ATE241584T1 - Verfahren zur selektiven abtrennung und reinigung von eicosapentaensäure und decosohexaensäure und deren estern - Google Patents

Verfahren zur selektiven abtrennung und reinigung von eicosapentaensäure und decosohexaensäure und deren estern

Info

Publication number
ATE241584T1
ATE241584T1 AT00113020T AT00113020T ATE241584T1 AT E241584 T1 ATE241584 T1 AT E241584T1 AT 00113020 T AT00113020 T AT 00113020T AT 00113020 T AT00113020 T AT 00113020T AT E241584 T1 ATE241584 T1 AT E241584T1
Authority
AT
Austria
Prior art keywords
acid
esters
decosohexaenic
purification
flowing
Prior art date
Application number
AT00113020T
Other languages
English (en)
Inventor
Satoshi Kiyohara
Shiro Fujita
Original Assignee
Nisshin Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Pharma Inc filed Critical Nisshin Pharma Inc
Application granted granted Critical
Publication of ATE241584T1 publication Critical patent/ATE241584T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00113020T 1999-06-28 2000-06-21 Verfahren zur selektiven abtrennung und reinigung von eicosapentaensäure und decosohexaensäure und deren estern ATE241584T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18140799 1999-06-28

Publications (1)

Publication Number Publication Date
ATE241584T1 true ATE241584T1 (de) 2003-06-15

Family

ID=16100230

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00113020T ATE241584T1 (de) 1999-06-28 2000-06-21 Verfahren zur selektiven abtrennung und reinigung von eicosapentaensäure und decosohexaensäure und deren estern

Country Status (7)

Country Link
US (1) US6313330B1 (de)
EP (1) EP1065196B1 (de)
AT (1) ATE241584T1 (de)
CA (1) CA2311974A1 (de)
DE (1) DE60002952T2 (de)
DK (1) DK1065196T3 (de)
NO (1) NO321273B1 (de)

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BRPI0418239B1 (pt) 2003-12-30 2013-10-01 processo de desaeraÇço
AU2006269405B2 (en) * 2005-07-08 2013-01-17 Dsm Ip Assets B.V. Polyunsaturated fatty acids for treatment of dementia and pre-dementia-related conditions
MX2010000263A (es) * 2007-06-29 2010-03-11 Martek Biosciences Corp Produccion y purificacion de esteres de acidos grasos poliinsaturados.
EP3578177A1 (de) 2008-09-02 2019-12-11 Amarin Pharmaceuticals Ireland Limited Pharmazeutische zusammensetzungen mit eicosapentaensäure und nikotinsäure und verfahren zur verwendung davon
JP5503856B2 (ja) * 2008-09-10 2014-05-28 キユーピー株式会社 高度不飽和脂肪酸誘導体の取得方法
MX2011010821A (es) 2009-04-17 2012-01-20 Cela Vista Pharmaceuticals Ltd Composiciones ricas en acidos grasos omega-3 con bajo contenido en acido fitanico.
NZ789295A (en) 2009-04-29 2024-02-23 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
NZ627238A (en) 2009-04-29 2016-02-26 Amarin Pharmaceuticals Ie Ltd Stable pharmaceutical composition comprising ethyl eicosapentaenoate
CN114053258A (zh) 2009-06-15 2022-02-18 阿马里纳药物爱尔兰有限公司 在相伴他汀类疗法的对象中降低甘油三酯、没有增加ldl-c水平的组合物和方法
SG10201405994UA (en) 2009-09-23 2014-10-30 Amarin Pharmaceuticals Ie Ltd Pharmaceutical Composition Comprising Omega-3 Fatty Acid And Hydroxy-derivative Of A Statin And Methods Of Using Same
CN104974030A (zh) * 2009-12-30 2015-10-14 巴斯夫制药（卡兰尼什）公司 用于纯化多不饱和脂肪酸的模拟移动床色谱分离方法
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ778131A (en) 2010-11-29 2023-03-31 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
WO2013070735A1 (en) 2011-11-07 2013-05-16 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
AU2013207368A1 (en) 2012-01-06 2014-07-24 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-CRP) in a subject
JP2015522029A (ja) 2012-06-29 2015-08-03 アマリン ファーマシューティカルス アイルランド リミテッド スタチン療法中の患者における心血管系イベントの危険性を減少させる方法
US20150265566A1 (en) 2012-11-06 2015-09-24 Amarin Pharmaceuticals Ireland Limited Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103962091B (zh) * 2013-11-28 2017-01-25 大连工业大学 一种银离子改性氨基硅胶分离epa和dha的方法
EP3118186B1 (de) 2013-12-11 2022-02-09 Novasep Process Chromatografische anlage zur herstellung von mehrfach ungesättigten fettsäuren
BR112016015718B1 (pt) 2014-01-07 2021-12-07 Novasep Process Solutions Processo de purificação de aminoácidos aromáticos
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
US10172818B2 (en) 2014-06-16 2019-01-08 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
WO2018213663A1 (en) 2017-05-19 2018-11-22 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
CN112218630A (zh) 2018-09-24 2021-01-12 阿马里纳药物爱尔兰有限公司 降低受试者的心血管事件的风险的方法
JPWO2020196749A1 (de) * 2019-03-26 2020-10-01
CN109912403A (zh) * 2019-04-18 2019-06-21 南京市第一医院 一种Omega-3制备大电导钙激活钾通道开放剂的方法
WO2022225896A1 (en) 2021-04-21 2022-10-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347509A1 (de) * 1988-06-21 1989-12-27 Century Laboratories Inc. Verfahren zur Extraktion und Reinigung von polyungesättigten Fettsäuren aus Naturquellen
JPH028298A (ja) * 1988-06-17 1990-01-11 Agency Of Ind Science & Technol イカ内臓からドコサヘキサエン酸及びエイコサペンタエン酸を選択的に分離精製する方法
JPH07242895A (ja) * 1993-03-16 1995-09-19 Ikeda Shiyotsuken Kk 高純度エイコサペンタエン酸又はその低級アルコールエステルの分離精製法
JPH09151390A (ja) * 1995-11-30 1997-06-10 Bizen Kasei Kk 高度不飽和脂肪酸及びその誘導体の精製方法
JPH10310551A (ja) * 1997-05-12 1998-11-24 Nippon Wax Polymer Kaihatsu Kenkyusho:Kk エイコサペンタエン酸又はそのエステルの精製方法

Also Published As

Publication number Publication date
DE60002952T2 (de) 2004-03-11
EP1065196A1 (de) 2001-01-03
US6313330B1 (en) 2001-11-06
NO20003335L (no) 2000-12-29
DE60002952D1 (de) 2003-07-03
DK1065196T3 (da) 2003-09-22
NO321273B1 (no) 2006-04-10
CA2311974A1 (en) 2000-12-28
EP1065196B1 (de) 2003-05-28
NO20003335D0 (no) 2000-06-26

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