DK0723546T3 - 1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelser - Google Patents
1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelserInfo
- Publication number
- DK0723546T3 DK0723546T3 DK94929537T DK94929537T DK0723546T3 DK 0723546 T3 DK0723546 T3 DK 0723546T3 DK 94929537 T DK94929537 T DK 94929537T DK 94929537 T DK94929537 T DK 94929537T DK 0723546 T3 DK0723546 T3 DK 0723546T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- halo
- cyano
- hydroxy
- optionally substituted
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title abstract 2
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- SRNKZYRMFBGSGE-UHFFFAOYSA-N [1,2,4]triazolo[1,5-a]pyrimidine Chemical compound N1=CC=CN2N=CN=C21 SRNKZYRMFBGSGE-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- -1 cyano, hydroxy Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 208000032843 Hemorrhage Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939321162A GB9321162D0 (en) | 1993-10-13 | 1993-10-13 | Therapeutic agents |
| PCT/EP1994/003364 WO1995010521A1 (en) | 1993-10-13 | 1994-10-12 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0723546T3 true DK0723546T3 (da) | 2000-05-01 |
Family
ID=10743505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94929537T DK0723546T3 (da) | 1993-10-13 | 1994-10-12 | 1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelser |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5753665A (enExample) |
| EP (1) | EP0723546B1 (enExample) |
| JP (1) | JPH09503771A (enExample) |
| CN (1) | CN1040537C (enExample) |
| AT (1) | ATE188966T1 (enExample) |
| AU (1) | AU679573B2 (enExample) |
| BG (1) | BG62405B1 (enExample) |
| BR (1) | BR9407812A (enExample) |
| CA (1) | CA2173857A1 (enExample) |
| CZ (1) | CZ106996A3 (enExample) |
| DE (1) | DE69422724T2 (enExample) |
| DK (1) | DK0723546T3 (enExample) |
| ES (1) | ES2142413T3 (enExample) |
| FI (1) | FI961630A7 (enExample) |
| GB (1) | GB9321162D0 (enExample) |
| GR (1) | GR3032480T3 (enExample) |
| HU (1) | HUT74580A (enExample) |
| IL (1) | IL111259A (enExample) |
| IN (1) | IN179169B (enExample) |
| MY (1) | MY112110A (enExample) |
| NO (1) | NO306509B1 (enExample) |
| NZ (1) | NZ274500A (enExample) |
| PL (1) | PL177920B1 (enExample) |
| PT (1) | PT723546E (enExample) |
| RO (1) | RO117020B1 (enExample) |
| RU (1) | RU2136684C1 (enExample) |
| SK (1) | SK282329B6 (enExample) |
| TW (1) | TW372237B (enExample) |
| UA (1) | UA42738C2 (enExample) |
| WO (1) | WO1995010521A1 (enExample) |
| ZA (1) | ZA947949B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506382D0 (en) * | 1995-03-29 | 1995-05-17 | Boots Co Plc | Pharmaceutical compositions |
| GB9507348D0 (en) * | 1995-04-08 | 1995-05-31 | Knoll Ag | Therapeutic agents |
| US5714607A (en) * | 1995-12-01 | 1998-02-03 | American Cyanamid Company | Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide |
| ATE236904T1 (de) | 1996-07-25 | 2003-04-15 | Merck Sharp & Dohme | Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren |
| GB9617727D0 (en) * | 1996-08-23 | 1996-10-02 | Knoll Ag | Process |
| GB9626746D0 (en) * | 1996-12-23 | 1997-02-12 | Knoll Ag | Process |
| DE19706336A1 (de) * | 1997-02-19 | 1998-08-20 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Alkoholen |
| DE19706337A1 (de) | 1997-02-19 | 1998-08-20 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Estern |
| DE19707008A1 (de) | 1997-02-21 | 1998-08-27 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Alkoholen |
| JP2002527519A (ja) * | 1998-10-16 | 2002-08-27 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体のリガンドとしてのピラゾロトリアジン誘導体 |
| GB9906126D0 (en) * | 1999-03-18 | 1999-05-12 | Knoll Ag | Pharmaceutical formulations |
| GB9906130D0 (en) * | 1999-03-18 | 1999-05-12 | Knoll Ag | Compounds for use in therapy |
| GB9906124D0 (en) * | 1999-03-18 | 1999-05-12 | Knoll Ag | Therapeutic agent |
| GB9914743D0 (en) * | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
| CA2413802A1 (en) * | 2000-06-30 | 2002-01-10 | Mark R. Schmitt | Substituted-triazolopyrimidines as anticancer agents |
| TWI334868B (en) * | 2003-06-03 | 2010-12-21 | Nippon Kayaku Kk | [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof |
| AU2005214167B2 (en) | 2004-02-13 | 2008-08-07 | Warner-Lambert Company Llc | Androgen receptor modulators |
| CA2563291A1 (en) | 2004-04-13 | 2005-10-27 | Warner-Lambert Company Llc | 4-cyano-phenoxy-alkyl carboxyl derivatives as androgen modulators |
| BRPI0509980A (pt) | 2004-04-22 | 2007-10-16 | Warner Lambert Co | moduladores de androgênio |
| TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| EP2328414B1 (en) * | 2008-08-29 | 2013-12-11 | Concert Pharmaceuticals Inc. | Substituted triazolo-pyridazine derivatives |
| WO2010112484A1 (en) * | 2009-04-01 | 2010-10-07 | Neurosearch A/S | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS |
| DK2414365T3 (da) | 2009-04-01 | 2014-03-31 | Aniona Aps | SUBSTITUEREDE [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINER OG ANVENDELSE HERAF SOM KALIUMKANALMODULATORER |
| EP2438069A1 (en) | 2009-04-01 | 2012-04-11 | NeuroSearch A/S | Substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as potassium channel modulators |
| CN113874377A (zh) | 2019-05-13 | 2021-12-31 | 埃科莱布美国股份有限公司 | 作为铜腐蚀抑制剂的1,2,4-三唑并[1,5-a]嘧啶衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE46306B1 (en) * | 1977-02-11 | 1983-05-04 | Ici Ltd | Safeguarded toxic chemical compositions containing an emetic |
| FR2549834B1 (fr) * | 1983-07-25 | 1985-10-18 | Sanofi Sa | Derives de triazolo-pyrimidine, leur procede de preparation et leur application therapeutique en tant que tonicardiaques |
| WO1989001478A1 (en) * | 1987-08-07 | 1989-02-23 | The Australian National University | ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES |
| US5387747A (en) * | 1992-02-24 | 1995-02-07 | Laboratoires Upsa | Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present |
-
1993
- 1993-10-13 GB GB939321162A patent/GB9321162D0/en active Pending
-
1994
- 1994-10-11 IN IN982MA1994 patent/IN179169B/en unknown
- 1994-10-12 CN CN94194265A patent/CN1040537C/zh not_active Expired - Fee Related
- 1994-10-12 BR BR9407812A patent/BR9407812A/pt not_active Application Discontinuation
- 1994-10-12 UA UA96041428A patent/UA42738C2/uk unknown
- 1994-10-12 WO PCT/EP1994/003364 patent/WO1995010521A1/en not_active Ceased
- 1994-10-12 IL IL111259A patent/IL111259A/en not_active IP Right Cessation
- 1994-10-12 PL PL94313970A patent/PL177920B1/pl unknown
- 1994-10-12 CA CA002173857A patent/CA2173857A1/en not_active Abandoned
- 1994-10-12 SK SK437-96A patent/SK282329B6/sk unknown
- 1994-10-12 DE DE69422724T patent/DE69422724T2/de not_active Expired - Lifetime
- 1994-10-12 DK DK94929537T patent/DK0723546T3/da active
- 1994-10-12 EP EP94929537A patent/EP0723546B1/en not_active Expired - Lifetime
- 1994-10-12 RU RU96108927A patent/RU2136684C1/ru active
- 1994-10-12 RO RO96-00795A patent/RO117020B1/ro unknown
- 1994-10-12 ES ES94929537T patent/ES2142413T3/es not_active Expired - Lifetime
- 1994-10-12 US US08/628,662 patent/US5753665A/en not_active Expired - Lifetime
- 1994-10-12 PT PT94929537T patent/PT723546E/pt unknown
- 1994-10-12 JP JP7511287A patent/JPH09503771A/ja not_active Ceased
- 1994-10-12 ZA ZA947949A patent/ZA947949B/xx unknown
- 1994-10-12 AU AU78554/94A patent/AU679573B2/en not_active Ceased
- 1994-10-12 AT AT94929537T patent/ATE188966T1/de not_active IP Right Cessation
- 1994-10-12 HU HU9600959A patent/HUT74580A/hu unknown
- 1994-10-12 NZ NZ274500A patent/NZ274500A/en unknown
- 1994-10-12 CZ CZ961069A patent/CZ106996A3/cs unknown
- 1994-10-13 MY MYPI94002724A patent/MY112110A/en unknown
-
1995
- 1995-04-12 TW TW084103591A patent/TW372237B/zh active
-
1996
- 1996-04-09 BG BG100485A patent/BG62405B1/bg unknown
- 1996-04-11 NO NO961435A patent/NO306509B1/no not_active IP Right Cessation
- 1996-04-12 FI FI961630A patent/FI961630A7/fi unknown
-
2000
- 2000-01-26 GR GR20000400175T patent/GR3032480T3/el not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0723546T3 (da) | 1,2,4-triazolo[1,5-a]pyrimidin og deres anvendelse til behandling af neurologiske lidelser | |
| PL308757A1 (en) | Therapeutic agents | |
| UA66825C2 (uk) | Азаполіциклічні сполуки, конденсовані з арилом, фармацевтична композиція, спосіб лікування та спосіб зниження нікотинової залежності | |
| GEP20033029B (en) | Substituted 1,8-Naphthyridin-4(1H)-Ones as Phosphodiesterase 4 Inhibitors | |
| PL309347A1 (en) | Application of anticonvulsive agents in therapy of neurological damages caused by or associated with injuries | |
| DE60224879D1 (de) | Verwendung von dpiv-inhibitoren als therapeutika für krankhafte neurologische zustände | |
| MX2007000051A (es) | Derivados de pirimidina fusionados y composiciones de los mismos como moduladores del receptor cxcr3, utiles en la prevencion y tratamiento de trastornos y enfermedades inflamatorias e inmunoregulatorias. | |
| PL313941A1 (en) | Alkoxyalkyl carbamates of imidazo /1,2-a/ pyrimidines | |
| CA2148194A1 (en) | Cyclopeptides of the formula i | |
| AU3582095A (en) | Isothiourea derivatives as no synthase inhibitors | |
| BG108180A (en) | Novel cyano-substituted dihydropyrimidine compounds and their use to treat diseases | |
| MXPA03003923A (es) | Compuestos de n-([1,2,4]triazoloazinil)tiofensulfonamida como herbicidas. | |
| AR032653A1 (es) | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. | |
| WO2006033795A3 (en) | Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth | |
| RO105807B1 (ro) | Procedeu de preparare a unor agenti terapeutici | |
| GB9309749D0 (en) | Therapeutic agents | |
| IE894039L (en) | Therapeutic agents | |
| TW359667B (en) | Tetralines | |
| CA2347939A1 (en) | Composition for the treatment of rheumatism, hepatitis or pancreatitis | |
| IL104478A (en) | N-5-protected 2,5-diamino-4, 6-dichloropyrimidines and processes for their preparation | |
| WO2001032650A3 (en) | Alkaline salts of n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-n'-isonicotinoylhydrazide, possess for their preparation, and pharmaceutical composition based on these salts | |
| JO1833B1 (en) | Therapeutic agents | |
| MXPA01009384A (es) | Composiciones farmaceuticas que comprenden un derivado de pirimidina y ciclodextrina. | |
| WO2000056292A3 (en) | Use of 1,2,4-triazolo[1,5-a]pyrimidine derivatives for treating migraine |