A1 (en) 2003-09-10
US6448399B1 (en) 2002-09-10
US20020103241A1 (en) 2002-08-01
DE60117059T2 (de) 2006-10-26
GT200100243A (es) 2002-06-04
JP4109111B2 (ja) 2008-07-02
CA2429642A1 (en) 2002-06-13
US20020103199A1 (en) 2002-08-01
WO2002046173A1 (en) 2002-06-13
ATE316965T1 (de) 2006-02-15
CN1226294C (zh) 2005-11-09
AU2002221902B2 (en) 2006-11-23
US20020107396A1 (en) 2002-08-08
KR100545431B1 (ko) 2006-01-24
DE60117059D1 (de) 2006-04-13
JP2004517087A (ja) 2004-06-10
KR20030068555A (ko) 2003-08-21
US6545155B2 (en) 2003-04-08
ES2256340T3 (es) 2006-07-16
PA8534301A1 (es) 2002-08-26
US6441184B1 (en) 2002-08-27
UY27055A1 (es) 2002-07-31
ZA200303748B (en) 2004-08-16
BR0115999A (pt) 2003-09-30
EP1341774B1 (en) 2006-02-01
CN1476438A (zh) 2004-02-18
PT1341774E (pt) 2006-05-31
AR031627A1 (es) 2003-09-24
AU2190202A (en) 2002-06-18

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