DE60116514D1 - Amlodipin-hemimaleat - Google Patents
Amlodipin-hemimaleatInfo
- Publication number
- DE60116514D1 DE60116514D1 DE60116514T DE60116514T DE60116514D1 DE 60116514 D1 DE60116514 D1 DE 60116514D1 DE 60116514 T DE60116514 T DE 60116514T DE 60116514 T DE60116514 T DE 60116514T DE 60116514 D1 DE60116514 D1 DE 60116514D1
- Authority
- DE
- Germany
- Prior art keywords
- amlodipine
- hemimaleat
- new
- amlodipine hemimaleate
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25860300P | 2000-12-29 | 2000-12-29 | |
US258603P | 2000-12-29 | ||
US80935601A | 2001-03-16 | 2001-03-16 | |
US809356 | 2001-03-16 | ||
PCT/NL2001/000602 WO2002053539A1 (en) | 2000-12-29 | 2001-08-15 | Amlodipine hemimaleate |
BE2001/0711A BE1014454A6 (nl) | 2000-12-29 | 2001-11-05 | Amlodipinehemimaleaat. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60116514D1 true DE60116514D1 (de) | 2006-03-30 |
DE60116514T2 DE60116514T2 (de) | 2006-08-17 |
Family
ID=29740327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60116514T Expired - Fee Related DE60116514T2 (de) | 2000-12-29 | 2001-08-15 | Amlodipinhemimaleat |
Country Status (10)
Country | Link |
---|---|
US (1) | US6538012B2 (de) |
EP (1) | EP1309557B9 (de) |
AT (1) | ATE315026T1 (de) |
BE (1) | BE1014454A6 (de) |
BR (1) | BR0116552A (de) |
CA (1) | CA2433190C (de) |
DE (1) | DE60116514T2 (de) |
ES (1) | ES2254495T4 (de) |
MX (1) | MXPA03005884A (de) |
WO (1) | WO2002053539A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0116557A (pt) * | 2000-12-29 | 2003-10-28 | Pfizer Ltd | Processo, processo para fabricação de um sal de maleato de amlodipina substancialmente livre de aspartato de amlodipina, processo para purificação, maleato de amlodipina, composição farmacêutica para tratar ou prevenir angina ou hipertenção, método para tratar hipertenção, angina ou ataque cardìaco, benzeno sulfonato de amlodipina, hidrocloreto de amlodipina e uso de maleato de amlodipina substancialmente livre de aspartato de amlodipina |
WO2002053541A1 (en) * | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amide derivative of amlodipine |
US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
MXPA03005882A (es) * | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
WO2004067512A1 (en) * | 2003-01-27 | 2004-08-12 | Hanmi Pharm. Co., Ltd. | Stable amorphous amlodipine camsylate, process for preparing same and composition for oral administration thereof |
ES2886067T3 (es) | 2016-10-07 | 2021-12-16 | Silvergate Pharmaceuticals Inc | Formulaciones de amlodipina |
CA3096101A1 (en) | 2018-04-11 | 2019-10-17 | Silvergate Pharmaceuticals, Inc. | Amlodipine formulations |
CN116332832A (zh) * | 2023-03-29 | 2023-06-27 | 安徽美致诚药业有限公司 | 一种马来酸左旋氨氯地平无定型晶型及其制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK161312C (da) | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
FR2602231B1 (fr) * | 1986-08-04 | 1988-10-28 | Adir | Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
US4983740A (en) | 1986-08-04 | 1991-01-08 | Adir Et Compagnie | Process for 1,4-dihydropyridine compounds |
GB8710493D0 (en) | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
US5155120A (en) | 1991-01-14 | 1992-10-13 | Pfizer Inc | Method for treating congestive heart failure |
WO1993006082A1 (en) | 1991-09-13 | 1993-04-01 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropyridines |
US5389654A (en) | 1992-11-26 | 1995-02-14 | Lek, Tovarna, Farmacevtskih In Kemicnih . . . | 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate |
HU221810B1 (hu) | 1997-08-12 | 2003-01-28 | EGIS Gyógyszergyár Rt. | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
ZA9810320B (en) | 1997-11-14 | 2000-05-11 | Gea Farmaceutisk Fabrik As | Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose. |
PL189666B1 (pl) | 1998-04-09 | 2005-09-30 | Adamed Sp Z Oo | Sposób otrzymywania benzenosulfonianu amlodypiny |
GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
ES2151850B1 (es) | 1998-10-26 | 2001-08-16 | Esteve Quimica Sa | Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente. |
GB9827387D0 (en) | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel process |
GB9827431D0 (en) | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel compound |
-
2001
- 2001-08-15 MX MXPA03005884A patent/MXPA03005884A/es active IP Right Grant
- 2001-08-15 EP EP01974984A patent/EP1309557B9/de not_active Expired - Lifetime
- 2001-08-15 AT AT01974984T patent/ATE315026T1/de not_active IP Right Cessation
- 2001-08-15 CA CA002433190A patent/CA2433190C/en not_active Expired - Fee Related
- 2001-08-15 BR BR0116552-6A patent/BR0116552A/pt not_active IP Right Cessation
- 2001-08-15 DE DE60116514T patent/DE60116514T2/de not_active Expired - Fee Related
- 2001-08-15 WO PCT/NL2001/000602 patent/WO2002053539A1/en active IP Right Grant
- 2001-08-15 ES ES01974984T patent/ES2254495T4/es not_active Expired - Lifetime
- 2001-08-27 US US09/938,821 patent/US6538012B2/en not_active Expired - Fee Related
- 2001-11-05 BE BE2001/0711A patent/BE1014454A6/nl not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2433190C (en) | 2005-11-15 |
DE60116514T2 (de) | 2006-08-17 |
US6538012B2 (en) | 2003-03-25 |
WO2002053539A1 (en) | 2002-07-11 |
MXPA03005884A (es) | 2005-04-08 |
BR0116552A (pt) | 2004-02-03 |
ATE315026T1 (de) | 2006-02-15 |
ES2254495T3 (es) | 2006-06-16 |
EP1309557B1 (de) | 2006-01-04 |
ES2254495T4 (es) | 2007-06-16 |
US20020128297A1 (en) | 2002-09-12 |
CA2433190A1 (en) | 2002-07-11 |
BE1014454A6 (nl) | 2003-10-07 |
EP1309557B9 (de) | 2006-11-15 |
EP1309557A1 (de) | 2003-05-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |