DK0839132T5 - Fremgangsmåde til fremstilling af amorft [R-(R*,R*)]-2-(4-fluorphenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyrecalciumsalt (2:1) - Google Patents

Fremgangsmåde til fremstilling af amorft [R-(R*,R*)]-2-(4-fluorphenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyrecalciumsalt (2:1)

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Publication number
DK0839132T5
DK0839132T5 DK96924553T DK96924553T DK0839132T5 DK 0839132 T5 DK0839132 T5 DK 0839132T5 DK 96924553 T DK96924553 T DK 96924553T DK 96924553 T DK96924553 T DK 96924553T DK 0839132 T5 DK0839132 T5 DK 0839132T5
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DK
Denmark
Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
dihydroxy
Prior art date
Application number
DK96924553T
Other languages
Danish (da)
English (en)
Other versions
DK0839132T3 (da
Inventor
Dieter Schweiss
Min Lin
Original Assignee
Warner Lambert Co
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696097&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0839132(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK0839132T3 publication Critical patent/DK0839132T3/da
Publication of DK0839132T5 publication Critical patent/DK0839132T5/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DK96924553T 1995-07-17 1996-07-16 Fremgangsmåde til fremstilling af amorft [R-(R*,R*)]-2-(4-fluorphenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyrecalciumsalt (2:1) DK0839132T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145395P 1995-07-17 1995-07-17
PCT/US1996/011807 WO1997003960A1 (en) 1995-07-17 1996-07-16 NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS [R-(R*,R*)]-2-(4-FLUOROPHENYL)-β,δ-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1)

Publications (2)

Publication Number Publication Date
DK0839132T3 DK0839132T3 (da) 2001-04-09
DK0839132T5 true DK0839132T5 (da) 2006-03-20

Family

ID=21696097

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96924553T DK0839132T5 (da) 1995-07-17 1996-07-16 Fremgangsmåde til fremstilling af amorft [R-(R*,R*)]-2-(4-fluorphenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyrecalciumsalt (2:1)

Country Status (37)

Country Link
US (1) US6274740B1 (cs)
EP (1) EP0839132B1 (cs)
JP (1) JP4064459B2 (cs)
KR (1) KR100400805B1 (cs)
CN (1) CN1087289C (cs)
AR (1) AR002849A1 (cs)
AT (1) ATE199542T1 (cs)
AU (1) AU700794B2 (cs)
BG (1) BG63631B1 (cs)
BR (1) BR9609714A (cs)
CA (1) CA2220455C (cs)
CO (1) CO4700441A1 (cs)
CZ (1) CZ289421B6 (cs)
DE (1) DE69611999T2 (cs)
DK (1) DK0839132T5 (cs)
EA (1) EA000625B1 (cs)
EE (1) EE03605B1 (cs)
ES (1) ES2156997T3 (cs)
GE (1) GEP20002027B (cs)
GR (1) GR3035859T3 (cs)
HR (1) HRP960312B1 (cs)
HU (1) HU220343B (cs)
IL (1) IL122161A (cs)
IN (1) IN185276B (cs)
MX (1) MX9708959A (cs)
NO (1) NO309322B1 (cs)
NZ (1) NZ313008A (cs)
PE (1) PE1698A1 (cs)
PL (1) PL191017B1 (cs)
PT (1) PT839132E (cs)
RO (1) RO120069B1 (cs)
SI (1) SI0839132T1 (cs)
SK (1) SK283204B6 (cs)
UA (1) UA50743C2 (cs)
UY (1) UY24286A1 (cs)
WO (1) WO1997003960A1 (cs)
ZA (1) ZA966043B (cs)

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SI20425A (sl) 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
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IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
CA2622727A1 (en) 2000-12-27 2002-07-04 Teva Pharmaceutical Industries Ltd. Crystalline forms of atorvastatin
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WO2003018547A2 (en) 2001-08-31 2003-03-06 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
AU2002247944B2 (en) * 2002-03-18 2009-05-21 Biocon Limited Amorphous Hmg-CoA reductase inhibitors of desired particle size
RU2309141C2 (ru) * 2002-03-18 2007-10-27 Байокон Лимитид АМОРФНЫЕ ИНГИБИТОРЫ ГМГ-КоА-РЕДУКТАЗЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
AU2002356423A1 (en) * 2002-05-28 2003-12-12 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
US7179942B2 (en) 2002-07-05 2007-02-20 Bicon Limited Halo-substituted active methylene compounds
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SI1631533T1 (sl) 2003-04-22 2009-08-31 Bicon Ltd Nov postopek za stereoselektivno redukcijo beta - ketoestrov
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
AU2003272080A1 (en) 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CZ298382B6 (cs) * 2004-03-10 2007-09-12 Zentiva, A. S. Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace
DK1727795T3 (da) * 2004-03-17 2012-04-16 Ranbaxy Lab Ltd Fremgangsmåde til fremstillingen af atorvastatin-calcium i amorf form
JP2007536373A (ja) 2004-05-05 2007-12-13 ファイザー・プロダクツ・インク アトルバスタチンの塩形態
CN1997651B (zh) * 2004-07-16 2012-06-06 力奇制药公司 阿托伐他汀钙的氧化降解产物
WO2006021969A1 (en) 2004-08-27 2006-03-02 Biocon Limited Process for atorvastatin calcium amorphous
KR20070106680A (ko) * 2004-09-30 2007-11-05 닥터 레디스 레보러터리즈 리미티드 비정질 아토르바스타틴 칼슘
EP1716114A1 (en) * 2004-10-18 2006-11-02 Teva Pharmaceutical Industries Ltd. Process for preparing amorphous atorvastatin hemi-calcium by dissolving the salt in an organic solvent which is a mixture of an alcohol and a ketone and/or an ester and removing the solvent
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EP1819319A1 (en) * 2004-12-02 2007-08-22 Warner-Lambert Company LLC Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
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EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
JP2007231018A (ja) * 2006-03-01 2007-09-13 Teva Pharmaceutical Industries Ltd アトルバスタチンヘミカルシウムの結晶形の調製方法
US20100113802A1 (en) * 2006-11-02 2010-05-06 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate
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US20090124817A1 (en) * 2007-11-09 2009-05-14 The Industry & Academic Cooperation In Chungnam National University Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles
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Also Published As

Publication number Publication date
UA50743C2 (uk) 2002-11-15
NO980209L (no) 1998-01-16
NO309322B1 (no) 2001-01-15
CN1190956A (zh) 1998-08-19
GEP20002027B (en) 2000-04-10
SK283204B6 (sk) 2003-03-04
DE69611999T2 (de) 2001-07-26
EE9700369A (et) 1998-06-15
HU220343B (hu) 2001-12-28
AU700794B2 (en) 1999-01-14
CA2220455C (en) 2002-09-24
IL122161A (en) 1999-07-14
BG63631B1 (bg) 2002-07-31
SK5898A3 (en) 1998-08-05
ZA966043B (en) 1997-02-03
CZ12298A3 (cs) 1998-12-16
PT839132E (pt) 2001-06-29
NZ313008A (en) 2000-01-28
PL324463A1 (en) 1998-05-25
CA2220455A1 (en) 1997-02-06
EE03605B1 (et) 2002-02-15
HRP960312A2 (en) 1998-02-28
GR3035859T3 (en) 2001-08-31
HUP9903017A3 (en) 2001-01-29
HRP960312B1 (en) 2001-10-31
SI0839132T1 (cs) 2001-06-30
CN1087289C (zh) 2002-07-10
AU6497896A (en) 1997-02-18
US6274740B1 (en) 2001-08-14
EA199800128A1 (ru) 1998-08-27
UY24286A1 (es) 1997-01-17
IL122161A0 (en) 1998-04-05
WO1997003960A1 (en) 1997-02-06
BG102188A (en) 1998-08-31
KR19990029045A (ko) 1999-04-15
MX9708959A (es) 1998-03-31
CO4700441A1 (es) 1998-12-29
RO120069B1 (ro) 2005-08-30
EA000625B1 (ru) 1999-12-29
ES2156997T3 (es) 2001-08-01
NO980209D0 (no) 1998-01-16
BR9609714A (pt) 1999-02-23
AR002849A1 (es) 1998-04-29
IN185276B (cs) 2000-12-16
HK1018054A1 (en) 1999-12-10
JPH11510486A (ja) 1999-09-14
PL191017B1 (pl) 2006-03-31
ATE199542T1 (de) 2001-03-15
CZ289421B6 (cs) 2002-01-16
KR100400805B1 (ko) 2003-12-24
JP4064459B2 (ja) 2008-03-19
EP0839132B1 (en) 2001-03-07
DE69611999D1 (de) 2001-04-12
PE1698A1 (es) 1998-02-19
DK0839132T3 (da) 2001-04-09
EP0839132A1 (en) 1998-05-06

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