ATE297383T1 - Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffen - Google Patents

Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffen

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Publication number
ATE297383T1
ATE297383T1 AT98964221T AT98964221T ATE297383T1 AT E297383 T1 ATE297383 T1 AT E297383T1 AT 98964221 T AT98964221 T AT 98964221T AT 98964221 T AT98964221 T AT 98964221T AT E297383 T1 ATE297383 T1 AT E297383T1
Authority
AT
Austria
Prior art keywords
ureases
kinase
symmetric
inhibition
asymmetric diphenyl
Prior art date
Application number
AT98964221T
Other languages
German (de)
English (en)
Inventor
Scott Miller
Martin Osterhout
Jacques Dumas
Uday Khire
Timothy Bruno Lowinger
Bernd Riedl
William J Scott
Roger A Smith
Jill E Wood
David Gunn
Holia Hatoum-Mokdad
Mareli Rodriguez
Robert Sibley
Ming Wang
Tiffany Turner
Catherine Brennan
Original Assignee
Bayer Pharmaceuticals Corp
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Publication date
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Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Application granted granted Critical
Publication of ATE297383T1 publication Critical patent/ATE297383T1/de

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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AT98964221T 1997-12-22 1998-12-22 Hemmung der p38 kinase unter verwendung von symmetrischen und asymmetrischen diphenylharnstoffen ATE297383T1 (de)

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