DK0752857T3 - Forbedret fremgangsmåde til syntese af 6,9-bis[(2-aminoethyl)-amino]bonzo[g]isoquinolin-5,10-dion og dimaleatsaltet deraf - Google Patents

Forbedret fremgangsmåde til syntese af 6,9-bis[(2-aminoethyl)-amino]bonzo[g]isoquinolin-5,10-dion og dimaleatsaltet deraf

Info

Publication number
DK0752857T3
DK0752857T3 DK95912387T DK95912387T DK0752857T3 DK 0752857 T3 DK0752857 T3 DK 0752857T3 DK 95912387 T DK95912387 T DK 95912387T DK 95912387 T DK95912387 T DK 95912387T DK 0752857 T3 DK0752857 T3 DK 0752857T3
Authority
DK
Denmark
Prior art keywords
isoquinoline
aminoethyl
bis
amino
dione
Prior art date
Application number
DK95912387T
Other languages
Danish (da)
English (en)
Inventor
Silvano Spinelli
Roberto Didomenico
Original Assignee
Novuspharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma Spa filed Critical Novuspharma Spa
Application granted granted Critical
Publication of DK0752857T3 publication Critical patent/DK0752857T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK95912387T 1994-03-28 1995-03-27 Forbedret fremgangsmåde til syntese af 6,9-bis[(2-aminoethyl)-amino]bonzo[g]isoquinolin-5,10-dion og dimaleatsaltet deraf DK0752857T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/220,007 US5506232A (en) 1994-03-28 1994-03-28 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
PCT/IB1995/000230 WO1995026189A1 (en) 1994-03-28 1995-03-27 AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS[(2-AMINOETHYL)AMINO]BENZO[g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT

Publications (1)

Publication Number Publication Date
DK0752857T3 true DK0752857T3 (da) 2001-09-24

Family

ID=22821665

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95912387T DK0752857T3 (da) 1994-03-28 1995-03-27 Forbedret fremgangsmåde til syntese af 6,9-bis[(2-aminoethyl)-amino]bonzo[g]isoquinolin-5,10-dion og dimaleatsaltet deraf

Country Status (24)

Country Link
US (3) US5506232A (ko)
EP (1) EP0752857B1 (ko)
JP (2) JP3151462B2 (ko)
KR (1) KR100224153B1 (ko)
CN (2) CN1130199C (ko)
AT (1) ATE203408T1 (ko)
AU (1) AU679627B2 (ko)
BR (1) BR9507257A (ko)
CA (1) CA2186485C (ko)
CZ (2) CZ598A3 (ko)
DE (1) DE69521887T2 (ko)
DK (1) DK0752857T3 (ko)
ES (1) ES2159313T3 (ko)
FI (1) FI113861B (ko)
GR (1) GR3037014T3 (ko)
HU (1) HU223311B1 (ko)
LU (1) LU92089I2 (ko)
NO (2) NO307564B1 (ko)
NZ (1) NZ282480A (ko)
PT (1) PT752857E (ko)
RU (1) RU2144028C1 (ko)
TW (1) TW397826B (ko)
WO (1) WO1995026189A1 (ko)
ZA (1) ZA952477B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
SK281254B6 (sk) * 1995-07-13 2001-01-18 Smithkline Beecham Corporation Použitie@kán-2-propánamínu, farmaceutický prostriedok s jeho obsahom a jeho použitie
IT1315253B1 (it) * 1999-10-22 2003-02-03 Novuspharma Spa Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato
WO2005097128A1 (en) * 2004-03-30 2005-10-20 Novacea, Inc. 1,4-bis-n-oxide azaanthracenediones and the use thereof
US20080081041A1 (en) * 2006-09-29 2008-04-03 Jeffrey Nemeth Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺
CN110873765B (zh) * 2018-09-04 2022-05-17 北京凯莱天成医药科技有限公司 一种马来酸匹杉琼有关物质的检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE920754A1 (en) * 1991-03-08 1992-09-09 Univ Vermont 6,9 BIS(SUBSTITUTED-AMINO) BENZO[g]-ISOQUINOLINE-5,10-DIONES
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
WO1995026189A1 (en) 1995-10-05
JP3151462B2 (ja) 2001-04-03
CA2186485A1 (en) 1995-10-05
NO964082L (no) 1996-09-27
NZ282480A (en) 1997-04-24
FI963864A (fi) 1996-09-27
HU9602655D0 (en) 1996-11-28
ZA952477B (en) 1996-09-27
HU223311B1 (hu) 2004-05-28
US5506232A (en) 1996-04-09
HUT75654A (en) 1997-05-28
PT752857E (pt) 2001-11-30
AU1958995A (en) 1995-10-17
JP3548099B2 (ja) 2004-07-28
DE69521887T2 (de) 2001-11-22
MX9603994A (es) 1997-12-31
NO2012020I2 (no) 2013-11-11
US5616709A (en) 1997-04-01
CZ285139B6 (cs) 1999-05-12
CN1130199C (zh) 2003-12-10
GR3037014T3 (en) 2002-01-31
RU2144028C1 (ru) 2000-01-10
CA2186485C (en) 1999-12-14
LU92089I2 (fr) 2012-12-27
CN1282738A (zh) 2001-02-07
NO964082D0 (no) 1996-09-27
TW397826B (en) 2000-07-11
FI113861B (fi) 2004-06-30
ATE203408T1 (de) 2001-08-15
JP2001089454A (ja) 2001-04-03
CZ284937B6 (cs) 1999-04-14
NO2012020I1 (no) 2012-12-27
CZ598A3 (cs) 1999-05-12
NO307564B1 (no) 2000-04-25
EP0752857B1 (en) 2001-07-25
CZ276796A3 (en) 1997-02-12
AU679627B2 (en) 1997-07-03
JPH09507674A (ja) 1997-08-05
DE69521887D1 (de) 2001-08-30
CN1145028A (zh) 1997-03-12
KR100224153B1 (ko) 1999-10-15
EP0752857A1 (en) 1997-01-15
ES2159313T3 (es) 2001-10-01
US5717099A (en) 1998-02-10
FI963864A0 (fi) 1996-09-27
BR9507257A (pt) 1997-10-07

Similar Documents

Publication Publication Date Title
NO2012020I2 (no) Piksantron dimaleatsalt
DK0582790T3 (da) Ny fremgangsmåde til fremstilling af 7-substituerede-9-[(substitueret glycyl)-amino]-6-demethyl-6-deoxytetracycliner
DE69816056D1 (de) Kristallinisches aminsalz von cefdinir
DK0629608T3 (da) Fremgangsmåde til fremstilling af N-acyl-N,N',N'-ethylendiamintrieddikesyrederivater
DK0789578T3 (da) Inhibitorer af multikatalytisk protease
KR960702830A (ko) 방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents)
ATE288900T1 (de) Substituierte benzoylcyclohexandione
NO962985D0 (no) Tverrbundne polymere ammoniumsalter
PT906303E (pt) Dihidropiranos de aneis geminados, processo para a sua producao bem como a sua utilizacao
BR0311590A (pt) Agonistas de brs-3 não-peptìdicos
EA200200389A1 (ru) Липосомный препарат 6,9-бис[(2-аминоэтил)-амино]бензо[g]изохинолин-5,10-диона дималеата
SE9602416D0 (sv) New forms of an organic salt of N'N-diacetylcystine
EP0816328A3 (en) Process for the manufacture of acetonylbenzamides
FI945414A0 (fi) Menetelmä N,N-disubstituoidun aminofenolin valmistamiseksi
BR0108622A (pt) Processo para a n-formilação seletiva de n-hidroxil aminas
FR2654430B1 (fr) Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes.
FR2705971B1 (fr) Production de gamma-décalactone par bioconversion.
DK0691986T3 (da) Hidtil ukendte fremgangsmåder og mellemproduktforbindelser til fremstillingen af blodpladeglycoprotein IIb/IIIa-inhibitorer
ES2091071T3 (es) Compuestos ternarios en el sistema al-b-p, procedimiento para su obtencion.
ES2115950T3 (es) Preparacion de n-cianoditioiminocarbonatos disustituidos, simetricos o asimetricos.
PT90831A (pt) Processo para a preparacao de eteres da 2-amino-7-hidroxitetralina
DK199801009A (da) Fremgangsmåde til fremstilling af et naphthalenderivat og naphthalenderivat anvendeligt som mellemprodukt i denne fremgangs
ATE168683T1 (de) Substituierte iminoacetonitrile mit myokardprotektiver wirkung
GR1001635B (el) Μέ?οδος παρασκευής 3-[2-(διμε?υλαμινο)-αι?υλο]-ν-με?υλο-1η-ινδόλης-5-με?ανοσουλφοναμίδης.
SU1690339A1 (ru) N-(3-хлоро-1,4-нафтохинонил-2)-2-d,l-аспарагиновая кислота, проявляющая кардиостимулирующие свойства