DK0966435T3 - Aminoindanderivater - Google Patents
AminoindanderivaterInfo
- Publication number
- DK0966435T3 DK0966435T3 DK97953541T DK97953541T DK0966435T3 DK 0966435 T3 DK0966435 T3 DK 0966435T3 DK 97953541 T DK97953541 T DK 97953541T DK 97953541 T DK97953541 T DK 97953541T DK 0966435 T3 DK0966435 T3 DK 0966435T3
- Authority
- DK
- Denmark
- Prior art keywords
- dementia
- alkyl
- compounds
- directed
- hydrogen
- Prior art date
Links
- XJEVHMGJSYVQBQ-UHFFFAOYSA-N 2,3-dihydro-1h-inden-1-amine Chemical class C1=CC=C2C(N)CCC2=C1 XJEVHMGJSYVQBQ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- 208000009829 Lewy Body Disease Diseases 0.000 abstract 1
- 201000002832 Lewy body dementia Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 201000004810 Vascular dementia Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Centrifugal Separators (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11985396A IL119853A0 (en) | 1996-12-18 | 1996-12-18 | Aminoindan derivatives |
| IL12051097A IL120510A0 (en) | 1997-03-24 | 1997-03-24 | Phenylethylamine derivatives |
| PCT/US1997/024155 WO1998027055A1 (en) | 1996-12-18 | 1997-12-18 | Aminoindan derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0966435T3 true DK0966435T3 (da) | 2005-08-15 |
Family
ID=26323338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97953541T DK0966435T3 (da) | 1996-12-18 | 1997-12-18 | Aminoindanderivater |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6303650B1 (https=) |
| EP (2) | EP1535902B1 (https=) |
| JP (1) | JP4222632B2 (https=) |
| AT (2) | ATE292619T1 (https=) |
| AU (1) | AU5726898A (https=) |
| CA (1) | CA2275425C (https=) |
| DE (2) | DE69738275T2 (https=) |
| DK (1) | DK0966435T3 (https=) |
| ES (1) | ES2241064T3 (https=) |
| HU (1) | HU229507B1 (https=) |
| IL (1) | IL130528A (https=) |
| PT (1) | PT966435E (https=) |
| WO (1) | WO1998027055A1 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2241064T3 (es) * | 1996-12-18 | 2005-10-16 | Teva Pharmaceutical Industries, Ltd. | Derivados de aminoindano. |
| US6486178B1 (en) * | 1998-06-03 | 2002-11-26 | Nissan Chemical Industries, Ltd. | Indane derivatives |
| JP2003512426A (ja) | 1999-10-27 | 2003-04-02 | テバ ファーマシューティカル インダストリーズ リミティド | 双極性気分障害における躁病の治療のための１−アミノインダンの使用。 |
| JP2005523289A (ja) * | 2002-02-27 | 2005-08-04 | テバ ファーマシューティカル インダストリーズ リミティド | 脳選択性ｍａｏ阻害剤としてのプロパルギルアミノインダン誘導体及びプロパルギルアミノテトラリン誘導体 |
| US20040010038A1 (en) * | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
| US8058442B2 (en) * | 2002-11-07 | 2011-11-15 | Technion Research And Development Foundation Ltd. | Neuroprotective iron chelators and pharmaceutical compositions comprising them |
| US8097608B2 (en) | 2003-11-25 | 2012-01-17 | Technion Research And Development Foundation Ltd. | Methods for treatment of cardiovascular disorders and diseases |
| WO2005051371A1 (en) * | 2003-11-25 | 2005-06-09 | Technion Research & Development Foundation Ltd. | Compositions and methods for treatment of cardiovascular disorders and diseases |
| JP2005232148A (ja) * | 2004-02-03 | 2005-09-02 | Technion Research & Development Foundation Ltd | 神経保護剤としてプロパルギルアミンの使用 |
| EP1574498A1 (en) * | 2004-02-19 | 2005-09-14 | PPG-Sipsy | Process for the synthesis of substituted alpha-aminoindan derivatives |
| WO2006014973A2 (en) * | 2004-07-26 | 2006-02-09 | Teva Pharmaceutical Industries, Ltd. | Pharmaceutical dosage forms including rasagiline |
| WO2006014968A2 (en) * | 2004-07-27 | 2006-02-09 | Teva Pharmaceutical Industries, Ltd. | Propargyl nitroxydes and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders |
| WO2006029135A1 (en) * | 2004-09-08 | 2006-03-16 | Teva Pharmaceutical Usa, Inc | Improved process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates |
| PL1848415T3 (pl) * | 2005-02-17 | 2013-10-31 | Teva Pharma | Terapia kombinowana obejmująca octan glatirameru oraz rasagilinę do leczenia stwardnienia rozsianego |
| AU2006245349A1 (en) | 2005-02-22 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Improved process for the synthesis of enantiomeric indanylamine derivatives |
| WO2006091657A1 (en) | 2005-02-23 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
| CN101128420A (zh) * | 2005-02-24 | 2008-02-20 | 泰华制药工业有限公司 | 拉多斯迪戈酒石酸盐结晶体、其制备方法及其药物组合物 |
| WO2006091836A1 (en) * | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Formulations of ladostigil tartrate |
| US20060276537A1 (en) * | 2005-06-01 | 2006-12-07 | Tamar Goren | Use of ladostigil for the treatment of multiple sclerosis |
| CA2620476A1 (en) * | 2005-06-02 | 2006-12-07 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
| US7539261B2 (en) * | 2005-08-22 | 2009-05-26 | Nec Laboratories America, Inc. | Multi-layer coded modulation for non-ergodic block fading channels |
| US20070088082A1 (en) * | 2005-09-28 | 2007-04-19 | Judith Aronhime | Polymorphic forms of ladostigil tartrate |
| WO2007038677A2 (en) * | 2005-09-28 | 2007-04-05 | Teva Pharmaceutical Industries Ltd. | Methods for preparation of ladostigil tartrate crystalline form a1 |
| US8263655B2 (en) * | 2005-10-06 | 2012-09-11 | Technion Research And Development Foundation Ltd | Methods for treatment of renal failure |
| US20070238893A1 (en) * | 2005-11-04 | 2007-10-11 | Lee Boulton | Asymmetric hydrogenation of acyl enamides |
| US20070238895A1 (en) * | 2005-11-07 | 2007-10-11 | Lee Boulton | N-protected aminoindanes and methods of their preparation |
| CA2630037C (en) * | 2005-11-17 | 2015-03-31 | Teva Pharmaceutical Industries Ltd. | Methods for isolating propargylated aminoindans |
| US7572834B1 (en) | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
| US20070135518A1 (en) * | 2005-12-09 | 2007-06-14 | Marta Weinstock-Rosin | Use of low-dose ladostigil for neuroprotection |
| ES2632638T3 (es) * | 2005-12-09 | 2017-09-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Ladostigilo de baja dosis para el tratamiento de la deficiencia cognitiva |
| ES2551481T3 (es) | 2006-02-21 | 2015-11-19 | Teva Pharmaceutical Industries, Ltd. | Uso de rasagilina para el tratamiento de atrofia multisistémica |
| TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
| WO2007126898A2 (en) * | 2006-03-31 | 2007-11-08 | Teva Pharmaceutical Industries, Ltd. | Use of ladostigil for the treatment of schizophrenia |
| JP5769923B2 (ja) * | 2006-04-03 | 2015-08-26 | テバ ファーマシューティカル インダストリーズ リミティド | レストレスレッグス症候群の治療のためのラサギリンの使用 |
| EP1892233A1 (de) * | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
| CN101557706B (zh) * | 2006-12-14 | 2013-08-07 | 泰华制药工业有限公司 | 雷沙吉兰碱结晶固体 |
| CN101600346B (zh) | 2006-12-14 | 2013-08-21 | 泰华制药工业有限公司 | 雷沙吉兰的单宁酸盐 |
| EP1987816A1 (de) * | 2007-04-30 | 2008-11-05 | Ratiopharm GmbH | Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff |
| US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
| EP2234478A4 (en) * | 2008-01-11 | 2013-01-23 | Teva Pharma | RASAGILINE FORMULATIONS, THEIR PREPARATION AND USE |
| WO2009151594A1 (en) * | 2008-06-10 | 2009-12-17 | Teva Pharmaceutical Industries, Ltd. | Rasagiline soft gelatin capsules |
| MX2010013766A (es) * | 2008-06-13 | 2011-03-15 | Teva Pharmaceutical Ind Ltd Star | Rasagilina para modificacion de enfermedad de parkinson. |
| BRPI0909997A2 (pt) | 2008-06-19 | 2015-10-27 | Teva Pharma | r(+)-n-propargil-1-aminoindano cristalino, composição farmacêutica, processo de secagem de r(+)-n-propargil-1-aminoindano sólido, processo de preparação de uma composição farmacêutica, processo de produção de um lote validado de um produto de farmaco que contém r(+)-n-propargil-1-aminoindano cristalino e pelo menos um veículo farmaceuticamente aceitável para distribuição e processo de prudução de r(+)-n-propargil-1-aminoindano cristalino |
| US8334409B2 (en) * | 2008-06-19 | 2012-12-18 | Teva Pharmaceutical Industries, Ltd. | Process for purifying rasagiline base |
| US20100189791A1 (en) * | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline malate formulation |
| SI2451771T1 (sl) | 2009-07-09 | 2014-10-30 | Ratiopharm Gmbh | Soli rasagilina in njihovi farmacevtski pripravki |
| JP6045347B2 (ja) | 2010-02-03 | 2016-12-14 | ファーマ ツー ビー リミテッド | ラサギリンの持続放出性製剤およびその使用 |
| AU2011282720B2 (en) | 2010-07-27 | 2016-12-22 | Teva Pharmaceutical Industries Ltd. | Use of rasagiline for the treatment of olfactory dysfunction |
| JP2013537530A (ja) | 2010-07-27 | 2013-10-03 | テバ ファーマシューティカル インダストリーズ リミティド | ラサギリンシトレートの分散物 |
| HK1200315A1 (en) | 2011-10-10 | 2015-08-07 | Teva Pharmaceutical Industries Ltd. | R(+)-n-formyl-propargyl-aminoindan |
| JP2014534197A (ja) | 2011-10-10 | 2014-12-18 | テバ ファーマシューティカル インダストリーズ リミティド | Ｒ（＋）−ｎ−メチル−プロパルギルアミノインダン |
| CN104379142B (zh) * | 2012-02-12 | 2018-02-13 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 用于免疫调节的拉多替吉治疗 |
| JP2015529196A (ja) | 2012-08-17 | 2015-10-05 | テバ ファーマシューティカル インダストリーズ リミティド | ラサギリンの非経口製剤 |
| WO2024204846A1 (ja) * | 2023-03-31 | 2024-10-03 | 三井化学株式会社 | カルバメート化合物 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3123642A (en) | 1964-03-03 | Indanyl and tetrahydronaphthyl | ||
| US2916490A (en) | 1959-12-08 | Ocjhs | ||
| US3201470A (en) | 1965-08-17 | Chsx c cech | ||
| US2982783A (en) | 1961-05-02 | Amevoevdanes | ||
| SE371190B (https=) | 1972-03-24 | 1974-11-11 | Kabi Ab | |
| US2573645A (en) | 1949-05-25 | 1951-10-30 | Smith Kline French Lab | N-hydroxyethyl aminoindanes |
| GB852735A (en) | 1956-04-13 | 1960-11-02 | Schering Ag | Manufacture of 1-aminoindanes |
| US3060091A (en) | 1961-02-13 | 1962-10-23 | Ciba Geigy Corp | Analgesic composition consisting of morphines and amino-indanes |
| US3178478A (en) | 1961-02-13 | 1965-04-13 | Ciba Geigy Corp | 2-amino-5-halo-indanes |
| US3253037A (en) | 1962-06-19 | 1966-05-24 | Ciba Geigy Corp | N-2-alkynyl-amino-benzocylo-alkanes |
| US3709996A (en) | 1963-08-02 | 1973-01-09 | Aspro Nicholas Ltd | Pharmaceutical compositions containing n-cyclopropyl-1-aminoindane compounds and adapted for administration to obtain inhibition of monoamine oxidase enzyme and process |
| GB1187017A (en) | 1966-07-16 | 1970-04-08 | Aspro Nicholas Ltd | Substituted 1-Amino Indanes and Tetrahydronaphthalens |
| NL6408165A (https=) | 1964-07-17 | 1966-01-18 | ||
| US3308157A (en) | 1964-08-07 | 1967-03-07 | Colgate Palmolive Co | N-(benzocyclobutene-1-loweralkyl)-carboxylic acid amides |
| US3637740A (en) | 1969-04-21 | 1972-01-25 | Pfizer | Aminobenzocycloalkane compounds |
| US3507962A (en) | 1969-05-09 | 1970-04-21 | Thompson Chem Co Hayward | Controlling leafminer insects with selected carbamate insecticides,including 3,5-dimethyl-4-dimethylamino-methyl phenyl-n-methylcarbamate |
| US3704323A (en) | 1969-12-23 | 1972-11-28 | Squibb & Sons Inc | Indane derivatives |
| NL7011683A (https=) | 1970-08-07 | 1972-02-09 | ||
| US3991207A (en) | 1971-03-18 | 1976-11-09 | Pfizer Inc. | Combination therapy for Parkinson's disease |
| US3751420A (en) | 1971-04-01 | 1973-08-07 | Squibb & Sons Inc | Monoolmonoene amines |
| BE786748A (fr) | 1971-07-26 | 1973-01-26 | Basf Ag | 1-aminomethyl-indanes-n-substitues |
| US4029731A (en) | 1974-11-06 | 1977-06-14 | Pfizer Inc. | Aminophenyltetralin compounds |
| US4134997A (en) | 1977-03-01 | 1979-01-16 | University Of Iowa Research Foundation | Effect of an aminotetralin derivative on coronary blood flow in infarcted hearts |
| US4096173A (en) | 1977-03-28 | 1978-06-20 | Eli Lilly And Company | Chlorinated 1-aminoindane N-methyl transferase inhibitors |
| US4128666A (en) | 1977-08-18 | 1978-12-05 | Smithkline Corporation | 4 AND 5-Halo substituted 2-indanamine compounds |
| US4132737A (en) | 1978-02-27 | 1979-01-02 | Eli Lilly And Company | Trifluoromethyl substituted 1-aminoindanes |
| US5286747A (en) | 1981-05-08 | 1994-02-15 | Per A. E. Carlsson | 1-alkyl-2-aminotetralin derivatives |
| DE3407842A1 (de) | 1983-03-04 | 1984-09-06 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Indanderivate und deren salze, verfahren zu deren herstellung und arzneimittel und antioxidationsmittel, welche diese enthalten |
| US4529723A (en) | 1983-04-29 | 1985-07-16 | William H. Rorer, Inc. | Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
| JPS6169747A (ja) | 1984-08-31 | 1986-04-10 | Otsuka Pharmaceut Co Ltd | ２，３―ジヒドロ―１ｈ―インデン誘導体及びその製造法 |
| US5242919A (en) | 1984-08-31 | 1993-09-07 | Otsuka Pharmaceutical Co., Ltd. | 2,3-dihydro-1H-indene derivatives |
| US5654301A (en) | 1985-02-15 | 1997-08-05 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
| US5378729A (en) | 1985-02-15 | 1995-01-03 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
| IL74497A (en) | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
| US4632939A (en) | 1985-03-15 | 1986-12-30 | Eli Lilly And Company | Anticonvulsant agents |
| US4833273A (en) | 1986-02-03 | 1989-05-23 | Warner-Lambert Company | Process for the resolution of 1-aminoindanes |
| ES2042520T3 (es) | 1986-06-10 | 1993-12-16 | Chiesi Farma Spa | Composiciones farmaceuticas que contienen el ester metilico de levodopa, preparacion y aplicaciones terapeuticas del mismo. |
| US5153225A (en) | 1986-12-10 | 1992-10-06 | Bayer Aktiengesellschaft | Substituted basic 2-aminotetralin in pharmaceuticals |
| HU201906B (en) | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
| US5011995A (en) | 1987-07-28 | 1991-04-30 | Ciba-Geigy Corporation | Process for the preparation of optically active secondary amines |
| US4873241A (en) | 1988-10-31 | 1989-10-10 | Fisons Corporation | 2-amino-N-(2-phenylindan-2-yl)acetamides useful as anti-epileptics |
| US5225596A (en) | 1989-01-09 | 1993-07-06 | The Upjohn Company | Halo substituted aminotetralins |
| CA1335106C (en) | 1989-02-27 | 1995-04-04 | John Mehnert Schaus | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes |
| JP2725378B2 (ja) * | 1989-05-29 | 1998-03-11 | 武田薬品工業株式会社 | カルバミド酸エステル誘導体 |
| IE902294A1 (en) | 1989-07-06 | 1991-01-16 | Abbott Lab | Alkynyl amines that regulate cholinergic neurotransmission |
| US5118704A (en) | 1989-08-30 | 1992-06-02 | Whitby Research, Inc. | Substituted 2-aminotetralins useful as dopaminergics |
| US5071875A (en) | 1989-09-25 | 1991-12-10 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
| FR2654104B1 (fr) | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH03176457A (ja) | 1989-12-04 | 1991-07-31 | Nippon Paint Co Ltd | 新規プロパルギル化合物、その製法ならびに該化合物を含む被覆材 |
| IL92952A (en) | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
| FR2662162B1 (fr) | 1990-05-18 | 1995-01-20 | Adir | Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| TW197435B (https=) | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
| IL99759A (en) | 1991-10-16 | 1997-06-10 | Teva Pharma | Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them |
| WO1994007890A1 (fr) | 1992-10-05 | 1994-04-14 | Ube Industries, Ltd. | Compose pyrimidine |
| US5350762A (en) | 1993-03-08 | 1994-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydrocyclopent[B]indole methanamines and related compounds |
| GB9315600D0 (en) | 1993-07-28 | 1993-09-08 | Smithkline Beecham Plc | Compounds |
| US5708018A (en) | 1993-08-06 | 1998-01-13 | Pharmacia & Upjohn Company | 2-aminoindans as selective dopamine D3 ligands |
| US5516943A (en) | 1993-09-14 | 1996-05-14 | Sepracor, Inc. | Process for preparing cyclic CIS-1-amino-2-alkanols |
| US5401758A (en) | 1993-10-07 | 1995-03-28 | Bristol-Myers Squibb Company | Pyridinyl cyanoguanidine compounds |
| IL111240A (en) | 1993-10-18 | 2001-10-31 | Teva Pharma | Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them |
| US5877218A (en) | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| EP0738149B1 (en) * | 1994-01-10 | 2006-11-29 | Teva Pharmaceutical Industries, Ltd. | 1-aminoindan derivatives and compositions thereof |
| FR2717175B1 (fr) | 1994-03-11 | 1996-06-14 | Adir | Nouveaux composés alkylaminoindanes, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| IT1271679B (it) | 1994-07-18 | 1997-06-04 | Mediolanum Farmaceutici Srl | Derivati del fenilcarbammato atti all'impiego come anticolinesterasici |
| US5646188A (en) | 1995-07-05 | 1997-07-08 | Teva Pharmaceutical Industries, Ltd. | Polyamine derivatives of 1-aminoindan |
| ES2241064T3 (es) * | 1996-12-18 | 2005-10-16 | Teva Pharmaceutical Industries, Ltd. | Derivados de aminoindano. |
| US6251938B1 (en) | 1996-12-18 | 2001-06-26 | Teva Pharmaceutical Industries, Ltd., | Phenylethylamine derivatives |
| JP3002155B2 (ja) | 1997-06-25 | 2000-01-24 | 日本サーボ株式会社 | 景品懸吊装置 |
| US20040010038A1 (en) | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
-
1997
- 1997-12-18 ES ES97953541T patent/ES2241064T3/es not_active Expired - Lifetime
- 1997-12-18 AT AT97953541T patent/ATE292619T1/de not_active IP Right Cessation
- 1997-12-18 JP JP52804898A patent/JP4222632B2/ja not_active Expired - Fee Related
- 1997-12-18 CA CA002275425A patent/CA2275425C/en not_active Expired - Lifetime
- 1997-12-18 DE DE69738275T patent/DE69738275T2/de not_active Expired - Lifetime
- 1997-12-18 AU AU57268/98A patent/AU5726898A/en not_active Abandoned
- 1997-12-18 EP EP05002578A patent/EP1535902B1/en not_active Expired - Lifetime
- 1997-12-18 DK DK97953541T patent/DK0966435T3/da active
- 1997-12-18 PT PT97953541T patent/PT966435E/pt unknown
- 1997-12-18 IL IL13052897A patent/IL130528A/en not_active IP Right Cessation
- 1997-12-18 DE DE69732984T patent/DE69732984T2/de not_active Expired - Lifetime
- 1997-12-18 WO PCT/US1997/024155 patent/WO1998027055A1/en not_active Ceased
- 1997-12-18 HU HU0101130A patent/HU229507B1/hu unknown
- 1997-12-18 EP EP97953541A patent/EP0966435B1/en not_active Expired - Lifetime
- 1997-12-18 AT AT05002578T patent/ATE377585T1/de not_active IP Right Cessation
-
1999
- 1999-06-18 US US09/336,493 patent/US6303650B1/en not_active Expired - Lifetime
-
2001
- 2001-08-31 US US09/944,850 patent/US6462222B1/en not_active Expired - Lifetime
- 2001-08-31 US US09/944,912 patent/US6538025B2/en not_active Ceased
-
2005
- 2005-03-25 US US11/091,008 patent/USRE39616E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0101130A2 (hu) | 2001-08-28 |
| EP1535902A1 (en) | 2005-06-01 |
| PT966435E (pt) | 2005-06-30 |
| HK1024462A1 (en) | 2000-10-13 |
| HUP0101130A3 (en) | 2003-02-28 |
| USRE39616E1 (en) | 2007-05-08 |
| DE69738275D1 (de) | 2007-12-20 |
| EP0966435A4 (en) | 2003-04-16 |
| US6303650B1 (en) | 2001-10-16 |
| US6462222B1 (en) | 2002-10-08 |
| DE69738275T2 (de) | 2008-08-28 |
| AU5726898A (en) | 1998-07-15 |
| WO1998027055A1 (en) | 1998-06-25 |
| ES2241064T3 (es) | 2005-10-16 |
| CA2275425A1 (en) | 1998-06-25 |
| EP0966435A1 (en) | 1999-12-29 |
| ATE292619T1 (de) | 2005-04-15 |
| HK1076098A1 (en) | 2006-01-06 |
| JP2001506269A (ja) | 2001-05-15 |
| JP4222632B2 (ja) | 2009-02-12 |
| DE69732984T2 (de) | 2006-02-16 |
| EP0966435B1 (en) | 2005-04-06 |
| US6538025B2 (en) | 2003-03-25 |
| ATE377585T1 (de) | 2007-11-15 |
| IL130528A (en) | 2004-12-15 |
| CA2275425C (en) | 2009-08-04 |
| HU229507B1 (en) | 2014-01-28 |
| DE69732984D1 (de) | 2005-05-12 |
| US20020188020A1 (en) | 2002-12-12 |
| EP1535902B1 (en) | 2007-11-07 |
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