DK118652B - Fremgangsmåde til fremstilling af et antibiotisk stof kaldet adriamycin eller dets aglycon eller dets syreadditionssalte. - Google Patents

Fremgangsmåde til fremstilling af et antibiotisk stof kaldet adriamycin eller dets aglycon eller dets syreadditionssalte.

Info

Publication number
DK118652B
DK118652B DK165868AA DK165868A DK118652B DK 118652 B DK118652 B DK 118652B DK 165868A A DK165868A A DK 165868AA DK 165868 A DK165868 A DK 165868A DK 118652 B DK118652 B DK 118652B
Authority
DK
Denmark
Prior art keywords
aglycone
preparation
acid addition
addition salts
antibiotic substance
Prior art date
Application number
DK165868AA
Other languages
Danish (da)
English (en)
Inventor
F Arcamone
G Cassinelli
Marco A Di
M Gaetani
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of DK118652B publication Critical patent/DK118652B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK165868AA 1967-04-18 1968-04-16 Fremgangsmåde til fremstilling af et antibiotisk stof kaldet adriamycin eller dets aglycon eller dets syreadditionssalte. DK118652B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1505667 1967-04-18

Publications (1)

Publication Number Publication Date
DK118652B true DK118652B (da) 1970-09-21

Family

ID=11146217

Family Applications (1)

Application Number Title Priority Date Filing Date
DK165868AA DK118652B (da) 1967-04-18 1968-04-16 Fremgangsmåde til fremstilling af et antibiotisk stof kaldet adriamycin eller dets aglycon eller dets syreadditionssalte.

Country Status (15)

Country Link
US (1) US3590028A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT276630B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE713773A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH496091A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE1770204B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK118652B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES352842A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (2) FR1583289A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1161278A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL29813A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL6804925A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO124883B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE333126B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU378026A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU33730B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965088A (en) * 1967-10-18 1976-06-22 Rhone-Poulenc S.A. Naphthacene derivatives
US3957755A (en) * 1967-10-18 1976-05-18 Rhone-Poulenc S.A. Naphthacene derivatives
FR2160716A1 (en) * 1971-11-23 1973-07-06 Rhone Poulenc Sa Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycin
JPS5233639B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1971-01-20 1977-08-30
GB1457632A (en) * 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
US3976667A (en) * 1975-06-19 1976-08-24 The Upjohn Company Steffimycinone, 7-deoxysteffimycinone and derivatives
US4012448A (en) * 1976-01-15 1977-03-15 Stanford Research Institute Synthesis of adriamycin and 7,9-epiadriamycin
ES444380A1 (es) * 1976-01-16 1977-06-16 Gosalvez Mario Un procedimiento para preparar derivados metalicos antraci- clinicos.
US4039736A (en) * 1976-04-15 1977-08-02 Bristol-Myers Company Antibiotic compounds marcellomycin and musettamycin
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4192915A (en) * 1976-08-16 1980-03-11 Bristol-Myers Company Anthracycline glycosides from streptomyces
CH637160A5 (fr) * 1976-10-05 1983-07-15 Microbial Chem Res Found Procede de fabrication de glucosides anthracyclines.
US4209588A (en) * 1976-10-05 1980-06-24 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing new antitumor anthracycline antibiotics
US4112071A (en) * 1977-01-10 1978-09-05 Bristol-Myers Company Antibiotic complex
US4089872A (en) * 1977-03-09 1978-05-16 The Upjohn Company Antibiotics steffimycinol and 7-deoxysteffimycinol and process for preparing the same
US4246399A (en) * 1977-03-21 1981-01-20 Interx Research Corporation Complexes of doxorubicin exhibiting enhanced stability
US4077844A (en) * 1977-03-30 1978-03-07 The Upjohn Company Process for preparing steffimycinol
NL7900869A (nl) * 1978-02-09 1979-08-13 Erba Farmitalia Anthracyclinenantibiotica.
US4248970A (en) * 1978-05-30 1981-02-03 Bristol-Myers Company Antibiotic complex producing bacterial culture
US4196127A (en) * 1978-06-01 1980-04-01 Research Corporation Anthracyclines
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
US4303785A (en) * 1978-08-05 1981-12-01 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antitumor anthracycline antibiotics
IT1196402B (it) * 1978-11-21 1988-11-16 Erba Farmitalia Antibiotici antitumorali
JPS5648893A (en) * 1979-09-07 1981-05-02 Sanraku Inc Preparation of anthracycline glycoside
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
JPS56156300A (en) * 1980-04-26 1981-12-02 Microbial Chem Res Found Novel preparative method of anthracyclin derivative
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4374979A (en) * 1981-04-27 1983-02-22 The University Of Kansas Endowment Association Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
US4471052A (en) * 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
GB2125030B (en) * 1982-08-13 1986-11-26 Erba Farmitalia Naphthacenequinone synthesis
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4548927A (en) * 1983-05-25 1985-10-22 Eaton John W Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
JPH03502327A (ja) * 1988-01-19 1991-05-30 ボード・オブ・リージェンツ，ザ・ユニバーシティ・オブ・テキサス・システム ３’‐デアミノドキソルビシンのエステル体、そのリポソーム組成物およびその使用方法
GB8812697D0 (en) * 1988-05-27 1988-06-29 Erba Carlo Spa Isolation & characterisation of genes resistant to anthracycline antibiotics
US5220001A (en) * 1989-10-25 1993-06-15 Zaidan Hojim Biseibutsu Dong-A Pharm Co. Anthracycline glycoside derivatives
KR100211417B1 (ko) * 1990-11-30 1999-10-01 유충식 L-탈로피라노시드 유도체 및 그의 제조방법
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
JP3871713B2 (ja) * 1995-05-10 2007-01-24 協和醗酵工業株式会社 新規毒素複合体
UA67732C2 (uk) 1996-10-15 2004-07-15 Г.Д. Сьорл & Ко. Інгібітори циклооксигенази-2 для лікування і попередження неоплазії та спосіб лікування
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
ATE258919T1 (de) 1997-11-10 2004-02-15 Searle & Co Verwendung von alkylierten iminozuckern zur behandlung von multipler medikamentenresistenz
GB9727546D0 (en) * 1997-12-31 1998-03-18 Pharmacia & Upjohn Spa Anthracycline glycosides
MY122185A (en) 1998-02-12 2006-03-31 Searle & Co Use of n-substituted-1, 5-dideoxy-1, 5-imino-d-glucitol compounds for treating hepatitis virus infections
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
CN1188424C (zh) * 1998-10-16 2005-02-09 美露香株式会社 盐酸阿霉素的结晶
EP1165080A2 (en) * 1999-02-12 2002-01-02 G.D. SEARLE & CO. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
WO2001008672A2 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
WO2001060366A1 (en) * 2000-02-14 2001-08-23 Pharmacia Corporation Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
US20060079463A1 (en) * 2003-05-20 2006-04-13 Zhong Hong J Anticancer compositions comprising methenamine
US7314886B2 (en) * 2003-10-02 2008-01-01 Cephalon, Inc. Tetrahydropyrano-indole derivatives
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
JP2008513519A (ja) * 2005-05-11 2008-05-01 シコール インコーポレイティド 安定した凍結乾燥されたアントラサイクリングリコシド
WO2008044782A2 (en) * 2006-10-06 2008-04-17 Takeda Pharmaceutical Company Limited Combination drug
JP5809415B2 (ja) 2007-11-09 2015-11-10 ペレグリン ファーマシューティカルズ，インコーポレーテッド 抗ｖｅｇｆ抗体の組成物および方法
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2189158A1 (en) 2008-11-20 2010-05-26 DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts Combination of rocaglamide and apoptosis inducing substances for the treatment of cancer
NZ593649A (en) * 2008-12-23 2013-11-29 Gilead Pharmasset Llc Nucleoside analogs
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
MX2011006892A (es) * 2008-12-23 2011-07-20 Pharmasset Inc Sintesis de nucleosidos de purina.
JP6058528B2 (ja) 2010-03-31 2017-01-11 ギリアド ファーマセット エルエルシー ヌクレオシドホスホルアミデート
EP3862440A1 (en) 2010-06-18 2021-08-11 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
DK2609216T3 (en) 2010-08-24 2016-09-12 Dana Farber Cancer Inst Inc Methods to predict anti-cancer response
CN102363755B (zh) * 2011-05-21 2013-04-03 浙江海正药业股份有限公司 一种链霉菌及其生产阿霉素的方法
ES3027988T3 (en) 2011-06-17 2025-06-17 Myriad Genetics Inc Methods and materials for assessing allelic imbalance
FI2794907T4 (fi) 2011-12-21 2023-03-27 Menetelmiä ja materiaaleja heterotsygoottisuuden menettämisen arvioimiseksi
CA3080441A1 (en) 2012-02-23 2013-09-06 The Children's Hospital Corporation Methods for predicting anti-cancer response
JP6104287B2 (ja) * 2012-03-06 2017-03-29 天津和美生物技術有限公司 四環系アントラキノン誘導体
CA2867434C (en) 2012-06-07 2021-10-12 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
US10308986B2 (en) 2013-03-14 2019-06-04 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
AU2014240950B2 (en) 2013-03-29 2018-11-01 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
US20140363521A1 (en) 2013-04-05 2014-12-11 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency
EP4023765A1 (en) 2013-12-09 2022-07-06 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
CN104774229A (zh) * 2014-01-10 2015-07-15 浙江华谱新创科技有限公司 一种阿霉素及其衍生物的制备方法
WO2016025958A1 (en) 2014-08-15 2016-02-18 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency
US20170312246A1 (en) 2016-04-27 2017-11-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis
CN107773556B (zh) * 2016-08-26 2020-08-18 广州安好医药科技有限公司 一种具有抗肿瘤药物功效的联合用药物
EP4141127B1 (en) 2021-08-30 2024-10-09 Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln Method for assessing homologous recombination deficiency in ovarian cancer cells

Also Published As

Publication number Publication date
CH496091A (de) 1970-09-15
YU71568A (en) 1977-08-31
NL6804925A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1968-10-21
GB1161278A (en) 1969-08-13
DE1770204B1 (de) 1971-12-23
FR7406M (fr) 1969-11-03
SE333126B (sv) 1971-03-08
IL29813A0 (en) 1968-06-20
IL29813A (en) 1971-04-28
SU378026A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-04-17
ES352842A1 (es) 1969-08-01
BE713773A (fr) 1968-10-17
FR1583289A (fr) 1969-10-24
YU33730B (en) 1978-02-28
US3590028A (en) 1971-06-29
AT276630B (de) 1969-11-25
NO124883B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1972-06-19

Similar Documents

Publication Publication Date Title
DK118652B (da) Fremgangsmåde til fremstilling af et antibiotisk stof kaldet adriamycin eller dets aglycon eller dets syreadditionssalte.
DK136697B (da) Fremgangsmåde til fremstilling af vandige opløsninger af sterolglykosider eller esterderivater deraf.
DK128458B (da) Fremgangsmåde til fremstilling af et antibiotisk stof kaldet pyrazomycin.
DK112091B (da) Fremgangsmåde til fremstilling af et antibiotisk stof, enduracidin, eller syreadditionssalte deraf.
DK130422B (da) Fremgangsmåde til fremstilling af et antibiotikum betegnet WS-4545 eller acylderivater deraf.
DK110033C (da) Fremgangsmåde til fremstilling af antibioticet Rhi-12-648.
DK125555B (da) Fremgangsmåde til fremstilling af 1,2-dihydro-5-aryl-5H- eller 1,2-dihydro-5-aryl-3H-1,4-benzodiazepin-4-oxider, 4-deoxyderivater deraf eller syreadditionssalte deraf.
DK111111B (da) Fremgangsmåde til fremstilling af det antibiotiske stof cephalosporin C.
DK129924B (da) Analogifremgangsmåde til fremstilling af aminoalkylaminobenzophenonderivater eller syreadditionssalte deraf.
DK137864B (da) Fremgangsmåde til fremstilling af et antibioticum kaldet fortimicin B eller syreadditionssalte deraf.
DK109803C (da) Fremgangsmåde til fremstilling af thiepin- eller oxepinderivater eller syreadditionssalte deraf.
DK117626C (da) Fremgangsmåde til fremstilling af det antibiotiske stof T-2636 eller dets komponenter.
DK127931B (da) Fremgangsmåde til fremstilling af et antibiotikum betegnet negamycin eller salte heraf.
DK118712B (da) Fremgangsmåde til fremstilling af et antibiotisk stof, lincomycin B, eller salte heraf.
DK109872C (da) Fremgangsmåde til fremstilling af oxepinderivater eller salte deraf.
DK111072B (da) Fremgangsmåde til fremstilling af N-aralkylpiperidin-derivater eller syreadditionssalte deraf.
DK124614B (da) Fremgangsmåde til fremstilling af 3-(3-piperidino- eller morpholinopropionyl)-5-phenylisoxazolderivater eller syreadditionssalte deraf.
DK115387B (da) Fremgangsmåde til fremstilling af et antibiotisk stof, alanosin, eller salte deraf.
DK115245B (da) Fremgangsmåde til fremstilling af et antibiotisk stof, lincomycin S.
DK126340B (da) Fremgangsmåde til fremstilling af antibiotiket lincomycin.
DK123097B (da) Fremgangsmåde til fremstilling af kasugamycinderivater eller syreadditionssalte deraf.
DK117624C (da) Fremgangsmåde til fremstilling af et antibiotisk stof, lincomycin C, eller salte deraf.
DK113565B (da) Fremgangsmåde til fremstilling af et antibiotisk stof, lincomycin D, eller salte deraf.
DK138998B (da) Fremgangsmåde til fremstilling af et antibiotisk stof, kasugamycin.
DK100042C (da) Fremgangsmåde til fremstilling af et antibiotikum, tylosin eller dets acylderivater eller syreadditionssalte.

Legal Events

Date Code Title Description
PUP Patent expired