DK1042305T3 - Inhibering af p38-kinase ved anvendelse af symmetriske og asymmetriske diphenylurinstoffer - Google Patents

Inhibering af p38-kinase ved anvendelse af symmetriske og asymmetriske diphenylurinstoffer

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Publication number
DK1042305T3
DK1042305T3 DK98964221T DK98964221T DK1042305T3 DK 1042305 T3 DK1042305 T3 DK 1042305T3 DK 98964221 T DK98964221 T DK 98964221T DK 98964221 T DK98964221 T DK 98964221T DK 1042305 T3 DK1042305 T3 DK 1042305T3
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Prior art keywords
diphenylureas
kinase
asymmetric
symmetric
inhibition
Prior art date
Application number
DK98964221T
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Danish (da)
English (en)
Inventor
Uday Khire
Bernd Riedl
William J Scott
Roger A Smith
Jill E Wood
David Gunn
Holia Hatoum-Mokdad
Scott Miller
Martin Osterhout
Jacques Dumas
Timothy Bruno Lowinger
Mareli Rodriguez
Robert Sibley
Ming Wang
Tiffany Turner
Catherine Brennan
Original Assignee
Bayer Pharmaceuticals Corp
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Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
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Publication of DK1042305T3 publication Critical patent/DK1042305T3/da

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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DK98964221T 1997-12-22 1998-12-22 Inhibering af p38-kinase ved anvendelse af symmetriske og asymmetriske diphenylurinstoffer DK1042305T3 (da)

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