NO20071702L - Fremgangsmate for fremstilling av 4,5-dihydro-pyrazolo[3,4-C]pyrid-oner - Google Patents

Fremgangsmate for fremstilling av 4,5-dihydro-pyrazolo[3,4-C]pyrid-oner Download PDF

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Publication number
NO20071702L
NO20071702L NO20071702A NO20071702A NO20071702L NO 20071702 L NO20071702 L NO 20071702L NO 20071702 A NO20071702 A NO 20071702A NO 20071702 A NO20071702 A NO 20071702A NO 20071702 L NO20071702 L NO 20071702L
Authority
NO
Norway
Prior art keywords
pyrazolo
dihydro
preparation
pyridones
phenylhydrazines
Prior art date
Application number
NO20071702A
Other languages
English (en)
Inventor
Bang-Chi Chen
Boguslaw M Mudryk
Nicolas Cuniere
Lucius Rossano
Huiping Zhang
Rafael Shapiro
Matthew Oberholzer
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20071702L publication Critical patent/NO20071702L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

En ny fremgangsmåte, og mellomprodukter fra denne, for fremstilling av 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-oner med formel (I), fra passende fenylhydraziner, er beskrevet. (I) Disse forbindelsene kan være anvendelige som faktor Xa-hemmere.

Claims (1)

  1. En ny fremgangsmåte, og mellomprodukter fra denne,
    for fremstilling av 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-oner med formel (I), fra passende fenylhydraziner, er beskrevet.
    Disse forbindelsene kan være anvendelige som faktor Xa-hemmere.
NO20071702A 2004-09-28 2007-03-30 Fremgangsmate for fremstilling av 4,5-dihydro-pyrazolo[3,4-C]pyrid-oner NO20071702L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61393804P 2004-09-28 2004-09-28
US68899905P 2005-06-09 2005-06-09
US11/235,510 US7396932B2 (en) 2004-09-28 2005-09-26 Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
PCT/US2005/034548 WO2007001385A2 (en) 2004-09-28 2005-09-27 Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

Publications (1)

Publication Number Publication Date
NO20071702L true NO20071702L (no) 2007-05-25

Family

ID=36100191

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071702A NO20071702L (no) 2004-09-28 2007-03-30 Fremgangsmate for fremstilling av 4,5-dihydro-pyrazolo[3,4-C]pyrid-oner

Country Status (12)

Country Link
US (1) US7396932B2 (no)
EP (1) EP1805178A2 (no)
JP (1) JP2008514712A (no)
KR (1) KR20070067177A (no)
AR (1) AR051304A1 (no)
AU (1) AU2005333566A1 (no)
BR (1) BRPI0516187A (no)
CA (1) CA2582233A1 (no)
IL (1) IL182177A0 (no)
MX (1) MX2007003702A (no)
NO (1) NO20071702L (no)
WO (1) WO2007001385A2 (no)

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TWI331526B (en) * 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TW200303201A (en) * 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
US20060069085A1 (en) * 2004-09-28 2006-03-30 Rulin Zhao Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US20070203178A1 (en) * 2004-09-28 2007-08-30 Malley Mary F Crystalline solvates of apixaban
US7304157B2 (en) * 2004-09-28 2007-12-04 Bristol-Myers Squibb Company Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US20060069260A1 (en) * 2004-09-28 2006-03-30 Huiping Zhang Preparation of N-aryl pyridones
US20060160841A1 (en) * 2005-01-19 2006-07-20 Chenkou Wei Crystallization via high-shear transformation
LT2442791T (lt) 2009-06-16 2020-02-25 Pfizer Inc. Apiksabano vaisto formos
BR112012021337A8 (pt) 2010-02-25 2016-11-29 Bristol Myers Squibb Co formulações de apixaban.
ITMI20111135A1 (it) * 2011-06-22 2012-12-23 Dipharma Francis Srl Procedimento per la preparazione di apixaban
JP2014516072A (ja) 2011-06-10 2014-07-07 ディフアルマ フランチス ソシエタ ア レスポンサビリタ リミタータ アピキサバン製造方法
ITMI20111047A1 (it) * 2011-06-10 2012-12-11 Dipharma Francis Srl Forma cristallina di apixaban
EP2554159A1 (en) 2011-08-04 2013-02-06 ratiopharm GmbH Dosage forms comprising apixaban and content uniformity enhancer
WO2013119328A1 (en) * 2012-02-07 2013-08-15 Assia Chemical Industries Ltd. Solid state forms of apixaban
US9045473B2 (en) * 2012-03-14 2015-06-02 Dr. Reddy's Laboratories Ltd. Forms of Apixaban
WO2013174498A1 (en) 2012-05-24 2013-11-28 Ratiopharm Gmbh Dosage forms comprising apixaban and matrix former
WO2014072884A1 (en) 2012-11-12 2014-05-15 Alembic Pharmaceuticals Limited Process for the synthesis of apixaban
CZ304846B6 (cs) 2012-11-13 2014-12-03 Zentiva, K.S. Způsob přípravy APIXABANU
EP2752414A1 (en) 2013-01-04 2014-07-09 Sandoz AG Crystalline form of apixaban
WO2014108919A2 (en) * 2013-01-09 2014-07-17 Msn Laboratories Limited NOVEL INTERMEDIATE AND POLYMORPHS OF 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-c] PYRIDINE-3-CARBOXAMIDE AND PROCESS THEREOF
CZ2013305A3 (cs) 2013-04-23 2014-11-05 Zentiva, K.S. Nové krystalické formy APIXABANU a způsob jejich přípravy
US20160113912A1 (en) 2013-06-18 2016-04-28 Cadila Healthcare Limited An improved process for the preparation of apixaban and intermediates thereof
CN103360391B (zh) * 2013-08-06 2015-03-25 齐鲁制药有限公司 阿哌沙班新晶型及其制备方法
CN104370902A (zh) * 2013-08-12 2015-02-25 药源药物化学（上海）有限公司 一种阿哌沙班新晶型及其制备方法
CN103923080B (zh) * 2014-04-04 2016-06-22 苏州景泓生物技术有限公司 一种制备抗血栓药物阿哌沙班的方法
WO2015177801A1 (en) * 2014-05-23 2015-11-26 Symed Labs Limited Novel process for the preparation of a lactam-containing compound
EP3166942B1 (en) * 2014-07-11 2017-09-13 Laboratorios Lesvi, S.L. Process for preparing apixaban
HU231122B1 (hu) 2014-08-06 2020-11-30 Egis Gyógyszergyár Zrt Eljárás apixaban előállítására
WO2016035007A2 (en) 2014-09-05 2016-03-10 Unichem Laboratories Limited An improved process for the preparation of apixaban and intermediates thereof
EP3009435B1 (en) * 2014-10-15 2016-08-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Apixaban glycol esters as key intermediates and impurities of the synthesis of Apixaban
WO2016067308A1 (en) * 2014-10-28 2016-05-06 Jubilant Generics Limited (Formerly Jubilant Life Sciences Division) Process for the preparation of apixaban and intermediates thereof
HU230991B1 (hu) 2014-11-19 2019-08-28 Egis Gyógyszergyár Zrt. Eljárás és köztitermék apixaban előállítására
US9603846B2 (en) 2014-11-25 2017-03-28 Cadila Healthcare Limited Process for the preparation of apixaban
CN104892601B (zh) * 2015-06-09 2017-09-19 江苏中邦制药有限公司 一种抗血栓药物阿哌沙班的制备方法
EP3064497A1 (en) 2015-07-20 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Dimer impurities of apixaban and method to remove them
WO2017088841A1 (en) 2015-11-26 2017-06-01 Zentiva, K.S. Preparation of a drug form containing amorphous apixaban
WO2017221209A1 (en) 2016-06-23 2017-12-28 Lupin Limited Pharmaceutical formulations of apixaban
KR102188341B1 (ko) 2018-10-24 2020-12-08 하나제약 주식회사 아픽사반의 제조방법
EP3666773A1 (en) 2018-12-11 2020-06-17 KRKA, D.D., Novo Mesto Process for preparing apixaban
JP2022022550A (ja) * 2020-06-26 2022-02-07 ダイト株式会社 アピキサバンの新規製造方法

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IE67187B1 (en) * 1990-06-15 1996-03-06 Merck & Co Inc A crystallization method to improve crystal structure and size
TWI236930B (en) * 2000-05-26 2005-08-01 Pfizer Prod Inc Reactive crystallization method to improve particle size
ES2329881T3 (es) 2001-09-21 2009-12-02 Bristol-Myers Squibb Company Compuestos que contienen lactama y derivados de los mismos como inhibidores del factor xa.
TWI331526B (en) * 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
AU2002350217A1 (en) 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200303201A (en) * 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
JP2008517974A (ja) 2004-10-25 2008-05-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗血栓薬と併用しての血栓塞栓性疾患の治療および予防のためのジピリダモールの使用
US20060160841A1 (en) 2005-01-19 2006-07-20 Chenkou Wei Crystallization via high-shear transformation

Also Published As

Publication number Publication date
BRPI0516187A (pt) 2008-08-26
US7396932B2 (en) 2008-07-08
WO2007001385A3 (en) 2007-05-31
MX2007003702A (es) 2007-04-20
JP2008514712A (ja) 2008-05-08
EP1805178A2 (en) 2007-07-11
AR051304A1 (es) 2007-01-03
CA2582233A1 (en) 2007-01-04
US20060069258A1 (en) 2006-03-30
AU2005333566A1 (en) 2007-01-04
WO2007001385B1 (en) 2007-07-12
KR20070067177A (ko) 2007-06-27
IL182177A0 (en) 2007-07-24
WO2007001385A2 (en) 2007-01-04

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