DK0788498T3 - Phenyloxazolidinoner med antimikrobiel virkning - Google Patents

Phenyloxazolidinoner med antimikrobiel virkning

Info

Publication number
DK0788498T3
DK0788498T3 DK95933718T DK95933718T DK0788498T3 DK 0788498 T3 DK0788498 T3 DK 0788498T3 DK 95933718 T DK95933718 T DK 95933718T DK 95933718 T DK95933718 T DK 95933718T DK 0788498 T3 DK0788498 T3 DK 0788498T3
Authority
DK
Denmark
Prior art keywords
phenyloxazolidinones
antimicrobial action
species
bacteroids
enterococci
Prior art date
Application number
DK95933718T
Other languages
Danish (da)
English (en)
Inventor
Steven J Brickner
Michael R Barbachyn
Douglas K Hutchinson
Mikio Taniguchi
Kiyotaka Munesada
Hiroyoshi Yamada
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0788498T3 publication Critical patent/DK0788498T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK95933718T 1994-10-26 1995-09-12 Phenyloxazolidinoner med antimikrobiel virkning DK0788498T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32971794A 1994-10-26 1994-10-26
PCT/US1995/010992 WO1996013502A1 (en) 1994-10-26 1995-09-12 Phenyloxazolidinone antimicrobials

Publications (1)

Publication Number Publication Date
DK0788498T3 true DK0788498T3 (da) 2001-11-05

Family

ID=23286694

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95933718T DK0788498T3 (da) 1994-10-26 1995-09-12 Phenyloxazolidinoner med antimikrobiel virkning

Country Status (22)

Country Link
EP (1) EP0788498B1 (ja)
JP (1) JP3933198B2 (ja)
KR (1) KR100383403B1 (ja)
CN (1) CN1068325C (ja)
AT (1) ATE204277T1 (ja)
AU (1) AU694271B2 (ja)
BR (1) BR9509136A (ja)
CA (1) CA2200433C (ja)
CZ (1) CZ291847B6 (ja)
DE (1) DE69522234T2 (ja)
DK (1) DK0788498T3 (ja)
ES (1) ES2162941T3 (ja)
FI (1) FI971774A (ja)
HU (1) HU224044B1 (ja)
NO (1) NO309478B1 (ja)
NZ (1) NZ293741A (ja)
PL (1) PL183512B1 (ja)
PT (1) PT788498E (ja)
RU (1) RU2134692C1 (ja)
SI (1) SI0788498T1 (ja)
SK (1) SK282869B6 (ja)
WO (1) WO1996013502A1 (ja)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6964096A (en) * 1995-09-15 1997-04-01 Pharmacia & Upjohn Company Aminoaryl oxazolidinone n-oxides
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
ES2166073T3 (es) * 1996-04-11 2002-04-01 Upjohn Co Procedimiento para preparar oxazolidinonas.
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
AU764184B2 (en) 1998-01-23 2003-08-14 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
WO1999041244A1 (en) * 1998-02-13 1999-08-19 Pharmacia & Upjohn Company Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
PL345162A1 (en) 1998-06-05 2001-12-03 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
CA2360740A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
DE19919708A1 (de) * 1999-04-30 2001-03-01 Univ Stuttgart Stufenweise Alkylierung von polymeren Aminen
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
FR2802091A1 (fr) * 1999-12-08 2001-06-15 Oreal Compositions pour la teinture des fibres keratiniques contenant des derives de paraphenylenediamine a groupement azetidinyle
MXPA03003473A (es) 2000-10-17 2003-08-19 Upjohn Co Metodos para producir compuestos de oxazolidinona.
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
US7160912B2 (en) 2000-12-26 2007-01-09 Dr.Reddy's Laboratories Ltd. Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
CA2405532A1 (en) 2001-02-07 2002-08-22 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
ES2186550B2 (es) * 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
US6914058B2 (en) * 2002-01-18 2005-07-05 Dr. Reddy's Laboratories, Limited Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
WO2004007489A2 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them
WO2004007488A2 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them
US7094900B2 (en) 2002-08-12 2006-08-22 Pharmacia & Upjohn Company Llc N-Aryl-2-oxazolidinones and their derivatives
AU2003280143A1 (en) 2002-11-21 2004-06-15 Pharmacia & Upjohn Company Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7223788B2 (en) 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
FR2862969A1 (fr) * 2003-11-28 2005-06-03 Oreal Procede de preparation de derives paraphenylenediamine a groupement pyrrolidinyle, substitue par un radical azote, et composes intermediaires
WO2007004049A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidinones containing azetidine as antibacterial agents
CA2614105A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidinone carboxamides containing azetidine and cyclobutane as antibacterial agents
EP2173176B1 (en) 2007-07-24 2017-09-06 Dow Global Technologies LLC Methods of and formulations for reducing and inhibiting the growth of the concentration of microbes in water-based fluids
CN101754685B (zh) 2007-07-24 2015-09-16 陶氏环球技术公司 用于降低和抑制水基流体和与它们一起使用的系统中微生物浓度增加的方法和制剂
EP2141162A1 (en) 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-(n-heterocyclyl)-pyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
EP2141161A1 (en) * 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-cyanopyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
CN101798302B (zh) * 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
US20130296569A1 (en) 2010-11-03 2013-11-07 Vijaykumar Jagdishwar Patil Process for the preparation of phosphoric acid mono-(1--4-methoxymethyl-piperidin-4-yl) ester
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
ATE95176T1 (de) * 1987-10-21 1993-10-15 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel.
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
DE68918792T2 (de) * 1988-09-15 1995-03-30 Upjohn Co 5-Indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(Nitrogen-substituierte)phenyl-5-beta-amidomethyloxazolidin-2-one.
AU667198B2 (en) * 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents

Also Published As

Publication number Publication date
AU3625495A (en) 1996-05-23
CZ121797A3 (en) 1997-07-16
HUT77602A (hu) 1998-06-29
PL319873A1 (en) 1997-09-01
KR970707123A (ko) 1997-12-01
CN1162312A (zh) 1997-10-15
NZ293741A (en) 1998-06-26
KR100383403B1 (ko) 2004-05-31
ATE204277T1 (de) 2001-09-15
DE69522234D1 (de) 2001-09-20
FI971774A0 (fi) 1997-04-25
JPH10508017A (ja) 1998-08-04
NO971946D0 (no) 1997-04-25
CA2200433C (en) 2006-02-07
DE69522234T2 (de) 2002-05-16
PT788498E (pt) 2002-02-28
NO309478B1 (no) 2001-02-05
CZ291847B6 (cs) 2003-06-18
SK282869B6 (sk) 2003-01-09
FI971774A (fi) 1997-04-25
RU2134692C1 (ru) 1999-08-20
NO971946L (no) 1997-06-25
SK49497A3 (en) 1998-01-14
PL183512B1 (pl) 2002-06-28
CN1068325C (zh) 2001-07-11
AU694271B2 (en) 1998-07-16
CA2200433A1 (en) 1996-05-09
HU224044B1 (hu) 2005-05-30
EP0788498B1 (en) 2001-08-16
EP0788498A1 (en) 1997-08-13
WO1996013502A1 (en) 1996-05-09
SI0788498T1 (en) 2001-12-31
JP3933198B2 (ja) 2007-06-20
ES2162941T3 (es) 2002-01-16
BR9509136A (pt) 1998-07-21

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