NO20071702L - Fremgangsmate for fremstilling av 4,5-dihydro-pyrazolo[3,4-C]pyrid-oner - Google Patents
Fremgangsmate for fremstilling av 4,5-dihydro-pyrazolo[3,4-C]pyrid-oner Download PDFInfo
- Publication number
- NO20071702L NO20071702L NO20071702A NO20071702A NO20071702L NO 20071702 L NO20071702 L NO 20071702L NO 20071702 A NO20071702 A NO 20071702A NO 20071702 A NO20071702 A NO 20071702A NO 20071702 L NO20071702 L NO 20071702L
- Authority
- NO
- Norway
- Prior art keywords
- pyrazolo
- dihydro
- preparation
- pyridones
- phenylhydrazines
- Prior art date
Links
- -1 4,5-dihydro-pyrazolo [3,4-C] pyridones Chemical class 0.000 title 1
- 229940123583 Factor Xa inhibitor Drugs 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 239000000543 intermediate Substances 0.000 claims abstract 2
- 150000004031 phenylhydrazines Chemical class 0.000 claims abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
Abstract
En ny fremgangsmåte, og mellomprodukter fra denne, for fremstilling av 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-oner med formel (I), fra passende fenylhydraziner, er beskrevet. (I) Disse forbindelsene kan være anvendelige som faktor Xa-hemmere.
Claims (1)
- En ny fremgangsmåte, og mellomprodukter fra denne,for fremstilling av 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-oner med formel (I), fra passende fenylhydraziner, er beskrevet.Disse forbindelsene kan være anvendelige som faktor Xa-hemmere.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61393804P | 2004-09-28 | 2004-09-28 | |
US68899905P | 2005-06-09 | 2005-06-09 | |
US11/235,510 US7396932B2 (en) | 2004-09-28 | 2005-09-26 | Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
PCT/US2005/034548 WO2007001385A2 (en) | 2004-09-28 | 2005-09-27 | Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20071702L true NO20071702L (no) | 2007-05-25 |
Family
ID=36100191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20071702A NO20071702L (no) | 2004-09-28 | 2007-03-30 | Fremgangsmate for fremstilling av 4,5-dihydro-pyrazolo[3,4-C]pyrid-oner |
Country Status (12)
Country | Link |
---|---|
US (1) | US7396932B2 (no) |
EP (1) | EP1805178A2 (no) |
JP (1) | JP2008514712A (no) |
KR (1) | KR20070067177A (no) |
AR (1) | AR051304A1 (no) |
AU (1) | AU2005333566A1 (no) |
BR (1) | BRPI0516187A (no) |
CA (1) | CA2582233A1 (no) |
IL (1) | IL182177A0 (no) |
MX (1) | MX2007003702A (no) |
NO (1) | NO20071702L (no) |
WO (1) | WO2007001385A2 (no) |
Families Citing this family (40)
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TWI331526B (en) * | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
TW200738672A (en) * | 2001-12-10 | 2007-10-16 | Bristol Myers Squibb Co | Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
US7304157B2 (en) * | 2004-09-28 | 2007-12-04 | Bristol-Myers Squibb Company | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
US20060069085A1 (en) * | 2004-09-28 | 2006-03-30 | Rulin Zhao | Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
US20070203178A1 (en) * | 2004-09-28 | 2007-08-30 | Malley Mary F | Crystalline solvates of apixaban |
US20060069260A1 (en) * | 2004-09-28 | 2006-03-30 | Huiping Zhang | Preparation of N-aryl pyridones |
US20060160841A1 (en) * | 2005-01-19 | 2006-07-20 | Chenkou Wei | Crystallization via high-shear transformation |
RU2012101214A (ru) | 2009-06-16 | 2013-07-27 | Пфайзер Инк. | Лекарственные формы апиксабана |
EP3251660B1 (en) | 2010-02-25 | 2019-10-16 | Bristol-Myers Squibb Holdings Ireland Unlimited Company | Apixaban formulations |
ITMI20111135A1 (it) * | 2011-06-22 | 2012-12-23 | Dipharma Francis Srl | Procedimento per la preparazione di apixaban |
JP2014516072A (ja) | 2011-06-10 | 2014-07-07 | ディフアルマ フランチス ソシエタ ア レスポンサビリタ リミタータ | アピキサバン製造方法 |
ITMI20111047A1 (it) * | 2011-06-10 | 2012-12-11 | Dipharma Francis Srl | Forma cristallina di apixaban |
EP2554159A1 (en) | 2011-08-04 | 2013-02-06 | ratiopharm GmbH | Dosage forms comprising apixaban and content uniformity enhancer |
WO2013119328A1 (en) * | 2012-02-07 | 2013-08-15 | Assia Chemical Industries Ltd. | Solid state forms of apixaban |
US9045473B2 (en) * | 2012-03-14 | 2015-06-02 | Dr. Reddy's Laboratories Ltd. | Forms of Apixaban |
CA2873949A1 (en) | 2012-05-24 | 2013-11-28 | Ratiopharm Gmbh | Dosage forms comprising apixaban and matrix former |
WO2014072884A1 (en) | 2012-11-12 | 2014-05-15 | Alembic Pharmaceuticals Limited | Process for the synthesis of apixaban |
CZ304846B6 (cs) | 2012-11-13 | 2014-12-03 | Zentiva, K.S. | Způsob přípravy APIXABANU |
EP2752414A1 (en) | 2013-01-04 | 2014-07-09 | Sandoz AG | Crystalline form of apixaban |
US9718779B2 (en) | 2013-01-09 | 2017-08-01 | Msn Laboratories Limited | Intermediate and polymorphs of 1-(4-methoxypheny1)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetra hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and process thereof |
CZ2013305A3 (cs) | 2013-04-23 | 2014-11-05 | Zentiva, K.S. | Nové krystalické formy APIXABANU a způsob jejich přípravy |
WO2014203275A2 (en) | 2013-06-18 | 2014-12-24 | Cadila Healthcare Limited | An improved process for the preparation of apixaban and intermediates thereof |
CN103360391B (zh) * | 2013-08-06 | 2015-03-25 | 齐鲁制药有限公司 | 阿哌沙班新晶型及其制备方法 |
CN104370902A (zh) * | 2013-08-12 | 2015-02-25 | 药源药物化学(上海)有限公司 | 一种阿哌沙班新晶型及其制备方法 |
CN103923080B (zh) * | 2014-04-04 | 2016-06-22 | 苏州景泓生物技术有限公司 | 一种制备抗血栓药物阿哌沙班的方法 |
WO2015177801A1 (en) * | 2014-05-23 | 2015-11-26 | Symed Labs Limited | Novel process for the preparation of a lactam-containing compound |
JP6340471B2 (ja) * | 2014-07-11 | 2018-06-06 | ラボラトリオス、レスビ、ソシエダッド、リミターダLaboratorios Lesvi,S.L. | アピキサバンの製造方法 |
HU231122B1 (hu) | 2014-08-06 | 2020-11-30 | Egis Gyógyszergyár Zrt | Eljárás apixaban előállítására |
ES2881373T3 (es) | 2014-09-05 | 2021-11-29 | Unichem Lab Ltd | Un procedimiento mejorado para la preparación de apixabán e intermedios del mismo |
ES2595508T3 (es) * | 2014-10-15 | 2016-12-30 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Ésteres de glicol de apixabán como intermedios clave e impurezas de la síntesis de apixabán |
EP3212620B1 (en) * | 2014-10-28 | 2020-11-25 | Jubilant Generics Limited (Formerly Jubilant Life Sciences Division) | Process for the preparation of apixaban and intermediates thereof |
HU230991B1 (hu) | 2014-11-19 | 2019-08-28 | Egis Gyógyszergyár Zrt. | Eljárás és köztitermék apixaban előállítására |
US9603846B2 (en) | 2014-11-25 | 2017-03-28 | Cadila Healthcare Limited | Process for the preparation of apixaban |
CN104892601B (zh) * | 2015-06-09 | 2017-09-19 | 江苏中邦制药有限公司 | 一种抗血栓药物阿哌沙班的制备方法 |
EP3064497A1 (en) | 2015-07-20 | 2016-09-07 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Dimer impurities of apixaban and method to remove them |
EP3380083A1 (en) | 2015-11-26 | 2018-10-03 | Zentiva, K.S. | Preparation of a drug form containing amorphous apixaban |
WO2017221209A1 (en) | 2016-06-23 | 2017-12-28 | Lupin Limited | Pharmaceutical formulations of apixaban |
KR102188341B1 (ko) | 2018-10-24 | 2020-12-08 | 하나제약 주식회사 | 아픽사반의 제조방법 |
EP3666773A1 (en) | 2018-12-11 | 2020-06-17 | KRKA, D.D., Novo Mesto | Process for preparing apixaban |
JP2022022550A (ja) * | 2020-06-26 | 2022-02-07 | ダイト株式会社 | アピキサバンの新規製造方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69112917T2 (de) * | 1990-06-15 | 1996-05-15 | Merck & Co Inc | Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse. |
CZ20011726A3 (cs) * | 2000-05-26 | 2002-02-13 | Pfizer Products Inc. | Způsob reakční krystalizace, který umoľňuje řídit velikost částic |
TWI331526B (en) * | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
CA2726702A1 (en) | 2001-09-21 | 2003-04-03 | Bristol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
WO2003048081A2 (en) * | 2001-12-04 | 2003-06-12 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
TW200738672A (en) | 2001-12-10 | 2007-10-16 | Bristol Myers Squibb Co | Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
CA2587026A1 (en) | 2004-10-25 | 2006-05-04 | Boehringer Ingelheim International Gmbh | Use of dipyridamole in combination with antithrombotics for treatment and prevention of thromboembolic diseases |
US20060160841A1 (en) | 2005-01-19 | 2006-07-20 | Chenkou Wei | Crystallization via high-shear transformation |
-
2005
- 2005-09-26 US US11/235,510 patent/US7396932B2/en active Active
- 2005-09-27 WO PCT/US2005/034548 patent/WO2007001385A2/en active Search and Examination
- 2005-09-27 AU AU2005333566A patent/AU2005333566A1/en not_active Abandoned
- 2005-09-27 KR KR1020077009653A patent/KR20070067177A/ko not_active Application Discontinuation
- 2005-09-27 EP EP05858179A patent/EP1805178A2/en not_active Withdrawn
- 2005-09-27 CA CA002582233A patent/CA2582233A1/en not_active Abandoned
- 2005-09-27 MX MX2007003702A patent/MX2007003702A/es not_active Application Discontinuation
- 2005-09-27 AR ARP050104070A patent/AR051304A1/es unknown
- 2005-09-27 JP JP2007534702A patent/JP2008514712A/ja not_active Withdrawn
- 2005-09-27 BR BRPI0516187-8A patent/BRPI0516187A/pt not_active Application Discontinuation
-
2007
- 2007-03-25 IL IL182177A patent/IL182177A0/en unknown
- 2007-03-30 NO NO20071702A patent/NO20071702L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2005333566A1 (en) | 2007-01-04 |
JP2008514712A (ja) | 2008-05-08 |
KR20070067177A (ko) | 2007-06-27 |
US20060069258A1 (en) | 2006-03-30 |
MX2007003702A (es) | 2007-04-20 |
CA2582233A1 (en) | 2007-01-04 |
AR051304A1 (es) | 2007-01-03 |
WO2007001385A3 (en) | 2007-05-31 |
WO2007001385A2 (en) | 2007-01-04 |
EP1805178A2 (en) | 2007-07-11 |
IL182177A0 (en) | 2007-07-24 |
WO2007001385B1 (en) | 2007-07-12 |
BRPI0516187A (pt) | 2008-08-26 |
US7396932B2 (en) | 2008-07-08 |
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