DK1165126T3 - Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler - Google Patents

Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler

Info

Publication number
DK1165126T3
DK1165126T3 DK00918248T DK00918248T DK1165126T3 DK 1165126 T3 DK1165126 T3 DK 1165126T3 DK 00918248 T DK00918248 T DK 00918248T DK 00918248 T DK00918248 T DK 00918248T DK 1165126 T3 DK1165126 T3 DK 1165126T3
Authority
DK
Denmark
Prior art keywords
remounted
disassembled
virus
particles
preparation
Prior art date
Application number
DK00918248T
Other languages
Danish (da)
English (en)
Inventor
David B Volkin
Li Shi
Henryk Mach
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26824774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1165126(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK1165126T3 publication Critical patent/DK1165126T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK00918248T 1999-03-26 2000-03-22 Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler DK1165126T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12652899P 1999-03-26 1999-03-26
US09/524,624 US6245568B1 (en) 1999-03-26 2000-03-13 Human papilloma virus vaccine with disassembled and reassembled virus-like particles

Publications (1)

Publication Number Publication Date
DK1165126T3 true DK1165126T3 (da) 2007-01-08

Family

ID=26824774

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00918248T DK1165126T3 (da) 1999-03-26 2000-03-22 Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler

Country Status (19)

Country Link
US (2) US6245568B1 (es)
EP (1) EP1165126B1 (es)
JP (1) JP4594534B2 (es)
KR (1) KR20020013516A (es)
AR (1) AR023166A1 (es)
AT (1) ATE339222T1 (es)
AU (1) AU778937B2 (es)
CA (1) CA2368391C (es)
CY (4) CY1105779T1 (es)
DE (4) DE122007000032I1 (es)
DK (1) DK1165126T3 (es)
ES (1) ES2270822T3 (es)
FR (1) FR07C0026I2 (es)
LT (1) LTC1165126I2 (es)
LU (3) LU91327I2 (es)
NL (3) NL300270I1 (es)
PT (1) PT1165126E (es)
SI (1) SI1165126T1 (es)
WO (1) WO2000057906A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351533B2 (en) 1997-09-05 2008-04-01 Medimmune, Inc. In vitro method for disassmbly/reassembly of papillomavirus virus-like particles (VLPs). Homogeneous VLP and cavsomere compositions produced by said methods: use thereof as vehicle for improved purification, and delivery of active agents
US6962777B1 (en) * 1997-09-05 2005-11-08 Medimmune, Inc. In vitro method for disassembly/reassembly of papillomavirus virus-like particles (vlps), homogeneous vlp and capsomere compositions produced by said methods; use thereof as vehicle for improved purification, and delivery of active agents
ES2325053T3 (es) * 1999-12-09 2009-08-25 Medimmune, Llc Metodo in vitro para desensamblaje/reensamblaje de particulas similares a virus de papilomavirus (vlp).
EP1409013B1 (en) * 2001-07-26 2009-11-18 Novartis Vaccines and Diagnostics S.r.l. Vaccines comprising aluminium adjuvants and histidine
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
DE10137102A1 (de) * 2001-07-30 2003-02-27 Deutsches Krebsforsch Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
AU2003219760A1 (en) * 2002-02-14 2003-09-04 Novavax, Inc. Optimization of gene sequences of virus-like particles for expression in insect cells
GB0206359D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
GB0206360D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
DE10237639A1 (de) * 2002-08-13 2004-02-26 Martin-Luther-Universität Halle-Wittenberg Verfahren zur Herstellung von virusanalogen Partikeln durch in vitro-Assemblierung von Kapsomeren oder von Kapsomeren, an die biologisch aktive Makromoleküle gebunden sind, bei gleichzeitiger Verpackung der Makromoleküle
GB0220194D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
WO2004039417A2 (en) 2002-11-01 2004-05-13 Glaxosmithkline Biologicals S.A. Drying process
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
KR20120118087A (ko) 2002-12-20 2012-10-25 글락소스미스클라인 바이오로지칼즈 에스.에이. Ｈｐｖ-16 ｌ1 ｖｌｐ 및 ｈｐｖ-18 ｌ1 ｖｌｐ 백신
JP4734608B2 (ja) * 2004-07-01 2011-07-27 国立大学法人東京工業大学 生理的条件下でのウイルス粒子様構造体及びその形成方法
RU2442822C2 (ru) * 2005-01-25 2012-02-20 Вайет Рисерч Айрлэнд Лимитед Вещества, защищающие клетки от рассечения при сборе микрофильтрацией
WO2007011711A2 (en) * 2005-07-14 2007-01-25 Mayo Foundation For Medical Education And Research Paramyxoviridae virus preparations
JPWO2007020871A1 (ja) * 2005-08-12 2009-02-26 アステラス製薬株式会社 デプシペプチド含有注射液
WO2007027076A1 (es) * 2005-09-01 2007-03-08 Nuno Ayala Jose Luis Formula estabilizadora de vacunas con antígenos vivos para su uso en sistemas de vacunación masiva
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
WO2007134252A1 (en) * 2006-05-11 2007-11-22 Becton, Dickinson And Company Method of protein extraction from cells
US9207240B2 (en) 2007-11-14 2015-12-08 Arbor Vita Corporation Method of efficient extraction of protein from cells
JP5313231B2 (ja) * 2008-03-31 2013-10-09 森永乳業株式会社 耐熱性を付与する薬剤及び組成物
JP5916610B2 (ja) * 2009-09-03 2016-05-11 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 直接的な化学的溶解のための方法および組成物
RU2580620C2 (ru) 2010-08-23 2016-04-10 ВАЙЕТ ЭлЭлСи СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086
PE20140173A1 (es) 2010-09-10 2014-02-20 Wyeth Llc Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MY198910A (en) 2012-03-09 2023-10-02 Pfizer Neisseria meningitidis compositions and methods thereof
JP2015514696A (ja) 2012-03-18 2015-05-21 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ヒト・パピローマウイルスに対するワクチン接種方法
KR101559622B1 (ko) * 2012-07-30 2015-10-13 중앙대학교 산학협력단 인유두종바이러스 바이러스 유사입자의 고효율 정제방법
EP2964665B1 (en) 2013-03-08 2018-08-01 Pfizer Inc Immunogenic fusion polypeptides
MX369534B (es) 2013-09-08 2019-11-11 Pfizer Composiciones de neisseria meningitidis y sus metodos.
CN107249626A (zh) 2015-02-19 2017-10-13 辉瑞大药厂 脑膜炎奈瑟球菌组合物及其方法
SG11201906519RA (en) 2017-01-31 2019-08-27 Pfizer Neisseria meningitidis compositions and methods thereof
WO2018152505A1 (en) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Efficient cell free production of papillomavirus gene transfer vectors
CN110987571A (zh) * 2019-12-31 2020-04-10 广州金域医学检验中心有限公司 一种单克隆多聚体m蛋白解聚方法
CN111812313B (zh) * 2020-06-22 2021-10-08 北京生物制品研究所有限责任公司 铝佐剂吸附型新型冠状病毒灭活疫苗中抗原的解离方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515056A (ja) * 1997-02-06 2002-05-21 メルク エンド カンパニー インコーポレーテッド ワクチン用チメロサールフリー保存剤
AU739829B2 (en) 1997-04-08 2001-10-18 Merck Sharp & Dohme Corp. Stabilized human papillomavirus formulations
CA2295316C (en) 1997-07-03 2007-06-26 University Of Colorado, University Technology Corporation Homogeneous human papilloma virus capsomere containing compositions, methods for manufacture, and the use thereof as diagnostic, prophylactic or therapy

Also Published As

Publication number Publication date
DE122007000033I1 (de) 2007-08-09
LU91326I2 (fr) 2007-05-14
AU778937B2 (en) 2004-12-23
DE122007000034I1 (de) 2007-08-09
NL300269I2 (nl) 2008-07-01
AR023166A1 (es) 2002-09-04
CY2007009I2 (el) 2010-07-28
NL300268I1 (nl) 2007-05-01
KR20020013516A (ko) 2002-02-20
LU91327I9 (es) 2019-03-01
CY1105779T1 (el) 2010-07-28
DE60030698D1 (de) 2006-10-26
WO2000057906A1 (en) 2000-10-05
LU91328I2 (fr) 2007-05-14
ATE339222T1 (de) 2006-10-15
CY2007010I2 (el) 2009-11-04
US6245568B1 (en) 2001-06-12
CA2368391A1 (en) 2000-10-05
LU91326I9 (es) 2018-12-31
CY2007009I1 (el) 2010-07-28
LTC1165126I2 (lt) 2020-04-27
JP4594534B2 (ja) 2010-12-08
FR07C0026I1 (es) 2007-04-27
DE122007000032I1 (de) 2007-08-09
JP2002540167A (ja) 2002-11-26
PT1165126E (pt) 2006-12-29
NL300269I1 (nl) 2007-05-01
EP1165126A1 (en) 2002-01-02
LU91327I2 (fr) 2007-05-14
CY2007008I2 (el) 2009-11-04
US20010021385A1 (en) 2001-09-13
CA2368391C (en) 2011-06-07
CY2007008I1 (el) 2009-11-04
EP1165126B1 (en) 2006-09-13
CY2007010I1 (el) 2009-11-04
LTPA2007002I1 (lt) 2020-03-25
AU3909300A (en) 2000-10-16
SI1165126T1 (sl) 2006-12-31
DE60030698T2 (de) 2007-07-19
NL300270I1 (nl) 2007-05-01
LU91328I9 (es) 2019-03-01
FR07C0026I2 (fr) 2012-08-03
ES2270822T3 (es) 2007-04-16

Similar Documents

Publication Publication Date Title
DK1165126T3 (da) Fremgangsmåde til fremstilling af en humant papillomvirus-vaccine med demonterede og remonterede viruslignende partikler
DE60040727D1 (de) Menschliche papillomavirus impfstoff-formulierungen
NO2012016I1 (no) Kombinasjon av HPV16 og HPV18 L1 viruslignende partikler
IL163814A0 (en) Virus-like particles of human papillomavirus
AU2003235707A1 (en) Immunogenic preparations and vaccines on the basis of mrna
AU2003227533A1 (en) Virus like particle from papillomavirus and their use in vaccine
PT1210112E (pt) Vacina contra hbv e hpv
EP1694694A4 (en) REPLICATION COMPETENT HEPATITIS C-VIRUS AND METHOD OF USE
TWI349557B (en) Use of hpv 16 and hpv 18 vlps for vaccine preparation
AU2001241918A1 (en) Methods of enhancing activity of vaccines and vaccine compositions
EP1575601A4 (en) RECOMBINANT VACCINE VIRUSES EXPRESSING IL-15 AND METHODS OF USING THE SAME VIRUSES
AU2003271021A1 (en) Immunogen for preparation of therapeutic vaccines or drugs for treatment of hepatitis b and the producing method and use thereof
HK1088827A1 (en) Method of obtaining cochlear structures, vaccine compositions, adjuvants and intermediates thereof
EP1651258A4 (en) HEPATITIS VIRUS CORE PROTEINS AS VACCINE PLATFORMS AND USE THEREOF
GB0006716D0 (en) Virus or viral antigen purification method and vaccine producing method
AU2003298578A1 (en) Vaccines containing viruses involved in avian malabsorption syndrome and methods of administration therefor
AU2003298984A1 (en) Method of preparing a vaccine and anti-tumor vaccines
AU2003281909A1 (en) Method of obtaining conjugate vaccines and vaccine compositions containing same
EP1485497A4 (en) CASTOR-BASED VACCINE AND METHODS OF MAKING AND USING THE SAME
AUPR020900A0 (en) Vaccines and methods of vaccination
AUPR042100A0 (en) Vaccines and methods of vaccination
AU2002242725A1 (en) Mhc-i-restricted presentation of hiv-1 virion antigens without viral replication. application to the stimulation of ctl and vaccination in vivo; analysis of vaccinating composition in vitro
PL354719A1 (en) Oral vaccine and new application of yeast capable of antigen expression
GB0103731D0 (en) Materials and methods relating to increasing viral tissue
AU2002362767A1 (en) Recombinant rabies vaccine and methods of preparation and use