MX2007002913A - Proceso para preparar n-(arilmetil sustituido)-4-sustituido-4-(met il disustituido)piperidinas y productos intermedios. - Google Patents

Proceso para preparar n-(arilmetil sustituido)-4-sustituido-4-(met il disustituido)piperidinas y productos intermedios.

Info

Publication number
MX2007002913A
MX2007002913A MX2007002913A MX2007002913A MX2007002913A MX 2007002913 A MX2007002913 A MX 2007002913A MX 2007002913 A MX2007002913 A MX 2007002913A MX 2007002913 A MX2007002913 A MX 2007002913A MX 2007002913 A MX2007002913 A MX 2007002913A
Authority
MX
Mexico
Prior art keywords
substituted
preparing
piperidines
intermediates
arylmethyl
Prior art date
Application number
MX2007002913A
Other languages
English (en)
Inventor
Jaidev Goudar
David S Rosen
Guozhi Wang
Qun Zhang
Russell Patera
Walter H Yeager
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of MX2007002913A publication Critical patent/MX2007002913A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describe un proceso mejorado para preparar una N-(arilmetil sustituido)-4-sustituido-4-(metil disustituido)-piperidina de la fórmula (I): en donde R1 y R2 se seleccionan independientemente del grupo que consiste de halógeno, CF3, OCF3, OCHF2, OCF2CHF2 Y SF5; y Z y B se seleccionan independientemente del grupo que consiste de CH y N; así como también procesos para preparar productos intermedios que son útiles en el proceso completo.
MX2007002913A 2004-09-13 2005-09-12 Proceso para preparar n-(arilmetil sustituido)-4-sustituido-4-(met il disustituido)piperidinas y productos intermedios. MX2007002913A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60953304P 2004-09-13 2004-09-13
PCT/US2005/032279 WO2006031674A1 (en) 2004-09-13 2005-09-12 Process for preparing n-(substituted arylmethyl)-4-substituted-4- (disubstituted methyl) piperidines and intermediates

Publications (1)

Publication Number Publication Date
MX2007002913A true MX2007002913A (es) 2009-02-12

Family

ID=36060365

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007002913A MX2007002913A (es) 2004-09-13 2005-09-12 Proceso para preparar n-(arilmetil sustituido)-4-sustituido-4-(met il disustituido)piperidinas y productos intermedios.

Country Status (10)

Country Link
US (1) US20080039631A1 (es)
EP (1) EP1791828A1 (es)
JP (1) JP2008512488A (es)
KR (1) KR20070106678A (es)
CN (1) CN101018777A (es)
AR (1) AR051082A1 (es)
BR (1) BRPI0515256A (es)
MX (1) MX2007002913A (es)
TW (1) TW200621749A (es)
WO (1) WO2006031674A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1673083A4 (en) * 2003-10-10 2008-12-17 Bayer Cropscience Ag N-SUBSTITUTED AZACYCLES

Also Published As

Publication number Publication date
BRPI0515256A (pt) 2008-07-15
KR20070106678A (ko) 2007-11-05
US20080039631A1 (en) 2008-02-14
EP1791828A1 (en) 2007-06-06
CN101018777A (zh) 2007-08-15
TW200621749A (en) 2006-07-01
AR051082A1 (es) 2006-12-20
WO2006031674A1 (en) 2006-03-23
JP2008512488A (ja) 2008-04-24

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal