CY1107983T1 - Πολυμορφικες και αλλες κρυσταλλικες μορφες cis-ftc - Google Patents

Πολυμορφικες και αλλες κρυσταλλικες μορφες cis-ftc

Info

Publication number
CY1107983T1
CY1107983T1 CY20061100192T CY061100192T CY1107983T1 CY 1107983 T1 CY1107983 T1 CY 1107983T1 CY 20061100192 T CY20061100192 T CY 20061100192T CY 061100192 T CY061100192 T CY 061100192T CY 1107983 T1 CY1107983 T1 CY 1107983T1
Authority
CY
Cyprus
Prior art keywords
ftc
cis
forms
manufacture
polymorphic
Prior art date
Application number
CY20061100192T
Other languages
English (en)
Inventor
Kenneth R Phares
Devalina Law
Yuerong Hu
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of CY1107983T1 publication Critical patent/CY1107983T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Στερεές φάσεις του (-)-cis-FTC, οι οποίες ορίζονται εδώ ως άμορφο (-)-PTC και Μορφές II και III (-)-cis-FTC) παρέχονται, οι οποίες μπορεί να διακρίνονται από τη Μορφή I (-)-cis-FTC με πρότυπα διάθλασης σκόνης ακτίνων-Χ, θερμικές ιδιότητες και μεθόδους βιομηχανικής κατασκευής. Μια ένυδρη κρυσταλλική μορφή (±)-cis-FTC (δηλ. ρακεμικό cis-FTC) και αφυδατωμένη μορφή του υδρίτη, επίσης παρέχονται και μπορεί παρομοίως να διακρίνονται από άλλες μορφές FTC με πρότυπα διάθλασης σκόνης ακτίνων-Χ, θερμικές ιδιότητες και μεθόδους βιομηχανικής κατασκευής. Αυτές οι FTC μορφές μπορεί να χρησιμοποιηθούν στη βιομηχανική κατασκευή άλλων μορφών FTC ή σε φαρμακευτικές συνθέσεις. Ιδιαιτέρως προτιμώμενες χρήσεις αυτών των μορφών είναι στη θεραπεία HIV ή ηπατίτιδας Β.
CY20061100192T 2001-03-01 2006-02-10 Πολυμορφικες και αλλες κρυσταλλικες μορφες cis-ftc CY1107983T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27256001P 2001-03-01 2001-03-01
US30960501P 2001-08-02 2001-08-02
EP02748367A EP1389207B1 (en) 2001-03-01 2002-03-01 Polymorphic and other crystalline forms of cis-ftc

Publications (1)

Publication Number Publication Date
CY1107983T1 true CY1107983T1 (el) 2013-09-04

Family

ID=26955597

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20061100192T CY1107983T1 (el) 2001-03-01 2006-02-10 Πολυμορφικες και αλλες κρυσταλλικες μορφες cis-ftc
CY20081100369T CY1107913T1 (el) 2001-03-01 2008-03-31 Πολυμορφικες και αλλες κρυσταλλικες μορφες cis-ftc

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20081100369T CY1107913T1 (el) 2001-03-01 2008-03-31 Πολυμορφικες και αλλες κρυσταλλικες μορφες cis-ftc

Country Status (14)

Country Link
US (3) US6723728B2 (el)
EP (3) EP1574512B1 (el)
JP (4) JP5105689B2 (el)
KR (4) KR101150250B1 (el)
CN (4) CN102911166B (el)
AT (2) ATE383355T1 (el)
AU (1) AU2002335489B2 (el)
CA (4) CA2788498C (el)
CY (2) CY1107983T1 (el)
DE (2) DE60207850T2 (el)
DK (2) DK1389207T3 (el)
ES (3) ES2537007T3 (el)
PT (2) PT1574512E (el)
WO (1) WO2002070518A1 (el)

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TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
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Also Published As

Publication number Publication date
ATE383355T1 (de) 2008-01-15
EP1903041B1 (en) 2015-02-18
EP1903041A3 (en) 2008-04-23
ES2299950T3 (es) 2008-06-01
CN1503796B (zh) 2012-07-04
WO2002070518A1 (en) 2002-09-12
ES2253544T3 (es) 2006-06-01
EP1574512A1 (en) 2005-09-14
PT1574512E (pt) 2008-03-05
DE60207850D1 (de) 2006-01-12
CA2439831C (en) 2010-01-12
CA2867970A1 (en) 2002-09-12
US8637535B2 (en) 2014-01-28
KR20080065317A (ko) 2008-07-11
JP2015028045A (ja) 2015-02-12
JP2013040192A (ja) 2013-02-28
DE60224592D1 (de) 2008-02-21
KR100927024B1 (ko) 2009-11-17
DE60207850T2 (de) 2006-08-10
CN102911165B (zh) 2016-08-17
PT1903041E (pt) 2015-06-23
KR101015510B1 (ko) 2011-02-16
CN1503796A (zh) 2004-06-09
US20030060645A1 (en) 2003-03-27
KR20040002871A (ko) 2004-01-07
DE60224592T2 (de) 2009-01-29
US20050026934A1 (en) 2005-02-03
JP2009197005A (ja) 2009-09-03
CN102942563A (zh) 2013-02-27
CA2690137C (en) 2012-11-13
CA2439831A1 (en) 2002-09-12
KR20100091265A (ko) 2010-08-18
JP2004530660A (ja) 2004-10-07
KR101150250B1 (ko) 2012-06-12
KR20080065316A (ko) 2008-07-11
CY1107913T1 (el) 2013-09-04
CN102911165A (zh) 2013-02-06
ES2537007T3 (es) 2015-06-01
EP1903041A2 (en) 2008-03-26
CN102911166B (zh) 2016-08-17
JP5105689B2 (ja) 2012-12-26
EP1389207B1 (en) 2005-12-07
EP1574512B1 (en) 2008-01-09
ATE312097T1 (de) 2005-12-15
CA2690137A1 (en) 2002-09-12
CA2788498C (en) 2016-02-16
US20090306114A1 (en) 2009-12-10
DK1389207T3 (da) 2006-04-18
CA2788498A1 (en) 2002-09-12
US6723728B2 (en) 2004-04-20
CN102911166A (zh) 2013-02-06
US7544692B2 (en) 2009-06-09
DK1574512T3 (da) 2008-03-03
AU2002335489B2 (en) 2008-06-05
EP1389207A1 (en) 2004-02-18

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