WO2001032650A3 - Alkaline salts of n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-n'-isonicotinoylhydrazide, possess for their preparation, and pharmaceutical composition based on these salts - Google Patents

Alkaline salts of n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-n'-isonicotinoylhydrazide, possess for their preparation, and pharmaceutical composition based on these salts Download PDF

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Publication number
WO2001032650A3
WO2001032650A3 PCT/RU2000/000438 RU0000438W WO0132650A3 WO 2001032650 A3 WO2001032650 A3 WO 2001032650A3 RU 0000438 W RU0000438 W RU 0000438W WO 0132650 A3 WO0132650 A3 WO 0132650A3
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WO
WIPO (PCT)
Prior art keywords
salts
alkyl
pyrimidinesulfone
isonicotinoylhydrazide
dioxo
Prior art date
Application number
PCT/RU2000/000438
Other languages
French (fr)
Other versions
WO2001032650A2 (en
Inventor
Alexandr Leonidovich Reshetov
Nikolai Mikhailovi Goloschapov
Tamara Petrovna Filipskikh
Ljubov Elizarovna Kostjuk
Elena Nikolaevna Goloschapova
Elena Andreevna Michurina
Anatoly Anatolievich Zavarzin
Original Assignee
Alexandr Leonidovich Reshetov
Nikolai Mikhailovi Goloschapov
Tamara Petrovna Filipskikh
Ljubov Elizarovna Kostjuk
Elena Nikolaevna Goloschapova
Elena Andreevna Michurina
Anatoly Anatolievich Zavarzin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to UA2002064588A priority Critical patent/UA72286C2/en
Application filed by Alexandr Leonidovich Reshetov, Nikolai Mikhailovi Goloschapov, Tamara Petrovna Filipskikh, Ljubov Elizarovna Kostjuk, Elena Nikolaevna Goloschapova, Elena Andreevna Michurina, Anatoly Anatolievich Zavarzin filed Critical Alexandr Leonidovich Reshetov
Priority to AU14237/01A priority patent/AU1423701A/en
Priority to EA200200540A priority patent/EA200200540A1/en
Publication of WO2001032650A2 publication Critical patent/WO2001032650A2/en
Publication of WO2001032650A3 publication Critical patent/WO2001032650A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Alkaline salts of N-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-N'-isonicotinoylhydrazide of formula (I), where R is 1-4 carbon atoms alkyl and M is alkali metal, which can possess antimicrobial and immunothrope activities and can be used as immunomodulator are offered, as well as the method for producing these salts and pharmaceutical composition based on them. The offered salts may be used in treating chronic recurring diseases complicated with bacterial infections on the immunodeficiency background, also they may be used as antimicrobial means.
PCT/RU2000/000438 1999-11-05 2000-11-03 Alkaline salts of n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-n'-isonicotinoylhydrazide, possess for their preparation, and pharmaceutical composition based on these salts WO2001032650A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
UA2002064588A UA72286C2 (en) 1999-11-05 2000-03-11 Alkaline salts n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinsulfone)-n'-izonicotinoylhydrazide which can be used as antimicrobial and immunotropic agents, a method for the preparation thereof, use thereof as immunomodulator and pharmaceutical composition based thereon
AU14237/01A AU1423701A (en) 1999-11-05 2000-11-03 Alkaline salts on n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone) -n'-isonicotinoylhydrazide, which can possess antimicrobial and immunothrope activity, the method for producing these salts, their use as immunomodulator and pharmaceutical
EA200200540A EA200200540A1 (en) 1999-11-05 2000-11-03 ALKALINE SALTS N- (6-ALKYL-2,4-DIOKSO-1,2,3,4-TETRAHIDRO4azkryv-kazakhnye-kazezhnye-krakryzhnychnykh okrashiv krakryzhnykh okrashnykh pokrypki-kazannykh orazovye okhnya komplekty okhmikotonilonononsulfonon) -N'-IZONIKOTINOINILHYDRAZID QUALITY IMMUNODULATOR AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU99123407 1999-11-05
RU99123407/14A RU2191015C2 (en) 1999-11-05 1999-11-05 N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulfone)-n′- isonicotinoyl hydrazide disodium salt eliciting antibacterial and immunotropic activity and medicinal agent based on thereof

Publications (2)

Publication Number Publication Date
WO2001032650A2 WO2001032650A2 (en) 2001-05-10
WO2001032650A3 true WO2001032650A3 (en) 2002-05-10

Family

ID=20226671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2000/000438 WO2001032650A2 (en) 1999-11-05 2000-11-03 Alkaline salts of n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-n'-isonicotinoylhydrazide, possess for their preparation, and pharmaceutical composition based on these salts

Country Status (5)

Country Link
AU (1) AU1423701A (en)
EA (1) EA200200540A1 (en)
RU (1) RU2191015C2 (en)
UA (1) UA72286C2 (en)
WO (1) WO2001032650A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005092344A1 (en) * 2004-03-26 2005-10-06 Zakrytoe Aktsionernoe Obschestvo 'novaya Linia' Medicinal preparation
CN1993318B (en) * 2004-06-23 2012-10-03 Synta医药公司 Bis(thio-hydrazide amide) salts for treatment of cancers
RU2368609C1 (en) * 2008-01-09 2009-09-27 Лев Давидович Раснецов Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt
MD4075C1 (en) * 2009-12-31 2011-07-31 Анатолий ЭФКАРПИДИС Process for obtaining highly dispersed colloidal silver

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620445A1 (en) * 1965-04-15 1970-04-16 Schering Ag Process for the preparation of substituted hydrazones
GB1206567A (en) * 1969-03-27 1970-09-23 Fargal Pharmasint Lab Biochim Substituted benzal hydrazone, organic and inorganic salts thereof and processes of preparation therefor
WO1999007699A1 (en) * 1997-08-12 1999-02-18 Reshetov, Alexandr Leonidovich Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting immuno-deficiency
WO1999018083A1 (en) * 1997-10-07 1999-04-15 Alexandr Leonidovich Reshetov N,n'-(sulphonyldi-1, 4-phenylen) bis (n'',n''- dimethylformamidin)-1, 2,3,4-tetrahydro- 6-methyl-2, 4-dioxo-5-pyrimidinsulphonate for stimulating cellular metabolism and having an immunotropic and anti-bacterial activity and method for producing the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620445A1 (en) * 1965-04-15 1970-04-16 Schering Ag Process for the preparation of substituted hydrazones
GB1206567A (en) * 1969-03-27 1970-09-23 Fargal Pharmasint Lab Biochim Substituted benzal hydrazone, organic and inorganic salts thereof and processes of preparation therefor
WO1999007699A1 (en) * 1997-08-12 1999-02-18 Reshetov, Alexandr Leonidovich Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting immuno-deficiency
RU2141322C1 (en) * 1997-08-12 1999-11-20 Голощапов Николай Михайлович Immunomodulating agent "izofon" showing antimycobacterial activity, method of its preparing and using
EP1031570A1 (en) * 1997-08-12 2000-08-30 Reshetov, Alexandr Leonidovich Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting immuno-deficiency
WO1999018083A1 (en) * 1997-10-07 1999-04-15 Alexandr Leonidovich Reshetov N,n'-(sulphonyldi-1, 4-phenylen) bis (n'',n''- dimethylformamidin)-1, 2,3,4-tetrahydro- 6-methyl-2, 4-dioxo-5-pyrimidinsulphonate for stimulating cellular metabolism and having an immunotropic and anti-bacterial activity and method for producing the same

Also Published As

Publication number Publication date
RU2191015C2 (en) 2002-10-20
WO2001032650A2 (en) 2001-05-10
AU1423701A (en) 2001-05-14
EA200200540A1 (en) 2002-10-31
UA72286C2 (en) 2005-02-15

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