BR0015022A - Processo para a preparação de cloridrato de n-(4,5-bismetanossulfonil-2-metilbenzoil) guanidina - Google Patents

Processo para a preparação de cloridrato de n-(4,5-bismetanossulfonil-2-metilbenzoil) guanidina

Info

Publication number
BR0015022A
BR0015022A BR0015022-3A BR0015022A BR0015022A BR 0015022 A BR0015022 A BR 0015022A BR 0015022 A BR0015022 A BR 0015022A BR 0015022 A BR0015022 A BR 0015022A
Authority
BR
Brazil
Prior art keywords
preparation
bismethanesulfonyl
methylbenzoyl
guanidine hydrochloride
guanidine
Prior art date
Application number
BR0015022-3A
Other languages
English (en)
Inventor
Rolf Gericke
Manfred Baumgarth
Hans Markus Bender
Bernhard Ladstetter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0015022A publication Critical patent/BR0015022A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE CLORIDRATO DE N-(4,5-BISMETANOSSULFONIL-2-METILBENZOIL) GUANIDINA". A presente invenção refere-se a um inibidor de antitransportador de Na^ +^/H^ +^ seletivo de NHE-1, cloridrato de N-(4,5-bismetanossulfonil-2-metilbenzoil) guanidina, ao seu cloridrato hidratado, e a um processo para a preparação.
BR0015022-3A 1999-10-26 2000-10-11 Processo para a preparação de cloridrato de n-(4,5-bismetanossulfonil-2-metilbenzoil) guanidina BR0015022A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19951418A DE19951418A1 (de) 1999-10-26 1999-10-26 Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
PCT/EP2000/009977 WO2001030750A1 (de) 1999-10-26 2000-10-11 Verfahren zur herstellung von n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid

Publications (1)

Publication Number Publication Date
BR0015022A true BR0015022A (pt) 2002-06-18

Family

ID=7926842

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015022-3A BR0015022A (pt) 1999-10-26 2000-10-11 Processo para a preparação de cloridrato de n-(4,5-bismetanossulfonil-2-metilbenzoil) guanidina

Country Status (26)

Country Link
US (1) US6673968B1 (pt)
EP (1) EP1224166B1 (pt)
JP (1) JP4969750B2 (pt)
KR (1) KR100699571B1 (pt)
CN (1) CN1202078C (pt)
AT (1) ATE250026T1 (pt)
AU (1) AU782471B2 (pt)
BR (1) BR0015022A (pt)
CA (1) CA2388915C (pt)
CZ (1) CZ299201B6 (pt)
DE (2) DE19951418A1 (pt)
DK (1) DK1224166T3 (pt)
ES (1) ES2204712T3 (pt)
HK (1) HK1051358A1 (pt)
HU (1) HU228634B1 (pt)
MX (1) MXPA02004144A (pt)
MY (1) MY122651A (pt)
NO (1) NO328250B1 (pt)
PL (1) PL199010B1 (pt)
PT (1) PT1224166E (pt)
RU (1) RU2276134C2 (pt)
SI (1) SI1224166T1 (pt)
SK (1) SK286603B6 (pt)
UA (1) UA73329C2 (pt)
WO (1) WO2001030750A1 (pt)
ZA (1) ZA200204119B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
DE502004007841D1 (de) * 2003-05-06 2008-09-25 Merck Patent Gmbh Verfahren zur kristallisation von guanidinium-salzen
WO2009135583A1 (en) * 2008-05-09 2009-11-12 Merck Patent Gmbh Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and beta-cell dysfunction
JOP20200296A1 (ar) * 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
WO2015198945A1 (ja) * 2014-06-23 2015-12-30 日産化学工業株式会社 スルホニル結合を有するシラン化合物の製造方法
CN117304079A (zh) * 2016-02-08 2023-12-29 默克专利股份有限公司 N-(4,5-双甲磺酰基-2-甲基苯甲酰基)胍盐酸盐和n-(4,5-双甲磺酰基-2-甲基苯甲酰基)胍盐的结晶变体
EP3960165A1 (en) * 2020-08-25 2022-03-02 Fondation EspeRare Nhe-1 inhibitors for the treatment of coronavirus infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59216865A (ja) * 1983-05-26 1984-12-06 Mitsui Toatsu Chem Inc システイン塩酸塩水和物の乾燥方法
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
ATE147375T1 (de) * 1992-09-22 1997-01-15 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
JP3755908B2 (ja) * 1994-08-17 2006-03-15 塩野義製薬株式会社 セファロスポリン化合物の晶析法
DK0723956T3 (da) * 1995-01-30 2000-04-17 Hoechst Ag Basisk substituerede benzoylguanidiner, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemiddel eller diagnos
DE19502895A1 (de) * 1995-01-31 1996-08-01 Merck Patent Gmbh 4-Mercapto-benzoylguanidin-Derivate
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
CA2388915C (en) 2009-12-15
CN1202078C (zh) 2005-05-18
UA73329C2 (uk) 2005-07-15
KR20020044572A (ko) 2002-06-15
HK1051358A1 (en) 2003-08-01
CZ20021354A3 (cs) 2002-09-11
DE50003759D1 (de) 2003-10-23
MXPA02004144A (es) 2006-01-12
ATE250026T1 (de) 2003-10-15
EP1224166A1 (de) 2002-07-24
WO2001030750A1 (de) 2001-05-03
JP2003512451A (ja) 2003-04-02
AU782471B2 (en) 2005-08-04
DE19951418A1 (de) 2001-05-03
RU2276134C2 (ru) 2006-05-10
JP4969750B2 (ja) 2012-07-04
SK5462002A3 (en) 2002-10-08
MY122651A (en) 2006-04-29
CZ299201B6 (cs) 2008-05-14
DK1224166T3 (da) 2004-01-05
NO20021950L (no) 2002-04-25
ES2204712T3 (es) 2004-05-01
NO328250B1 (no) 2010-01-18
CA2388915A1 (en) 2001-05-03
PL199010B1 (pl) 2008-08-29
AU1136101A (en) 2001-05-08
HUP0203132A2 (hu) 2003-01-28
CN1382120A (zh) 2002-11-27
SK286603B6 (sk) 2009-02-05
SI1224166T1 (en) 2004-04-30
US6673968B1 (en) 2004-01-06
KR100699571B1 (ko) 2007-03-23
EP1224166B1 (de) 2003-09-17
NO20021950D0 (no) 2002-04-25
HUP0203132A3 (en) 2004-12-28
PT1224166E (pt) 2004-02-27
HU228634B1 (en) 2013-04-29
ZA200204119B (en) 2003-10-29
PL355149A1 (en) 2004-04-05

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: C07C 315/00, C07C 315/04, C07C 317/44

Ipc: C07C 315/04 (2009.01), C07C 315/00 (2009.01), C07C

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.