DK1065196T3 - Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf - Google Patents
Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere derafInfo
- Publication number
- DK1065196T3 DK1065196T3 DK00113020T DK00113020T DK1065196T3 DK 1065196 T3 DK1065196 T3 DK 1065196T3 DK 00113020 T DK00113020 T DK 00113020T DK 00113020 T DK00113020 T DK 00113020T DK 1065196 T3 DK1065196 T3 DK 1065196T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid
- esters
- eicosan
- purification
- selective separation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18140799 | 1999-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1065196T3 true DK1065196T3 (da) | 2003-09-22 |
Family
ID=16100230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00113020T DK1065196T3 (da) | 1999-06-28 | 2000-06-21 | Fremgangsmåde til selektiv adskillelse og oprensning af eicosanpentaensyre og docosahexaensyre eller estere deraf |
Country Status (7)
Country | Link |
---|---|
US (1) | US6313330B1 (de) |
EP (1) | EP1065196B1 (de) |
AT (1) | ATE241584T1 (de) |
CA (1) | CA2311974A1 (de) |
DE (1) | DE60002952T2 (de) |
DK (1) | DK1065196T3 (de) |
NO (1) | NO321273B1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2563649T3 (es) | 2003-12-30 | 2016-03-15 | Dsm Ip Assets B.V. | Proceso de desaireación |
KR20130101596A (ko) * | 2005-07-08 | 2013-09-13 | 마텍 바이오싸이언스스 코포레이션 | 치매 및 치매-전단계와 관련된 용태의 치료를 위한 다중불포화 지방산 |
JP2010532418A (ja) * | 2007-06-29 | 2010-10-07 | マーテック バイオサイエンシーズ コーポレーション | 多価不飽和脂肪酸のエステルの製造方法および精製方法 |
PL2334295T3 (pl) | 2008-09-02 | 2017-12-29 | Amarin Pharmaceuticals Ltd | Kompozycja farmaceutyczna zawierająca kwas eikozapentaenowy i kwas nikotynowy oraz sposoby jej zastosowania |
JP5503856B2 (ja) | 2008-09-10 | 2014-05-28 | キユーピー株式会社 | 高度不飽和脂肪酸誘導体の取得方法 |
ES2574136T5 (es) | 2009-04-17 | 2019-08-30 | Natac Pharma S L | Composiciones ricas en ácidos grasos omega 3 con un bajo contenido en ácido fitánico |
CN102458109B (zh) | 2009-04-29 | 2015-02-11 | 阿马里纳制药公司 | 稳定的药物组合物和使用其的方法 |
EP2424521A4 (de) | 2009-04-29 | 2015-03-04 | Amarin Pharmaceuticals Ie Ltd | Pharmazeutische zusammensetzungen mit epa und einem kardiovaskulären mittel sowie verwendungsverfahren dafür |
KR102012111B1 (ko) | 2009-06-15 | 2019-08-19 | 아마린 파마, 인크. | 병용 스타틴 요법을 받는 대상체에서 ldl-c 수준을 상승시키지 않으면서 트리글리세리드를 저하시키기 위한 조성물 및 방법 |
SG10201405994UA (en) | 2009-09-23 | 2014-10-30 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical Composition Comprising Omega-3 Fatty Acid And Hydroxy-derivative Of A Statin And Methods Of Using Same |
CA2785742C (en) | 2009-12-30 | 2015-02-17 | Basf Pharma (Callanish) Limited | Simulated moving bed chromatographic separation process |
NZ712068A (en) | 2010-11-29 | 2017-03-31 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
GB201111595D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Improved process |
GB201111601D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New process |
GB201111591D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Further new process |
GB201111589D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New modified process |
GB201111594D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
EP2775837A4 (de) | 2011-11-07 | 2015-10-28 | Amarin Pharmaceuticals Ie Ltd | Verfahren zur behandlung von hypertriglyceridämie |
WO2013103958A1 (en) | 2012-01-06 | 2013-07-11 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
SG11201408769QA (en) | 2012-06-29 | 2015-01-29 | Amarin Pharmaceuticals Ie Ltd | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy |
US20150265566A1 (en) | 2012-11-06 | 2015-09-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy |
US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
GB201300354D0 (en) | 2013-01-09 | 2013-02-20 | Basf Pharma Callanish Ltd | Multi-step separation process |
US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
US8802880B1 (en) | 2013-05-07 | 2014-08-12 | Group Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
CN103962091B (zh) * | 2013-11-28 | 2017-01-25 | 大连工业大学 | 一种银离子改性氨基硅胶分离epa和dha的方法 |
EP2883860B1 (de) | 2013-12-11 | 2016-08-24 | Novasep Process | Chromatografisches Verfahren zur Herstellung von mehrfach ungesättigten Fettsäuren |
US10975031B2 (en) | 2014-01-07 | 2021-04-13 | Novasep Process | Method for purifying aromatic amino acids |
US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
TW201900160A (zh) | 2017-05-19 | 2019-01-01 | 愛爾蘭商艾瑪琳製藥愛爾蘭有限公司 | 用於降低腎功能下降之個體中的三酸甘油酯之組合物及方法 |
US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
KR102296068B1 (ko) | 2018-09-24 | 2021-09-02 | 애머린 파마슈티칼스 아일랜드 리미티드 | 대상체에서 심혈관 사건의 위험도를 감소시키는 방법 |
US11767491B2 (en) | 2019-03-26 | 2023-09-26 | Nisshin Pharma Inc. | Eicosapentaenoic acid alkyl ester-containing composition and method for producing same |
CN109912403A (zh) * | 2019-04-18 | 2019-06-21 | 南京市第一医院 | 一种Omega-3制备大电导钙激活钾通道开放剂的方法 |
KR20240012390A (ko) | 2021-04-21 | 2024-01-29 | 애머린 파마슈티칼스 아일랜드 리미티드 | 심부전의 위험을 감소시키는 방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0347509A1 (de) * | 1988-06-21 | 1989-12-27 | Century Laboratories Inc. | Verfahren zur Extraktion und Reinigung von polyungesättigten Fettsäuren aus Naturquellen |
JPH028298A (ja) * | 1988-06-17 | 1990-01-11 | Agency Of Ind Science & Technol | イカ内臓からドコサヘキサエン酸及びエイコサペンタエン酸を選択的に分離精製する方法 |
JPH07242895A (ja) * | 1993-03-16 | 1995-09-19 | Ikeda Shiyotsuken Kk | 高純度エイコサペンタエン酸又はその低級アルコールエステルの分離精製法 |
JPH09151390A (ja) * | 1995-11-30 | 1997-06-10 | Bizen Kasei Kk | 高度不飽和脂肪酸及びその誘導体の精製方法 |
JPH10310551A (ja) * | 1997-05-12 | 1998-11-24 | Nippon Wax Polymer Kaihatsu Kenkyusho:Kk | エイコサペンタエン酸又はそのエステルの精製方法 |
-
2000
- 2000-06-19 CA CA002311974A patent/CA2311974A1/en not_active Abandoned
- 2000-06-21 AT AT00113020T patent/ATE241584T1/de not_active IP Right Cessation
- 2000-06-21 DE DE60002952T patent/DE60002952T2/de not_active Expired - Fee Related
- 2000-06-21 EP EP00113020A patent/EP1065196B1/de not_active Expired - Lifetime
- 2000-06-21 DK DK00113020T patent/DK1065196T3/da active
- 2000-06-26 NO NO20003335A patent/NO321273B1/no unknown
- 2000-06-28 US US09/604,766 patent/US6313330B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6313330B1 (en) | 2001-11-06 |
DE60002952D1 (de) | 2003-07-03 |
ATE241584T1 (de) | 2003-06-15 |
NO321273B1 (no) | 2006-04-10 |
CA2311974A1 (en) | 2000-12-28 |
DE60002952T2 (de) | 2004-03-11 |
NO20003335D0 (no) | 2000-06-26 |
EP1065196B1 (de) | 2003-05-28 |
NO20003335L (no) | 2000-12-29 |
EP1065196A1 (de) | 2001-01-03 |
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