ATE95176T1 - Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel. - Google Patents

Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel.

Info

Publication number
ATE95176T1
ATE95176T1 AT88117304T AT88117304T ATE95176T1 AT E95176 T1 ATE95176 T1 AT E95176T1 AT 88117304 T AT88117304 T AT 88117304T AT 88117304 T AT88117304 T AT 88117304T AT E95176 T1 ATE95176 T1 AT E95176T1
Authority
AT
Austria
Prior art keywords
ethenylbenzene
aminomethyl
derivates
oxazolidinyl
oxo
Prior art date
Application number
AT88117304T
Other languages
English (en)
Inventor
David Ross Brittelli
Walter Adelman Gregory
Peter Franklin Corless
Chung-Ho Park
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Application granted granted Critical
Publication of ATE95176T1 publication Critical patent/ATE95176T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT88117304T 1987-10-21 1988-10-18 Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel. ATE95176T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11083787A 1987-10-21 1987-10-21
EP88117304A EP0316594B1 (de) 1987-10-21 1988-10-18 Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel

Publications (1)

Publication Number Publication Date
ATE95176T1 true ATE95176T1 (de) 1993-10-15

Family

ID=22335197

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88117304T ATE95176T1 (de) 1987-10-21 1988-10-18 Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel.

Country Status (18)

Country Link
EP (1) EP0316594B1 (de)
JP (1) JPH01135777A (de)
KR (1) KR890006603A (de)
AT (1) ATE95176T1 (de)
AU (1) AU617697B2 (de)
CA (1) CA1317594C (de)
DE (1) DE3884563T2 (de)
DK (1) DK584188A (de)
ES (1) ES2059467T3 (de)
FI (1) FI884849A7 (de)
HU (1) HU201915B (de)
IL (1) IL88107A (de)
MY (1) MY103433A (de)
NO (1) NO884676L (de)
NZ (1) NZ226631A (de)
PT (1) PT88811B (de)
RU (1) RU1801109C (de)
ZA (1) ZA887853B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032605A (en) * 1987-10-09 1991-07-16 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
HUT74099A (en) * 1992-12-08 1996-11-28 Upjohn Co Tropone-substituted phenyloxazolidinone antibacterial agents and pharmaceutical compositions containing the same
TW299332B (de) * 1992-12-08 1997-03-01 Upjohn Co
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
EP0730591B1 (de) * 1993-11-22 1999-07-14 PHARMACIA & UPJOHN COMPANY Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester
CA2200433C (en) * 1994-10-26 2006-02-07 Douglas K. Hutchinson Phenyloxazolidinone antimicrobials
PT792273E (pt) * 1994-11-15 2003-06-30 Upjohn Co Produtos antibacterianos de oxazolidinona substituida com oxazina e tiazina biciclicas
DK0807112T3 (da) * 1995-02-03 2001-12-17 Upjohn Co Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon
DE69614847T2 (de) * 1995-05-11 2002-04-04 Pharmacia & Upjohn Co., Kalamazoo Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone
MX9703040A (es) * 1995-09-12 1997-07-31 Upjohn Co Antimicrobianos de feniloxazolidinona.
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
DK0918746T3 (da) 1996-08-12 2003-08-04 Celgene Corp Immunterapeutiske midler og deres anvendelse til reduktion af cytokinniveauer
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
ES2207010T3 (es) * 1997-11-12 2004-05-16 PHARMACIA & UPJOHN COMPANY Derivados de oxazolidinona y composiciones farmaceuticas.
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6239152B1 (en) 1998-01-23 2001-05-29 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
AU773359B2 (en) * 1999-07-28 2004-05-20 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
WO2002018354A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Oxazolidinones and their use as antibacterial agents
WO2002020515A1 (en) * 2000-09-08 2002-03-14 Abbott Laboratories Oxazolidinone antibacterial agents
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
US7470723B2 (en) 2003-03-05 2008-12-30 Celgene Corporation Diphenylethylene compounds and uses thereof
WO2004078144A2 (en) 2003-03-05 2004-09-16 Celgene Corporation Diphenylethylene compounds and uses thereof
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
JP2008512378A (ja) 2004-09-03 2008-04-24 セルジーン・コーポレーション 置換複素環式化合物及びその使用
EP1685841A1 (de) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prophylaxe und Behandlung von thrombolischen Erkrankungen
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
RU2429236C2 (ru) 2005-10-04 2011-09-20 Байер Шеринг Фарма Акциенгезельшафт Новая полиморфная форма и аморфная форма 5-хлор-n-({(5s)-2-оксо-3-[4-(3-оксо-4-морфолинил)-фенил]-1, 3-оксазолидин-5-ил}-метил)-2-тиофенкарбоксамида
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
NZ587096A (en) 2008-03-26 2011-11-25 Global Alliance For Tb Drug Dev Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
EP3498273A1 (de) * 2017-12-14 2019-06-19 Universität Wien Pharmazeutische zusammensetzung zur modulierung der response des gaba-a rezeptors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
DK584188A (da) 1989-04-22
FI884849A0 (fi) 1988-10-20
DE3884563D1 (de) 1993-11-04
NZ226631A (en) 1991-01-29
CA1317594C (en) 1993-05-11
NO884676D0 (no) 1988-10-20
PT88811B (pt) 1993-04-30
RU1801109C (ru) 1993-03-07
ZA887853B (en) 1990-06-27
NO884676L (no) 1989-04-24
ES2059467T3 (es) 1994-11-16
HUT52075A (en) 1990-06-28
DE3884563T2 (de) 1994-02-17
IL88107A (en) 1993-02-21
AU617697B2 (en) 1991-12-05
EP0316594B1 (de) 1993-09-29
IL88107A0 (en) 1989-06-30
EP0316594A1 (de) 1989-05-24
AU2404388A (en) 1989-04-27
KR890006603A (ko) 1989-06-14
FI884849A7 (fi) 1989-04-22
DK584188D0 (da) 1988-10-20
HU201915B (en) 1991-01-28
JPH01135777A (ja) 1989-05-29
MY103433A (en) 1993-06-30

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