DK1065196T3 - Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf - Google Patents

Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf

Info

Publication number
DK1065196T3
DK1065196T3 DK00113020T DK00113020T DK1065196T3 DK 1065196 T3 DK1065196 T3 DK 1065196T3 DK 00113020 T DK00113020 T DK 00113020T DK 00113020 T DK00113020 T DK 00113020T DK 1065196 T3 DK1065196 T3 DK 1065196T3
Authority
DK
Denmark
Prior art keywords
acid
esters
eicosan
purification
selective separation
Prior art date
Application number
DK00113020T
Other languages
Danish (da)
English (en)
Inventor
Satoshi Kiyohara
Shiro Nisshin Fujita
Original Assignee
Nisshin Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Pharma Inc filed Critical Nisshin Pharma Inc
Application granted granted Critical
Publication of DK1065196T3 publication Critical patent/DK1065196T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK00113020T 1999-06-28 2000-06-21 Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf DK1065196T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18140799 1999-06-28

Publications (1)

Publication Number Publication Date
DK1065196T3 true DK1065196T3 (da) 2003-09-22

Family

ID=16100230

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00113020T DK1065196T3 (da) 1999-06-28 2000-06-21 Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf

Country Status (7)

Country Link
US (1) US6313330B1 (no)
EP (1) EP1065196B1 (no)
AT (1) ATE241584T1 (no)
CA (1) CA2311974A1 (no)
DE (1) DE60002952T2 (no)
DK (1) DK1065196T3 (no)
NO (1) NO321273B1 (no)

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CN103357199B (zh) 2003-12-30 2019-02-01 帝斯曼知识产权资产管理有限公司 脱气方法
BRPI0613358A8 (pt) * 2005-07-08 2017-12-26 Dsm Ip Assets Bv ácidos de gordura poli - insaturada para o tratamento da demência e condições relacionadas à pré-demência
CA2692355C (en) * 2007-06-29 2018-09-11 Martek Biosciences Corporation Production and purification of esters of polyunsaturated fatty acids
EP3578177A1 (en) 2008-09-02 2019-12-11 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
JP5503856B2 (ja) 2008-09-10 2014-05-28 キユーピー株式会社 高度不飽和脂肪酸誘導体の取得方法
BRPI0924012A2 (pt) 2009-04-17 2019-09-24 Cela Vista Pharmaceuticals Ltd processo para obtenção de uma composição rica em ácidos graxos ômega 3 de um óleo de origem marinha, com um teor de af interior 90 mg/g composição, suplemento nutricional produto alimentar, composição farmacêutica, e, uso de um composto
RU2538691C2 (ru) 2009-04-29 2015-01-10 Амарин Фарма, Инк. Стабильные фармацевтические композиции и способы их применения
EP3563842A1 (en) 2009-04-29 2019-11-06 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
LT3318255T (lt) 2009-06-15 2021-05-25 Amarin Pharmaceuticals Ireland Limited Kompozicijos ir būdai, skirti insulto gydymui pacientui kartu su statinų terapija
CA2775339C (en) 2009-09-23 2017-03-28 Amarin Corporation Plc Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
EP2519332B1 (en) * 2009-12-30 2014-03-05 BASF Pharma (Callanish) Limited Simulated moving bed chromatographic separation process for the purification of polyunsaturated fatty acids
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ744990A (en) 2010-11-29 2019-10-25 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2775837A4 (en) 2011-11-07 2015-10-28 Amarin Pharmaceuticals Ie Ltd METHODS OF TREATING HYPERTRIGLYCERIDEMIA
EP2800469B1 (en) 2012-01-06 2021-08-25 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject
EP4342546A3 (en) 2012-06-29 2024-05-22 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
US20150265566A1 (en) 2012-11-06 2015-09-24 Amarin Pharmaceuticals Ireland Limited Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103962091B (zh) * 2013-11-28 2017-01-25 大连工业大学 一种银离子改性氨基硅胶分离epa和dha的方法
EP2883860B1 (fr) 2013-12-11 2016-08-24 Novasep Process Procédé chromatographique de production d'acides gras polyinsaturés
WO2015104464A1 (fr) 2014-01-07 2015-07-16 Novasep Process Procédé de purification d'acides aminés aromatiques
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
TW201900160A (zh) 2017-05-19 2019-01-01 愛爾蘭商艾瑪琳製藥愛爾蘭有限公司 用於降低腎功能下降之個體中的三酸甘油酯之組合物及方法
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
FI4056176T3 (fi) 2018-09-24 2024-05-30 Amarin Pharmaceuticals Ie Ltd Menetelmät kardiovaskulaaristen tapahtumien riskin pienentämiseksi tutkittavassa
CN113574154A (zh) * 2019-03-26 2021-10-29 日清药业股份有限公司 含二十碳五烯酸烷基酯的组合物的制造方法
CN109912403A (zh) * 2019-04-18 2019-06-21 南京市第一医院 一种Omega-3制备大电导钙激活钾通道开放剂的方法
AU2022263358A1 (en) 2021-04-21 2023-11-30 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure

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EP0347509A1 (en) * 1988-06-21 1989-12-27 Century Laboratories Inc. A process of extraction and purification of polyunsaturated fatty acids from natural sources
JPH028298A (ja) * 1988-06-17 1990-01-11 Agency Of Ind Science & Technol イカ内臓からドコサヘキサエン酸及びエイコサペンタエン酸を選択的に分離精製する方法
JPH07242895A (ja) * 1993-03-16 1995-09-19 Ikeda Shiyotsuken Kk 高純度エイコサペンタエン酸又はその低級アルコールエステルの分離精製法
JPH09151390A (ja) * 1995-11-30 1997-06-10 Bizen Kasei Kk 高度不飽和脂肪酸及びその誘導体の精製方法
JPH10310551A (ja) * 1997-05-12 1998-11-24 Nippon Wax Polymer Kaihatsu Kenkyusho:Kk エイコサペンタエン酸又はそのエステルの精製方法

Also Published As

Publication number Publication date
DE60002952D1 (de) 2003-07-03
EP1065196A1 (en) 2001-01-03
CA2311974A1 (en) 2000-12-28
EP1065196B1 (en) 2003-05-28
NO321273B1 (no) 2006-04-10
NO20003335L (no) 2000-12-29
ATE241584T1 (de) 2003-06-15
US6313330B1 (en) 2001-11-06
NO20003335D0 (no) 2000-06-26
DE60002952T2 (de) 2004-03-11

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