DK0919619T4 - Optimering af celler til endogen genaktivering - Google Patents
Optimering af celler til endogen genaktiveringInfo
- Publication number
- DK0919619T4 DK0919619T4 DK98122807.5T DK98122807T DK0919619T4 DK 0919619 T4 DK0919619 T4 DK 0919619T4 DK 98122807 T DK98122807 T DK 98122807T DK 0919619 T4 DK0919619 T4 DK 0919619T4
- Authority
- DK
- Denmark
- Prior art keywords
- optimization
- cells
- endogenous gene
- gene activation
- activation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97121075 | 1997-12-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK0919619T3 DK0919619T3 (da) | 2006-07-10 |
| DK0919619T4 true DK0919619T4 (da) | 2013-09-23 |
Family
ID=8227717
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98122807.5T DK0919619T4 (da) | 1997-12-01 | 1998-12-01 | Optimering af celler til endogen genaktivering |
| DK99112607T DK0957165T3 (da) | 1997-12-01 | 1998-12-01 | Optimering af celler til endogen genaktivering |
| DK04006966T DK1464705T3 (da) | 1997-12-01 | 1998-12-01 | Optimering af celler til endogen genaktivering |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99112607T DK0957165T3 (da) | 1997-12-01 | 1998-12-01 | Optimering af celler til endogen genaktivering |
| DK04006966T DK1464705T3 (da) | 1997-12-01 | 1998-12-01 | Optimering af celler til endogen genaktivering |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7008764B1 (da) |
| EP (3) | EP0957165B1 (da) |
| JP (1) | JP4629813B2 (da) |
| KR (1) | KR100367062B1 (da) |
| CN (2) | CN1232644C (da) |
| AR (4) | AR018022A1 (da) |
| AT (3) | ATE318904T1 (da) |
| AU (1) | AU757930B2 (da) |
| BR (1) | BR9805682A (da) |
| CA (1) | CA2252970C (da) |
| DE (3) | DE59813976D1 (da) |
| DK (3) | DK0919619T4 (da) |
| ES (3) | ES2259422T3 (da) |
| PT (3) | PT957165E (da) |
| TR (1) | TR199802503A3 (da) |
| ZA (1) | ZA9810915B (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2278021A3 (en) * | 1999-11-01 | 2011-05-18 | Novartis Vaccines and Diagnostics, Inc. | Expression vectors, transfection systems, and method of use thereof |
| CA2401677A1 (en) * | 2000-03-03 | 2001-09-13 | University Of Utah Research Foundation | Gene targeting method |
| DE10023887A1 (de) * | 2000-05-17 | 2001-11-29 | Axel Haverich | Verfahren zur transienten Insertion genetischer Elemente |
| ATE375388T1 (de) | 2001-07-27 | 2007-10-15 | Us Gov Health & Human Serv | Systeme zur stellengerichteten in-vivo-mutagenese mit oligonukleotiden |
| CA2474486C (en) | 2002-01-23 | 2013-05-14 | The University Of Utah Research Foundation | Targeted chromosomal mutagenesis using zinc finger nucleases |
| EP2806025B1 (en) | 2002-09-05 | 2019-04-03 | California Institute of Technology | Use of zinc finger nucleases to stimulate gene targeting |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US20120196370A1 (en) | 2010-12-03 | 2012-08-02 | Fyodor Urnov | Methods and compositions for targeted genomic deletion |
| US11311574B2 (en) | 2003-08-08 | 2022-04-26 | Sangamo Therapeutics, Inc. | Methods and compositions for targeted cleavage and recombination |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| CA2579677A1 (en) * | 2004-09-16 | 2006-03-30 | Sangamo Biosciences, Inc. | Compositions and methods for protein production |
| KR101419729B1 (ko) * | 2005-07-26 | 2014-07-17 | 상가모 바이오사이언스 인코포레이티드 | 외래 핵산 서열의 표적화된 통합 및 발현 |
| CN103484496A (zh) * | 2013-07-31 | 2014-01-01 | 新乡医学院 | 一种报告基因重组在染色体目的基因上的方法、位点及用途 |
| US9857328B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same |
| US10020300B2 (en) | 2014-12-18 | 2018-07-10 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US10006910B2 (en) | 2014-12-18 | 2018-06-26 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
| US9859394B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| WO2016100049A1 (en) | 2014-12-18 | 2016-06-23 | Edico Genome Corporation | Chemically-sensitive field effect transistor |
| US9618474B2 (en) | 2014-12-18 | 2017-04-11 | Edico Genome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| EP3459115A4 (en) | 2016-05-16 | 2020-04-08 | Agilome, Inc. | GRAPHEN-FET DEVICES, SYSTEMS AND METHODS FOR USE THEREOF FOR SEQUENCING NUCLEIC ACIDS |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US568772A (en) * | 1896-10-06 | Albert s | ||
| CA1293460C (en) | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Site-specific recombination of dna in yeast |
| GB2187415A (en) | 1986-03-05 | 1987-09-09 | Deere & Co | Machine for forming cylindrical bales of crop |
| JPS62265992A (ja) * | 1986-05-12 | 1987-11-18 | Ajinomoto Co Inc | ヒト細胞を用いる有用物質の製造方法 |
| US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
| FR2646438B1 (fr) * | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| EP0747485B1 (en) * | 1989-11-06 | 1998-12-02 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
| JP3501286B2 (ja) * | 1989-12-22 | 2004-03-02 | アプライド リサーチ システムズ，エーアールエス ホールディング ナームロゼ ベノートスハップ | 一定の細胞系又は微生物の内因性遺伝子の発現特徴の変性のための方法 |
| US5272071A (en) * | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| WO1992015694A1 (en) * | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
| US6270989B1 (en) * | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| WO1993015191A1 (en) * | 1992-01-24 | 1993-08-05 | Life Technologies, Inc. | Modulation of enzyme activities in the in vivo cloning of dna |
| TW402639B (en) * | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| US5527695A (en) | 1993-01-29 | 1996-06-18 | Purdue Research Foundation | Controlled modification of eukaryotic genomes |
| JP3654446B2 (ja) * | 1993-12-23 | 2005-06-02 | メルク アンド カンパニー， インコーポレイテッド | マウス細胞のための相同的組換え抗体発現系 |
| US6130364A (en) * | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US5882914A (en) | 1995-06-06 | 1999-03-16 | The Johns Hopkins University School Of Medicine | Nucleic acids encoding the hypoxia inducible factor-1 |
| US5695977A (en) * | 1995-08-31 | 1997-12-09 | Genetic Information Research Institute | Site directed recombination |
| AUPN903196A0 (en) * | 1996-03-29 | 1996-04-26 | Australian National University, The | Single-step excision means |
| US6020144A (en) * | 1996-09-12 | 2000-02-01 | Symbiontics, Inc. | Sustained delivery device comprising a Leishmania protozoa and methods of making and using the same |
-
1998
- 1998-11-19 AU AU93284/98A patent/AU757930B2/en not_active Expired
- 1998-11-30 CA CA2252970A patent/CA2252970C/en not_active Expired - Lifetime
- 1998-11-30 KR KR10-1998-0051930A patent/KR100367062B1/ko active IP Right Grant
- 1998-11-30 ZA ZA9810915A patent/ZA9810915B/xx unknown
- 1998-12-01 PT PT99112607T patent/PT957165E/pt unknown
- 1998-12-01 US US09/203,500 patent/US7008764B1/en not_active Expired - Lifetime
- 1998-12-01 AR ARP980106075A patent/AR018022A1/es active IP Right Grant
- 1998-12-01 AT AT98122807T patent/ATE318904T1/de active
- 1998-12-01 CN CNB981271782A patent/CN1232644C/zh not_active Expired - Lifetime
- 1998-12-01 EP EP99112607A patent/EP0957165B1/de not_active Revoked
- 1998-12-01 PT PT04006966T patent/PT1464705E/pt unknown
- 1998-12-01 EP EP98122807.5A patent/EP0919619B2/de not_active Expired - Lifetime
- 1998-12-01 BR BR9805682-4A patent/BR9805682A/pt not_active Application Discontinuation
- 1998-12-01 DK DK98122807.5T patent/DK0919619T4/da active
- 1998-12-01 DE DE59813976T patent/DE59813976D1/de not_active Revoked
- 1998-12-01 DE DE59813413T patent/DE59813413D1/de not_active Expired - Lifetime
- 1998-12-01 PT PT98122807T patent/PT919619E/pt unknown
- 1998-12-01 EP EP04006966A patent/EP1464705B1/de not_active Expired - Lifetime
- 1998-12-01 ES ES04006966T patent/ES2259422T3/es not_active Expired - Lifetime
- 1998-12-01 DK DK99112607T patent/DK0957165T3/da active
- 1998-12-01 DE DE59813438T patent/DE59813438D1/de not_active Expired - Lifetime
- 1998-12-01 TR TR1998/02503A patent/TR199802503A3/tr unknown
- 1998-12-01 CN CNB2004100638729A patent/CN100519751C/zh not_active Expired - Lifetime
- 1998-12-01 DK DK04006966T patent/DK1464705T3/da active
- 1998-12-01 AT AT04006966T patent/ATE320491T1/de active
- 1998-12-01 JP JP34223498A patent/JP4629813B2/ja not_active Expired - Fee Related
- 1998-12-01 ES ES98122807T patent/ES2258809T5/es not_active Expired - Lifetime
- 1998-12-01 ES ES99112607T patent/ES2284228T3/es not_active Expired - Lifetime
- 1998-12-01 AT AT99112607T patent/ATE360067T1/de active
-
1999
- 1999-10-08 AR ARP990105095A patent/AR020750A2/es active IP Right Grant
- 1999-10-08 AR ARP990105096A patent/AR020892A2/es active IP Right Grant
- 1999-10-08 AR ARP990105097A patent/AR020893A2/es active IP Right Grant
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