DK1296685T3 - Præparater af quinolonantibiotika med forhalet frigivelse og fremgangsmåde til fremstilling deraf - Google Patents

Præparater af quinolonantibiotika med forhalet frigivelse og fremgangsmåde til fremstilling deraf

Info

Publication number
DK1296685T3
DK1296685T3 DK01949412T DK01949412T DK1296685T3 DK 1296685 T3 DK1296685 T3 DK 1296685T3 DK 01949412 T DK01949412 T DK 01949412T DK 01949412 T DK01949412 T DK 01949412T DK 1296685 T3 DK1296685 T3 DK 1296685T3
Authority
DK
Denmark
Prior art keywords
delayed
release
preparation
methods
quinolone antibiotics
Prior art date
Application number
DK01949412T
Other languages
Danish (da)
English (en)
Inventor
Roland Rupp
Venkata-Rangarao Kanikanti
Wolfgang Weber
Jan-Olav Henck
Heino Stass
Takaaki Nishioka
Yoshifumi Katakawa
Chika Taniguchi
Peter Deuringer
Hitoshi Ichihashi
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Application granted granted Critical
Publication of DK1296685T3 publication Critical patent/DK1296685T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK01949412T 2000-06-26 2001-06-13 Præparater af quinolonantibiotika med forhalet frigivelse og fremgangsmåde til fremstilling deraf DK1296685T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10031043A DE10031043A1 (de) 2000-06-26 2000-06-26 Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
PCT/EP2001/006695 WO2002000219A1 (de) 2000-06-26 2001-06-13 Retard-zubereitungen von chinolon-antibiotika und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DK1296685T3 true DK1296685T3 (da) 2007-05-07

Family

ID=7646816

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01949412T DK1296685T3 (da) 2000-06-26 2001-06-13 Præparater af quinolonantibiotika med forhalet frigivelse og fremgangsmåde til fremstilling deraf

Country Status (41)

Country Link
US (3) US7709022B2 (ko)
EP (1) EP1296685B1 (ko)
JP (1) JP4958373B2 (ko)
KR (1) KR100939617B1 (ko)
CN (1) CN1273138C (ko)
AR (1) AR029688A1 (ko)
AT (1) ATE355062T1 (ko)
AU (1) AU2001270573A1 (ko)
BG (1) BG65914B1 (ko)
BR (1) BRPI0111911B8 (ko)
CA (1) CA2414271C (ko)
CU (1) CU23264B7 (ko)
CY (1) CY1107574T1 (ko)
CZ (1) CZ301812B6 (ko)
DE (2) DE10031043A1 (ko)
DK (1) DK1296685T3 (ko)
DO (1) DOP2001000199A (ko)
EE (1) EE04992B1 (ko)
ES (1) ES2282270T3 (ko)
GT (1) GT200100126A (ko)
HK (1) HK1058479A1 (ko)
HN (1) HN2001000132A (ko)
HR (1) HRP20030050B1 (ko)
HU (1) HU229806B1 (ko)
IL (2) IL153333A0 (ko)
MA (1) MA25761A1 (ko)
MX (1) MXPA02012727A (ko)
MY (1) MY140994A (ko)
NO (1) NO325415B1 (ko)
NZ (1) NZ523352A (ko)
PE (1) PE20020207A1 (ko)
PL (1) PL203710B1 (ko)
PT (1) PT1296685E (ko)
RU (1) RU2332204C2 (ko)
SI (1) SI1296685T1 (ko)
SK (1) SK287384B6 (ko)
SV (1) SV2002000505A (ko)
TW (1) TWI279232B (ko)
UA (1) UA83616C2 (ko)
WO (1) WO2002000219A1 (ko)
ZA (1) ZA200210350B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031043A1 (de) * 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US7491768B2 (en) * 2002-06-25 2009-02-17 Woong-Sig Moon Polymer resin formulation having anti-microbial or anti-coagulability and preparation method thereof
SI1594500T1 (sl) * 2003-02-10 2011-02-28 Bayer Schering Pharma Ag Zdravljenje bakterijskih bolezni dihalnih organov z lokalno aplikacijo fluorokinolonov
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
USRE45404E1 (en) 2003-03-27 2015-03-03 Shin Nippon Biomedical Laboratories, Ltd. Powder medicine applicator for nasal cavity
CN1842333A (zh) * 2003-08-04 2006-10-04 杏林制药株式会社 口服缓释片剂
US7943585B2 (en) * 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
WO2006007323A2 (en) * 2004-06-28 2006-01-19 Alza Corporation Dosage forms for low solubility and/or low dissolution rate free acid pharmaceutical agents
US20080206329A1 (en) * 2004-12-03 2008-08-28 Sanjay Verma Modified Release Ciprofloxacin Compositions
PT1868581E (pt) * 2005-04-11 2012-06-22 Abbott Lab Composições farmacêuticas que possuem perfis de dissolução melhorados para fármacos pouco solúveis
EP1880722B1 (en) * 2006-07-19 2010-03-17 Tabuk Pharmaceutical Manufacturing Co. Pharmaceutical compositions of ciprofloxacin
EP2116264B1 (en) 2006-12-26 2017-09-27 Shin Nippon Biomedical Laboratories, Ltd. Preparation for transnasal application
MX2010010280A (es) * 2008-03-21 2010-12-15 Mylan Pharmaceuticals Inc Formulacion de liberacion prolongada que contiene una cera.
PL2395840T3 (pl) 2009-02-13 2020-09-07 Romark Laboratories, L.C. Preparaty farmaceutyczne nitazoksanidu o kontrolowanym uwalnianiu
WO2010131486A1 (en) * 2009-05-15 2010-11-18 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
US11033624B2 (en) * 2010-06-02 2021-06-15 Novaflux Inc. Medical item for prevention and treatment of ear infection
CN102247313A (zh) * 2010-06-11 2011-11-23 北京润德康医药技术有限公司 一种以莫西沙星为活性成分的口服缓释固体制剂
WO2015168642A1 (en) 2014-05-02 2015-11-05 Labib Mohamed E Drug-releasing device usable in mucosal body cavities
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951792A (en) * 1959-11-18 1960-09-06 Smith Kline French Lab Sustained release pharmaceutical tablets
FR2100858B1 (ko) 1970-07-03 1975-06-06 Daiichi Seiyaku Co
US4122157A (en) * 1977-03-04 1978-10-24 Richardson-Merrell Inc. Nitrofurantoin sustained release tablet
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
FR2470599A1 (fr) * 1979-12-07 1981-06-12 Panoz Donald Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus
DE3142854A1 (de) 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4370313A (en) * 1981-10-26 1983-01-25 Eaton Laboratories, Inc. Nitrofurantoin dosage form
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4530928A (en) * 1982-01-13 1985-07-23 Merck & Co., Inc. Quinoline carboxylic acid complexes with guanidinium carbonate
US4440740A (en) * 1982-04-26 1984-04-03 Merck & Co., Inc. α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
IT1198386B (it) 1982-07-06 1988-12-21 Lepetit Spa Un prodotto a rilascio protratto contenente il suloctidile
IL70071A (en) 1982-11-01 1987-12-31 Merrell Dow Pharma Multilayered sustained release pharmaceutical tablets having non-uniform distribution of active ingredient
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4639458A (en) * 1985-01-22 1987-01-27 Merck & Co., Inc. Tablet and formulation
NL8500724A (nl) * 1985-03-13 1986-10-01 Univ Groningen Inrichtingen voor geregelde afgifte van werkzame stoffen, alsmede werkwijze ter vervaardiging daarvan.
FR2585246A1 (fr) * 1985-07-26 1987-01-30 Cortial Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
US5188840A (en) * 1985-09-26 1993-02-23 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions
IT1188212B (it) * 1985-12-20 1988-01-07 Paolo Colombo Sistema per il rilascio a velocita' controllata di sostanze attive
US5286754A (en) * 1986-01-21 1994-02-15 Bayer Aktiengesellschaft Pharmaceutical formulations of ciprofloxacin
DE3601566A1 (de) * 1986-01-21 1987-07-23 Bayer Ag Pharmazeutische zubereitungen von ciprofloxacin
JPS62195323A (ja) * 1986-02-24 1987-08-28 Eisai Co Ltd 胃内滞留型粒子
EP0265061B1 (en) 1986-09-18 1992-01-08 London School of Pharmacy Innovations Ltd Pharmaceutical formulation
US4869908A (en) * 1987-01-09 1989-09-26 K.V. Pharmaceutical Co. Fibre formulations
US4786503A (en) 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US5200193A (en) * 1987-04-22 1993-04-06 Mcneilab, Inc. Pharmaceutical sustained release matrix and process
DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
US5472710A (en) * 1988-04-16 1995-12-05 Schwarz Pharma Ag Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture
US5032406A (en) * 1989-02-21 1991-07-16 Norwich Eaton Pharmaceuticals, Inc. Dual-action tablet
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5085865A (en) * 1989-04-12 1992-02-04 Warner-Lambert Company Sustained release pharmaceutical preparations containing an analgesic and a decongestant
DK469989D0 (da) * 1989-09-22 1989-09-22 Bukh Meditec Farmaceutisk praeparat
IT1237904B (it) * 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive
JPH0624959A (ja) * 1991-10-04 1994-02-01 Bayer Yakuhin Kk 胃内浮遊型薬物徐放性固形製剤
DE4200821A1 (de) * 1992-01-15 1993-07-22 Bayer Ag Geschmacksmaskierte pharmazeutische mittel
JP2958731B2 (ja) * 1992-02-14 1999-10-06 日本特殊陶業株式会社 酸化アルミニウム基焼結体及びその製造方法
US5582837A (en) * 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
IT1255522B (it) * 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
IT1256393B (it) * 1992-11-17 1995-12-04 Inverni Della Beffa Spa Forme matriciali multistrato per il rilascio controllato di principi attivi
JP2686215B2 (ja) 1993-04-28 1997-12-08 信越化学工業株式会社 徐放性錠剤
IT1264696B1 (it) 1993-07-09 1996-10-04 Applied Pharma Res Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata
DE4406424A1 (de) * 1994-02-28 1995-08-31 Bayer Ag Expandierbare Arzneiformen
US5464633A (en) * 1994-05-24 1995-11-07 Jagotec Ag Pharmaceutical tablets releasing the active substance after a definite period of time
US5900425A (en) * 1995-05-02 1999-05-04 Bayer Aktiengesellschaft Pharmaceutical preparations having controlled release of active compound and processes for their preparation
CN1048628C (zh) 1995-07-06 2000-01-26 东北制药总厂 环丙沙星注射液的制备方法
US5705190A (en) * 1995-12-19 1998-01-06 Abbott Laboratories Controlled release formulation for poorly soluble basic drugs
IT1282650B1 (it) * 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
CA2290624C (en) * 1997-06-06 2006-12-05 John W. Shell Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs
IN186245B (ko) * 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
PL192273B1 (pl) * 1997-09-25 2006-09-29 Bayer Ag Preparat środka leczniczego w postaci pastylki o kontrolowanej dyfuzji lub w postaci układu matrycowego, o kontrolowanym uwalnianiu substancji czynnej
PA8466701A1 (es) * 1998-01-21 2000-09-29 Pfizer Prod Inc Comprimido de mesilato de trovafloxacino
EA004443B1 (ru) 1998-09-14 2004-04-29 Рэнбакси Лабораториз Лимитед Лекарственная форма для контролируемого высвобождения ципрофлоксацина для приема один раз в день
EP1242057A2 (en) 1999-11-02 2002-09-25 DepoMed, Inc. Pharmacological inducement of the fed mode for enhanced drug administration to the stomach
CA2396782A1 (en) 2000-02-04 2001-08-09 Depomed, Inc. Shell-and-core dosage form approaching zero-order drug release
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
DE10031043A1 (de) * 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US6780057B2 (en) * 2001-12-21 2004-08-24 Intel Corporation Coaxial dual pin sockets for high speed I/O applications

Also Published As

Publication number Publication date
MXPA02012727A (es) 2003-05-14
BG107372A (bg) 2003-09-30
NO20026160L (no) 2002-12-20
ATE355062T1 (de) 2006-03-15
HK1058479A1 (en) 2004-05-21
HU229806B1 (en) 2014-07-28
US8187632B2 (en) 2012-05-29
SV2002000505A (es) 2002-12-02
EP1296685B1 (de) 2007-02-28
EP1296685A1 (de) 2003-04-02
CN1438889A (zh) 2003-08-27
CU23264B7 (es) 2008-03-14
PL360632A1 (en) 2004-09-20
EE200200707A (et) 2004-08-16
MA25761A1 (fr) 2003-04-01
CA2414271C (en) 2005-09-27
HN2001000132A (es) 2001-09-11
EE04992B1 (et) 2008-04-15
HRP20030050A2 (en) 2004-06-30
BR0111911A (pt) 2003-05-13
BG65914B1 (bg) 2010-05-31
SI1296685T1 (sl) 2007-06-30
US7709022B2 (en) 2010-05-04
SK287384B6 (sk) 2010-08-09
PE20020207A1 (es) 2002-04-27
IL153333A (en) 2010-05-31
CZ301812B6 (cs) 2010-06-30
BRPI0111911B1 (pt) 2015-08-25
KR20030023883A (ko) 2003-03-20
JP4958373B2 (ja) 2012-06-20
HUP0300953A3 (en) 2009-04-28
IL153333A0 (en) 2003-07-06
DOP2001000199A (es) 2002-05-15
TWI279232B (en) 2007-04-21
DE50112123D1 (de) 2007-04-12
WO2002000219A1 (de) 2002-01-03
JP2004504278A (ja) 2004-02-12
AU2001270573A1 (en) 2002-01-08
DE10031043A1 (de) 2002-02-14
RU2332204C2 (ru) 2008-08-27
MY140994A (en) 2010-02-12
US20070237824A1 (en) 2007-10-11
ZA200210350B (en) 2004-02-10
CA2414271A1 (en) 2002-12-23
HRP20030050B1 (en) 2011-07-31
NO20026160D0 (no) 2002-12-20
US7780986B2 (en) 2010-08-24
US20040024018A1 (en) 2004-02-05
UA83616C2 (uk) 2008-08-11
ES2282270T3 (es) 2007-10-16
AR029688A1 (es) 2003-07-10
SK18212002A3 (sk) 2003-04-01
NO325415B1 (no) 2008-04-21
KR100939617B1 (ko) 2010-02-01
HUP0300953A2 (hu) 2003-08-28
CZ20024216A3 (cs) 2003-04-16
PL203710B1 (pl) 2009-11-30
CY1107574T1 (el) 2013-03-13
CN1273138C (zh) 2006-09-06
GT200100126A (es) 2002-01-31
US20070065509A1 (en) 2007-03-22
PT1296685E (pt) 2007-05-31
NZ523352A (en) 2004-08-27
BRPI0111911B8 (pt) 2021-05-25

Similar Documents

Publication Publication Date Title
DK1296685T3 (da) Præparater af quinolonantibiotika med forhalet frigivelse og fremgangsmåde til fremstilling deraf
DK2128246T3 (da) Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar.
NO20000011D0 (no) Skumdempersammensetninger og fremgangsmåter
DK1417175T3 (da) Substituerede dihydro-3-halo-1h-pyrazol-5-carboxylater og fremstillingog anvendelse heraf
DK1334182T4 (da) Fremgangsmåde til fremstilling af ikke-bovint chymosin og anvendelse heraf
DK1265482T3 (da) Vandige formulationer og fremgangsmåde til fremstilling af samme
NO20032332D0 (no) Benzodiazepinderivatforbindelser, fremgangsmåte til fremstilling og anvendelse derav
DK1328538T3 (da) Fremgangsmåde og mellemprodukter til fremstilling af 7-substituerede antiöstrogener
NO20035562L (no) System og fremgangsmate for forenklet initiering av konferanser
DK1147075T3 (da) Fremgangsmåde til fremstilling af L-phenylephrinhydrochlorid
DE60130173D1 (de) Kamerakalibrierungsverfahren
DE60141615D1 (de) Videospielsystem
DK1311731T3 (da) Fremgangsmåde og arrangement til stolpesystem
DK1456229T3 (da) Fremgangsmåe til fremstilling af echinocandin-derivater
NO20013735D0 (no) Fremgangsmåte til fremstilling av di-iso-butaner, di-iso- butener og di-n-butener fra feltbutaner
NO20030156L (no) Farmasöytiske sammensetninger og fremgangsmåter for anvendelse derav
DK1292586T3 (da) Fremgangsmåde til fremstilling af pyrazolopyrimidinoner
ATE523892T1 (de) Klemmhilfe
DK1406895T3 (da) Lactonformuleringer og fremgangsmåde til anvendelse deraf
DK1294694T3 (da) Fremgangsmåde til fremstilling af quinolinderivater
DK1341758T3 (da) Coniosetin og derivater af denne, fremgangsmåde til fremstilling og anvendelse af samme
DK1316239T3 (da) Höreapparat og fremgangsmåde til fremstilling af samme
NO20020080D0 (no) Sekvenser og fremgangsmåter for deteksjon av HIV-1
DE50205568D1 (de) Klemmring
DE60201909D1 (de) Zoom-verfahren