EA200200540A1 - ALKALINE SALTS N- (6-ALKYL-2,4-DIOKSO-1,2,3,4-TETRAHIDRO4azkryv-kazakhnye-kazezhnye-krakryzhnychnykh okrashiv krakryzhnykh okrashnykh pokrypki-kazannykh orazovye okhnya komplekty okhmikotonilonononsulfonon) -N'-IZONIKOTINOINILHYDRAZID QUALITY IMMUNODULATOR AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS - Google Patents

ALKALINE SALTS N- (6-ALKYL-2,4-DIOKSO-1,2,3,4-TETRAHIDRO4azkryv-kazakhnye-kazezhnye-krakryzhnychnykh okrashiv krakryzhnykh okrashnykh pokrypki-kazannykh orazovye okhnya komplekty okhmikotonilonononsulfonon) -N'-IZONIKOTINOINILHYDRAZID QUALITY IMMUNODULATOR AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS

Info

Publication number
EA200200540A1
EA200200540A1 EA200200540A EA200200540A EA200200540A1 EA 200200540 A1 EA200200540 A1 EA 200200540A1 EA 200200540 A EA200200540 A EA 200200540A EA 200200540 A EA200200540 A EA 200200540A EA 200200540 A1 EA200200540 A1 EA 200200540A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
pharmaceutical composition
pokrypki
orazovye
okrashnykh
Prior art date
Application number
EA200200540A
Other languages
Russian (ru)
Inventor
Николай Михайлович Голощапов
Тамара Петровна Филипских
Любовь Елизаровна Костюк
Елена Николаевна Голощапова
Елена Андреевна Мичурина
Анатолий Анатольевич Заварзин
Original Assignee
Решетов, Александр Леонидович
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Решетов, Александр Леонидович filed Critical Решетов, Александр Леонидович
Publication of EA200200540A1 publication Critical patent/EA200200540A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предложены щелочные соли N-(6-алкил-2,4-диоксо-1,2,3,4-тетрагидро-5-пиримидинсульфон)-N'-изоникотиноилгидразида формулы I, где R является алкилом с 1-4 атомами углерода и М является щелочным металлом, которые могут обладать антимикробной и иммунотропной активностями и могут быть использованы в качестве иммуномодулятора, а также способ их получения и фармацевтическая композиция на их основе. Предложенные соли могут быть использованы при лечении хронических рецидивирующих болезней, осложненных бактериальными инфекциями на фоне иммунодефицита, а также в качестве антимикробных средств.Отчет о международном поиске был опубликован 2002.05.10.Alkali salts of N- (6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidine sulfone) -N'-isonicotinoyl hydrazide of the formula I, where R is alkyl with 1-4 carbon atoms and M is an alkaline metal, which may have antimicrobial and immunotropic activities and can be used as an immunomodulator, as well as a method for their preparation and a pharmaceutical composition based on them. The proposed salts can be used in the treatment of chronic recurrent diseases, complicated by bacterial infections on the background of immunodeficiency, as well as antimicrobial agents. The international search report was published 2002.05.10.

EA200200540A 1999-11-05 2000-11-03 ALKALINE SALTS N- (6-ALKYL-2,4-DIOKSO-1,2,3,4-TETRAHIDRO4azkryv-kazakhnye-kazezhnye-krakryzhnychnykh okrashiv krakryzhnykh okrashnykh pokrypki-kazannykh orazovye okhnya komplekty okhmikotonilonononsulfonon) -N'-IZONIKOTINOINILHYDRAZID QUALITY IMMUNODULATOR AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS EA200200540A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU99123407/14A RU2191015C2 (en) 1999-11-05 1999-11-05 N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulfone)-n′- isonicotinoyl hydrazide disodium salt eliciting antibacterial and immunotropic activity and medicinal agent based on thereof
PCT/RU2000/000438 WO2001032650A2 (en) 1999-11-05 2000-11-03 Alkaline salts of n-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-n'-isonicotinoylhydrazide, possess for their preparation, and pharmaceutical composition based on these salts

Publications (1)

Publication Number Publication Date
EA200200540A1 true EA200200540A1 (en) 2002-10-31

Family

ID=20226671

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200540A EA200200540A1 (en) 1999-11-05 2000-11-03 ALKALINE SALTS N- (6-ALKYL-2,4-DIOKSO-1,2,3,4-TETRAHIDRO4azkryv-kazakhnye-kazezhnye-krakryzhnychnykh okrashiv krakryzhnykh okrashnykh pokrypki-kazannykh orazovye okhnya komplekty okhmikotonilonononsulfonon) -N'-IZONIKOTINOINILHYDRAZID QUALITY IMMUNODULATOR AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS

Country Status (5)

Country Link
AU (1) AU1423701A (en)
EA (1) EA200200540A1 (en)
RU (1) RU2191015C2 (en)
UA (1) UA72286C2 (en)
WO (1) WO2001032650A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013052B1 (en) * 2004-03-26 2010-02-26 Закрытое Акционерное Общество "Новая Линия" Medical preparation
ME01644B (en) * 2004-06-23 2014-09-20 Synta Pharmaceuticals Corp Bis(thio-hydrazide amide) salts for treatment of cancers
RU2368609C1 (en) * 2008-01-09 2009-09-27 Лев Давидович Раснецов Silver salt of n-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5h-pyrimidinesulphone)-n'-isonicotinoylhydrazide, which exhibits immunotropic, antimicrobial, antifungal (antimycotic) activity and medicinal agent based on said salt
MD4075C1 (en) * 2009-12-31 2011-07-31 Анатолий ЭФКАРПИДИС Process for obtaining highly dispersed colloidal silver

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620445A1 (en) * 1965-04-15 1970-04-16 Schering Ag Process for the preparation of substituted hydrazones
GB1206567A (en) * 1969-03-27 1970-09-23 Fargal Pharmasint Lab Biochim Substituted benzal hydrazone, organic and inorganic salts thereof and processes of preparation therefor
RU2141322C1 (en) * 1997-08-12 1999-11-20 Голощапов Николай Михайлович Immunomodulating agent "izofon" showing antimycobacterial activity, method of its preparing and using
RU2136668C1 (en) * 1997-10-07 1999-09-10 Голощапов Николай Михайлович N,n'-(sulfonyldi-1,4-phenylene)-bis-(n'',n''-dimethylform- -amidine)-1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidine sulfonate stimulating cellular metabolism and showing immunotropic and antibacterial activity

Also Published As

Publication number Publication date
UA72286C2 (en) 2005-02-15
AU1423701A (en) 2001-05-14
RU2191015C2 (en) 2002-10-20
WO2001032650A2 (en) 2001-05-10
WO2001032650A3 (en) 2002-05-10

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