BR0311590A - Agonistas de brs-3 não-peptìdicos - Google Patents
Agonistas de brs-3 não-peptìdicosInfo
- Publication number
- BR0311590A BR0311590A BR0311590-9A BR0311590A BR0311590A BR 0311590 A BR0311590 A BR 0311590A BR 0311590 A BR0311590 A BR 0311590A BR 0311590 A BR0311590 A BR 0311590A
- Authority
- BR
- Brazil
- Prior art keywords
- brs
- agonists
- peptide
- compounds
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
"AGONISTAS DE BRS-3 NãO-PEPTìDICOS". A presente invenção refere-se a novos compostos da fórmula geral (I) com atividade agonista seletiva de BRS-3, em que A^ 1^, A^ 2^ , A^ 3^ , R^ 1^, R^ 2^, R^ 3^, Ar^ 1^, Ar^ 2^, Ar^ 3^, m e n possuem os significados definidos na descrição, bem como os medicamentos que contêm estes compostos e um processo para a preparação de compostos da fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10224844A DE10224844A1 (de) | 2002-06-05 | 2002-06-05 | Nicht-peptidische BRS-3-Agonisten |
PCT/EP2003/005678 WO2003104196A1 (de) | 2002-06-05 | 2003-05-30 | Nicht-peptidische brs-3-agonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311590A true BR0311590A (pt) | 2005-05-10 |
Family
ID=29718840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311590-9A BR0311590A (pt) | 2002-06-05 | 2003-05-30 | Agonistas de brs-3 não-peptìdicos |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1513811B1 (pt) |
JP (1) | JP4594084B2 (pt) |
CN (1) | CN1649840A (pt) |
AT (1) | ATE427934T1 (pt) |
AU (1) | AU2003232842A1 (pt) |
BR (1) | BR0311590A (pt) |
CA (1) | CA2497609A1 (pt) |
DE (2) | DE10224844A1 (pt) |
ES (1) | ES2324709T3 (pt) |
HK (1) | HK1080077A1 (pt) |
MX (1) | MXPA04011991A (pt) |
WO (1) | WO2003104196A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10311984A1 (de) * | 2003-03-12 | 2004-09-23 | Freie Universität Berlin | Verwendung von NEP-assoziierten Molekülen zur Behandlung von nichtimmunogenen-nichthypertensiven Zivilisationskrankheiten |
GB0328796D0 (en) * | 2003-12-12 | 2004-01-14 | Biofocus Plc | Compounds which interact with the G-protein coupled receptor family |
AU2006285393A1 (en) * | 2005-04-27 | 2007-03-08 | Arena Pharmaceuticals, Inc. | Combination therapy for the treatment of obesity and diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level |
JP2010506916A (ja) | 2006-10-20 | 2010-03-04 | メルク エンド カムパニー インコーポレーテッド | ボンベシンレセプターサブタイプ3モジュレーターとしての置換イミダゾール |
EP2083623A1 (en) | 2006-10-20 | 2009-08-05 | Merck & Co., Inc. | Substituted imidazoles as bombesin receptor subtype-3 modulators |
KR20090064458A (ko) | 2006-10-20 | 2009-06-18 | 머크 앤드 캄파니 인코포레이티드 | 봄베신 수용체 아형-3 조절제로서의 치환된 이미다졸 |
US8153626B2 (en) | 2006-12-11 | 2012-04-10 | Merck Sharp & Dohme Corp. | Substituted diazepine sulfonamides as bombesin receptor subtype-3 modulators |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565568A (en) * | 1995-04-06 | 1996-10-15 | Eli Lilly And Company | 2-acylaminopropanamides as tachykinin receptor antagonists |
EP0761220A1 (en) * | 1995-08-21 | 1997-03-12 | Eli Lilly And Company | 2-Acylaminopropanamides as growth hormone secretagogues |
-
2002
- 2002-06-05 DE DE10224844A patent/DE10224844A1/de not_active Withdrawn
-
2003
- 2003-05-30 ES ES03757007T patent/ES2324709T3/es not_active Expired - Lifetime
- 2003-05-30 BR BR0311590-9A patent/BR0311590A/pt not_active IP Right Cessation
- 2003-05-30 WO PCT/EP2003/005678 patent/WO2003104196A1/de active Application Filing
- 2003-05-30 AU AU2003232842A patent/AU2003232842A1/en not_active Abandoned
- 2003-05-30 CN CNA038100762A patent/CN1649840A/zh active Pending
- 2003-05-30 CA CA002497609A patent/CA2497609A1/en not_active Abandoned
- 2003-05-30 JP JP2004511266A patent/JP4594084B2/ja not_active Expired - Fee Related
- 2003-05-30 EP EP03757007A patent/EP1513811B1/de not_active Expired - Lifetime
- 2003-05-30 AT AT03757007T patent/ATE427934T1/de not_active IP Right Cessation
- 2003-05-30 DE DE50311388T patent/DE50311388D1/de not_active Expired - Lifetime
- 2003-05-30 MX MXPA04011991A patent/MXPA04011991A/es unknown
-
2006
- 2006-01-04 HK HK06100076.1A patent/HK1080077A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003232842A1 (en) | 2003-12-22 |
EP1513811A1 (de) | 2005-03-16 |
JP2005535610A (ja) | 2005-11-24 |
HK1080077A1 (zh) | 2006-04-21 |
DE10224844A1 (de) | 2004-01-08 |
WO2003104196A1 (de) | 2003-12-18 |
CA2497609A1 (en) | 2003-12-18 |
ES2324709T3 (es) | 2009-08-13 |
MXPA04011991A (es) | 2005-03-07 |
EP1513811B1 (de) | 2009-04-08 |
CN1649840A (zh) | 2005-08-03 |
JP4594084B2 (ja) | 2010-12-08 |
ATE427934T1 (de) | 2009-04-15 |
DE50311388D1 (de) | 2009-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2064 DE 27/07/2010. |