ES444380A1 - Un procedimiento para preparar derivados metalicos antraci- clinicos. - Google Patents
Un procedimiento para preparar derivados metalicos antraci- clinicos.Info
- Publication number
- ES444380A1 ES444380A1 ES444380A ES444380A ES444380A1 ES 444380 A1 ES444380 A1 ES 444380A1 ES 444380 A ES444380 A ES 444380A ES 444380 A ES444380 A ES 444380A ES 444380 A1 ES444380 A1 ES 444380A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- glycoside
- parent
- glycosides
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182470 glycoside Natural products 0.000 title abstract 6
- 150000002338 glycosides Chemical class 0.000 title abstract 6
- 229940045799 anthracyclines and related substance Drugs 0.000 title abstract 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
- 206010048610 Cardiotoxicity Diseases 0.000 abstract 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 231100000259 cardiotoxicity Toxicity 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000009920 chelation Effects 0.000 abstract 1
- 229960000975 daunorubicin Drugs 0.000 abstract 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 230000003292 diminished effect Effects 0.000 abstract 1
- 229960004679 doxorubicin Drugs 0.000 abstract 1
- 230000002489 hematologic effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 231100001274 therapeutic index Toxicity 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS METALICOS ANTRACICLINICOS DE FE3+, CU2+, NI2+, CO2+, FE2+, ZN2+, CD2+, PB2+, AL3+ HG2+. EL ANTIBIOTICO DAUNORUBICINA O EL DOXORUBICINA SE HACE REACCIONAR CON UN CLORURO, SULFATO, NITRATO U OTRA SAL DE LOS METALES ANTERIORES. LA REACCION SE LLEVA A CABO EN MEDIO ACUOSO A TEMPERATURA DE 15 A 50 GRADOS C Y A UN PH NEUTRO O PROXIMO A LA NEUTRALIDAD. LA PROPORCION METAL ANTIBIOTICO ES 1:1, 2:1, 3:1, 4:1, METAL EN EXCESO O METAL EN OTRA FRACCION SUPERIOR A 1:1. LOS DERIVADOS METALICOS OBTENIDOS SE UTILIZAN EN LA QUIMIOTERAPIA ANTICANCEROSA.
Priority Applications (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES444380A ES444380A1 (es) | 1976-01-16 | 1976-01-16 | Un procedimiento para preparar derivados metalicos antraci- clinicos. |
| EG12/77A EG12735A (en) | 1976-01-16 | 1977-01-08 | Process for preparing of metal chelate derivatives of anthracychine |
| US05/758,446 US4138480A (en) | 1976-01-16 | 1977-01-11 | Novel anthracycline glycosides and methods of preparing the same |
| HU77GO1361A HU177832B (en) | 1976-01-16 | 1977-01-11 | Process for producing new antracycline glucisides |
| AR266173A AR218620A1 (es) | 1976-01-16 | 1977-01-12 | Metodo para preparar nuevos derivados ferricos de doxorrubicina |
| DK11877A DK11877A (da) | 1976-01-16 | 1977-01-13 | Antracyklinglykosider og fremgangsmade til fremstilling deraf |
| PT66067A PT66067B (en) | 1976-01-16 | 1977-01-13 | Process for preparing novel anthracycline glycosides |
| AU21319/77A AU513698B2 (en) | 1976-01-16 | 1977-01-13 | Anthracycline glycosides |
| NL7700379A NL7700379A (nl) | 1976-01-16 | 1977-01-14 | Werkwijze ter bereiding van anthracyclinegly- cosiden, alsmede farmaceutische preparaten die deze verbindingen als actieve component bevatten. |
| NZ183084A NZ183084A (en) | 1976-01-16 | 1977-01-14 | Metal chelates or daunorubicin and doxorubicin and pharmaceutical compositions |
| FR7701034A FR2338285A1 (fr) | 1976-01-16 | 1977-01-14 | Nouveaux derives de glycosides d'anthracycline et procede pour les preparer |
| PH19347A PH16582A (en) | 1976-01-16 | 1977-01-14 | Novel anthracycline glycosides and methods of preparing the same |
| IL51264A IL51264A (en) | 1976-01-16 | 1977-01-14 | Metal derivatives of anthracycline glycoside antibiotics |
| NO770122A NO770122L (no) | 1976-01-16 | 1977-01-14 | Nye antracyklinglykosider og fremgangsm}te for fremstilling av dette. |
| DE2701405A DE2701405C2 (de) | 1976-01-16 | 1977-01-14 | Triferridoxorubicin, Verfahren zu dessen Herstellung und diese Verbindung enthaltendes pharmazeutisches Mittel |
| AT19677A AT349634B (de) | 1976-01-16 | 1977-01-14 | Verfahren zur herstellung von neuen anthra- cyclinglycosiden |
| SE7700398A SE7700398L (sv) | 1976-01-16 | 1977-01-14 | Antracyklinderivat och forfarande for framstellning derav |
| SU772439103A SU886748A3 (ru) | 1976-01-16 | 1977-01-14 | Способ получени антрациклиновых гликозидов |
| CH48477A CH629219A5 (de) | 1976-01-16 | 1977-01-14 | Verfahren zur herstellung von neuen anthracyclinglycosid-derivaten. |
| FI770115A FI770115A (es) | 1976-01-16 | 1977-01-14 | |
| JP252277A JPS52111555A (en) | 1976-01-16 | 1977-01-14 | Novel anthracycline glycoside |
| CA269,807A CA1070680A (en) | 1976-01-16 | 1977-01-14 | Anthracycline glycosides and methods of preparing the same |
| PL1977195344A PL108660B1 (en) | 1976-01-16 | 1977-01-15 | Method of producing new metallic derivatives of anthracycline glycosides |
| GR52580A GR70696B (es) | 1976-01-16 | 1977-01-15 | |
| GB2367/77A GB1568263A (en) | 1976-01-16 | 1977-01-17 | Metallic chelates of daunorubicin and doxorubicin |
| BE174119A BE850438A (fr) | 1976-01-16 | 1977-01-17 | Nouveaux derives de glycosides d'enthracycline et procede pour les preparer |
| DD7700196969A DD129452A5 (de) | 1976-01-16 | 1977-01-17 | Neue anthracyclinglycoside und verfahren zu deren herstellung |
| IE87/77A IE44689B1 (en) | 1976-01-16 | 1977-01-17 | Metallic chelates of daunorubicin and doxorubicin |
| YU00054/77A YU5477A (en) | 1976-01-16 | 1977-03-21 | Improved lock for a door with front closing process for obtaining new anthracyclin glucosides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES444380A ES444380A1 (es) | 1976-01-16 | 1976-01-16 | Un procedimiento para preparar derivados metalicos antraci- clinicos. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES444380A1 true ES444380A1 (es) | 1977-06-16 |
Family
ID=8470743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES444380A Expired ES444380A1 (es) | 1976-01-16 | 1976-01-16 | Un procedimiento para preparar derivados metalicos antraci- clinicos. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4138480A (es) |
| JP (1) | JPS52111555A (es) |
| AR (1) | AR218620A1 (es) |
| AT (1) | AT349634B (es) |
| AU (1) | AU513698B2 (es) |
| BE (1) | BE850438A (es) |
| CA (1) | CA1070680A (es) |
| CH (1) | CH629219A5 (es) |
| DD (1) | DD129452A5 (es) |
| DE (1) | DE2701405C2 (es) |
| DK (1) | DK11877A (es) |
| EG (1) | EG12735A (es) |
| ES (1) | ES444380A1 (es) |
| FI (1) | FI770115A (es) |
| FR (1) | FR2338285A1 (es) |
| GB (1) | GB1568263A (es) |
| GR (1) | GR70696B (es) |
| HU (1) | HU177832B (es) |
| IE (1) | IE44689B1 (es) |
| IL (1) | IL51264A (es) |
| NL (1) | NL7700379A (es) |
| NO (1) | NO770122L (es) |
| NZ (1) | NZ183084A (es) |
| PH (1) | PH16582A (es) |
| PL (1) | PL108660B1 (es) |
| PT (1) | PT66067B (es) |
| SE (1) | SE7700398L (es) |
| SU (1) | SU886748A3 (es) |
| YU (1) | YU5477A (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2959798A (en) * | 1958-03-24 | 1960-11-15 | Champlin Oil & Refining Co | Pipe line cleaner |
| US4337335A (en) * | 1978-05-18 | 1982-06-29 | Schering Corporation | Transition metal salt complexes of polyamino organic compounds |
| IT1184161B (it) * | 1985-03-14 | 1987-10-22 | Franco Conti | Derivati del chitosano costituiti da complessi di coordinazione con ioni ferrosi |
| JPS63310830A (ja) * | 1987-06-10 | 1988-12-19 | Meiji Seika Kaisha Ltd | 抗レトロウイルス剤 |
| GB9613182D0 (en) * | 1996-06-24 | 1996-08-28 | Nycomed Imaging As | Method |
| NL1009226C2 (nl) * | 1998-05-20 | 1999-11-24 | Faculteit Geneeskunde Universi | Toepassing van een nucleïnezuur-bindend chemotherapeutisch agens, een farmaceutisch preparaat en een geneesmiddelcombinatie. |
| EP1610763A2 (en) * | 2003-03-31 | 2006-01-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Stable liposomes or micelles comprising a sphingolipid and a peg-lipopolymer |
| EP1817004A2 (en) * | 2004-11-15 | 2007-08-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Combination therapy associating preferably a ceramide with a cytotoxic drug |
| WO2008100591A2 (en) * | 2007-02-14 | 2008-08-21 | The General Hospital Corporation | Modulation of nitric oxide signaling to normalize tumor vasculature |
| EP3012329B1 (en) | 2010-06-18 | 2017-10-25 | Myriad Genetics, Inc. | Methods and materials for assessing loss of heterozygosity |
| US9512485B2 (en) | 2010-08-24 | 2016-12-06 | Dana-Farber Cancer Institute. Inc. | Methods for predicting anti-cancer response |
| JP6117194B2 (ja) | 2011-06-17 | 2017-04-19 | ミリアド・ジェネティックス・インコーポレイテッド | アレル不均衡を評価するための方法および材料 |
| EP2794907B2 (en) | 2011-12-21 | 2022-11-23 | Myriad Genetics, Inc. | Methods and materials for assessing loss of heterozygosity |
| ES2687024T3 (es) | 2012-02-23 | 2018-10-23 | Children's Medical Center Corporation | Procedimientos para predecir la respuesta contra el cáncer |
| CA3190075A1 (en) | 2012-06-07 | 2013-12-12 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| WO2014160080A1 (en) | 2013-03-14 | 2014-10-02 | Children's Medical Center Corporation | Cancer diagnosis, treatment selection and treatment |
| NZ712663A (en) | 2013-04-05 | 2021-07-30 | Myriad Genetics Inc | Methods and materials for assessing homologous recombination deficiency |
| EP4023765A1 (en) | 2013-12-09 | 2022-07-06 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| WO2016025958A1 (en) | 2014-08-15 | 2016-02-18 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
| EP4141127A1 (en) | 2021-08-30 | 2023-03-01 | Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln | Method for assessing homologous recombination deficiency in ovarian cancer cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3074927A (en) * | 1960-04-12 | 1963-01-22 | Paul D Saltman | Metallic complexes of reducing sugars |
| YU33730B (en) * | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
| GB1469430A (en) * | 1974-12-24 | 1977-04-06 | Farmaceutici Italia | Daunomycin derivatives |
-
1976
- 1976-01-16 ES ES444380A patent/ES444380A1/es not_active Expired
-
1977
- 1977-01-08 EG EG12/77A patent/EG12735A/xx active
- 1977-01-11 US US05/758,446 patent/US4138480A/en not_active Expired - Lifetime
- 1977-01-11 HU HU77GO1361A patent/HU177832B/hu unknown
- 1977-01-12 AR AR266173A patent/AR218620A1/es active
- 1977-01-13 DK DK11877A patent/DK11877A/da not_active Application Discontinuation
- 1977-01-13 PT PT66067A patent/PT66067B/pt unknown
- 1977-01-13 AU AU21319/77A patent/AU513698B2/en not_active Expired
- 1977-01-14 FR FR7701034A patent/FR2338285A1/fr active Granted
- 1977-01-14 AT AT19677A patent/AT349634B/de not_active IP Right Cessation
- 1977-01-14 IL IL51264A patent/IL51264A/xx unknown
- 1977-01-14 SE SE7700398A patent/SE7700398L/xx unknown
- 1977-01-14 DE DE2701405A patent/DE2701405C2/de not_active Expired
- 1977-01-14 FI FI770115A patent/FI770115A/fi not_active Application Discontinuation
- 1977-01-14 CA CA269,807A patent/CA1070680A/en not_active Expired
- 1977-01-14 NL NL7700379A patent/NL7700379A/xx not_active Application Discontinuation
- 1977-01-14 PH PH19347A patent/PH16582A/en unknown
- 1977-01-14 SU SU772439103A patent/SU886748A3/ru active
- 1977-01-14 CH CH48477A patent/CH629219A5/de not_active IP Right Cessation
- 1977-01-14 NZ NZ183084A patent/NZ183084A/xx unknown
- 1977-01-14 NO NO770122A patent/NO770122L/no unknown
- 1977-01-14 JP JP252277A patent/JPS52111555A/ja active Granted
- 1977-01-15 GR GR52580A patent/GR70696B/el unknown
- 1977-01-15 PL PL1977195344A patent/PL108660B1/pl not_active IP Right Cessation
- 1977-01-17 IE IE87/77A patent/IE44689B1/en unknown
- 1977-01-17 GB GB2367/77A patent/GB1568263A/en not_active Expired
- 1977-01-17 DD DD7700196969A patent/DD129452A5/xx unknown
- 1977-01-17 BE BE174119A patent/BE850438A/xx not_active IP Right Cessation
- 1977-03-21 YU YU00054/77A patent/YU5477A/xx unknown
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