DE1016419T1 - Nicht-invasive Lokalisierung von ein lichtemittierend Konjugat in ein Säugetier - Google Patents

Nicht-invasive Lokalisierung von ein lichtemittierend Konjugat in ein Säugetier

Info

Publication number
DE1016419T1
DE1016419T1 DE1016419T DE99124640T DE1016419T1 DE 1016419 T1 DE1016419 T1 DE 1016419T1 DE 1016419 T DE1016419 T DE 1016419T DE 99124640 T DE99124640 T DE 99124640T DE 1016419 T1 DE1016419 T1 DE 1016419T1
Authority
DE
Germany
Prior art keywords
mammal
light
disclosed
methods
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1016419T
Other languages
English (en)
Other versions
DE19924640A1 (de
DE19924640B4 (de
Inventor
Designation Of The Inventor Has The
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27170688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE1016419(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of DE1016419T1 publication Critical patent/DE1016419T1/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Eye Examination Apparatus (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Push-Button Switches (AREA)
DE1016419T 1994-07-01 1995-11-17 Nicht-invasive Lokalisierung von ein lichtemittierend Konjugat in ein Säugetier Pending DE1016419T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/270,631 US5650135A (en) 1994-07-01 1994-07-01 Non-invasive localization of a light-emitting conjugate in a mammal
CA002237983A CA2237983C (en) 1994-07-01 1995-11-17 Non-invasive localization of a light-emitting conjugate in a mammal
PCT/US1995/015040 WO1997018841A1 (en) 1994-07-01 1995-11-17 Non-invasive localization of a light-emitting conjugate in a mammal

Publications (1)

Publication Number Publication Date
DE1016419T1 true DE1016419T1 (de) 2001-01-25

Family

ID=27170688

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1016419T Pending DE1016419T1 (de) 1994-07-01 1995-11-17 Nicht-invasive Lokalisierung von ein lichtemittierend Konjugat in ein Säugetier
DE69517344T Expired - Lifetime DE69517344T2 (de) 1994-07-01 1995-11-17 Nicht-invasive Feststellung der Integration eines Transgens bei Säugetieren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69517344T Expired - Lifetime DE69517344T2 (de) 1994-07-01 1995-11-17 Nicht-invasive Feststellung der Integration eines Transgens bei Säugetieren

Country Status (13)

Country Link
US (1) US5650135A (de)
EP (2) EP1016419B1 (de)
JP (1) JP3786704B2 (de)
AT (1) ATE193453T1 (de)
AU (1) AU4285096A (de)
BR (1) BR9510664A (de)
CA (1) CA2237983C (de)
DE (2) DE1016419T1 (de)
DK (1) DK0861093T3 (de)
ES (2) ES2147621T3 (de)
GR (1) GR3034110T3 (de)
HK (1) HK1018747A1 (de)
WO (1) WO1997018841A1 (de)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US6649143B1 (en) 1994-07-01 2003-11-18 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US6540981B2 (en) * 1997-12-04 2003-04-01 Amersham Health As Light imaging contrast agents
EP1820517A3 (de) * 1995-11-17 2009-10-21 The Board Of Trustees Of The Leland Stanford Junior University Nichtinvasive Lokalisierung eines lichtemittierenden Konjugats bei einem Säugetier
US6247995B1 (en) 1996-02-06 2001-06-19 Bruce Bryan Bioluminescent novelty items
US8349602B1 (en) 1996-04-19 2013-01-08 Xenogen Corporation Biodetectors targeted to specific ligands
US6416960B1 (en) 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
EP1015872B1 (de) 1996-12-12 2005-03-02 Prolume, Ltd. Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen
US6251384B1 (en) 1997-04-28 2001-06-26 Anticancer, Inc. Metastasis models using green fluorescent protein (GFP) as a marker
US6235968B1 (en) 1997-04-28 2001-05-22 Anticancer, Inc. Metastasis models using green fluorescent protein (GFP) as a marker
US6232523B1 (en) 1997-04-28 2001-05-15 Anticancer, Inc. Metastasis models using green fluorescent protein (GFP) as a marker
JP2001526650A (ja) * 1997-04-29 2001-12-18 ニユコメド・イメージング・アクシエセルカペト 光画像造影剤
CA2242035C (en) 1997-07-01 2004-11-23 Transgene S.A. Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy
US6638501B1 (en) 1997-09-29 2003-10-28 Neurospheres Holdings Ltd. Use of multipotent neural stem cell progeny to augment non-neural tissues
US7294755B1 (en) 1997-11-14 2007-11-13 Cedars-Sinai Medical Center Genetic modification of male germ cells for generation of transgenic species and genetic therapies
US6734338B1 (en) 1997-11-14 2004-05-11 Cedars-Sinai Medical Center Transfection, storage and transfer of male germ cells for generation of transgenic species and genetic therapies
ATE426036T1 (de) * 1997-11-14 2009-04-15 Cedars Sinai Medical Center Transfektion und transfer nicht humaner mannlicher keimzellen zur generierung transgener nicht humaner saugetiere
US6846625B1 (en) * 1998-01-09 2005-01-25 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combination for drug development
AU2512299A (en) * 1998-01-27 1999-08-09 Novo Nordisk A/S Method for producing transgenic animals
WO1999045354A2 (en) * 1998-03-02 1999-09-10 Biosensing Technologies Ltd. Luminescent microbe assay
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
AU3550099A (en) * 1998-04-07 1999-10-25 Windy Hill Technology, Inc. Methods and devices for the localization of lesions in solid tissue
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US20010038682A1 (en) * 1998-09-08 2001-11-08 Jesse Salb Radiographic assessment of tissue response to compounds
US6226352B1 (en) * 1998-09-08 2001-05-01 Veritas Pharmaceuticals, Inc. System and method for radiographic imaging of tissue
US6751290B2 (en) 1998-09-08 2004-06-15 Veritas Pharmaceuticals, Inc. Radiographic assessment of tissue after exposure to a compound
US6723746B2 (en) 1998-09-08 2004-04-20 Veritas Pharmaceuticals, Inc. Functional radiographic imaging methods and agents
US6284223B1 (en) 1998-10-15 2001-09-04 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6299860B1 (en) 1998-10-15 2001-10-09 Fluoro Probe, Inc. Method for viewing diseased tissue located within a body cavity
US6652836B2 (en) 1998-10-15 2003-11-25 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
WO2000036106A2 (en) * 1998-12-17 2000-06-22 Xenogen Corporation Non-invasive evaluation of physiological response in a mammal
US6610503B1 (en) * 1999-03-17 2003-08-26 Xenogen Corporation Animal models for predicting sepsis mortality
US6495355B1 (en) 1999-06-22 2002-12-17 The Board Of Trustees Of The Leland Stanford Junior University Red-shifted luciferase
US6737245B1 (en) 1999-09-08 2004-05-18 Xenogen Corporation Luciferase expression cassettes and methods of use
EP1305412A2 (de) 1999-10-14 2003-05-02 Clontech Laboratories Inc. Chromo/fluoroproteine aus anthozoa und verwendung der gleichen
US6614452B1 (en) * 1999-11-15 2003-09-02 Xenogen Corporation Graphical user interface for in-vivo imaging
US7581191B2 (en) * 1999-11-15 2009-08-25 Xenogen Corporation Graphical user interface for 3-D in-vivo imaging
US6867348B1 (en) * 1999-12-16 2005-03-15 Xenogen Corporation Methods and compositions for screening for angiogenesis modulating compounds
IT1311335B1 (it) 1999-12-21 2002-03-12 Otc Optical Technologies Ct S Procedimento e dispositivo per realizzare reticoli in fibra ottica.
AU2001230471A1 (en) * 2000-01-31 2001-08-14 Hadasit Medical Research Services And Development Ltd. Tracking gene expression and metabolic processes in subjects
US6775567B2 (en) * 2000-02-25 2004-08-10 Xenogen Corporation Imaging apparatus
DE60137501D1 (de) * 2000-03-17 2009-03-12 Anticancer Inc Optisches abbildungssystem zur darstellung der genexpression des gesamten körpers und anwendungen
US6748259B1 (en) * 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US7056728B2 (en) * 2000-07-06 2006-06-06 Xenogen Corporation Compositions and methods for use thereof in modifying the genomes of microorganisms
WO2002008431A1 (en) * 2000-07-06 2002-01-31 Xenogen Corporation Compositions and methods for use thereof in modifying the genomes of microorganisms
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US20020073441A1 (en) 2000-12-13 2002-06-13 Ross Brian D. Compositions and methods for detecting proteolytic activity
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
AU2002251830A1 (en) * 2001-01-26 2002-08-06 Colorado State University Research Foundation Analysis of gene expression and biological function using optical imaging
EP1373481A4 (de) 2001-03-07 2005-04-13 Xenogen Corp Verfahren zum screening auf die einführung von dna in eine zielzelle
EP1373528B1 (de) * 2001-03-09 2008-08-13 Gene Stream Pty Ltd. Neue expressionsvektoren
US6855510B2 (en) 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
US7176345B2 (en) * 2001-03-20 2007-02-13 Dana-Farber Cancer Institute, Inc. Transgenic animals expressing light-emitting fusion proteins and diagnostic and therapeutic methods therefor
US7919274B2 (en) 2001-03-20 2011-04-05 Dana-Farber Cancer Institute, Inc. Light-emitting fusion proteins and diagnostic and therapeutic methods therefor
AU2006200164B2 (en) * 2001-04-09 2007-03-08 Oncofluor, Inc. Method for viewing tumor tissue located within a body cavity
US6858773B2 (en) * 2001-04-20 2005-02-22 Xenogen Corporation Transgenic mice comprising transcription control elements associated with mouse eosinophil peroxidase expression
DE60213993T2 (de) * 2001-05-17 2007-03-15 Xenogen Corp., Alameda Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion
US6919919B2 (en) * 2002-02-06 2005-07-19 Xenogen Corporation Light calibration device for use in low level light imaging systems
US7116354B2 (en) * 2001-06-20 2006-10-03 Xenogen Corporation Absolute intensity determination for a light source in low level light imaging systems
EP1404375A1 (de) * 2001-07-09 2004-04-07 Anticancer, Inc. Abbildung von infektionen durch verwendung eines fluoreszierenden proteins als marker
US7113217B2 (en) * 2001-07-13 2006-09-26 Xenogen Corporation Multi-view imaging apparatus
US7298415B2 (en) * 2001-07-13 2007-11-20 Xenogen Corporation Structured light imaging apparatus
US20040033555A1 (en) * 2001-07-20 2004-02-19 Shawn Louise Anderson Methods using light emission for determining the effeciveness of plant treatment agents in controlling plant disease organisms
US20030053951A1 (en) * 2001-07-26 2003-03-20 Millennium Pharmaceuticals, Inc. Use of non-invasive imaging technologies to monitor in vivo gene-expression
EP1281767A3 (de) 2001-07-31 2003-05-28 Aladar A. Szalay Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren
JP4700281B2 (ja) * 2001-12-19 2011-06-15 ザ・ユニバーシティ・オブ・シカゴ 急速に成熟する蛍光タンパク質およびその使用法
DE10202050A1 (de) * 2002-01-18 2003-07-31 Siemens Ag Optisches Bildgebungsverfahren und Vorrichtung zur optischen Bildgebung
WO2003063777A2 (en) * 2002-01-25 2003-08-07 Albany Medical College Rapid phenotypic cell-based hiv assay
US7649185B2 (en) * 2002-02-06 2010-01-19 Xenogen Corporation Fluorescent phantom device
US7629573B2 (en) * 2002-02-06 2009-12-08 Xenogen Corporation Tissue phantom calibration device for low level light imaging systems
US7503323B2 (en) * 2002-02-20 2009-03-17 Xenogen Corporation Multiple output anesthesia system
US6922246B2 (en) * 2002-02-22 2005-07-26 Xenogen Corporation Bottom fluorescence illumination assembly for an imaging apparatus
US7474399B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Dual illumination system for an imaging apparatus and method
US7474398B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Illumination system for an imaging apparatus with low profile output device
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1369491A1 (de) * 2002-06-05 2003-12-10 Aladar A. Szalay Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe
US20030228261A1 (en) * 2002-06-05 2003-12-11 Aladar Szalay Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
US7616985B2 (en) * 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
US7599731B2 (en) * 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
CA2497560A1 (en) * 2002-09-20 2004-04-01 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
WO2004042363A2 (en) * 2002-11-04 2004-05-21 Dana-Farber Cancer Institute, Inc. In vivo imaging of e2f-regulated bioluminescent proteins
EP1565559B1 (de) 2002-11-12 2011-05-18 Zakrytoe Aktsionernoe Obschestvo " Evrogen" Fluoreszenzproteine und chromoproteine aus nicht-aequorea-hydrozoa-spezies sowie verfahren zur verwendung davon
AU2003287115A1 (en) 2002-12-26 2004-07-22 Zakrytoe Aktsionernoe Obschestvo "Evrogen" Fluorescent proteins from copepoda species and methods for using same
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
EP1603935A4 (de) 2003-03-03 2007-03-21 Dyax Corp SPEZIFISCH AN HGF-REZEPTOR (cMet) BINDENDE PEPTIDE UND DEREN VERWENDUNG
WO2004078984A1 (en) * 2003-03-05 2004-09-16 Janssen Pharmaceutica N.V. Animal model for the fast identification of pharmaceutical active compounds in vivo
MXPA05013879A (es) 2003-06-18 2006-06-27 Genelux Corp Virus de la vaccinia recombinantes modificados y otros microorganismos, y usos de los mismos.
US7190991B2 (en) * 2003-07-01 2007-03-13 Xenogen Corporation Multi-mode internal imaging
US7555334B2 (en) * 2003-10-20 2009-06-30 Xenogen Corporation Small animal light intensity monitor
WO2005043138A1 (en) * 2003-10-31 2005-05-12 Art Advanced Research Technologies Inc. A time-domain method and apparatus for determining the depth and concentration of a fluorophore in a turbid medium
US7155274B1 (en) 2003-11-21 2006-12-26 Imaging Diagnostic Systems, Inc. Optical computed tomography scanner for small laboratory animals
EP2251695B1 (de) 2003-12-23 2013-07-17 Mount Sinai Hospital Corporation Mit endometrialer krankheit assoziierte marker
EP1732944B1 (de) * 2004-04-07 2012-09-05 The University of Chicago Monomere, rotfluoreszierende proteine
US8044996B2 (en) * 2005-05-11 2011-10-25 Xenogen Corporation Surface construction using combined photographic and structured light information
EP2272973B1 (de) * 2005-05-31 2015-05-27 Promega Corporation Luminogene und fluorogene Verbindungen und Verfahren für den Nachweis von Molekülen oder Leiden
US20070025917A1 (en) * 2005-07-26 2007-02-01 General Electric Company Optical imaging based on locally activated bioluminescence
US20090281383A1 (en) * 2005-09-08 2009-11-12 Rao Papineni Apparatus and method for external fluorescence imaging of internal regions of interest in a small animal using an endoscope for internal illumination
US20090086908A1 (en) * 2005-09-08 2009-04-02 John William Harder Apparatus and method for multi-modal imaging using nanoparticle multi-modal imaging probes
US8660631B2 (en) * 2005-09-08 2014-02-25 Bruker Biospin Corporation Torsional support apparatus and method for craniocaudal rotation of animals
US8203132B2 (en) * 2005-09-08 2012-06-19 Carestream Health, Inc. Apparatus and method for imaging ionizing radiation
US8050735B2 (en) * 2005-09-08 2011-11-01 Carestream Health, Inc. Apparatus and method for multi-modal imaging
US20100220836A1 (en) 2005-09-08 2010-09-02 Feke Gilbert D Apparatus and method for multi-modal imaging
WO2007052102A2 (en) * 2005-11-04 2007-05-10 Evrogen, Jsc Modified green fluorescent proteins and methods for using same
NZ569818A (en) 2005-12-16 2012-07-27 Catherine M Shachaf Diagnostic system for the detection and diagnosis of skin cancer
US8563703B2 (en) 2006-01-25 2013-10-22 Evrogen IP Joint Stock Company Fluorescent proteins and methods for using same
RU2395581C2 (ru) 2006-01-25 2010-07-27 Закрытое Акционерное Общество "Евроген Айпи" Новые флуоресцентные белки из entacmaea quadricolor и способ их получения
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
US10335038B2 (en) 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
US10775308B2 (en) * 2006-08-24 2020-09-15 Xenogen Corporation Apparatus and methods for determining optical tissue properties
WO2008094316A2 (en) * 2006-09-22 2008-08-07 Stowers Institute Of Medical Research Novel branchiostoma derived fluorescent proteins
WO2008100292A2 (en) 2006-10-16 2008-08-21 Genelux Corporation Modified vaccinia virus strains for use in diagnostic and therapeutic methods
EP2680007A1 (de) 2007-02-08 2014-01-01 Biogen Idec MA Inc. Nrf2-screening-Assays sowie entsprechende Verfahren und Zusammensetzungen
JP2008224312A (ja) * 2007-03-09 2008-09-25 Olympus Corp 蛍光観察装置
JP4969273B2 (ja) 2007-03-09 2012-07-04 オリンパス株式会社 蛍光観察装置
US20090117034A1 (en) 2007-06-15 2009-05-07 Nanhai Chen Microorganisms for imaging and/or treatment of tumors
US20090060843A1 (en) 2007-08-31 2009-03-05 Biocrine Ab Non-Invasive In Vivo Imaging and Methods for Treating Type I Diabetes
US20090081715A1 (en) * 2007-09-07 2009-03-26 Cobalt Technologies, Inc., A Delaware Corporation Engineered Light-Emitting Reporter Genes
EP2197340A4 (de) 2007-09-19 2015-10-21 Oncofluor Inc Verfahren zur darstellung und behandlung von organen und geweben
WO2009059305A2 (en) * 2007-11-01 2009-05-07 The University Of Chicago Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
US8791427B2 (en) * 2007-12-26 2014-07-29 Olympus Corporation Biological-specimen observation apparatus
DK2244741T3 (en) 2008-01-18 2015-05-26 Visen Medical Inc Fluorescent imaging agents
CA2618163A1 (en) 2008-02-07 2009-08-07 K. W. Michael Siu Head and neck cancer biomarkers
CL2009000879A1 (es) 2008-04-09 2010-05-07 Talfryn S A Metodo para fabricar un producto en un biorreactor que comprende cultivar microorganismos que son adaptados o mutagenizados para que exhiban por lo menos un 150% de tolerancia al producto; sistema para fabricar un producto; biorreactor.
JP2009257967A (ja) * 2008-04-17 2009-11-05 Olympus Corp 蛍光観察装置および蛍光観察方法
JP5597200B2 (ja) * 2008-08-18 2014-10-01 プロメガ コーポレイション ルミネッセンスを生じる化合物およびチトクロムｐ４５０３ａ酵素を検出するための方法
WO2010062787A1 (en) 2008-11-03 2010-06-03 Washington University Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor
EP2436756B1 (de) 2009-05-27 2016-08-17 Industry Foundation Of Chonnam National University Auf selektives gebrochenes gewebe abzielende bakterien und verwendung davon
US8497105B2 (en) 2009-06-26 2013-07-30 Cobalt Technologies, Inc. Integrated system and process for bioproduct production
DE202009009799U1 (de) 2009-07-17 2009-09-10 Berthold Technologies Gmbh & Co. Kg Vorrichtung zur Untersuchung von lebenden Tieren
KR101199570B1 (ko) 2009-09-09 2012-11-13 경북대학교 산학협력단 신규한 테트라아자 거대고리 화합물, 제조방법 및 그 용도
EP4151746A1 (de) 2009-09-18 2023-03-22 Caliper Life Sciences, Inc. Zusammensetzungen und verfahren zur in-vivo-evaluation einer biolumineszenz
BR112012015876A2 (pt) 2009-12-17 2016-11-16 Sanofi Sa modelo animal expressando luciferase sob controle do promotor de proteína básica de mielina (mbp-luci) e utilização do modelo bioliminescência imagem in vivo
JP5978424B2 (ja) * 2010-07-29 2016-08-24 国立大学法人京都大学 抗がん剤のスクリーニング方法
EP2618849B1 (de) 2010-09-20 2020-10-21 Caliper Life Sciences, Inc. Multivalente fluoreszierende sonden
US8569254B2 (en) 2010-12-10 2013-10-29 National Yang Ming University Methods for modulating the expression and aggregation of CAG-expanded gene product in cells and methods for identifying agents useful for doing the same
WO2012142392A2 (en) 2011-04-13 2012-10-18 Caliper Life Sciences, Inc. In vivo imaging of enzymatic activity
EP2697368B1 (de) 2011-04-15 2019-06-05 Genelux Corporation Klonale stämme von abgeschwächten vaccinia-viren und verwendungsverfahren davon
US9314218B2 (en) 2011-06-20 2016-04-19 Caliper Life Sciences, Inc. Integrated microtomography and optical imaging systems
US9657329B2 (en) 2011-11-07 2017-05-23 The Broad Institute Inc. Propeptide-luciferase fusion proteins and methods of use thereof
JP6049305B2 (ja) * 2012-05-25 2016-12-21 オリンパス株式会社 生体試料由来の被験試料の画像を取得する方法
CA2882028C (en) 2012-07-31 2023-11-07 Basil M. Hantash Human leukocyte antigen-g (hla-g) modified cells and methods
EP2719703A1 (de) 2012-10-12 2014-04-16 Ecole Polytechnique Fédérale de Lausanne (EPFL) Vorläufermolekül für die Synthese von D-Luciferin
JP2014115151A (ja) * 2012-12-07 2014-06-26 Shimadzu Corp 光イメージング装置
WO2015038968A1 (en) 2013-09-13 2015-03-19 The General Hospital Corporation Activatable fibrin-binding probes
JP6703484B2 (ja) 2014-01-29 2020-06-03 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 細胞による取り込み測定のための、標識用試薬としての、キノンでマスクされたプローブ
CN105994086B (zh) * 2016-07-08 2022-02-11 中国人民解放军军事医学科学院毒物药物研究所 一种可控投影模拟实景的斑马鱼行为测试系统
EP3759494A4 (de) * 2018-02-27 2022-01-26 The Board of Trustees of the Leland Stanford Junior University Manipulierte immunzellen als diagnostische sonden einer krankheit
EP3841173A1 (de) 2018-08-23 2021-06-30 Promega Corporation Coelenterazin-analoga
US20240150363A1 (en) 2022-10-14 2024-05-09 Promega Corporation Coelenterazine analogues
CN115992264A (zh) * 2023-02-21 2023-04-21 华中农业大学 一种鸡黄白肤色分子鉴定引物组及其方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350973B1 (de) * 1983-09-26 1997-11-05 Udo Dr. Ehrenfeld Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr
GB8422650D0 (en) * 1984-09-07 1984-10-10 Technology Licence Co Ltd Monoclonal antibodies
GB8422653D0 (en) * 1984-09-07 1984-10-10 Technology Licence Co Ltd Monoclonal antibodies
CN85109047A (zh) * 1985-11-13 1987-06-03 科技研究公司 应用生物发光或引入其它外源性遗传标记检测或鉴定测试样品中的微生物
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4762701A (en) * 1986-10-31 1988-08-09 Smithkline Beckman Corporation In vivo cellular tracking
US4912031A (en) * 1987-10-23 1990-03-27 E. I. Du Pont De Nemours And Company Method for detecting carcinomatous and precarcinomatous colo-rectal disease
GB8916806D0 (en) * 1989-07-22 1989-09-06 Univ Wales Medicine Modified proteins
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal

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EP1016419A3 (de) 2000-07-12
BR9510664A (pt) 2001-07-17
DK0861093T3 (da) 2000-09-11
ATE193453T1 (de) 2000-06-15
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US5650135A (en) 1997-07-22

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