DK1224166T3 - Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid - Google Patents

Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid

Info

Publication number
DK1224166T3
DK1224166T3 DK00972725T DK00972725T DK1224166T3 DK 1224166 T3 DK1224166 T3 DK 1224166T3 DK 00972725 T DK00972725 T DK 00972725T DK 00972725 T DK00972725 T DK 00972725T DK 1224166 T3 DK1224166 T3 DK 1224166T3
Authority
DK
Denmark
Prior art keywords
preparation
methanesulfonyl
benzoyl
bis
methyl
Prior art date
Application number
DK00972725T
Other languages
Danish (da)
English (en)
Inventor
Rolf Gericke
Manfred Baumgarth
Hans Markus Bender
Bernhard Ladstetter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1224166T3 publication Critical patent/DK1224166T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00972725T 1999-10-26 2000-10-11 Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid DK1224166T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19951418A DE19951418A1 (de) 1999-10-26 1999-10-26 Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
PCT/EP2000/009977 WO2001030750A1 (de) 1999-10-26 2000-10-11 Verfahren zur herstellung von n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid

Publications (1)

Publication Number Publication Date
DK1224166T3 true DK1224166T3 (da) 2004-01-05

Family

ID=7926842

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00972725T DK1224166T3 (da) 1999-10-26 2000-10-11 Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid

Country Status (26)

Country Link
US (1) US6673968B1 (no)
EP (1) EP1224166B1 (no)
JP (1) JP4969750B2 (no)
KR (1) KR100699571B1 (no)
CN (1) CN1202078C (no)
AT (1) ATE250026T1 (no)
AU (1) AU782471B2 (no)
BR (1) BR0015022A (no)
CA (1) CA2388915C (no)
CZ (1) CZ299201B6 (no)
DE (2) DE19951418A1 (no)
DK (1) DK1224166T3 (no)
ES (1) ES2204712T3 (no)
HK (1) HK1051358A1 (no)
HU (1) HU228634B1 (no)
MX (1) MXPA02004144A (no)
MY (1) MY122651A (no)
NO (1) NO328250B1 (no)
PL (1) PL199010B1 (no)
PT (1) PT1224166E (no)
RU (1) RU2276134C2 (no)
SI (1) SI1224166T1 (no)
SK (1) SK286603B6 (no)
UA (1) UA73329C2 (no)
WO (1) WO2001030750A1 (no)
ZA (1) ZA200204119B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
US7629493B2 (en) * 2003-05-06 2009-12-08 Merck Patent Gmbh Process for the crystallisation of guandinium salts
AU2009243749B2 (en) 2008-05-09 2013-11-21 Merck Patent Gmbh Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and beta-cell dysfunction
JOP20200296A1 (ar) * 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
JP6562221B2 (ja) * 2014-06-23 2019-08-21 日産化学株式会社 スルホニル結合を有するシラン化合物の製造方法
MX2018009558A (es) * 2016-02-08 2018-09-06 Merck Patent Gmbh Modificaciones cristalinas de clorhidrato de n-(4,5-bismetansulfon il-2-metilbenzoil)guanidina y sales de n-(4,5-bismetansulfonil-2-m etilbenzoil)guanidina.
EP3960165A1 (en) * 2020-08-25 2022-03-02 Fondation EspeRare Nhe-1 inhibitors for the treatment of coronavirus infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59216865A (ja) * 1983-05-26 1984-12-06 Mitsui Toatsu Chem Inc システイン塩酸塩水和物の乾燥方法
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0589336B1 (de) * 1992-09-22 1997-01-08 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
JP3755908B2 (ja) * 1994-08-17 2006-03-15 塩野義製薬株式会社 セファロスポリン化合物の晶析法
ATE185557T1 (de) * 1995-01-30 1999-10-15 Hoechst Ag Basisch-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
DE19502895A1 (de) * 1995-01-31 1996-08-01 Merck Patent Gmbh 4-Mercapto-benzoylguanidin-Derivate
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
NO20021950L (no) 2002-04-25
ATE250026T1 (de) 2003-10-15
ES2204712T3 (es) 2004-05-01
SI1224166T1 (en) 2004-04-30
WO2001030750A1 (de) 2001-05-03
JP4969750B2 (ja) 2012-07-04
US6673968B1 (en) 2004-01-06
HU228634B1 (en) 2013-04-29
PL199010B1 (pl) 2008-08-29
CZ299201B6 (cs) 2008-05-14
HUP0203132A3 (en) 2004-12-28
HUP0203132A2 (hu) 2003-01-28
CA2388915A1 (en) 2001-05-03
UA73329C2 (uk) 2005-07-15
AU1136101A (en) 2001-05-08
AU782471B2 (en) 2005-08-04
DE19951418A1 (de) 2001-05-03
HK1051358A1 (en) 2003-08-01
JP2003512451A (ja) 2003-04-02
MY122651A (en) 2006-04-29
PL355149A1 (en) 2004-04-05
BR0015022A (pt) 2002-06-18
SK5462002A3 (en) 2002-10-08
NO328250B1 (no) 2010-01-18
RU2276134C2 (ru) 2006-05-10
PT1224166E (pt) 2004-02-27
MXPA02004144A (es) 2006-01-12
KR100699571B1 (ko) 2007-03-23
SK286603B6 (sk) 2009-02-05
ZA200204119B (en) 2003-10-29
CN1382120A (zh) 2002-11-27
DE50003759D1 (de) 2003-10-23
CZ20021354A3 (cs) 2002-09-11
EP1224166A1 (de) 2002-07-24
EP1224166B1 (de) 2003-09-17
CA2388915C (en) 2009-12-15
CN1202078C (zh) 2005-05-18
KR20020044572A (ko) 2002-06-15
NO20021950D0 (no) 2002-04-25

Similar Documents

Publication Publication Date Title
DE69729583D1 (de) N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3-on derivative als faktor xa inhibitoren
RS51444B (sr) JEDINJENJA KOJA SADRŽE LAKTAM I NJIHOVI DERIVATI KAO INHIBITORI FAKTORA Xa
ATE465146T1 (de) 1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren
DK1542977T3 (da) 2,5-dioxoimidazolidin-4-ylacetamider og analoger som inhibitorer af metalloproteinase MMP12
DK0956282T3 (da) Sulfinsyrederivater, fremgangsmåde til deres fremstilling og anvendelse
IS7220A (is) Latar af þætti XA og öðrum rað-próteösum sem tengjast storknunar keðjuverkun
DK1200418T3 (da) Nematodicide trifluorbutener
IS6957A (is) Tatrat sölt af 5,8,14,-tríasatetrasýkló[10.3.1.02,11.04,9]-hexadeka-2(11),3,5,7,9,-pentaen og lyfjafræðilegar samsetningar af þeim
KR960702830A (ko) 방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents)
NO20043016L (no) 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
EA200400280A1 (ru) Новые неочищенные и кристаллические формы гидрохлорида лерканидипина
DK1224166T3 (da) Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid
DK0870763T3 (da) Kondenserede piperidinderivater som inhibitorer for syntese af nitrogenmonoxid
BR0009453A (pt) Processo para a preparação de um composto
DK1161239T3 (da) 3- cyclopropylmethoxy-4-difluormethoxy-N-(3,5-dichlorpyrid-4-yl)benzamid til behandling af dissemineret sklerose
ATE348800T1 (de) 4'-methansulfonylbiphenylderivate als hochselektive cyclooxygenase-2-inhibitoren
DE60116514D1 (de) Amlodipin-hemimaleat
DE50311388D1 (de) Nicht-peptidische brs-3-agonisten
DK1373232T3 (da) Fremgangsmåde til fremstilling af N-substituerede 2,6-dialkylmorpholiner
ATE223405T1 (de) Modifizierte form des hydrochlorids der r(-)-n-(4,4-di(-3-methylthien-2-yl)but-3-enyl)- nipecotinsäure
DK0703232T3 (da) 2,3-Dihydro-1H-isoindolderivater, fremgangsmåde til deres fremstilling og deres anvendelse som hæmmere af serotoningenoptagelsen
DE60043228D1 (de) Herstellungsverfahren von 2-cyanopyridinen
DE59803066D1 (de) Substituierte benzyloxyimino-verbindungen
NO20021821L (no) Natrium-hydrogen utvekslingstype 1 inhibitor krystaller
AR026231A1 (es) Proceso para preparar clorhidrato de n-(4,5-bis-metansulfonil-2-metilbenzoil)-guanidina