DK1196383T3 - Fremgangsmåde til fremstilling af amlodipinbenzensulfonat - Google Patents
Fremgangsmåde til fremstilling af amlodipinbenzensulfonatInfo
- Publication number
- DK1196383T3 DK1196383T3 DK99933061T DK99933061T DK1196383T3 DK 1196383 T3 DK1196383 T3 DK 1196383T3 DK 99933061 T DK99933061 T DK 99933061T DK 99933061 T DK99933061 T DK 99933061T DK 1196383 T3 DK1196383 T3 DK 1196383T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- methyl
- amlodipine benzenesulfonate
- formula
- amalodipine
- Prior art date
Links
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 title 1
- 229910052783 alkali metal Chemical group 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 229910052784 alkaline earth metal Chemical group 0.000 abstract 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 abstract 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/HU1999/000050 WO2001002360A1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1196383T3 true DK1196383T3 (da) | 2005-02-21 |
Family
ID=10991279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99933061T DK1196383T3 (da) | 1999-07-05 | 1999-07-05 | Fremgangsmåde til fremstilling af amlodipinbenzensulfonat |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6596874B1 (enExample) |
| EP (1) | EP1196383B1 (enExample) |
| JP (1) | JP3764386B2 (enExample) |
| KR (1) | KR100585442B1 (enExample) |
| CN (1) | CN1141297C (enExample) |
| AT (1) | ATE283841T1 (enExample) |
| AU (1) | AU777565B2 (enExample) |
| BG (1) | BG65657B1 (enExample) |
| CA (1) | CA2376540C (enExample) |
| CZ (1) | CZ300509B6 (enExample) |
| DE (1) | DE69922417T2 (enExample) |
| DK (1) | DK1196383T3 (enExample) |
| EA (1) | EA004208B1 (enExample) |
| EE (1) | EE05398B1 (enExample) |
| ES (1) | ES2234272T3 (enExample) |
| HK (1) | HK1044151B (enExample) |
| MX (1) | MXPA01013407A (enExample) |
| NO (1) | NO321714B1 (enExample) |
| NZ (1) | NZ517013A (enExample) |
| PL (1) | PL194193B1 (enExample) |
| PT (1) | PT1196383E (enExample) |
| SK (1) | SK285611B6 (enExample) |
| UA (1) | UA72768C2 (enExample) |
| WO (1) | WO2001002360A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100354806B1 (ko) * | 2000-06-21 | 2002-10-05 | 한국유나이티드제약 주식회사 | 암로디핀 베실레이트의 신규 중간체 및 그의 제조방법 |
| KR100452491B1 (ko) * | 2001-03-29 | 2004-10-12 | 한미약품 주식회사 | 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법 |
| EP1435954B1 (en) * | 2001-07-06 | 2010-01-13 | LEK Pharmaceuticals D.D. | A PROCESS FOR THE PREPARATION OF HIGHlLY PUREAMLODIPINE BENZENESULFONATE |
| US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
| AR037565A1 (es) * | 2001-11-21 | 2004-11-17 | Synthon Bv | Formas de sales de amlodipina y procedimientos para prepararlas. |
| KR100462304B1 (ko) * | 2002-07-30 | 2004-12-17 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100496436B1 (ko) * | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100467669B1 (ko) * | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| US6784297B2 (en) | 2002-09-04 | 2004-08-31 | Kopran Limited | Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate |
| JP2008013489A (ja) * | 2006-07-06 | 2008-01-24 | Ohara Yakuhin Kogyo Kk | ベシル酸アムロジピン含有錠剤 |
| EP1975167A1 (en) | 2007-03-30 | 2008-10-01 | Esteve Quimica, S.A. | Acetone solvate of phthaloyl amlodipine |
| CN101812014B (zh) * | 2010-04-28 | 2011-08-24 | 王明 | 一种苯磺酸氨氯地平化合物及其制法 |
| CN102993083A (zh) * | 2012-12-21 | 2013-03-27 | 王学军 | 一种苯磺酸氨氯地平的制备方法 |
| CN104262237A (zh) * | 2014-09-28 | 2015-01-07 | 常州瑞明药业有限公司 | 氨氯地平自由碱的合成方法 |
| US11452690B1 (en) | 2021-01-27 | 2022-09-27 | ECI Pharmaceuticals, LLC | Oral liquid compositions comprising amlodipine besylate and methods of using the same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| SI9200344B (sl) * | 1992-11-26 | 1998-06-30 | Lek, | Postopek za pripravo amlodipin benzensulfonata |
| HU221810B1 (hu) * | 1997-08-12 | 2003-01-28 | EGIS Gyógyszergyár Rt. | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
| DE19738943B4 (de) | 1997-09-05 | 2008-01-03 | Siemens Ag | Verfahren und Einrichtung zur Bestimmung von Eigenschaften eines Stahls |
-
1999
- 1999-05-07 UA UA2002020897A patent/UA72768C2/uk unknown
- 1999-07-05 JP JP2001507800A patent/JP3764386B2/ja not_active Expired - Lifetime
- 1999-07-05 EP EP99933061A patent/EP1196383B1/en not_active Expired - Lifetime
- 1999-07-05 AU AU49237/99A patent/AU777565B2/en not_active Expired
- 1999-07-05 MX MXPA01013407A patent/MXPA01013407A/es not_active IP Right Cessation
- 1999-07-05 WO PCT/HU1999/000050 patent/WO2001002360A1/en not_active Ceased
- 1999-07-05 AT AT99933061T patent/ATE283841T1/de active
- 1999-07-05 EA EA200200125A patent/EA004208B1/ru not_active IP Right Cessation
- 1999-07-05 CA CA002376540A patent/CA2376540C/en not_active Expired - Lifetime
- 1999-07-05 SK SK2-2002A patent/SK285611B6/sk not_active IP Right Cessation
- 1999-07-05 US US10/019,424 patent/US6596874B1/en not_active Expired - Lifetime
- 1999-07-05 NZ NZ517013A patent/NZ517013A/en not_active IP Right Cessation
- 1999-07-05 PL PL99352493A patent/PL194193B1/pl unknown
- 1999-07-05 HK HK02105733.9A patent/HK1044151B/zh not_active IP Right Cessation
- 1999-07-05 CN CNB998167746A patent/CN1141297C/zh not_active Expired - Lifetime
- 1999-07-05 ES ES99933061T patent/ES2234272T3/es not_active Expired - Lifetime
- 1999-07-05 KR KR1020027000052A patent/KR100585442B1/ko not_active Expired - Lifetime
- 1999-07-05 PT PT99933061T patent/PT1196383E/pt unknown
- 1999-07-05 CZ CZ20014690A patent/CZ300509B6/cs unknown
- 1999-07-05 DE DE69922417T patent/DE69922417T2/de not_active Expired - Lifetime
- 1999-07-05 DK DK99933061T patent/DK1196383T3/da active
- 1999-07-05 EE EEP200100686A patent/EE05398B1/xx unknown
-
2001
- 2001-12-03 BG BG106164A patent/BG65657B1/bg unknown
-
2002
- 2002-01-04 NO NO20020029A patent/NO321714B1/no not_active IP Right Cessation
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