DK0711292T3 - Aza-spiro-forbindelser, der virker på det cholinerge system med muskarin-agonist aktivitet - Google Patents
Aza-spiro-forbindelser, der virker på det cholinerge system med muskarin-agonist aktivitetInfo
- Publication number
- DK0711292T3 DK0711292T3 DK94921036T DK94921036T DK0711292T3 DK 0711292 T3 DK0711292 T3 DK 0711292T3 DK 94921036 T DK94921036 T DK 94921036T DK 94921036 T DK94921036 T DK 94921036T DK 0711292 T3 DK0711292 T3 DK 0711292T3
- Authority
- DK
- Denmark
- Prior art keywords
- image
- aza
- agonist activity
- spiro compounds
- compounds acting
- Prior art date
Links
- 150000008627 azaspiro compounds Chemical class 0.000 title 1
- 230000001713 cholinergic effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000000472 muscarinic agonist Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/094,855 US5534520A (en) | 1990-04-10 | 1993-07-20 | Spiro compounds containing five-membered rings |
PCT/GB1994/001543 WO1995003303A2 (en) | 1993-07-20 | 1994-07-15 | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0711292T3 true DK0711292T3 (da) | 2002-05-06 |
Family
ID=22247578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94921036T DK0711292T3 (da) | 1993-07-20 | 1994-07-15 | Aza-spiro-forbindelser, der virker på det cholinerge system med muskarin-agonist aktivitet |
Country Status (25)
Country | Link |
---|---|
US (1) | US5534520A (bg) |
EP (1) | EP0711292B1 (bg) |
JP (1) | JP3802050B2 (bg) |
KR (1) | KR100341683B1 (bg) |
CN (1) | CN1129942B (bg) |
AT (1) | ATE212347T1 (bg) |
AU (1) | AU696530B2 (bg) |
BG (1) | BG62774B1 (bg) |
BR (1) | BR9407088A (bg) |
CA (1) | CA2167584C (bg) |
CZ (1) | CZ295929B6 (bg) |
DE (1) | DE69429724T2 (bg) |
DK (1) | DK0711292T3 (bg) |
ES (1) | ES2171458T3 (bg) |
FI (1) | FI113777B (bg) |
HU (1) | HU224638B1 (bg) |
IL (1) | IL110340A (bg) |
NO (1) | NO310075B1 (bg) |
NZ (1) | NZ268637A (bg) |
PL (1) | PL178931B1 (bg) |
PT (1) | PT711292E (bg) |
RO (1) | RO117851B1 (bg) |
RU (1) | RU2129555C1 (bg) |
WO (1) | WO1995003303A2 (bg) |
ZA (1) | ZA945284B (bg) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
HUT67539A (en) * | 1991-11-25 | 1995-04-28 | American Home Prod | 1-amino-2-[(benzothiazolyl)-methyl]-spiro-[isoquinoline-4(1h),-3'-pyrrolidine]-1,2',3,5'(2h)-tetrones, analogs thereof, process for producing them and pharmaceutical compositions containing them |
WO1996006098A1 (en) * | 1994-08-24 | 1996-02-29 | Astra Aktiebolag | Spiro-azabicyclic compounds useful in therapy |
FR2725206B1 (fr) * | 1994-09-29 | 1996-12-06 | Roussel Uclaf | Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
DE69633245T2 (de) | 1995-09-29 | 2005-09-08 | Eli Lilly And Co., Indianapolis | Spiroverbindungen als Inhibitoren der Fibrinogen-abhängigen Blutplättchenaggregation |
ES2259804T3 (es) | 1996-04-02 | 2006-10-16 | Bayer Cropscience Ag | Fenilcetoenoles sustituidos como pesticidas y herbicidas. |
WO1998000016A1 (en) * | 1996-07-01 | 1998-01-08 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate |
US8048875B1 (en) * | 1997-02-24 | 2011-11-01 | S.L.A. Pharma Ag | Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker |
AU733047C (en) | 1997-02-24 | 2002-05-16 | S.L.A. Pharma Ag | Pharmaceutical composition |
DE69819891T2 (de) | 1997-05-30 | 2004-08-26 | Neurosearch A/S | Spiro chinuclidin-derivate, ihre herstellung und verwendung |
TW402591B (en) | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
NZ505329A (en) * | 1998-06-08 | 2003-05-30 | Theravance Inc | Two heteroaryl or aryl containing compounds covalently attached via a linker useful as muscarinic receptor antagonists |
ATE234302T1 (de) * | 1998-06-12 | 2003-03-15 | Hoffmann La Roche | Di- oder triazaspiro(4,5)decanderivate |
DE69902606T2 (de) * | 1998-06-12 | 2003-04-24 | Hoffmann La Roche | Spiro(piperidin-4,1'-pyrrolo(3,4-c)pyrrole) |
US6353006B1 (en) | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
WO2001066546A1 (fr) * | 2000-03-09 | 2001-09-13 | Mitsubishi Pharma Corporation | Composes spiro, leur procede de preparation et leur utilisation comme medicaments |
DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
NZ533567A (en) * | 2001-12-28 | 2007-06-29 | Acadia Pharm Inc | Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events |
DE10210195B4 (de) * | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
NZ536610A (en) * | 2002-05-03 | 2009-02-28 | Israel Inst Biolog Res | Spiro agonists and antagonists of M1 and M3 muscarinic receptors for treatment of central and peripheral nervous system disorders |
GB0323204D0 (en) | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
US7700603B2 (en) * | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) * | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
CN101068545A (zh) * | 2004-10-13 | 2007-11-07 | 默克公司 | 作为β-分泌酶抑制剂用于治疗阿尔茨海默病的螺哌啶化合物 |
WO2006060918A1 (en) * | 2004-12-09 | 2006-06-15 | Virochem Pharma Inc. | Novel spirotropane compounds and methods for the modulation of chemokine receptor activity |
KR20070095310A (ko) * | 2004-12-09 | 2007-09-28 | 바이로켐 파마 인코포레이티드 | 신규 스피로트로판 화합물 및 케모카인 수용체 활성의 조절방법 |
WO2007011833A2 (en) * | 2005-07-18 | 2007-01-25 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
CA2620333A1 (en) * | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
ITMI20061279A1 (it) * | 2006-06-30 | 2008-01-01 | Consiglio Nazionale Ricerche | Agonisti nicotinici selettivi per il sottotipo recettoriale alfa7,procedimento per la loro preparazione e relative composizioni farmaceutiche |
EP2063889A4 (en) * | 2006-09-07 | 2009-09-16 | Merck & Co Inc | SPIROPIPERIDINE BETA SEKRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER DISEASE |
MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
EP2091328B1 (en) * | 2006-10-30 | 2011-12-28 | Merck Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
KR20090087487A (ko) | 2006-12-12 | 2009-08-17 | 쉐링 코포레이션 | 아스파르틸 프로테아제 억제제 |
EP2061771A1 (en) * | 2006-12-12 | 2009-05-27 | Schering Corporation | Aspartyl protease inhibitors containing a tricyclic ring system |
US7863291B2 (en) * | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
RU2506266C2 (ru) * | 2009-01-26 | 2014-02-10 | Израэл Инститьют Фо Байолоджикал Рисерч | Бициклические гетероциклические спиросоединения |
US9034891B2 (en) | 2009-01-26 | 2015-05-19 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
US8563543B2 (en) | 2009-10-08 | 2013-10-22 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
WO2011044185A2 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
US8557826B2 (en) | 2009-10-08 | 2013-10-15 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use |
BR112012010054A2 (pt) * | 2009-10-29 | 2016-05-24 | Bristol Myers Squibb Co | compostos quinuclidina como ligantes de receptor de acetilcolina alfa-7 nicotínicos |
WO2012138734A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
WO2012138590A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
JP2014514302A (ja) | 2011-04-13 | 2014-06-19 | メルク・シャープ・アンド・ドーム・コーポレーション | Bace阻害薬としての5−置換されたイミノチアジン類およびそれのモノおよびジオキシド、組成物およびそれらの使用 |
EP2747769B1 (en) | 2011-08-22 | 2017-08-02 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use |
WO2014011917A2 (en) | 2012-07-13 | 2014-01-16 | Pain Therapeutics, Inc. | A method of inhibiting tau phosphorylation |
US9416129B2 (en) | 2012-10-17 | 2016-08-16 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use |
WO2014062549A1 (en) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
US9489013B2 (en) | 2012-12-20 | 2016-11-08 | Merck Sharp & Dohme Corp. | C6-azaspiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use |
WO2014099794A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | C5, c6 oxacyclic-fused iminothiazine dioxide compounds as bace inhibitors |
US9580396B2 (en) | 2012-12-21 | 2017-02-28 | Merck Sharp & Dohme Corp. | C6-spiro iminothiadiazine dioxides as BACE inhibitors, compositions, and their use |
EP2968353B1 (en) | 2013-03-15 | 2018-12-19 | Merck Sharp & Dohme Corp. | C2-azaspiro iminothiazine dioxides as bace inhibitors |
US9433604B2 (en) | 2013-10-08 | 2016-09-06 | Pain Therapeutics Inc. | Method for inhibiting growth of cancer cells |
WO2015094930A1 (en) | 2013-12-18 | 2015-06-25 | Merck Sharp & Dohme Corp. | C-6 spirocarbocyclic iminothiadiazine dioxides as bace inhibitors, compositions, and their use |
US10307409B2 (en) | 2015-03-06 | 2019-06-04 | Chase Pharmaceuticals Corporation | Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system |
EP3265466A4 (en) * | 2015-03-06 | 2018-12-26 | Chase Pharmaceuticals Corporation | Peripheral-anticholinergic muscarinic agonist combination |
WO2017044693A1 (en) | 2015-09-11 | 2017-03-16 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
HRP20220962T1 (hr) | 2016-10-05 | 2022-10-28 | Nsc Therapeutics Gmbh | Kristalni polimorfi agonista muskarinskog acetilkolinskog receptora |
EP3768261A1 (en) | 2018-03-22 | 2021-01-27 | NSC THERAPEUTICS GmbH | Compounds and methods for use in the treatment of microglia-mediated disorders |
CN113966337B (zh) * | 2020-05-12 | 2024-01-02 | 北京广为医药科技有限公司 | 调节nmda受体活性的化合物、其药物组合物及用途 |
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US3161644A (en) * | 1962-06-22 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-benzyl-4-substituted piperidines |
JPS4917534B1 (bg) * | 1970-10-06 | 1974-05-01 | ||
BE790675A (fr) * | 1971-10-29 | 1973-04-27 | Science Union & Cie | Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane |
EP0189370A3 (de) * | 1985-01-16 | 1988-01-27 | Sandoz Ag | Spiro-dioxolane, -dithiolane und -oxothiolane |
US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
EP0273659A1 (en) * | 1986-12-27 | 1988-07-06 | Takeda Chemical Industries, Ltd. | Azaspiro compounds, their production and use |
JPS63208590A (ja) * | 1987-02-24 | 1988-08-30 | Yamanouchi Pharmaceut Co Ltd | ヘテロ環式スピロ化合物及びその製造法 |
IL87234A (en) * | 1987-08-13 | 1992-02-16 | Israel Inst Biolog Res | Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them |
ATE122353T1 (de) * | 1987-10-05 | 1995-05-15 | Yamanouchi Pharma Co Ltd | Heterozyklische spiroverbindungen und ihre herstellung. |
US4876260A (en) * | 1987-10-28 | 1989-10-24 | State Of Israel, Israel Institute Of Biological Research | Oxathiolanes |
JPH02164882A (ja) * | 1988-12-20 | 1990-06-25 | Yamanouchi Pharmaceut Co Ltd | スピロ化合物及びその中間体 |
JPH02247183A (ja) * | 1989-03-20 | 1990-10-02 | Yamanouchi Pharmaceut Co Ltd | ヘテロ環スピロ化合物 |
YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
IL97726A (en) * | 1990-04-10 | 1994-12-29 | Israel Inst Biolog Res | Pharmaceutical preparations containing compounds with bridged and unbridged heterocyclic groups connected via spiro-atop with oxazoline and thiazoline groups, and sharp compounds |
US5073560A (en) * | 1990-07-20 | 1991-12-17 | Fisons Corporation | Spiro-isoxazolidine derivatives as cholinergic agents |
TW201312B (en) * | 1991-04-09 | 1993-03-01 | Israel State | Spiro bridged and unbridged heterocyclic compounds |
-
1993
- 1993-07-20 US US08/094,855 patent/US5534520A/en not_active Expired - Lifetime
-
1994
- 1994-07-15 CZ CZ1996182A patent/CZ295929B6/cs not_active IP Right Cessation
- 1994-07-15 AU AU71915/94A patent/AU696530B2/en not_active Ceased
- 1994-07-15 EP EP94921036A patent/EP0711292B1/en not_active Expired - Lifetime
- 1994-07-15 IL IL11034094A patent/IL110340A/xx not_active IP Right Cessation
- 1994-07-15 AT AT94921036T patent/ATE212347T1/de not_active IP Right Cessation
- 1994-07-15 PT PT94921036T patent/PT711292E/pt unknown
- 1994-07-15 CA CA002167584A patent/CA2167584C/en not_active Expired - Fee Related
- 1994-07-15 CN CN94192839XA patent/CN1129942B/zh not_active Expired - Fee Related
- 1994-07-15 BR BR9407088A patent/BR9407088A/pt not_active Application Discontinuation
- 1994-07-15 RO RO96-00099A patent/RO117851B1/ro unknown
- 1994-07-15 ES ES94921036T patent/ES2171458T3/es not_active Expired - Lifetime
- 1994-07-15 RU RU96103370A patent/RU2129555C1/ru not_active IP Right Cessation
- 1994-07-15 WO PCT/GB1994/001543 patent/WO1995003303A2/en active IP Right Grant
- 1994-07-15 DK DK94921036T patent/DK0711292T3/da active
- 1994-07-15 JP JP50499595A patent/JP3802050B2/ja not_active Expired - Fee Related
- 1994-07-15 PL PL94312684A patent/PL178931B1/pl not_active IP Right Cessation
- 1994-07-15 NZ NZ268637A patent/NZ268637A/en not_active IP Right Cessation
- 1994-07-15 HU HU9600126A patent/HU224638B1/hu not_active IP Right Cessation
- 1994-07-15 KR KR1019960700296A patent/KR100341683B1/ko not_active IP Right Cessation
- 1994-07-15 DE DE69429724T patent/DE69429724T2/de not_active Expired - Lifetime
- 1994-07-19 ZA ZA945284A patent/ZA945284B/xx unknown
-
1996
- 1996-01-17 FI FI960238A patent/FI113777B/fi active
- 1996-01-18 NO NO960225A patent/NO310075B1/no not_active IP Right Cessation
- 1996-02-19 BG BG100370A patent/BG62774B1/bg unknown
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