DK0741710T3 - Chlorpyrimidin-mellemprodukter - Google Patents

Chlorpyrimidin-mellemprodukter

Info

Publication number
DK0741710T3
DK0741710T3 DK95907107T DK95907107T DK0741710T3 DK 0741710 T3 DK0741710 T3 DK 0741710T3 DK 95907107 T DK95907107 T DK 95907107T DK 95907107 T DK95907107 T DK 95907107T DK 0741710 T3 DK0741710 T3 DK 0741710T3
Authority
DK
Denmark
Prior art keywords
intermediates
processes
chloropyrimidine
chloropyrimidine intermediates
aminopurines
Prior art date
Application number
DK95907107T
Other languages
Danish (da)
English (en)
Inventor
Susan Mary Daluge
Michael Tolar Martin
Michelle Joanne Ferry Fugett
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10749873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0741710(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of DK0741710T3 publication Critical patent/DK0741710T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Liquid Crystal Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK95907107T 1994-02-04 1995-02-03 Chlorpyrimidin-mellemprodukter DK0741710T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9402161A GB9402161D0 (en) 1994-02-04 1994-02-04 Chloropyrimidine intermediates
PCT/GB1995/000225 WO1995021161A1 (en) 1994-02-04 1995-02-03 Chloropyrimide intermediates

Publications (1)

Publication Number Publication Date
DK0741710T3 true DK0741710T3 (da) 2000-08-14

Family

ID=10749873

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95907107T DK0741710T3 (da) 1994-02-04 1995-02-03 Chlorpyrimidin-mellemprodukter

Country Status (28)

Country Link
US (8) US6448403B1 (de)
EP (1) EP0741710B1 (de)
JP (1) JP3670012B2 (de)
KR (1) KR100355983B1 (de)
CN (2) CN1105109C (de)
AT (1) ATE192742T1 (de)
AU (1) AU690203B2 (de)
BR (1) BR9506667A (de)
DE (1) DE69516847T2 (de)
DK (1) DK0741710T3 (de)
ES (1) ES2148486T3 (de)
FI (1) FI112477B (de)
GB (1) GB9402161D0 (de)
GR (1) GR3033850T3 (de)
HK (1) HK1004087A1 (de)
HU (1) HU223096B1 (de)
IL (1) IL112539A (de)
MX (1) MX9603091A (de)
MY (1) MY113775A (de)
NO (1) NO310819B1 (de)
NZ (1) NZ278948A (de)
PL (1) PL183885B1 (de)
PT (1) PT741710E (de)
RU (1) RU2140913C1 (de)
SG (1) SG47918A1 (de)
TW (1) TW390877B (de)
WO (1) WO1995021161A1 (de)
ZA (1) ZA95884B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
CA2145928C (en) * 1994-04-27 2007-10-09 Gerhard Stucky N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation
SK285229B6 (sk) 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu
GB9721780D0 (en) * 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
AU2702899A (en) * 1997-10-24 1999-05-17 Glaxo Group Limited Process for preparing a chiral nucleoside analogue
WO1999024431A1 (en) * 1997-11-12 1999-05-20 Glaxo Group Limited Process for preparing a chiral nucleoside analogue
CZ298144B6 (cs) 1997-11-27 2007-07-04 Lonza Ag Zpusob výroby (1S,4R)- nebo (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyklopenten-1-methanolu
DK1013647T3 (da) * 1998-12-21 2003-03-10 Lonza Ag Fremgangsmåde til fremstilling af N-(amino-4,6-dihalogenpyrimidin)-formamider
AU2002252179A1 (en) * 2001-03-01 2002-09-19 Conforma Therapeutics Corp. Methods for treating genetically-defined proliferative disorders with hsp90 inhibitors
US20070129334A1 (en) * 2001-10-30 2007-06-07 Conforma Therapeutics Corporation Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
WO2003037860A2 (en) * 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
KR100573859B1 (ko) * 2002-07-15 2006-04-25 경동제약 주식회사 9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의제조방법
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
US20040266795A1 (en) * 2003-04-30 2004-12-30 Genny Shamai Process for the preparation of famciclovir
JPWO2004103979A1 (ja) * 2003-05-26 2006-07-20 住友化学株式会社 Ｎ−（２−アミノ−４，６−ジクロロピリミジン−５−イル）ホルムアミドの製造方法
KR100573860B1 (ko) * 2003-06-13 2006-04-25 경동제약 주식회사 2-아미노-9-(2-치환에틸)푸린을 이용한 9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의 제조방법
US6930093B2 (en) * 2003-07-10 2005-08-16 Valeant Research & Development Use of ribofuranose derivatives against inflammatory bowel diseases
KR100573861B1 (ko) * 2003-07-18 2006-04-25 경동제약 주식회사 2-아미노-9-(2-할로게노에틸)푸린 및 그 중간체로서의 2-아미노-6,8-디클로로-9-(2-히드록시에틸)푸린의 제조방법
GB0320738D0 (en) 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
EP1556383A1 (de) * 2003-09-04 2005-07-27 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von famciclovir
WO2005028434A2 (en) * 2003-09-18 2005-03-31 Conforma Therapeutics Corporation Novel heterocyclic compounds as hsp90-inhibitors
DE102004002055A1 (de) * 2004-01-15 2005-08-11 Degussa Ag Verfahren zur Herstellung von 2-Amino-4,6-dichlor-5-formamidopyrimidin
CA2577423C (en) * 2004-08-16 2012-11-06 Quark Biotech, Inc. Therapeutic uses of inhibitors of rtp801
CN101180297A (zh) * 2005-03-30 2008-05-14 康福玛医药公司 作为hsp90-抑制剂的炔基吡咯并嘧啶及相关类似物
GB2426247A (en) 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
WO2007035963A2 (en) * 2005-09-23 2007-03-29 Conforma Therapeutics Corporation Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors
EP1857458A1 (de) * 2006-05-05 2007-11-21 SOLMAG S.p.A. Verfahren zur Herstellung von Abacavir
CN100465174C (zh) * 2006-06-13 2009-03-04 中国科学院上海有机化学研究所 制备光学纯阿巴卡韦的方法
WO2008072074A1 (en) * 2006-12-11 2008-06-19 Aurobindo Pharma Limited An improved process for the preparation of purine derivative
EP1939196A1 (de) 2006-12-21 2008-07-02 Esteve Quimica, S.A. Abacavir-Herstellungsprozess
WO2008155613A1 (en) * 2007-06-21 2008-12-24 Aurobindo Pharma Ltd An improved process for preparing purine derivative
EP2085397A1 (de) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Kristalline Form von Abacavir
CA3003988C (en) 2010-01-27 2020-01-07 Viiv Healthcare Company Combinations for use in the inhibition of hiv-1
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
EP2962693B1 (de) 2013-02-27 2019-01-09 Kyoto University Pharmazeutische zusammensetzung enthaltend abacavir zur behandlung von krebs
CN104672239A (zh) * 2013-11-26 2015-06-03 上海迪赛诺化学制药有限公司 一种采用一锅法制备阿巴卡韦式v中间体的工艺
CN109456329B (zh) * 2018-11-19 2021-03-09 迪嘉药业集团有限公司 一种泛昔洛韦的制备方法
CN113292507B (zh) * 2021-06-25 2022-07-19 潍坊奥通药业有限公司 一种2-氨基-6-氯鸟嘌呤及其中间体的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
EP0182024B1 (de) 1984-09-20 1991-04-03 Beecham Group Plc Purin-Derivate und ihre pharmazeutische Verwendung
US4965270A (en) 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
GB8724765D0 (en) 1987-10-22 1987-11-25 Beecham Group Plc Process
GB2243609B (en) 1988-01-20 1992-03-11 Univ Minnesota Dideoxydidehydrocarbocyclic pyrimidines
US4916224A (en) 1988-01-20 1990-04-10 Regents Of The University Of Minnesota Dideoxycarbocyclic nucleosides
US5631370A (en) 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB8916698D0 (en) 1989-07-21 1989-09-06 Beecham Group Plc Novel process
GB8918827D0 (en) 1989-08-17 1989-09-27 Beecham Group Plc Novel compounds
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
CZ287049B6 (cs) * 1992-01-22 2000-08-16 Lonza A. G. N-5-chráněné 2,5-diamino-4,6-dichlorpyrimidiny a způsob jejich přípravy
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
CA2145928C (en) * 1994-04-27 2007-10-09 Gerhard Stucky N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation

Also Published As

Publication number Publication date
US20020173649A1 (en) 2002-11-21
RU2140913C1 (ru) 1999-11-10
WO1995021161A1 (en) 1995-08-10
PL183885B1 (pl) 2002-07-31
NO963239D0 (no) 1996-08-02
PT741710E (pt) 2000-09-29
GR3033850T3 (en) 2000-10-31
US6087501A (en) 2000-07-11
KR100355983B1 (ko) 2002-12-28
HU9602114D0 (en) 1996-09-30
BR9506667A (pt) 1997-09-16
PL315713A1 (en) 1996-11-25
GB9402161D0 (en) 1994-03-30
FI963070A0 (fi) 1996-08-02
IL112539A (en) 2000-08-31
NO310819B1 (no) 2001-09-03
DE69516847D1 (de) 2000-06-15
FI112477B (fi) 2003-12-15
SG47918A1 (en) 1998-04-17
JPH09508412A (ja) 1997-08-26
US5917041A (en) 1999-06-29
TW390877B (en) 2000-05-21
AU1543895A (en) 1995-08-21
JP3670012B2 (ja) 2005-07-13
US5917042A (en) 1999-06-29
MX9603091A (es) 1998-01-31
CN1105109C (zh) 2003-04-09
CN1388123A (zh) 2003-01-01
US20030187263A1 (en) 2003-10-02
EP0741710A1 (de) 1996-11-13
NZ278948A (en) 1998-01-26
IL112539A0 (en) 1995-05-26
EP0741710B1 (de) 2000-05-10
ZA95884B (en) 1996-08-05
HU223096B1 (hu) 2004-03-29
US6555687B1 (en) 2003-04-29
DE69516847T2 (de) 2000-10-26
MY113775A (en) 2002-05-31
FI963070A (fi) 1996-08-02
US6448403B1 (en) 2002-09-10
HK1004087A1 (en) 1998-11-13
ES2148486T3 (es) 2000-10-16
US6552193B1 (en) 2003-04-22
HUT75300A (en) 1997-05-28
AU690203B2 (en) 1998-04-23
US6870053B2 (en) 2005-03-22
ATE192742T1 (de) 2000-05-15
CN1139924A (zh) 1997-01-08
CN1161343C (zh) 2004-08-11
NO963239L (no) 1996-10-02

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