ATE307830T1 - Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper - Google Patents

Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper

Info

Publication number
ATE307830T1
ATE307830T1 AT00907506T AT00907506T ATE307830T1 AT E307830 T1 ATE307830 T1 AT E307830T1 AT 00907506 T AT00907506 T AT 00907506T AT 00907506 T AT00907506 T AT 00907506T AT E307830 T1 ATE307830 T1 AT E307830T1
Authority
AT
Austria
Prior art keywords
human
polyclonal antibodies
transgenic animals
antibodies derived
antisera
Prior art date
Application number
AT00907506T
Other languages
English (en)
Inventor
Jens-Ulrich Buelow
Original Assignee
Therapeutic Human Polyclonals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therapeutic Human Polyclonals filed Critical Therapeutic Human Polyclonals
Application granted granted Critical
Publication of ATE307830T1 publication Critical patent/ATE307830T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8777—Rabbit embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00907506T 1999-02-05 2000-02-04 Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper ATE307830T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11881099P 1999-02-05 1999-02-05
US13139899P 1999-04-28 1999-04-28
US13467499P 1999-05-18 1999-05-18
PCT/EP2000/000933 WO2000046251A2 (en) 1999-02-05 2000-02-04 Human polyclonal antibodies from transgenic nonhuman animals

Publications (1)

Publication Number Publication Date
ATE307830T1 true ATE307830T1 (de) 2005-11-15

Family

ID=27382221

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00907506T ATE307830T1 (de) 1999-02-05 2000-02-04 Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper

Country Status (10)

Country Link
US (3) US20020178456A1 (de)
EP (1) EP1151010B1 (de)
JP (2) JP5694623B2 (de)
AT (1) ATE307830T1 (de)
AU (1) AU2907200A (de)
CA (1) CA2362098C (de)
DE (1) DE60023451T2 (de)
DK (1) DK1151010T3 (de)
ES (1) ES2250105T3 (de)
WO (1) WO2000046251A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2907200A (en) * 1999-02-05 2000-08-25 Jens-Ulrich Bulow Human polyclonal antibodies from genetically engineered animals
AU7491800A (en) * 1999-09-15 2001-04-17 Therapeutic Human Polyclonals, Inc. Immunotherapy with substantially human polyclonal antibody preparations purifiedfrom genetically engineered birds
EA013564B1 (ru) * 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US6586251B2 (en) * 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JP2002316944A (ja) * 2001-04-17 2002-10-31 Chemo Sero Therapeut Res Inst ヒトポリクローナル抗体組成物
KR20050093761A (ko) 2002-11-08 2005-09-23 헤마테크, 엘엘씨 프리온 단백질 활성이 감소된 트랜스제닉 유제동물 및 그의용도
WO2005007696A2 (en) 2003-07-15 2005-01-27 Therapeutic Human Polyclonals, Inc. Humanized immunoglobulin loci
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
JP5087625B2 (ja) 2006-09-01 2012-12-05 セラピューティック・ヒューマン・ポリクローナルズ・インコーポレーテッド 非ヒトトランスジェニック動物におけるヒトまたはヒト化免疫グロブリンの発現強化
WO2017072208A1 (en) * 2015-10-29 2017-05-04 F. Hoffmann-La Roche Ag Transgenic rabbit with common light chain
JP2021508471A (ja) 2017-12-29 2021-03-11 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ｖｅｇｆ抗体のｖｅｇｆ受容体遮断選択性を改善する方法
JP2021516954A (ja) * 2018-03-21 2021-07-15 クリスタル バイオサイエンス インコーポレイテッドＣｒｙｓｔａｌ Ｂｉｏｓｃｉｅｎｃｅ Ｉｎｃ． ヒト型抗体を産生するトランスジェニックニワトリ
JP2022521358A (ja) 2019-02-18 2022-04-06 バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド ヒト化免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物
WO2020260326A1 (en) 2019-06-27 2020-12-30 F. Hoffmann-La Roche Ag Novel icos antibodies and tumor-targeted antigen binding molecules comprising them
AR119382A1 (es) 2019-07-12 2021-12-15 Hoffmann La Roche Anticuerpos de pre-direccionamiento y métodos de uso
AR119393A1 (es) 2019-07-15 2021-12-15 Hoffmann La Roche Anticuerpos que se unen a nkg2d
KR20230018439A (ko) 2020-06-02 2023-02-07 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 공동 경쇄 면역글로불린 좌위를 갖는 유전자 변형 비인간 동물
AR128031A1 (es) 2021-12-20 2024-03-20 Hoffmann La Roche Anticuerpos agonistas anti-ltbr y anticuerpos biespecíficos que los comprenden

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567607A (en) * 1981-10-28 1996-10-22 Incell Method of producing transgenic animals
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
EP0950707B1 (de) * 1989-07-25 2009-02-18 Cell Genesys, Inc. Homologe Rekombination für universelle Donorzellen und chimerische Säugetierzellen
DE69133566T2 (de) * 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
US5814318A (en) * 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) * 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
CA2124967C (en) * 1991-12-17 2008-04-08 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
EP1288229A3 (de) * 1991-12-17 2003-07-30 GenPharm International, Inc. Transgene nicht-menschliche Tiere, die heterologe Antikörper erzeugen können
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
WO1994014294A1 (en) * 1992-12-08 1994-06-23 Linaeum Corporation Audio transducer with flexible foam enclosure
JPH08140528A (ja) * 1993-12-03 1996-06-04 Genpharm Internatl Inc 異種抗体を産生することができるトランスジェニック非ヒト動物
KR20050085971A (ko) * 1995-04-27 2005-08-29 아브게닉스, 인크. 면역화된 제노마우스 유래의 인간 항체
KR19990008197A (ko) * 1995-04-28 1999-01-25 레이몬드 엠. 위티 면역화된 제노마우스 유래의 인체 항체
GB9823930D0 (en) * 1998-11-03 1998-12-30 Babraham Inst Murine expression of human ig\ locus
KR100345463B1 (ko) * 1998-11-19 2003-01-08 주)녹십자 B형간염바이러스의표면항원프리-s1에대한인간화항체및이의제조방법
AU2907200A (en) * 1999-02-05 2000-08-25 Jens-Ulrich Bulow Human polyclonal antibodies from genetically engineered animals
US6342587B1 (en) * 1999-10-22 2002-01-29 Ludwig Institute For Cancer Research A33 antigen specific immunoglobulin products and uses thereof

Also Published As

Publication number Publication date
JP6073550B2 (ja) 2017-02-01
US20020178456A1 (en) 2002-11-28
WO2000046251A2 (en) 2000-08-10
JP2012072184A (ja) 2012-04-12
ES2250105T3 (es) 2006-04-16
US20080299112A1 (en) 2008-12-04
DK1151010T3 (da) 2006-01-09
DE60023451T2 (de) 2006-07-20
US20150307595A1 (en) 2015-10-29
JP5694623B2 (ja) 2015-04-01
JP2002540069A (ja) 2002-11-26
DE60023451D1 (de) 2005-12-01
EP1151010A2 (de) 2001-11-07
WO2000046251A3 (en) 2001-01-11
AU2907200A (en) 2000-08-25
CA2362098C (en) 2011-10-11
CA2362098A1 (en) 2000-08-10
EP1151010B1 (de) 2005-10-26

Similar Documents

Publication Publication Date Title
ATE307830T1 (de) Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper
ATE390933T1 (de) Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
Hansen Vocal learning: its role in adapting sound structures to long-distance propagation, and a hypothesis on its evolution.
DE69933886D1 (de) Transgene mäuse, die den menschliche immunoglobulinlambdalokus exprimieren
ATE278023T1 (de) Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit
ATE401787T1 (de) Menschliches cd20 exprimierende transgene mäuse
DE69517344T2 (de) Nicht-invasive Feststellung der Integration eines Transgens bei Säugetieren
DE68926508D1 (de) Erzeugung von antikörpern aus transgenen tieren
DK37290D0 (da) Humant immunsystem i ikke-humane dyr
DE60138832D1 (de) Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen rindern
NO912442D0 (no) Kunstig agn for fisk, o.l.
WO2001019394A3 (en) Immunotherapy with substantially human polyclonal antibody preparations purified from genetically engineered birds
EA200100653A1 (ru) Способ борьбы с членистоногими у животных
Zimmermann High frequency/ultrasonic communication in basal primates: The mouse and dwarf lemurs of Madagascar
Johnson et al. Phylogenetic constraint on male parental care in the dabbling ducks
SE9802998L (sv) Djurbås
Noakes et al. Behavioural ecology and production of riverine fishes.
Linzey Postnatal growth and development of Peromyscus maniculatus nubiterrae
ATE407555T1 (de) Efficienter kerntransfer mit primordialen keimzellen
DE3667235D1 (de) Schutzvorrichtung fuer pferde.
Selaas A comparison of the diet of sympatric owls in Aust-Agder county, southern Norway.
Meinig et al. The masked singer: vocalization in the Garden Dormouse (Eliomys quercinus)
DK1280404T3 (da) Model for neurodegenerativ sygdom
ITMI921912A1 (it) Guanto, reversibile in sacchetto per la raccolta e l'eliminazione di escrementi di animali domestici
RU97107909A (ru) Штамм гибридных культивируемых клеток животного rattus norvegicus, используемый для получения моноклональных антител к вирусу гепатита а человека

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1151010

Country of ref document: EP

REN Ceased due to non-payment of the annual fee