GR20010300006T1 - Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas - Google Patents
Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureasInfo
- Publication number
- GR20010300006T1 GR20010300006T1 GR20010300006T GR20010300006T GR20010300006T1 GR 20010300006 T1 GR20010300006 T1 GR 20010300006T1 GR 20010300006 T GR20010300006 T GR 20010300006T GR 20010300006 T GR20010300006 T GR 20010300006T GR 20010300006 T1 GR20010300006 T1 GR 20010300006T1
- Authority
- GR
- Greece
- Prior art keywords
- inhibition
- symmetrical
- raf kinase
- substituted diphenyl
- diphenyl ureas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99634497A | 1997-12-22 | 1997-12-22 | |
PCT/US1998/026081 WO1999032436A1 (en) | 1997-12-22 | 1998-12-22 | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas |
Publications (1)
Publication Number | Publication Date |
---|---|
GR20010300006T1 true GR20010300006T1 (en) | 2001-02-28 |
Family
ID=25542802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20010300006T GR20010300006T1 (en) | 1997-12-22 | 2001-02-28 | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas |
Country Status (25)
Country | Link |
---|---|
EP (2) | EP1449834A3 (en) |
JP (1) | JP4607318B2 (en) |
KR (1) | KR100704977B1 (en) |
CN (1) | CN1213022C (en) |
AT (1) | ATE291011T1 (en) |
AU (1) | AU763024B2 (en) |
BG (1) | BG64594B1 (en) |
BR (1) | BR9814375A (en) |
CA (1) | CA2315646C (en) |
CU (1) | CU23393A3 (en) |
CZ (1) | CZ301102B6 (en) |
DE (2) | DE69829412T2 (en) |
ES (1) | ES2153809T3 (en) |
GR (1) | GR20010300006T1 (en) |
HU (1) | HU227711B1 (en) |
ID (1) | ID26956A (en) |
IL (2) | IL136690A0 (en) |
MX (1) | MXPA00006231A (en) |
NO (1) | NO329181B1 (en) |
NZ (1) | NZ505843A (en) |
PL (1) | PL195808B1 (en) |
RU (1) | RU2247109C9 (en) |
SK (1) | SK286564B6 (en) |
TR (2) | TR200002616T2 (en) |
WO (1) | WO1999032436A1 (en) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291425B1 (en) * | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
EP1140840B1 (en) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
SV2001000004A (en) * | 1999-01-13 | 2001-01-10 | Bayer Corp | DIFENIL UREAS W-CARBOXYARIL SUBSTITUTED, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THEIR USE AS RAF QUINASA INHIBITORS |
ATE556713T1 (en) * | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS P38 KINASE INHIBITORS |
SI1140840T1 (en) * | 1999-01-13 | 2006-06-30 | Bayer Pharmaceuticals Corp | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
JP2003514906A (en) | 1999-11-22 | 2003-04-22 | スミスクライン ビーチャム パブリック リミテッド カンパニー | Imidazole derivatives and their use as RAF kinase inhibitors |
EP1263753B1 (en) | 2000-03-06 | 2004-05-06 | SmithKline Beecham plc | Imidazol derivatives as raf kinase inhibitors |
GB0005357D0 (en) * | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
ATE399766T1 (en) | 2000-10-20 | 2008-07-15 | Eisai R&D Man Co Ltd | AROMATIC HETEROCYCLES CONTAINING NITROGEN |
EP1341771A2 (en) | 2000-11-29 | 2003-09-10 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
JP2004528311A (en) * | 2001-03-07 | 2004-09-16 | テリック,インコーポレイテッド | Substituted diaryl ureas as stimulators of Fas-mediated apoptosis |
CA2443950C (en) * | 2001-04-20 | 2011-10-18 | Bayer Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
AU2002317377A1 (en) * | 2001-07-20 | 2003-03-03 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
US8110587B2 (en) * | 2002-02-11 | 2012-02-07 | Bayer Healthcare Llc | Aryl ureas as kinase inhibitors |
DK1478358T3 (en) | 2002-02-11 | 2013-10-07 | Bayer Healthcare Llc | Sorafenibtosylate for the treatment of diseases characterized by abnormal angiogenesis |
WO2003068229A1 (en) * | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
US10653684B2 (en) | 2002-02-11 | 2020-05-19 | Bayer Healthcare Llc | Aryl ureas with angiogenisis inhibiting activity |
PE20040522A1 (en) | 2002-05-29 | 2004-09-28 | Novartis Ag | DIARYLUREA DERIVATIVES DEPENDENT ON PROTEIN KINASE |
CA2493253A1 (en) * | 2002-08-01 | 2004-02-12 | Neurosearch A/S | Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy |
US7056925B2 (en) | 2002-08-13 | 2006-06-06 | Abbott Laboratories | Urea kinase inhibitors |
US20040034038A1 (en) * | 2002-08-13 | 2004-02-19 | Goaquan Li | Urea kinase inhibitors |
KR20050100615A (en) | 2003-01-14 | 2005-10-19 | 싸이토키네틱스, 인코포레이티드 | Compounds, compositions and methods |
MXPA05009102A (en) * | 2003-02-28 | 2006-05-31 | Bayer Pharmaceuticals Corp | Substituted pyridine derivatives useful in the treatment of cancer and other disorders. |
JP5229853B2 (en) | 2003-02-28 | 2013-07-03 | ニッポネックス インコーポレイテッド | Novel bicyclic urea derivatives useful for the treatment of cancer and other diseases |
ATE534649T1 (en) | 2003-05-15 | 2011-12-15 | Arqule Inc | IMIDAZOTHIAZOLES AND IMIDAZOXAZOLE DERIVATIVES AS INHIBITORS OF P38 |
US20070020704A1 (en) | 2003-05-20 | 2007-01-25 | Scott Wilhelm | Diaryl ureas with kinase inhibiting activity |
TW200523253A (en) | 2003-07-22 | 2005-07-16 | Arena Pharm Inc | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
BR122016015715B8 (en) | 2003-07-23 | 2021-05-25 | Bayer Healthcare Llc | pharmaceutical compositions of 4[4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy)-pyridine-2-carboxylic acid methylamide |
DE10334663A1 (en) * | 2003-07-30 | 2005-03-10 | Merck Patent Gmbh | urea derivatives |
US7683172B2 (en) | 2003-11-11 | 2010-03-23 | Eisai R&D Management Co., Ltd. | Urea derivative and process for preparing the same |
EP1730111A2 (en) * | 2004-01-30 | 2006-12-13 | MERCK PATENT GmbH | Substituted bisarylurea derivatives as kinase inhibitors |
TW200530236A (en) | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
WO2005103011A1 (en) | 2004-03-23 | 2005-11-03 | Arena Pharmaceuticals, Inc. | Processes for preparing substituted n-aryl-n’-[3-(1h-pyrazol-5-yl) phenyl] ureas and intermediates thereof |
JP2007535565A (en) | 2004-04-30 | 2007-12-06 | バイエル ファーマシューティカルス コーポレーション | Substituted pyrazolyl urea derivatives useful for the treatment of cancer |
WO2006009726A2 (en) | 2004-06-17 | 2006-01-26 | Cytokinetics, Inc. | Substituted urea derivatives for treating cardiac diseases |
EP2522659A3 (en) | 2004-06-24 | 2013-11-27 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
WO2006014359A2 (en) * | 2004-07-02 | 2006-02-09 | Icos Corporation | Compounds useful for inhibiting chk1 |
US7829560B2 (en) | 2004-07-08 | 2010-11-09 | Arqule, Inc. | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase |
KR20070054205A (en) * | 2004-08-19 | 2007-05-28 | 이코스 코포레이션 | Compounds useful for inhibiting chk 1 |
MY191349A (en) * | 2004-08-27 | 2022-06-17 | Bayer Pharmaceuticals Corp | New pharmaceutical compositions for the treatment of hyper-proliferative disorders |
ES2322175T3 (en) | 2004-09-17 | 2009-06-17 | EISAI R&D MANAGEMENT CO., LTD. | MEDICINAL COMPOSITION WITH IMPROVED STABILITY AND REDUCED GELIFICATION. |
KR20070062998A (en) * | 2004-10-13 | 2007-06-18 | 메르크 파텐트 게엠베하 | Heterocyclic substituted bisarylurea derivatives as kinase inhibitors |
JP2008517064A (en) | 2004-10-19 | 2008-05-22 | アークル インコーポレイテッド | Synthesis of imidazooxazole and imidazothiazole inhibitors of P38 MAP kinase |
PE20061130A1 (en) | 2004-11-19 | 2007-01-05 | Arena Pharm Inc | 3-PHENYL-PIRAZOLE DERIVATIVES AS MODULATORS OF THE SEROTONIN 5-HT2A RECEPTOR |
CA2594449A1 (en) * | 2005-01-14 | 2006-07-20 | Cgi Pharmaceuticals, Inc. | 1,3-diaryl substituted ureas as modulators of kinase activity |
US7625931B2 (en) | 2005-01-14 | 2009-12-01 | Cgi Pharmaceuticals, Inc. | Certain substituted diphenyl ureas, as modulators of kinase activity |
DE602006017188D1 (en) | 2005-03-07 | 2010-11-11 | Bayer Schering Pharma Ag | PHARMACEUTICAL COMPOSITION USING AN OMEGA CARBOXYARYL-SUBSTITUTED DIPHENYL HEAVEN IN THE TREATMENT OF CANCER |
WO2007024294A2 (en) | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
EP2281901B1 (en) | 2005-08-02 | 2013-11-27 | Eisai R&D Management Co., Ltd. | Anti-tumour pharmaceutical composition with angiogenesis inhibitors |
US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
US8299252B2 (en) | 2005-08-05 | 2012-10-30 | Chugai Seiyaku Kabushiki Kaisha | Pyrazolopyridine and pyrrolopyridine multikinase inhibitors |
JP5301284B2 (en) | 2005-12-15 | 2013-09-25 | サイトキネティクス・インコーポレーテッド | Specific chemicals, compositions and methods |
US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
US7718657B2 (en) | 2005-12-16 | 2010-05-18 | Cytokinetics, Inc. | Certain indanyl urea modulators of the cardiac sarcomere |
WO2007078839A2 (en) | 2005-12-19 | 2007-07-12 | Cytokinetics, Inc. | Compounds, compositions and methods |
CN101384172B (en) | 2005-12-28 | 2014-05-07 | 沃泰克斯药物股份有限公司 | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
WO2007136103A1 (en) | 2006-05-18 | 2007-11-29 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
EP2027119A2 (en) | 2006-05-18 | 2009-02-25 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
NZ594353A (en) | 2006-05-18 | 2013-02-22 | Arena Pharm Inc | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor |
WO2007136703A1 (en) | 2006-05-18 | 2007-11-29 | Arena Pharmaceuticals, Inc. | Primary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
WO2007139930A2 (en) | 2006-05-26 | 2007-12-06 | Bayer Healthcare Llc | Drug combinations with substituted diaryl ureas for the treatment of cancer |
JP5368096B2 (en) | 2006-08-28 | 2013-12-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Anti-tumor agent for undifferentiated gastric cancer |
TWI415845B (en) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
WO2008044688A1 (en) * | 2006-10-11 | 2008-04-17 | Daiichi Sankyo Company, Limited | Urea derivative |
EP2134677B1 (en) | 2006-12-20 | 2011-10-12 | Bayer HealthCare LLC | 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)phenyl]-1h-pyrazol-5-yl}carbamoyl)-amino]-3-chlorophenoxy}-n-methylpyridine-2-carboxamide as an inhibitor of the vegfr kinase for the treatment of cancer |
EP2119707B1 (en) | 2007-01-29 | 2015-01-14 | Eisai R&D Management Co., Ltd. | Composition for treatment of undifferentiated-type of gastric cancer |
AU2007349284B2 (en) * | 2007-03-20 | 2012-10-04 | Curis, Inc. | Raf kinase inhibitors containing a zinc binding moiety |
US9567327B2 (en) | 2007-08-15 | 2017-02-14 | Arena Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
WO2009035949A2 (en) * | 2007-09-13 | 2009-03-19 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
CN101848895B (en) | 2007-11-09 | 2013-10-23 | 卫材R&D管理有限公司 | Combination of anti-angiogenic substance and anti-tumor platinum complex |
US8198279B2 (en) * | 2007-12-19 | 2012-06-12 | Institute Of Cancer Research: Royal Cancer Hospital (The) | Pyrido[2,3-b]pyrazin-8-substituted compounds and their use |
JP2011513330A (en) | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | RAF inhibitory compounds and methods of use thereof |
AR072657A1 (en) | 2008-02-29 | 2010-09-15 | Genentech Inc | RAF INHIBITING COMPOUNDS AND METHODS FOR USE |
CN101372475B (en) * | 2008-03-19 | 2012-01-04 | 南京工业大学 | Aromatic heterocyclic substituted acardite derivative and use thereof |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
CN104784173B (en) | 2008-10-28 | 2019-07-26 | 艾尼纳制药公司 | For treating 5-HT2AThe 5-HT of 5-hydroxytryptamine receptor associated disorders2A5-hydroxytryptamine receptor regulating composition |
WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
SI2408750T1 (en) | 2009-03-20 | 2015-11-30 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
US20120157482A1 (en) * | 2009-08-28 | 2012-06-21 | Graves Iii Alan Peterson | Compounds and methods |
US8980891B2 (en) | 2009-12-18 | 2015-03-17 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
US9012458B2 (en) | 2010-06-25 | 2015-04-21 | Eisai R&D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
JP2013531067A (en) | 2010-07-19 | 2013-08-01 | バイエル ヘルスケア リミティド ライアビリティ カンパニー | Combinations using fluoro-substituted omega-carboxyaryl diphenylureas for the treatment and prevention of diseases and conditions |
US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
CN102134207B (en) * | 2011-01-14 | 2013-04-17 | 厦门大学 | Urea compound and preparation method and application thereof |
MX2013009931A (en) | 2011-04-18 | 2013-10-01 | Eisai R&D Man Co Ltd | Therapeutic agent for tumor. |
EP3444363B1 (en) | 2011-06-03 | 2020-11-25 | Eisai R&D Management Co., Ltd. | Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
TWI507191B (en) * | 2011-08-03 | 2015-11-11 | 國立陽明大學 | Agonists of src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same |
WO2013130669A1 (en) | 2012-02-27 | 2013-09-06 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administration thereof |
AU2013364953A1 (en) | 2012-12-21 | 2015-04-30 | Eisai R&D Management Co., Ltd. | Amorphous form of quinoline derivative, and method for producing same |
ES2687968T3 (en) | 2013-05-14 | 2018-10-30 | Eisai R&D Management Co., Ltd. | Biomarkers to predict and evaluate the reactivity of subjects with endometrial cancer to compounds with lenvatinib |
WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
WO2015041533A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | Rock in combination with mapk-pathway |
WO2015156674A2 (en) | 2014-04-10 | 2015-10-15 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
WO2015178770A1 (en) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions for cancer treatment |
ES2896400T3 (en) | 2014-08-01 | 2022-02-24 | Nuevolution As | Active compounds against bromdomains |
EP4089076A1 (en) | 2014-08-28 | 2022-11-16 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
WO2016057730A1 (en) | 2014-10-07 | 2016-04-14 | Strohmeier Mark | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
US9638690B2 (en) | 2014-11-07 | 2017-05-02 | The University Of British Columbia | Compounds and compositions for use as alkylating agent sensors and methods of use thereof |
KR20170122734A (en) | 2015-02-25 | 2017-11-06 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | A method for inhibiting the quinoline derivative |
CA2978226A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharpe & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
CN104817493A (en) * | 2015-03-11 | 2015-08-05 | 西安交通大学 | Aromatic heterocyclic amide substituted diarylurea compound, preparation method and application thereof |
CN104744350A (en) * | 2015-03-11 | 2015-07-01 | 西安交通大学 | Pyridine-substituted diarylurea compound and preparation method and application thereof |
JP2018516992A (en) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーAxovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives useful for the prevention and treatment of REM sleep behavior disorder |
KR20180018695A (en) | 2015-06-16 | 2018-02-21 | 가부시키가이샤 프리즘 파마 | Anticancer drug |
AU2016291673A1 (en) | 2015-07-15 | 2018-01-25 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
US10155722B2 (en) * | 2015-07-30 | 2018-12-18 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Antitumor compound targeting IDH2 mutation and method of use thereof |
CN108997209B (en) * | 2018-06-11 | 2020-08-04 | 山东罗欣药业集团恒欣药业有限公司 | Preparation method of regorafenib |
CN112351969A (en) * | 2018-06-21 | 2021-02-09 | 塞莱斯蒂亚生物技术股份公司 | Process for preparing aminodiaryl ethers and aminodiaryl ether hydrochlorides |
CN110128299B (en) * | 2019-05-13 | 2020-11-10 | 浙江大学 | Diphenylurea antitumor small-molecule inhibitor and preparation method thereof |
CN113121484A (en) | 2019-12-31 | 2021-07-16 | 复星弘创(苏州)医药科技有限公司 | Method for preparing coumarin compound with 3-substituted acylaminoalkyl, product and related intermediate thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2140495A (en) * | 1932-03-26 | 1938-12-20 | Ici Ltd | Bis (2, 3-hydroxy-naphthoyl-maminophenyl) urea |
JP2717481B2 (en) * | 1992-08-25 | 1998-02-18 | 富士写真フイルム株式会社 | Silver halide color photographic materials |
US5470882A (en) * | 1994-06-02 | 1995-11-28 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
WO1996025157A1 (en) * | 1995-02-17 | 1996-08-22 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
US5773459A (en) * | 1995-06-07 | 1998-06-30 | Sugen, Inc. | Urea- and thiourea-type compounds |
JP4009681B2 (en) * | 1995-11-07 | 2007-11-21 | キリンファーマ株式会社 | Quinoline derivatives and quinazoline derivatives that inhibit platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing them |
US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
IL132107A (en) * | 1997-04-22 | 2004-09-27 | Neurosearch As | Substituted phenyl derivatives, their preparation and use |
US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
DE1042305T1 (en) * | 1997-12-22 | 2001-04-19 | Bayer Ag | INHIBITION OF p38 KINASE USING SYMMETRIC AND ASYMMETRIC DIPHENYL UREAS |
SK286213B6 (en) * | 1997-12-22 | 2008-05-06 | Bayer Corporation | Substituted heterocyclic ureas, pharmaceutical preparation containing them and their use |
-
1998
- 1998-12-22 IL IL13669098A patent/IL136690A0/en active IP Right Grant
- 1998-12-22 EP EP03026051A patent/EP1449834A3/en not_active Withdrawn
- 1998-12-22 CN CNB98812503XA patent/CN1213022C/en not_active Expired - Fee Related
- 1998-12-22 DE DE69829412T patent/DE69829412T2/en not_active Expired - Lifetime
- 1998-12-22 SK SK961-2000A patent/SK286564B6/en not_active IP Right Cessation
- 1998-12-22 TR TR2000/02616T patent/TR200002616T2/en unknown
- 1998-12-22 EP EP98963809A patent/EP1049664B1/en not_active Expired - Lifetime
- 1998-12-22 KR KR1020007007015A patent/KR100704977B1/en not_active IP Right Cessation
- 1998-12-22 JP JP2000525373A patent/JP4607318B2/en not_active Expired - Fee Related
- 1998-12-22 BR BR9814375-1A patent/BR9814375A/en not_active IP Right Cessation
- 1998-12-22 MX MXPA00006231A patent/MXPA00006231A/en not_active IP Right Cessation
- 1998-12-22 WO PCT/US1998/026081 patent/WO1999032436A1/en active IP Right Grant
- 1998-12-22 HU HU0004437A patent/HU227711B1/en not_active IP Right Cessation
- 1998-12-22 CA CA2315646A patent/CA2315646C/en not_active Expired - Fee Related
- 1998-12-22 AT AT98963809T patent/ATE291011T1/en not_active IP Right Cessation
- 1998-12-22 CZ CZ20002351A patent/CZ301102B6/en not_active IP Right Cessation
- 1998-12-22 NZ NZ505843A patent/NZ505843A/en not_active IP Right Cessation
- 1998-12-22 ES ES98963809T patent/ES2153809T3/en not_active Expired - Lifetime
- 1998-12-22 PL PL98342078A patent/PL195808B1/en not_active IP Right Cessation
- 1998-12-22 ID IDW20001415A patent/ID26956A/en unknown
- 1998-12-22 TR TR2001/00874T patent/TR200100874T2/en unknown
- 1998-12-22 RU RU2000120165/04A patent/RU2247109C9/en not_active IP Right Cessation
- 1998-12-22 AU AU19054/99A patent/AU763024B2/en not_active Ceased
- 1998-12-22 DE DE1049664T patent/DE1049664T1/en active Pending
-
2000
- 2000-06-12 IL IL136690A patent/IL136690A/en not_active IP Right Cessation
- 2000-06-21 NO NO20003230A patent/NO329181B1/en not_active IP Right Cessation
- 2000-06-22 CU CU20000153A patent/CU23393A3/en not_active IP Right Cessation
- 2000-07-12 BG BG104599A patent/BG64594B1/en unknown
-
2001
- 2001-02-28 GR GR20010300006T patent/GR20010300006T1/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GR20010300006T1 (en) | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas | |
HK1155944A1 (en) | W-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | |
HK1032050A1 (en) | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas. | |
CA2359510A1 (en) | .omega.-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | |
EP1140840A4 (en) | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | |
UA26213C2 (en) | MEANS FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS AND PHARMACEUTICAL COMPOSITION AND THEIR BASES | |
IL136738A0 (en) | Inhibition of p38 kinase activity using substituted heterocyclic ureas | |
WO2002085857A3 (en) | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas | |
HK1013993A1 (en) | Novel carbamates and ureas as modifiers of multi-drug resistance | |
ZA943744B (en) | Therapeutic substituted guanidines | |
AP9701041A0 (en) | Pyridylpyrrole compounds. | |
MX9704030A (en) | 2-heterocyclyloxy and thiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof. | |
SE9802937D0 (en) | Novel compounds | |
MXPA94009086A (en) | Therapeutic substituted guanidines. | |
BR9814945A (en) | Use of phanquinone for the treatment of alzheimer's disease, pharmaceutical composition and kit | |
ID20165A (en) | USE OF ACID 2- (3,4-DIMETOXICINAMOIL) AMINOBENZOAT FOR MAKING MEDICINES FOR TREATMENT OR PREVENTION OF RESTENOSIS | |
BG105763A (en) | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | |
DE500713T1 (en) | DERIVATIVES OF 3,3,5-TRIMETHYLCYCLOHEXYLESTER OF 2-METHYLPROPIONIC ACID, THEIR PRODUCTION METHOD AND THE THERAPEUTIC COMPOSITIONS CONTAINING IT. | |
ITFI930001A1 (en) | MEDICATION FOR THE TREATMENT OF ASTHMA. | |
ATE338541T1 (en) | MEDICINAL FORMULATIONS CONTAINING LABDAN FOR THE TREATMENT OF TUMORS OR LEUKEMIA |