DK0985032T4 - Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner - Google Patents

Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner

Info

Publication number
DK0985032T4
DK0985032T4 DK98924468T DK98924468T DK0985032T4 DK 0985032 T4 DK0985032 T4 DK 0985032T4 DK 98924468 T DK98924468 T DK 98924468T DK 98924468 T DK98924468 T DK 98924468T DK 0985032 T4 DK0985032 T4 DK 0985032T4
Authority
DK
Denmark
Prior art keywords
complexes
protein
peptide
mrna
antibody
Prior art date
Application number
DK98924468T
Other languages
Danish (da)
English (en)
Other versions
DK0985032T3 (da
Inventor
Michael John Taussig
Mingyue He
Original Assignee
Crescendo Biolog Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0985032(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9710829.4A external-priority patent/GB9710829D0/en
Priority claimed from GBGB9724850.4A external-priority patent/GB9724850D0/en
Priority claimed from GBGB9804195.7A external-priority patent/GB9804195D0/en
Application filed by Crescendo Biolog Ltd filed Critical Crescendo Biolog Ltd
Publication of DK0985032T3 publication Critical patent/DK0985032T3/da
Application granted granted Critical
Publication of DK0985032T4 publication Critical patent/DK0985032T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK98924468T 1997-05-28 1998-05-28 Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner DK0985032T4 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9710829.4A GB9710829D0 (en) 1997-05-28 1997-05-28 Selection particles for in vitro display and evolution of antibody combining sites
GBGB9724850.4A GB9724850D0 (en) 1997-11-26 1997-11-26 Selection particles for in vitro display and evolution of antibody combining sites
GBGB9804195.7A GB9804195D0 (en) 1998-02-28 1998-02-28 Selection particles for in vitro display and evolution of antibody combining sites
PCT/GB1998/001564 WO1998054312A1 (en) 1997-05-28 1998-05-28 Ribosome complexes as selection particles for in vitro display and evolution of proteins

Publications (2)

Publication Number Publication Date
DK0985032T3 DK0985032T3 (da) 2004-02-02
DK0985032T4 true DK0985032T4 (da) 2009-08-31

Family

ID=27268863

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98924468T DK0985032T4 (da) 1997-05-28 1998-05-28 Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner

Country Status (10)

Country Link
US (1) US6620587B1 (de)
EP (1) EP0985032B2 (de)
JP (1) JP4060892B2 (de)
AT (1) ATE250668T1 (de)
CA (1) CA2291721C (de)
DE (1) DE69818458T3 (de)
DK (1) DK0985032T4 (de)
ES (1) ES2209145T5 (de)
PT (1) PT985032E (de)
WO (1) WO1998054312A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4854999A (en) * 1998-07-02 2000-01-24 Invitro Diagnostics, Inc. Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
GB9917027D0 (en) * 1999-07-20 1999-09-22 Affibody Technology Sweeden Ab In vitro selection and optional identification of polypeptides using solid support carriers
US20010039014A1 (en) * 2000-01-11 2001-11-08 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
JP2003529369A (ja) * 2000-03-31 2003-10-07 ケンブリッジ アンティボディー テクノロジー リミティド リボソーム・ディスプレイの改良
EP1652919A1 (de) * 2000-03-31 2006-05-03 Cambridge Antibody Technology LTD Verbesserungen in Bezug auf Ribosom-Komplexe als Selektionspartikel
PT1360500E (pt) 2000-04-14 2010-04-19 Genencor Int Métodos para direccionamento selectivo
US7129326B2 (en) 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
BR0208051A (pt) 2001-03-07 2006-02-21 Childrens Medical Center método de seleção de bibliotecas de apresentação de peptìdeo que usa apresentação em minicélula
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
DE10145226A1 (de) * 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt Mfd Gmbh & Co Kg Festwalzgerät einer Festwalzmaschine für Kurbelwellen
WO2003078446A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
ATE414769T1 (de) 2002-03-15 2008-12-15 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
AU2003253069A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c-c bond upon reaction
AU2003218630A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
ATE488586T1 (de) * 2002-09-06 2010-12-15 Isogenica Ltd In vitro peptid-expressionsbank
LT2348125T (lt) 2002-10-30 2017-09-11 Nuevolution A/S Bifunkcinio komplekso sintezės būdas
US20060171885A1 (en) 2002-11-25 2006-08-03 Giselle Janssen Skin or hair binding peptides
ATE450609T1 (de) * 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
WO2004074429A2 (en) * 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US20060269920A1 (en) * 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
EP1604044B1 (de) * 2003-03-19 2009-05-13 Discerna Limited Gewinnung von dna
EP1608748B1 (de) * 2003-03-20 2009-03-04 Nuevolution A/S Ligationsvermittelnde codierung von kleinen molekülen
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
GB0316314D0 (en) * 2003-07-12 2003-08-13 Univ Belfast Method
US11118215B2 (en) * 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
EP1723255B1 (de) * 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
DE602005017370D1 (de) * 2004-03-22 2009-12-10 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
US20050250112A1 (en) * 2004-05-07 2005-11-10 Padmabandu Gothami A Nucleic acids, compositions, methods, and kits for detecting mycoplasma and acholeplasma species
US9006393B1 (en) 2004-08-26 2015-04-14 Patricia L. Clark Molecular constructs and uses thereof in ribosomal translational events
DE102004049479A1 (de) 2004-10-11 2006-04-13 Scil Proteins Gmbh Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
DK2341140T3 (da) 2005-12-01 2017-11-06 Nuevolution As Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
US7923533B2 (en) * 2006-06-29 2011-04-12 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7888465B2 (en) * 2006-06-29 2011-02-15 The Invention Science Fund, I, LLC Methods for arbitrary peptide synthesis
US7910695B2 (en) 2006-06-29 2011-03-22 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7777002B2 (en) * 2006-06-29 2010-08-17 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7879975B2 (en) * 2006-06-29 2011-02-01 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
EP1925664A1 (de) 2006-11-15 2008-05-28 Scil proteins GmbH Künstliche Bindungsproteine auf Grundlage einer modifizierten alpha-Helix Region von Ubiquitin
US8865179B2 (en) * 2008-01-26 2014-10-21 Swey-Shen Alexchen Aptameric IgE peptides in a protein scaffold as an allergy vaccine
EP3629022A1 (de) 2008-07-25 2020-04-01 Richard W. Wagner Proteinscreeningverfahren
KR20110076906A (ko) * 2008-09-30 2011-07-06 아보트 러보러터리즈 개선된 ｒｎａ 디스플레이 방법
US8748351B2 (en) 2009-12-14 2014-06-10 Scil Proteins Gmbh Method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands
JP5863045B2 (ja) 2010-03-11 2016-02-16 国立研究開発法人理化学研究所 ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
EP2466310A1 (de) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Mittel und Verfahren für den Nachweis von mehrstrangigen Brüchen
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
JP5948673B2 (ja) 2011-03-10 2016-07-06 ジーンフロンティア株式会社 リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US9863936B2 (en) 2011-05-23 2018-01-09 Riken Nucleic acid construct, nucleic acid-protein complex, and use thereof
JP6146821B2 (ja) 2011-06-15 2017-06-14 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ 修飾ユビキチンに基づく二量体型結合タンパク質
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
JP6814634B2 (ja) 2014-02-05 2021-01-20 モレキュラー テンプレーツ，インク．Ｍｏｌｅｃｕｌａｒ Ｔｅｍｐｌａｔｅｓ， Ｉｎｃ． リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法
EP3209776A1 (de) * 2014-10-22 2017-08-30 Crescendo Biologics Limited Humane vh-domänengerüste
CA2975362A1 (en) 2015-02-06 2016-08-11 Navigo Proteins Gmbh Egfr binding proteins comprising ubiquitin muteins
BR112018000477A2 (pt) 2015-07-16 2018-09-18 Navigo Proteins Gmbh proteína de ligação de imunoglobulina não natural, composição, uso da proteína de ligação de ig não natural, método de purificação de afinidade de imunoglobulinas, método de geração de uma proteína de ligação de imunoglobulina não natural, molécula de ácido nucleico, vetor, célula hospedeira ou um hospedeiro não humano, e método para a produção de uma proteína de ligação de imunoglobulina não natural
JP2018520675A (ja) 2015-07-20 2018-08-02 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法
ES2928681T3 (es) 2015-09-24 2022-11-21 Abvitro Llc Conjugados de afinidad-oligonucleótido y usos de los mismos
AU2017260274A1 (en) 2016-05-04 2018-11-01 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
CN109963864B (zh) 2016-08-11 2024-01-02 瑞普利金公司 用于亲和色谱的碱性稳定性fc结合蛋白
BR112019005748A2 (pt) 2016-09-24 2019-06-18 Abvitro Llc afinidade-conjugados de oligonucleotídeo e usos destes
US11414466B2 (en) 2017-11-07 2022-08-16 Navigo Proteins Gmbh Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer
BR112022002365A2 (pt) 2019-08-09 2022-04-26 Nutcracker Therapeutics Inc Métodos e aparelhos para fabricar e para remover material de uma composição terapêutica

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06178688A (ja) 1992-12-11 1994-06-28 Mitsui Toatsu Chem Inc Ｅ型緑膿菌を抗原とするヒト抗体をコードする遺伝子
AU8124694A (en) * 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
JP2003529369A (ja) 2000-03-31 2003-10-07 ケンブリッジ アンティボディー テクノロジー リミティド リボソーム・ディスプレイの改良

Also Published As

Publication number Publication date
DE69818458T2 (de) 2004-07-08
DE69818458D1 (de) 2003-10-30
PT985032E (pt) 2004-02-27
US6620587B1 (en) 2003-09-16
ES2209145T5 (es) 2009-10-30
ATE250668T1 (de) 2003-10-15
EP0985032A1 (de) 2000-03-15
AU725957B2 (en) 2000-10-26
AU7666698A (en) 1998-12-30
JP2002500514A (ja) 2002-01-08
DE69818458T3 (de) 2009-12-17
WO1998054312A1 (en) 1998-12-03
EP0985032B1 (de) 2003-09-24
EP0985032B2 (de) 2009-06-03
DK0985032T3 (da) 2004-02-02
JP4060892B2 (ja) 2008-03-12
CA2291721C (en) 2011-08-09
ES2209145T3 (es) 2004-06-16
CA2291721A1 (en) 1998-12-03

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