DK0861093T3 - Ikke-invasiv påvisning af integrering af et transgen i pattedyr - Google Patents

Ikke-invasiv påvisning af integrering af et transgen i pattedyr

Info

Publication number
DK0861093T3
DK0861093T3 DK95941424T DK95941424T DK0861093T3 DK 0861093 T3 DK0861093 T3 DK 0861093T3 DK 95941424 T DK95941424 T DK 95941424T DK 95941424 T DK95941424 T DK 95941424T DK 0861093 T3 DK0861093 T3 DK 0861093T3
Authority
DK
Denmark
Prior art keywords
disclosed
methods
integration
disease
invasive detection
Prior art date
Application number
DK95941424T
Other languages
English (en)
Inventor
Christopher H Contag
Pamela R Contag
David A Benaron
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27170688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0861093(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of DK0861093T3 publication Critical patent/DK0861093T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Eye Examination Apparatus (AREA)
  • Push-Button Switches (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
DK95941424T 1994-07-01 1995-11-17 Ikke-invasiv påvisning af integrering af et transgen i pattedyr DK0861093T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/270,631 US5650135A (en) 1994-07-01 1994-07-01 Non-invasive localization of a light-emitting conjugate in a mammal
PCT/US1995/015040 WO1997018841A1 (en) 1994-07-01 1995-11-17 Non-invasive localization of a light-emitting conjugate in a mammal
CA002237983A CA2237983C (en) 1994-07-01 1995-11-17 Non-invasive localization of a light-emitting conjugate in a mammal

Publications (1)

Publication Number Publication Date
DK0861093T3 true DK0861093T3 (da) 2000-09-11

Family

ID=27170688

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95941424T DK0861093T3 (da) 1994-07-01 1995-11-17 Ikke-invasiv påvisning af integrering af et transgen i pattedyr

Country Status (13)

Country Link
US (1) US5650135A (da)
EP (2) EP0861093B1 (da)
JP (1) JP3786704B2 (da)
AT (1) ATE193453T1 (da)
AU (1) AU4285096A (da)
BR (1) BR9510664A (da)
CA (1) CA2237983C (da)
DE (2) DE1016419T1 (da)
DK (1) DK0861093T3 (da)
ES (2) ES2147621T3 (da)
GR (1) GR3034110T3 (da)
HK (1) HK1018747A1 (da)
WO (1) WO1997018841A1 (da)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US6217847B1 (en) * 1994-07-01 2001-04-17 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US6540981B2 (en) * 1997-12-04 2003-04-01 Amersham Health As Light imaging contrast agents
EP1820517A3 (en) * 1995-11-17 2009-10-21 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US6247995B1 (en) 1996-02-06 2001-06-19 Bruce Bryan Bioluminescent novelty items
US8349602B1 (en) 1996-04-19 2013-01-08 Xenogen Corporation Biodetectors targeted to specific ligands
US6416960B1 (en) 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
EP1015872B1 (en) 1996-12-12 2005-03-02 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
US6251384B1 (en) * 1997-04-28 2001-06-26 Anticancer, Inc. Metastasis models using green fluorescent protein (GFP) as a marker
US6232523B1 (en) 1997-04-28 2001-05-15 Anticancer, Inc. Metastasis models using green fluorescent protein (GFP) as a marker
US6235968B1 (en) 1997-04-28 2001-05-22 Anticancer, Inc. Metastasis models using green fluorescent protein (GFP) as a marker
AU7221698A (en) * 1997-04-29 1998-11-24 Nycomed Imaging As Light imaging contrast agents
CA2242035C (en) 1997-07-01 2004-11-23 Transgene S.A. Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy
US6638501B1 (en) 1997-09-29 2003-10-28 Neurospheres Holdings Ltd. Use of multipotent neural stem cell progeny to augment non-neural tissues
US7294755B1 (en) 1997-11-14 2007-11-13 Cedars-Sinai Medical Center Genetic modification of male germ cells for generation of transgenic species and genetic therapies
AU761758B2 (en) * 1997-11-14 2003-06-12 Cedars-Sinai Medical Center Transfection and transfer of male germ cells for generation of transgenic species
US6734338B1 (en) 1997-11-14 2004-05-11 Cedars-Sinai Medical Center Transfection, storage and transfer of male germ cells for generation of transgenic species and genetic therapies
US6846625B1 (en) * 1998-01-09 2005-01-25 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combination for drug development
AU2512299A (en) * 1998-01-27 1999-08-09 Novo Nordisk A/S Method for producing transgenic animals
AU2638199A (en) * 1998-03-02 1999-09-20 Biosensing Technologies Ltd. Luminescent microbe assay
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
ATE397887T1 (de) * 1998-04-07 2008-07-15 Cytyc Corp Vorrichtungen zur lokalisierung von läsionen in festem gewebe
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US20010038682A1 (en) * 1998-09-08 2001-11-08 Jesse Salb Radiographic assessment of tissue response to compounds
US6751290B2 (en) 1998-09-08 2004-06-15 Veritas Pharmaceuticals, Inc. Radiographic assessment of tissue after exposure to a compound
US6723746B2 (en) 1998-09-08 2004-04-20 Veritas Pharmaceuticals, Inc. Functional radiographic imaging methods and agents
US6226352B1 (en) * 1998-09-08 2001-05-01 Veritas Pharmaceuticals, Inc. System and method for radiographic imaging of tissue
US6652836B2 (en) 1998-10-15 2003-11-25 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6284223B1 (en) * 1998-10-15 2001-09-04 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6299860B1 (en) 1998-10-15 2001-10-09 Fluoro Probe, Inc. Method for viewing diseased tissue located within a body cavity
WO2001027150A2 (en) 1999-10-14 2001-04-19 Clontech Laboratories Inc. Anthozoa derived chromo/fluoroproteins and methods for using the same
US7449615B2 (en) * 1998-12-17 2008-11-11 Xenogen Corporation Non-invasive evaluation of physiological response in a transgenic mouse
US6610503B1 (en) * 1999-03-17 2003-08-26 Xenogen Corporation Animal models for predicting sepsis mortality
US6495355B1 (en) 1999-06-22 2002-12-17 The Board Of Trustees Of The Leland Stanford Junior University Red-shifted luciferase
US6737245B1 (en) 1999-09-08 2004-05-18 Xenogen Corporation Luciferase expression cassettes and methods of use
US6614452B1 (en) * 1999-11-15 2003-09-02 Xenogen Corporation Graphical user interface for in-vivo imaging
US7581191B2 (en) * 1999-11-15 2009-08-25 Xenogen Corporation Graphical user interface for 3-D in-vivo imaging
US6867348B1 (en) 1999-12-16 2005-03-15 Xenogen Corporation Methods and compositions for screening for angiogenesis modulating compounds
IT1311335B1 (it) 1999-12-21 2002-03-12 Otc Optical Technologies Ct S Procedimento e dispositivo per realizzare reticoli in fibra ottica.
AU2001230471A1 (en) * 2000-01-31 2001-08-14 Hadasit Medical Research Services And Development Ltd. Tracking gene expression and metabolic processes in subjects
US6775567B2 (en) * 2000-02-25 2004-08-10 Xenogen Corporation Imaging apparatus
CA2403090C (en) * 2000-03-17 2014-06-10 Anticancer, Inc. Whole-body optical imaging of gene expression and uses thereof
US6748259B1 (en) * 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US7056728B2 (en) * 2000-07-06 2006-06-06 Xenogen Corporation Compositions and methods for use thereof in modifying the genomes of microorganisms
AU2001242019A1 (en) * 2000-07-06 2002-02-05 Xenogen Corporation Compositions and methods for use thereof in modifying the genomes of microorganisms
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
US20020073441A1 (en) 2000-12-13 2002-06-13 Ross Brian D. Compositions and methods for detecting proteolytic activity
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
AU2002251830A1 (en) * 2001-01-26 2002-08-06 Colorado State University Research Foundation Analysis of gene expression and biological function using optical imaging
KR20040010606A (ko) 2001-03-07 2004-01-31 제노젠 코퍼레이션 표적 세포로의 ｄｎａ 도입에 대한 스크리닝 방법
ATE404679T1 (de) * 2001-03-09 2008-08-15 Gene Stream Pty Ltd Neue expressionsvektoren
US6855510B2 (en) 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
US7176345B2 (en) * 2001-03-20 2007-02-13 Dana-Farber Cancer Institute, Inc. Transgenic animals expressing light-emitting fusion proteins and diagnostic and therapeutic methods therefor
US7919274B2 (en) 2001-03-20 2011-04-05 Dana-Farber Cancer Institute, Inc. Light-emitting fusion proteins and diagnostic and therapeutic methods therefor
AU2006200164B2 (en) * 2001-04-09 2007-03-08 Oncofluor, Inc. Method for viewing tumor tissue located within a body cavity
US6858773B2 (en) * 2001-04-20 2005-02-22 Xenogen Corporation Transgenic mice comprising transcription control elements associated with mouse eosinophil peroxidase expression
EP1402243B1 (en) * 2001-05-17 2006-08-16 Xenogen Corporation Method and apparatus for determining target depth, brightness and size within a body region
US7116354B2 (en) * 2001-06-20 2006-10-03 Xenogen Corporation Absolute intensity determination for a light source in low level light imaging systems
US6919919B2 (en) * 2002-02-06 2005-07-19 Xenogen Corporation Light calibration device for use in low level light imaging systems
US20030031628A1 (en) * 2001-07-09 2003-02-13 Ming Zhao Imaging infection using fluorescent protein as a marker
US7113217B2 (en) * 2001-07-13 2006-09-26 Xenogen Corporation Multi-view imaging apparatus
US7298415B2 (en) * 2001-07-13 2007-11-20 Xenogen Corporation Structured light imaging apparatus
US20040033555A1 (en) * 2001-07-20 2004-02-19 Shawn Louise Anderson Methods using light emission for determining the effeciveness of plant treatment agents in controlling plant disease organisms
US20030053951A1 (en) * 2001-07-26 2003-03-20 Millennium Pharmaceuticals, Inc. Use of non-invasive imaging technologies to monitor in vivo gene-expression
EP1281767A3 (en) 2001-07-31 2003-05-28 Aladar A. Szalay Light emitting microorganisms and cells for diagnosis and therapy of tumors
ATE439368T1 (de) * 2001-12-19 2009-08-15 Univ Chicago Schnellreifende fluoreszierende proteine und verfahren zu deren anwendung
DE10202050A1 (de) * 2002-01-18 2003-07-31 Siemens Ag Optisches Bildgebungsverfahren und Vorrichtung zur optischen Bildgebung
US20030181375A1 (en) * 2002-01-25 2003-09-25 Mcsharry James J. Rapid phenotypic cell-based HIV assay
US7629573B2 (en) * 2002-02-06 2009-12-08 Xenogen Corporation Tissue phantom calibration device for low level light imaging systems
US7649185B2 (en) * 2002-02-06 2010-01-19 Xenogen Corporation Fluorescent phantom device
US7503323B2 (en) * 2002-02-20 2009-03-17 Xenogen Corporation Multiple output anesthesia system
US7474399B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Dual illumination system for an imaging apparatus and method
US7474398B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Illumination system for an imaging apparatus with low profile output device
US6922246B2 (en) 2002-02-22 2005-07-26 Xenogen Corporation Bottom fluorescence illumination assembly for an imaging apparatus
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP1572724A4 (en) 2002-03-01 2007-03-14 Dyax Corp KDR AND VEGF / KDR BINDING SPEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20030228261A1 (en) * 2002-06-05 2003-12-11 Aladar Szalay Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
EP1369491A1 (en) * 2002-06-05 2003-12-10 Aladar A. Szalay Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
US7599731B2 (en) * 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
US7616985B2 (en) * 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
ATE513838T1 (de) 2002-09-20 2011-07-15 Promega Corp Auf lumineszenz basierende verfahren und sonden zur messung der cytochrom-p450-aktivität
WO2004042363A2 (en) * 2002-11-04 2004-05-21 Dana-Farber Cancer Institute, Inc. In vivo imaging of e2f-regulated bioluminescent proteins
ATE509946T1 (de) 2002-11-12 2011-06-15 Zakrytoe Aktsionernoe Obschestvo S Evrogens Fluoreszenzproteine und chromoproteine aus nicht- aequorea-hydrozoa-spezies sowie verfahren zur verwendung davon
EP1576157B1 (en) 2002-12-26 2010-07-21 Zakrytoe Aktsionernoe Obschestvo " Evrogen" Fluorescent proteins from copepoda species and methods for using same
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
AU2004217894B2 (en) 2003-03-03 2010-07-15 Bracco International B.V. Peptides that specifically bind HGF receptor (cMet) and uses thereof
WO2004078984A1 (en) 2003-03-05 2004-09-16 Janssen Pharmaceutica N.V. Animal model for the fast identification of pharmaceutical active compounds in vivo
JP3934673B1 (ja) * 2003-06-18 2007-06-20 ジェネラックス・コーポレイション 修飾組換えワクシニアウイルスおよびその他の微生物、その使用
US7190991B2 (en) * 2003-07-01 2007-03-13 Xenogen Corporation Multi-mode internal imaging
US7555334B2 (en) * 2003-10-20 2009-06-30 Xenogen Corporation Small animal light intensity monitor
EP1682878A1 (en) * 2003-10-31 2006-07-26 Art Advanced Research Technologies Inc. A time-domain method and apparatus for determining the depth and concentration of a fluorophore in a turbid medium
US7155274B1 (en) 2003-11-21 2006-12-26 Imaging Diagnostic Systems, Inc. Optical computed tomography scanner for small laboratory animals
WO2005061725A1 (en) 2003-12-23 2005-07-07 Mount Sinai Hospital Methods for detecting markers associated with endometrial disease or phase
US7250298B2 (en) * 2004-04-07 2007-07-31 The University Of Chicago Monomeric red fluorescent proteins
US8044996B2 (en) * 2005-05-11 2011-10-25 Xenogen Corporation Surface construction using combined photographic and structured light information
EP2272972A1 (en) * 2005-05-31 2011-01-12 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
US20070025917A1 (en) * 2005-07-26 2007-02-01 General Electric Company Optical imaging based on locally activated bioluminescence
US8050735B2 (en) * 2005-09-08 2011-11-01 Carestream Health, Inc. Apparatus and method for multi-modal imaging
US8660631B2 (en) * 2005-09-08 2014-02-25 Bruker Biospin Corporation Torsional support apparatus and method for craniocaudal rotation of animals
US20100220836A1 (en) 2005-09-08 2010-09-02 Feke Gilbert D Apparatus and method for multi-modal imaging
US20090086908A1 (en) * 2005-09-08 2009-04-02 John William Harder Apparatus and method for multi-modal imaging using nanoparticle multi-modal imaging probes
US20090281383A1 (en) * 2005-09-08 2009-11-12 Rao Papineni Apparatus and method for external fluorescence imaging of internal regions of interest in a small animal using an endoscope for internal illumination
US8203132B2 (en) * 2005-09-08 2012-06-19 Carestream Health, Inc. Apparatus and method for imaging ionizing radiation
US7417131B2 (en) * 2005-11-04 2008-08-26 Evrogen Joint Stock Company Modified green fluorescent proteins and methods for using same
WO2007075565A2 (en) 2005-12-16 2007-07-05 Shachaf Catherine M Diagnostic system for the detection and diagnosis of skin cancer
US8563703B2 (en) 2006-01-25 2013-10-22 Evrogen IP Joint Stock Company Fluorescent proteins and methods for using same
US7638615B1 (en) 2006-01-25 2009-12-29 Evrogen IP Joint Stock Company Fluorescent proteins and methods for using same
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
US10335038B2 (en) 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
US10775308B2 (en) * 2006-08-24 2020-09-15 Xenogen Corporation Apparatus and methods for determining optical tissue properties
US8680235B2 (en) * 2006-09-22 2014-03-25 Stowers Institute For Medical Research Branchiostoma derived fluorescent proteins
EP2415783B1 (en) 2006-10-16 2016-12-14 Genelux Corporation Modified vaccinia virus strains for use in a diagnostic and therapeutic method
RS63489B1 (sr) 2007-02-08 2022-09-30 Biogen Ma Inc Kompozicije i upotrebe za tretiranje multiple skleroze
JP2008224312A (ja) 2007-03-09 2008-09-25 Olympus Corp 蛍光観察装置
JP4969273B2 (ja) * 2007-03-09 2012-07-04 オリンパス株式会社 蛍光観察装置
WO2008156655A2 (en) 2007-06-15 2008-12-24 Genelux Corporation Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors
US20090060843A1 (en) 2007-08-31 2009-03-05 Biocrine Ab Non-Invasive In Vivo Imaging and Methods for Treating Type I Diabetes
US20090081715A1 (en) * 2007-09-07 2009-03-26 Cobalt Technologies, Inc., A Delaware Corporation Engineered Light-Emitting Reporter Genes
CA2699912A1 (en) 2007-09-19 2009-03-26 Oncofluor, Inc. Method for imaging and treating organs and tissues
WO2009059305A2 (en) * 2007-11-01 2009-05-07 The University Of Chicago Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
US8791427B2 (en) * 2007-12-26 2014-07-29 Olympus Corporation Biological-specimen observation apparatus
DK2244741T3 (da) 2008-01-18 2015-05-26 Visen Medical Inc Fluorescerende billeddannelsesmidler
CA2618163A1 (en) 2008-02-07 2009-08-07 K. W. Michael Siu Head and neck cancer biomarkers
WO2009126795A2 (en) 2008-04-09 2009-10-15 Cobalt Technologies, Inc. Immobilized product tolerant microorganisms
JP2009257967A (ja) * 2008-04-17 2009-11-05 Olympus Corp 蛍光観察装置および蛍光観察方法
EP2323996B1 (en) * 2008-08-18 2014-10-22 Promega Corporation Luminogenic compounds and methods to detect cytochrome p450 3a enzymes
WO2010062787A1 (en) 2008-11-03 2010-06-03 Washington University Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor
KR101711399B1 (ko) 2009-05-27 2017-03-03 전남대학교산학협력단 선택적 경색 조직 타겟팅 박테리아 및 그의 용도
WO2010151706A1 (en) 2009-06-26 2010-12-29 Cobalt Technologies, Inc. Integrated system and process for bioproduct production
DE202009009799U1 (de) 2009-07-17 2009-09-10 Berthold Technologies Gmbh & Co. Kg Vorrichtung zur Untersuchung von lebenden Tieren
KR101199570B1 (ko) 2009-09-09 2012-11-13 경북대학교 산학협력단 신규한 테트라아자 거대고리 화합물, 제조방법 및 그 용도
EP2478113B1 (en) * 2009-09-18 2020-09-02 Caliper Life Sciences, Inc. Compositions and methods for in vivo evaluation of bioluminescence
CN104975042A (zh) 2009-12-17 2015-10-14 赛诺菲 在髓鞘碱性蛋白启动子的控制下表达荧光素酶的动物模型及其用途
WO2012015023A1 (ja) * 2010-07-29 2012-02-02 国立大学法人京都大学 抗がん剤のスクリーニング方法
US9012242B2 (en) 2010-09-20 2015-04-21 Caliper Life Sciences Multivalent fluorescent probes
US8569254B2 (en) 2010-12-10 2013-10-29 National Yang Ming University Methods for modulating the expression and aggregation of CAG-expanded gene product in cells and methods for identifying agents useful for doing the same
JP6084203B2 (ja) 2011-04-13 2017-02-22 キャリパー ライフ サイエンシーズ， インコーポレイテッド 酵素活性のインビボでの画像化
JP6415977B2 (ja) 2011-04-15 2018-10-31 ジェネラックス・コーポレイションＧｅｎｅｌｕｘ Ｃｏｒｐｏｒａｔｉｏｎ 弱毒化ワクシニアウイルスのクローン株およびその使用方法
US9314218B2 (en) 2011-06-20 2016-04-19 Caliper Life Sciences, Inc. Integrated microtomography and optical imaging systems
WO2013070796A2 (en) 2011-11-07 2013-05-16 The Broad Institute, Inc. Propeptide-luciferase fusion proteins and methods of use thereof
JP6049305B2 (ja) * 2012-05-25 2016-12-21 オリンパス株式会社 生体試料由来の被験試料の画像を取得する方法
CN105612176B (zh) 2012-07-31 2021-01-19 阿格克斯治疗有限公司 Hla g修饰的细胞及方法
EP2719703A1 (en) 2012-10-12 2014-04-16 Ecole Polytechnique Fédérale de Lausanne (EPFL) Precursor molecule for the synthesis of D-luciferin
JP2014115151A (ja) * 2012-12-07 2014-06-26 Shimadzu Corp 光イメージング装置
WO2015038968A1 (en) 2013-09-13 2015-03-19 The General Hospital Corporation Activatable fibrin-binding probes
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
CN105994086B (zh) * 2016-07-08 2022-02-11 中国人民解放军军事医学科学院毒物药物研究所 一种可控投影模拟实景的斑马鱼行为测试系统
JP2021514619A (ja) * 2018-02-27 2021-06-17 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 疾患の診断プローブとしての改変免疫細胞
CN112513188B (zh) 2018-08-23 2024-01-26 普洛麦格公司 腔肠素类似物
US20240150363A1 (en) 2022-10-14 2024-05-09 Promega Corporation Coelenterazine analogues
CN115992264A (zh) * 2023-02-21 2023-04-21 华中农业大学 一种鸡黄白肤色分子鉴定引物组及其方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE59966T1 (de) * 1983-09-26 1991-02-15 Ehrenfeld Udo Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
GB8422650D0 (en) * 1984-09-07 1984-10-10 Technology Licence Co Ltd Monoclonal antibodies
GB8422653D0 (en) * 1984-09-07 1984-10-10 Technology Licence Co Ltd Monoclonal antibodies
CN85109047A (zh) * 1985-11-13 1987-06-03 科技研究公司 应用生物发光或引入其它外源性遗传标记检测或鉴定测试样品中的微生物
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4762701A (en) * 1986-10-31 1988-08-09 Smithkline Beckman Corporation In vivo cellular tracking
US4912031A (en) * 1987-10-23 1990-03-27 E. I. Du Pont De Nemours And Company Method for detecting carcinomatous and precarcinomatous colo-rectal disease
GB8916806D0 (en) * 1989-07-22 1989-09-06 Univ Wales Medicine Modified proteins
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal

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ES2152198T1 (es) 2001-02-01
EP1016419A3 (en) 2000-07-12
EP1016419A2 (en) 2000-07-05
EP0861093B1 (en) 2000-05-31
WO1997018841A1 (en) 1997-05-29
DE69517344T2 (de) 2001-01-18
US5650135A (en) 1997-07-22
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EP1016419B1 (en) 2013-02-27
GR3034110T3 (en) 2000-11-30
EP0861093A1 (en) 1998-09-02
DE69517344D1 (de) 2000-07-06
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