DK1153023T3 - Fremgangsmåde til fremstilling af paroxetin - Google Patents
Fremgangsmåde til fremstilling af paroxetinInfo
- Publication number
- DK1153023T3 DK1153023T3 DK00909228T DK00909228T DK1153023T3 DK 1153023 T3 DK1153023 T3 DK 1153023T3 DK 00909228 T DK00909228 T DK 00909228T DK 00909228 T DK00909228 T DK 00909228T DK 1153023 T3 DK1153023 T3 DK 1153023T3
- Authority
- DK
- Denmark
- Prior art keywords
- paroxetine
- sesamol
- derivatisation
- dealkylation
- tetrahydropyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI000364A IT1308629B1 (it) | 1999-02-23 | 1999-02-23 | Processo per la produzione di paroxetina. |
PCT/EP2000/001430 WO2000050422A1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1153023T3 true DK1153023T3 (da) | 2003-08-11 |
Family
ID=11382007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00909228T DK1153023T3 (da) | 1999-02-23 | 2000-02-22 | Fremgangsmåde til fremstilling af paroxetin |
Country Status (28)
Country | Link |
---|---|
US (1) | US6583287B1 (ko) |
EP (1) | EP1153023B1 (ko) |
JP (1) | JP2002537394A (ko) |
KR (1) | KR20010102366A (ko) |
CN (1) | CN1161353C (ko) |
AT (1) | ATE238295T1 (ko) |
AU (1) | AU759441B2 (ko) |
BR (1) | BR0008220A (ko) |
CA (1) | CA2361758A1 (ko) |
CZ (1) | CZ20012997A3 (ko) |
DE (1) | DE60002303T2 (ko) |
DK (1) | DK1153023T3 (ko) |
ES (1) | ES2195876T3 (ko) |
HK (1) | HK1040516B (ko) |
HR (1) | HRP20010608A2 (ko) |
HU (1) | HUP0105482A3 (ko) |
IL (1) | IL144883A (ko) |
IT (1) | IT1308629B1 (ko) |
MX (1) | MXPA01008502A (ko) |
NO (1) | NO319724B1 (ko) |
PL (1) | PL349358A1 (ko) |
PT (1) | PT1153023E (ko) |
RU (1) | RU2242473C2 (ko) |
SK (1) | SK12042001A3 (ko) |
TR (1) | TR200102441T2 (ko) |
TW (1) | TWI221473B (ko) |
WO (1) | WO2000050422A1 (ko) |
YU (1) | YU60801A (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2289650T3 (es) * | 2004-03-03 | 2008-02-01 | Chemi S.P.A. | Sal monosodica del acido 3-piridil-1-hidroxietiliden-1,1-bifosfonico amorfa y procedimiento para la preparacion de la misma. |
US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
TW201334783A (zh) * | 2012-01-31 | 2013-09-01 | Eisai R&D Man Co Ltd | 帕羅西汀(Paroxetine)衍生物 |
CN106831736A (zh) * | 2017-02-15 | 2017-06-13 | 浙江华海药业股份有限公司 | 一种制备帕罗西汀杂质的方法 |
CN112521377A (zh) * | 2020-11-26 | 2021-03-19 | 北京福元医药股份有限公司 | 一种盐酸帕罗西汀的连续化制备方法 |
CN115260153B (zh) * | 2022-07-21 | 2023-10-27 | 威尚(上海)生物医药有限公司 | 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0757758B2 (ja) | 1988-10-24 | 1995-06-21 | 高砂香料工業株式会社 | ルテニウム―ホスフィン錯体 |
DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
US5233084A (en) | 1989-06-22 | 1993-08-03 | Monsanto Company | Method for preparing α-arylpropionic acids |
FR2651152B1 (fr) * | 1989-08-23 | 1991-11-29 | Elf Aquitaine | Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore. |
GB9209687D0 (en) | 1992-05-06 | 1992-06-17 | Smithkline Beecham Plc | Novel process |
DE4422672A1 (de) * | 1994-06-30 | 1996-01-04 | Hoechst Ag | Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung |
HUP9900318A3 (en) | 1995-05-17 | 2001-09-28 | Novo Nordisk As | Process for preparing 4-aryl-piperidine derivatives |
HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
WO1998050359A1 (en) * | 1997-05-06 | 1998-11-12 | Novo Nordisk A/S | Novel heterocyclic compounds |
WO1998052687A1 (en) * | 1997-05-20 | 1998-11-26 | Firmenich S.A. | Ruthenium catalysts and their use in the asymmetric hydrogenation of weakly coordinating substrates |
-
1999
- 1999-02-23 IT IT1999MI000364A patent/IT1308629B1/it active
-
2000
- 2000-02-18 TW TW089102997A patent/TWI221473B/zh not_active IP Right Cessation
- 2000-02-22 RU RU2001125933/04A patent/RU2242473C2/ru not_active IP Right Cessation
- 2000-02-22 AU AU31583/00A patent/AU759441B2/en not_active Ceased
- 2000-02-22 DE DE60002303T patent/DE60002303T2/de not_active Expired - Fee Related
- 2000-02-22 US US09/890,414 patent/US6583287B1/en not_active Expired - Fee Related
- 2000-02-22 EP EP00909228A patent/EP1153023B1/en not_active Expired - Lifetime
- 2000-02-22 KR KR1020017010760A patent/KR20010102366A/ko not_active Application Discontinuation
- 2000-02-22 SK SK1204-2001A patent/SK12042001A3/sk unknown
- 2000-02-22 AT AT00909228T patent/ATE238295T1/de not_active IP Right Cessation
- 2000-02-22 JP JP2000601002A patent/JP2002537394A/ja active Pending
- 2000-02-22 BR BR0008220-1A patent/BR0008220A/pt not_active IP Right Cessation
- 2000-02-22 DK DK00909228T patent/DK1153023T3/da active
- 2000-02-22 MX MXPA01008502A patent/MXPA01008502A/es active IP Right Grant
- 2000-02-22 YU YU60801A patent/YU60801A/sh unknown
- 2000-02-22 TR TR2001/02441T patent/TR200102441T2/xx unknown
- 2000-02-22 CA CA002361758A patent/CA2361758A1/en not_active Abandoned
- 2000-02-22 HU HU0105482A patent/HUP0105482A3/hu unknown
- 2000-02-22 WO PCT/EP2000/001430 patent/WO2000050422A1/en not_active Application Discontinuation
- 2000-02-22 CZ CZ20012997A patent/CZ20012997A3/cs unknown
- 2000-02-22 ES ES00909228T patent/ES2195876T3/es not_active Expired - Lifetime
- 2000-02-22 IL IL14488300A patent/IL144883A/en not_active IP Right Cessation
- 2000-02-22 PL PL00349358A patent/PL349358A1/xx not_active IP Right Cessation
- 2000-02-22 PT PT00909228T patent/PT1153023E/pt unknown
- 2000-02-22 CN CNB008041873A patent/CN1161353C/zh not_active Expired - Fee Related
-
2001
- 2001-08-17 HR HR20010608A patent/HRP20010608A2/hr not_active Application Discontinuation
- 2001-08-22 NO NO20014078A patent/NO319724B1/no unknown
-
2002
- 2002-03-14 HK HK02101971.9A patent/HK1040516B/zh not_active IP Right Cessation
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