DK1335898T3 - Carbaminsyreforbindelser omfattende en amidbinding som HDAC-inhibitorer - Google Patents

Carbaminsyreforbindelser omfattende en amidbinding som HDAC-inhibitorer

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Publication number
DK1335898T3
DK1335898T3 DK01970014T DK01970014T DK1335898T3 DK 1335898 T3 DK1335898 T3 DK 1335898T3 DK 01970014 T DK01970014 T DK 01970014T DK 01970014 T DK01970014 T DK 01970014T DK 1335898 T3 DK1335898 T3 DK 1335898T3
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Prior art keywords
infection
disorder
carbamic acid
acid compounds
disease
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DK01970014T
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Danish (da)
English (en)
Inventor
Clare J Watkins
Maria-Rosario Romero-Martin
Kathryn G Prolifix Ltd Moore
James Ritchie
Paul W Finn
Ivars Kalvinsh
Einars Loza
Igor Starchenkov
Klara Dikovska
Rasma M Bokaldere
Vija Gailite
Maxim Vorona
Victor Andrianov
Daina Lolya
Valentina Semenikhina
Andris Amolins
C John Harris
James E S Duffy
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Topotarget Uk Ltd
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Priority claimed from GB0023985A external-priority patent/GB0023985D0/en
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Publication of DK1335898T3 publication Critical patent/DK1335898T3/da

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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