DK1270575T3 - Hidtil ukendt krystallinsk form af et pyrrolidylthiocarbapenemderivat - Google Patents
Hidtil ukendt krystallinsk form af et pyrrolidylthiocarbapenemderivatInfo
- Publication number
- DK1270575T3 DK1270575T3 DK01917764T DK01917764T DK1270575T3 DK 1270575 T3 DK1270575 T3 DK 1270575T3 DK 01917764 T DK01917764 T DK 01917764T DK 01917764 T DK01917764 T DK 01917764T DK 1270575 T3 DK1270575 T3 DK 1270575T3
- Authority
- DK
- Denmark
- Prior art keywords
- hitherto
- crystalline form
- pyrrolidylthiocarbapenem derivative
- pyrrolidylthiocarbapenem
- derivative
- Prior art date
Links
- XLJMOHKQRRPBDS-IENPIDJESA-N (5S)-4-pyrrolidin-1-ylsulfanyl-1-azabicyclo[3.2.0]hept-2-en-7-one Chemical class N1(CCCC1)SC1C=CN2[C@H]1CC2=O XLJMOHKQRRPBDS-IENPIDJESA-N 0.000 title abstract 2
- 239000013078 crystal Substances 0.000 abstract 2
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000099868 | 2000-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1270575T3 true DK1270575T3 (da) | 2006-01-16 |
Family
ID=18614158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01917764T DK1270575T3 (da) | 2000-03-31 | 2001-03-30 | Hidtil ukendt krystallinsk form af et pyrrolidylthiocarbapenemderivat |
Country Status (17)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02009592A (es) * | 2000-03-31 | 2003-03-12 | Shionogi & Co | Nueva forma cristalina de derivado de pirrolidiltiocarbapenema. |
| JP5004355B2 (ja) * | 2001-05-10 | 2012-08-22 | 塩野義製薬株式会社 | アセチルチオピロリジン誘導体の製法 |
| EA200400682A1 (ru) * | 2001-11-16 | 2004-10-28 | Рэнбакси Лабораториз Лимитед | Способ получения кристаллического имипенема |
| TWI353855B (en) | 2005-05-26 | 2011-12-11 | Shionogi & Co | Method for preparing an aqueous solution of doripe |
| JP5671204B2 (ja) * | 2006-04-28 | 2015-02-18 | 株式会社カネカ | カルバペネム抗生物質中間体の改良された晶析方法 |
| WO2008006298A1 (fr) * | 2006-07-03 | 2008-01-17 | Chengdu Di'ao Jiuhong Pharmaceutical Factory | Nouvelle forme cristalline de doripenem, préparation, procédé et utilisations de celle-ci |
| CN101191787B (zh) * | 2006-11-21 | 2011-07-27 | 上海医药工业研究院 | 高效液相色谱法测定多利培南含量的方法 |
| US8445673B2 (en) * | 2008-03-24 | 2013-05-21 | Ranbaxy Laboratories Limited | Process for the preparation of sterile doripenem |
| CN103025733B (zh) * | 2010-06-03 | 2015-11-25 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
| CN102977101A (zh) * | 2011-09-07 | 2013-03-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 多尼培南一水合物、其药物组合物、其制备方法和用途 |
| CN102285988B (zh) * | 2011-09-08 | 2012-09-05 | 上海希迈医药科技有限公司 | 一种多尼培南水合物晶体及其制备方法 |
| EP2776440A1 (en) * | 2011-11-08 | 2014-09-17 | Ranbaxy Laboratories Limited | Process for the preparation of polymorphs of doripenem |
| CN104072497B (zh) * | 2013-03-29 | 2017-10-03 | 石药集团中奇制药技术（石家庄）有限公司 | 一种多尼培南新结晶及其制备方法 |
| CN103389347B (zh) * | 2013-07-26 | 2015-12-09 | 深圳市海滨制药有限公司 | 高效液相色谱法测定多尼培南的方法 |
| JP6477728B2 (ja) * | 2014-04-28 | 2019-03-06 | ジェイダブリュ ファーマセウティカル コーポレーション | ドリペネムの新規な結晶およびその製造方法 |
| KR20160007679A (ko) | 2016-01-04 | 2016-01-20 | 제일약품주식회사 | 도리페넴의 신규한 결정형 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
| US5539102A (en) * | 1992-02-21 | 1996-07-23 | Shionogi Seiyaku Kabushiki Kaisha | Production method for sulfamide |
| DE69528166T2 (de) * | 1994-05-02 | 2003-04-30 | Shionogi & Co., Ltd. | Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung |
| JP3558684B2 (ja) * | 1994-06-28 | 2004-08-25 | 塩野義製薬株式会社 | ピロリジルチオカルバペネム誘導体の乾燥方法 |
| MXPA02009592A (es) * | 2000-03-31 | 2003-03-12 | Shionogi & Co | Nueva forma cristalina de derivado de pirrolidiltiocarbapenema. |
| EP1595883A4 (en) * | 2003-02-14 | 2008-11-26 | Shionogi & Co | INTERMEDIATE PRODUCT CRYSTAL FOR CARBAPENEM |
| US20120035357A1 (en) | 2009-02-26 | 2012-02-09 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of carbapenem antibiotic |
-
2001
- 2001-03-30 MX MXPA02009592A patent/MXPA02009592A/es active IP Right Grant
- 2001-03-30 TW TW090107676A patent/TWI293631B/zh not_active IP Right Cessation
- 2001-03-30 ES ES01917764T patent/ES2252205T3/es not_active Expired - Lifetime
- 2001-03-30 US US10/240,465 patent/US20030153191A1/en not_active Abandoned
- 2001-03-30 AU AU4469201A patent/AU4469201A/xx active Pending
- 2001-03-30 KR KR10-2002-7012979A patent/KR100472842B1/ko not_active Expired - Lifetime
- 2001-03-30 AU AU2001244692A patent/AU2001244692B2/en not_active Ceased
- 2001-03-30 AT AT01917764T patent/ATE304014T1/de active
- 2001-03-30 EP EP01917764A patent/EP1270575B1/en not_active Expired - Lifetime
- 2001-03-30 CN CNB01810309XA patent/CN1192030C/zh not_active Ceased
- 2001-03-30 JP JP2001570660A patent/JP3375084B2/ja not_active Expired - Lifetime
- 2001-03-30 CA CA002404703A patent/CA2404703C/en not_active Expired - Fee Related
- 2001-03-30 WO PCT/JP2001/002834 patent/WO2001072750A1/ja active IP Right Grant
- 2001-03-30 BR BRPI0109712-1 patent/BRPI0109712B8/pt not_active IP Right Cessation
- 2001-03-30 DK DK01917764T patent/DK1270575T3/da active
- 2001-03-30 DE DE60113243T patent/DE60113243T2/de not_active Expired - Lifetime
-
2002
- 2002-09-25 ZA ZA200207675A patent/ZA200207675B/xx unknown
-
2005
- 2005-11-28 CY CY20051101453T patent/CY1105674T1/el unknown
-
2006
- 2006-11-10 US US11/595,348 patent/US20070060562A1/en not_active Abandoned
-
2008
- 2008-02-05 US US12/012,932 patent/US8247402B2/en not_active Expired - Fee Related
-
2009
- 2009-01-23 CY CY200900001C patent/CY2009001I1/el unknown
-
2012
- 2012-08-14 US US13/585,611 patent/US20130059831A1/en not_active Abandoned
-
2014
- 2014-02-21 US US14/187,010 patent/US9221823B2/en not_active Expired - Fee Related
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