HUT77602A - Mikrobicid hatású fenil-oxazolidinon-származékok és alkalmazásuk gyógyszerkészítmények előállítására - Google Patents

Mikrobicid hatású fenil-oxazolidinon-származékok és alkalmazásuk gyógyszerkészítmények előállítására

Info

Publication number
HUT77602A
HUT77602A HU9702015A HU9702015A HUT77602A HU T77602 A HUT77602 A HU T77602A HU 9702015 A HU9702015 A HU 9702015A HU 9702015 A HU9702015 A HU 9702015A HU T77602 A HUT77602 A HU T77602A
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
producing pharmaceutical
phenyloxazolidinone
antimicrobials
species
Prior art date
Application number
HU9702015A
Other languages
English (en)
Other versions
HU224044B1 (hu
Inventor
Michael R. Barbachyn
Steven Joseph Brickner
Douglas K. Hutchinson
Kiyotaka Munesada
Mikio Taniguchi
Hiroyoshi Yamada
Original Assignee
The Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Upjohn Company filed Critical The Upjohn Company
Publication of HUT77602A publication Critical patent/HUT77602A/hu
Publication of HU224044B1 publication Critical patent/HU224044B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU9702015A 1994-10-26 1995-09-12 Mikrobicid hatású fenil-oxazolidinon-származékok és alkalmazásuk gyógyszerkészítmények előállítására HU224044B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32971794A 1994-10-26 1994-10-26
PCT/US1995/010992 WO1996013502A1 (en) 1994-10-26 1995-09-12 Phenyloxazolidinone antimicrobials

Publications (2)

Publication Number Publication Date
HUT77602A true HUT77602A (hu) 1998-06-29
HU224044B1 HU224044B1 (hu) 2005-05-30

Family

ID=23286694

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702015A HU224044B1 (hu) 1994-10-26 1995-09-12 Mikrobicid hatású fenil-oxazolidinon-származékok és alkalmazásuk gyógyszerkészítmények előállítására

Country Status (22)

Country Link
EP (1) EP0788498B1 (hu)
JP (1) JP3933198B2 (hu)
KR (1) KR100383403B1 (hu)
CN (1) CN1068325C (hu)
AT (1) ATE204277T1 (hu)
AU (1) AU694271B2 (hu)
BR (1) BR9509136A (hu)
CA (1) CA2200433C (hu)
CZ (1) CZ291847B6 (hu)
DE (1) DE69522234T2 (hu)
DK (1) DK0788498T3 (hu)
ES (1) ES2162941T3 (hu)
FI (1) FI971774A0 (hu)
HU (1) HU224044B1 (hu)
NO (1) NO309478B1 (hu)
NZ (1) NZ293741A (hu)
PL (1) PL183512B1 (hu)
PT (1) PT788498E (hu)
RU (1) RU2134692C1 (hu)
SI (1) SI0788498T1 (hu)
SK (1) SK282869B6 (hu)
WO (1) WO1996013502A1 (hu)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2214546T3 (es) * 1995-09-15 2004-09-16 PHARMACIA & UPJOHN COMPANY N-oxidos de aminoariloxazolidinona.
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
CN1167701C (zh) * 1996-04-11 2004-09-22 法玛西雅厄普约翰美国公司 制备噁唑烷酮胺的方法
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1049682A1 (en) 1998-01-23 2000-11-08 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
NZ506292A (en) * 1998-02-13 2003-05-30 Upjohn Co Substituted aminophenyl isoxazoline methylamide derivatives useful as antimicrobials
IL140084A0 (en) 1998-06-05 2002-02-10 Astra Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
DE19919708A1 (de) * 1999-04-30 2001-03-01 Univ Stuttgart Stufenweise Alkylierung von polymeren Aminen
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
FR2802091A1 (fr) * 1999-12-08 2001-06-15 Oreal Compositions pour la teinture des fibres keratiniques contenant des derives de paraphenylenediamine a groupement azetidinyle
DE60118241T2 (de) 2000-10-17 2006-12-28 Pharmacia & Upjohn Co. Llc, Kalamazoo Verfahren zur herstellung von oxazolidinonverbindungen
US7160912B2 (en) 2000-12-26 2007-01-09 Dr.Reddy's Laboratories Ltd. Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
YU52403A (sh) * 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
JP2004518724A (ja) * 2001-02-07 2004-06-24 オーソーマクニール ファーマシューティカル， インコーポレイテッド ピリドアリールフェニル・オキサゾリジノン抗菌剤、および関連の組成物および方法
ES2186550B2 (es) * 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
US6914058B2 (en) * 2002-01-18 2005-07-05 Dr. Reddy's Laboratories, Limited Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
WO2004007488A2 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them
AU2003272071A1 (en) * 2002-07-11 2004-02-02 Wockhardt Limited Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them
EP1539745B1 (en) 2002-08-12 2006-03-29 Pharmacia & Upjohn Company LLC N-aryl-2-oxazolidinones and their derivatives
US7141570B2 (en) 2002-11-21 2006-11-28 Pharmacia & Upjohn Company N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
US7223788B2 (en) 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
FR2862969A1 (fr) * 2003-11-28 2005-06-03 Oreal Procede de preparation de derives paraphenylenediamine a groupement pyrrolidinyle, substitue par un radical azote, et composes intermediaires
WO2007004049A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidinones containing azetidine as antibacterial agents
JP2009500389A (ja) * 2005-07-06 2009-01-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのアゼチジンおよびシクロブタンを含むオキサゾリジノンカルボキサミド
CN101754685B (zh) * 2007-07-24 2015-09-16 陶氏环球技术公司 用于降低和抑制水基流体和与它们一起使用的系统中微生物浓度增加的方法和制剂
WO2009015089A2 (en) 2007-07-24 2009-01-29 Dow Global Technologies Inc. Methods of and formulations for reducing and inhibiting the growth of the concentration of microbes in water-based fluids and systems used with them
EP2141162A1 (en) 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-(n-heterocyclyl)-pyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
EP2141161A1 (en) * 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-cyanopyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
CN101798302B (zh) * 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
EP2635589A1 (en) 2010-11-03 2013-09-11 Wockhardt Limited Process for the preparation of phosphoric acid mono- (l-{4- [(s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- 3 - yl]- 2, 6 - difluorophenyl} - 4 -methoxymethylpiperidin- 4 - yl) ester
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1317594C (en) * 1987-10-21 1993-05-11 Chung-Ho Park Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
EP0609905B1 (en) * 1988-09-15 2001-06-06 PHARMACIA & UPJOHN COMPANY 3-(Nitrogen substituted)phenyl-5beta-amidomethyloxazolidin-2-ones
WO1993009103A1 (en) * 1991-11-01 1993-05-13 The Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents

Also Published As

Publication number Publication date
BR9509136A (pt) 1998-07-21
PL183512B1 (pl) 2002-06-28
CN1162312A (zh) 1997-10-15
HU224044B1 (hu) 2005-05-30
JP3933198B2 (ja) 2007-06-20
CA2200433C (en) 2006-02-07
SI0788498T1 (en) 2001-12-31
RU2134692C1 (ru) 1999-08-20
DE69522234D1 (de) 2001-09-20
WO1996013502A1 (en) 1996-05-09
JPH10508017A (ja) 1998-08-04
CN1068325C (zh) 2001-07-11
CZ291847B6 (cs) 2003-06-18
FI971774A (fi) 1997-04-25
EP0788498B1 (en) 2001-08-16
NZ293741A (en) 1998-06-26
ES2162941T3 (es) 2002-01-16
FI971774A0 (fi) 1997-04-25
NO971946L (no) 1997-06-25
PL319873A1 (en) 1997-09-01
AU3625495A (en) 1996-05-23
NO971946D0 (no) 1997-04-25
NO309478B1 (no) 2001-02-05
CA2200433A1 (en) 1996-05-09
SK49497A3 (en) 1998-01-14
SK282869B6 (sk) 2003-01-09
AU694271B2 (en) 1998-07-16
ATE204277T1 (de) 2001-09-15
KR100383403B1 (ko) 2004-05-31
EP0788498A1 (en) 1997-08-13
DE69522234T2 (de) 2002-05-16
DK0788498T3 (da) 2001-11-05
KR970707123A (ko) 1997-12-01
PT788498E (pt) 2002-02-28
CZ121797A3 (en) 1997-07-16

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20050318

MM4A Lapse of definitive patent protection due to non-payment of fees