FR7406M - Substance antibiotique, ses derives et leur procede de preparation - Google Patents

Substance antibiotique, ses derives et leur procede de preparation

Info

Publication number
FR7406M
FR7406M FR148359A FR148359A FR7406M FR 7406 M FR7406 M FR 7406M FR 148359 A FR148359 A FR 148359A FR 148359 A FR148359 A FR 148359A FR 7406 M FR7406 M FR 7406M
Authority
FR
France
Prior art keywords
derivatives
preparation process
antibiotic substance
antibiotic
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR148359A
Other languages
English (en)
Inventor
F Cassinelli G Di Mar Arcamone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Application granted granted Critical
Publication of FR7406M publication Critical patent/FR7406M/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR148359A 1967-04-18 1968-04-17 Substance antibiotique, ses derives et leur procede de preparation Expired FR7406M (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1505667 1967-04-18

Publications (1)

Publication Number Publication Date
FR7406M true FR7406M (fr) 1969-11-03

Family

ID=11146217

Family Applications (2)

Application Number Title Priority Date Filing Date
FR1583289D Expired FR1583289A (fr) 1967-04-18 1968-04-16 Procede de preparation d'une nouvelle substance antibiotique et de ses derives
FR148359A Expired FR7406M (fr) 1967-04-18 1968-04-17 Substance antibiotique, ses derives et leur procede de preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR1583289D Expired FR1583289A (fr) 1967-04-18 1968-04-16 Procede de preparation d'une nouvelle substance antibiotique et de ses derives

Country Status (15)

Country Link
US (1) US3590028A (fr)
AT (1) AT276630B (fr)
BE (1) BE713773A (fr)
CH (1) CH496091A (fr)
DE (1) DE1770204B1 (fr)
DK (1) DK118652B (fr)
ES (1) ES352842A1 (fr)
FR (2) FR1583289A (fr)
GB (1) GB1161278A (fr)
IL (1) IL29813A (fr)
NL (1) NL6804925A (fr)
NO (1) NO124883B (fr)
SE (1) SE333126B (fr)
SU (1) SU378026A3 (fr)
YU (1) YU33730B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424285A1 (fr) * 1978-02-09 1979-11-23 Erba Farmitalia Procede microbiologique de preparation de glycosides antibiotiques et substances medicamenteuses

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957755A (en) * 1967-10-18 1976-05-18 Rhone-Poulenc S.A. Naphthacene derivatives
US3965088A (en) * 1967-10-18 1976-06-22 Rhone-Poulenc S.A. Naphthacene derivatives
FR2160716A1 (en) * 1971-11-23 1973-07-06 Rhone Poulenc Sa Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycin
US3970641A (en) * 1971-01-20 1976-07-20 Rhone-Poulenc S.A. Antibiotic 27,706 RP and salt thereof
GB1457632A (en) * 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
US3976667A (en) * 1975-06-19 1976-08-24 The Upjohn Company Steffimycinone, 7-deoxysteffimycinone and derivatives
US4012448A (en) * 1976-01-15 1977-03-15 Stanford Research Institute Synthesis of adriamycin and 7,9-epiadriamycin
ES444380A1 (es) * 1976-01-16 1977-06-16 Gosalvez Mario Un procedimiento para preparar derivados metalicos antraci- clinicos.
US4039736A (en) * 1976-04-15 1977-08-02 Bristol-Myers Company Antibiotic compounds marcellomycin and musettamycin
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4192915A (en) * 1976-08-16 1980-03-11 Bristol-Myers Company Anthracycline glycosides from streptomyces
CH637160A5 (fr) * 1976-10-05 1983-07-15 Microbial Chem Res Found Procede de fabrication de glucosides anthracyclines.
US4209588A (en) * 1976-10-05 1980-06-24 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing new antitumor anthracycline antibiotics
US4112071A (en) * 1977-01-10 1978-09-05 Bristol-Myers Company Antibiotic complex
US4089872A (en) * 1977-03-09 1978-05-16 The Upjohn Company Antibiotics steffimycinol and 7-deoxysteffimycinol and process for preparing the same
US4246399A (en) * 1977-03-21 1981-01-20 Interx Research Corporation Complexes of doxorubicin exhibiting enhanced stability
US4077844A (en) * 1977-03-30 1978-03-07 The Upjohn Company Process for preparing steffimycinol
US4248970A (en) * 1978-05-30 1981-02-03 Bristol-Myers Company Antibiotic complex producing bacterial culture
US4196127A (en) * 1978-06-01 1980-04-01 Research Corporation Anthracyclines
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
US4303785A (en) * 1978-08-05 1981-12-01 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antitumor anthracycline antibiotics
IT1196402B (it) * 1978-11-21 1988-11-16 Erba Farmitalia Antibiotici antitumorali
JPS5648893A (en) * 1979-09-07 1981-05-02 Sanraku Inc Preparation of anthracycline glycoside
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
JPS56156300A (en) * 1980-04-26 1981-12-02 Microbial Chem Res Found Novel preparative method of anthracyclin derivative
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4374979A (en) * 1981-04-27 1983-02-22 The University Of Kansas Endowment Association Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
US4471052A (en) * 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
GB2125030B (en) * 1982-08-13 1986-11-26 Erba Farmitalia Naphthacenequinone synthesis
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4548927A (en) * 1983-05-25 1985-10-22 Eaton John W Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
WO1989006654A1 (fr) * 1988-01-19 1989-07-27 Board Of Regents, The University Of Texas System Glycosides, compositions liposomiques a base de ces composes et procedes d'utilisation
GB8812697D0 (en) * 1988-05-27 1988-06-29 Erba Carlo Spa Isolation & characterisation of genes resistant to anthracycline antibiotics
US5220001A (en) * 1989-10-25 1993-06-15 Zaidan Hojim Biseibutsu Dong-A Pharm Co. Anthracycline glycoside derivatives
KR100211417B1 (ko) * 1990-11-30 1999-10-01 유충식 L-탈로피라노시드 유도체 및 그의 제조방법
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
ATE381948T1 (de) 1995-05-10 2008-01-15 Kyowa Hakko Kogyo Kk Cytotoxinkonjugate umfassend dipeptide
IL154501A0 (en) 1996-10-15 2003-09-17 Searle & Co Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
EP1030839B1 (fr) 1997-11-10 2004-02-04 G.D. SEARLE & CO. Emploi d'iminosucres alkyles pour traiter la resistance multiple aux anticancereux
GB9727546D0 (en) * 1997-12-31 1998-03-18 Pharmacia & Upjohn Spa Anthracycline glycosides
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
KR20010040937A (ko) 1998-02-12 2001-05-15 윌리암스 로저 에이 간염 바이러스 감염의 치료를 위한 ｎ-치환된1,5-디데옥시-1,5-이미노-ｄ-글루시톨 화합물의 용도
ATE284893T1 (de) * 1998-10-16 2005-01-15 Mercian Corp Kristallisation von doxorubicin-hydrochlorid
US6545021B1 (en) 1999-02-12 2003-04-08 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
JP2003505501A (ja) 1999-02-12 2003-02-12 ジー・ディー・サール・アンド・カンパニー 肝炎ウィルス感染の処置のためのグルカミン化合物
AU2001236938A1 (en) * 2000-02-14 2001-08-27 Pharmacia Corporation Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
US20060079463A1 (en) * 2003-05-20 2006-04-13 Zhong Hong J Anticancer compositions comprising methenamine
JP2007507523A (ja) * 2003-10-02 2007-03-29 セフアロン・インコーポレーテツド 置換インドール誘導体
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
EP1814525A2 (fr) * 2005-05-11 2007-08-08 Sicor Inc. Glycosides d'anthracycline lyophylises stables
CL2007002878A1 (es) * 2006-10-06 2008-08-01 Takeda Pharmaceutical Agente farmaceutico que comprende 1) un inhibidor de her2 que tiene un esqueleto de pirrolopirimidina o de pirazolopirimidina y 2) un agente terapeutico hormonal o anticancerigeno en combinacion; y uso pra la prevencion o el tratamiento del cancer.
KR20100102110A (ko) 2007-11-09 2010-09-20 페레그린 파마수티컬즈, 인크 항-ｖｅｇｆ 항체 조성물 및 방법
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2189158A1 (fr) 2008-11-20 2010-05-26 DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts Combinaison de rocaglamide et de substances induisant l'apoptose pour le traitement du cancer
NZ593648A (en) * 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
EP2376514A2 (fr) * 2008-12-23 2011-10-19 Pharmasset, Inc. Analogues de nucléoside
CL2009002206A1 (es) * 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
KR101715981B1 (ko) 2010-03-31 2017-03-13 길리애드 파마셋 엘엘씨 뉴클레오사이드 포스포르아미데이트
ES2609931T3 (es) 2010-06-18 2017-04-25 Myriad Genetics, Inc. Métodos y materiales para evaluar la pérdida de heterocigosidad
CA2807823C (fr) 2010-08-24 2023-02-07 The Brigham And Women's Hospital, Inc. Methodes de prediction d'une reponse anticancereuse
CN102363755B (zh) * 2011-05-21 2013-04-03 浙江海正药业股份有限公司 一种链霉菌及其生产阿霉素的方法
EP3693473A1 (fr) 2011-06-17 2020-08-12 Myriad Genetics, Inc. Méthodes et matériaux pour évaluer le déséquilibre allélique
FI2794907T4 (fi) 2011-12-21 2023-03-27 Menetelmiä ja materiaaleja heterotsygoottisuuden menettämisen arvioimiseksi
NZ628813A (en) 2012-02-23 2015-10-30 Univ Denmark Tech Dtu Methods for predicting anti-cancer response
WO2014059740A1 (fr) * 2012-03-06 2014-04-24 天津和美生物技术有限公司 Dérivés d'anthraquinone tétracyclique
CA3190075A1 (fr) 2012-06-07 2013-12-12 Institut Curie Methodes de detection de l'inactivation de la voie de recombinaison homologue (brca1/2) dans les tumeurs humaines
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
US10308986B2 (en) 2013-03-14 2019-06-04 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
EP2978422A4 (fr) 2013-03-29 2017-04-05 Avoscience, LLC Composés de furane, pyrrole et thiophène lipidiques pour le traitement du cancer, de troubles neurologiques et de troubles fibrotiques
CA2908745C (fr) 2013-04-05 2023-03-14 Myriad Genetics, Inc. Methodes et substances destinees a evaluer le deficit de recombinaison homologue
US11149316B2 (en) 2013-12-09 2021-10-19 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors
CN104774229A (zh) * 2014-01-10 2015-07-15 浙江华谱新创科技有限公司 一种阿霉素及其衍生物的制备方法
CA2958801A1 (fr) 2014-08-15 2016-02-18 Myriad Genetics, Inc. Procedes et materiaux permettant d'evaluer une deficience de recombinaison homologue
US20170312246A1 (en) 2016-04-27 2017-11-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis
CN107773556B (zh) 2016-08-26 2020-08-18 广州安好医药科技有限公司 一种具有抗肿瘤药物功效的联合用药物
EP4141127B1 (fr) 2021-08-30 2024-10-09 Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln Procédé d'évaluation de déficience de recombinaison homologue dans des cellules du cancer de l'ovaire

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424285A1 (fr) * 1978-02-09 1979-11-23 Erba Farmitalia Procede microbiologique de preparation de glycosides antibiotiques et substances medicamenteuses

Also Published As

Publication number Publication date
SE333126B (sv) 1971-03-08
CH496091A (de) 1970-09-15
DE1770204B1 (de) 1971-12-23
IL29813A (en) 1971-04-28
FR1583289A (fr) 1969-10-24
NO124883B (fr) 1972-06-19
YU71568A (en) 1977-08-31
DK118652B (da) 1970-09-21
IL29813A0 (en) 1968-06-20
YU33730B (en) 1978-02-28
GB1161278A (en) 1969-08-13
BE713773A (fr) 1968-10-17
US3590028A (en) 1971-06-29
SU378026A3 (fr) 1973-04-17
NL6804925A (fr) 1968-10-21
AT276630B (de) 1969-11-25
ES352842A1 (es) 1969-08-01

Similar Documents

Publication Publication Date Title
FR7406M (fr) Substance antibiotique, ses derives et leur procede de preparation
BE748017R (fr) Nouveaux composes du bis-stilbene, leur procede de preparation et leur
BE794669A (fr) Derives de 3,4-dihydrocarbostyryle et leur procede de preparation
BE798059A (fr) Derives de chromone et leur procede de preparation
BE745863A (fr) Derives de furanne-3-carboxamides et leur procede de preparation
BE751342A (fr) La novenamine, ses derives acyles et leur preparation
BE749102A (fr) 2-(5-nitro-2-imidazolyl)-benzimidazoles et leur procede de preparation
BE760402A (fr) Nouveaux derives bis-aroxazolyliques, leur procede de preparation et leur utilisation
BE801720A (fr) Derives de benzomorphane et leur procede de preparation
BE795636A (fr) Nitroimidazolylpyrimidines, et leur procede de preparation
BE751562A (fr) 4-pyrazolidinols 1,2-disubstitues et leur procede de preparation
BE792724A (fr) Derives de pyrazinoindole et leur procede de preparation
FR2002212A1 (fr) Derives de la l-amino-anthraquinone et leur procede de preparation
BE753632A (fr) Nitrofuryl-aminoalkoxy-pyrimidines et leur procede de preparation
BE749928A (fr) Derives du dibenzo (a,d) 5h-cycloheptene, leur procede de preparation et leur application
BE749101A (fr) 3-(5-nitro-2-imidazolyl-methyleneamino)-2-oxazolidinones et leur procede de preparation
BE785998A (fr) Derives de thieno-diazepine et leur procede de preparation
BE806516A (fr) Derives de 9,10-seco-oestrane et leur procede de preparation
BE755922A (fr) Polyisocyanurates-polyurees et leur procede de preparation
BE754110A (fr) 14beta-hydroxy-15alpha-acyloxy-cardenolides et leur procede de preparation
BE753633A (fr) 2-(5-nitro-2-furfurylidene)-1-tetralones et leur procede de preparatio
BE790549A (fr) Derives de thiazoloquinoleine et leur procede de preparation
BE764509A (fr) Derives de dicycloalkane optiquement actifs et leur procede de preparation
BE785366A (fr) Derives de 5-nitrothiazole et leur procede de
BE751743A (fr) Nitro-steroides et procede de leur preparation

Legal Events

Date Code Title Description
CD Change of name or company name
TP Transmission of property