DK0692489T3 - Fremstilling af stabile zinkinsulinanalogkrystaller - Google Patents

Fremstilling af stabile zinkinsulinanalogkrystaller

Info

Publication number
DK0692489T3
DK0692489T3 DK95304098T DK95304098T DK0692489T3 DK 0692489 T3 DK0692489 T3 DK 0692489T3 DK 95304098 T DK95304098 T DK 95304098T DK 95304098 T DK95304098 T DK 95304098T DK 0692489 T3 DK0692489 T3 DK 0692489T3
Authority
DK
Denmark
Prior art keywords
preparation
insulin analog
zinc insulin
stable zinc
analog crystals
Prior art date
Application number
DK95304098T
Other languages
Danish (da)
English (en)
Inventor
Bruce Hill Frank
Jeffrey Clayton Baker
Nancy Delores Carter
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22990041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0692489(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0692489T3 publication Critical patent/DK0692489T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DK95304098T 1994-06-16 1995-06-14 Fremstilling af stabile zinkinsulinanalogkrystaller DK0692489T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/260,647 US5504188A (en) 1994-06-16 1994-06-16 Preparation of stable zinc insulin analog crystals

Publications (1)

Publication Number Publication Date
DK0692489T3 true DK0692489T3 (da) 2003-03-31

Family

ID=22990041

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95304098T DK0692489T3 (da) 1994-06-16 1995-06-14 Fremstilling af stabile zinkinsulinanalogkrystaller

Country Status (29)

Country Link
US (1) US5504188A (https=)
EP (1) EP0692489B1 (https=)
JP (1) JP3595607B2 (https=)
KR (1) KR100369951B1 (https=)
CN (1) CN1184234C (https=)
AT (1) ATE233278T1 (https=)
AU (1) AU697794B2 (https=)
BR (1) BR9502798A (https=)
CA (1) CA2151563C (https=)
CO (1) CO4410205A1 (https=)
CZ (1) CZ286066B6 (https=)
DE (1) DE69529708T2 (https=)
DK (1) DK0692489T3 (https=)
ES (1) ES2188637T3 (https=)
FI (1) FI952930A7 (https=)
HU (1) HUT73495A (https=)
IL (1) IL114152A (https=)
IN (1) IN178919B (https=)
MY (1) MY130551A (https=)
NO (1) NO952334L (https=)
NZ (1) NZ272358A (https=)
PE (1) PE21896A1 (https=)
PL (1) PL180968B1 (https=)
RO (1) RO113529B1 (https=)
RU (1) RU2156257C2 (https=)
SI (1) SI0692489T1 (https=)
TW (1) TW379228B (https=)
YU (1) YU39595A (https=)
ZA (1) ZA954942B (https=)

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US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5869604A (en) * 1995-11-09 1999-02-09 Georgia Institute Of Technology Crystallization and purification of polypeptides
US6043214A (en) * 1997-03-20 2000-03-28 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
JP2001518915A (ja) * 1997-03-20 2001-10-16 ノボ ノルディスク アクティーゼルスカブ インシュリンと吸収増強剤の共沈殿による治療用粉末の調整法
ES2230727T3 (es) * 1997-11-12 2005-05-01 Alza Corporation Procedimiento de administracion dermal de polipeptidos.
RU2205188C2 (ru) 1998-06-30 2003-05-27 Ново Нордиск А/С Затравочные кристаллы для получения пептидов или протеинов
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US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
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CN106117345B (zh) * 2015-05-05 2020-11-24 宜昌东阳光长江药业股份有限公司 一种制备甘精胰岛素结晶的方法
CN104892749B (zh) * 2015-06-16 2019-02-05 珠海联邦制药股份有限公司 一种德谷胰岛素结晶的制备方法及应用
CN105753966A (zh) * 2016-05-05 2016-07-13 通化东宝药业股份有限公司 一种重组人胰岛素结晶的制备方法
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BE533252A (https=) *
BE515508A (https=) *
BE533298A (https=) *
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US2920104A (en) 1958-07-01 1960-01-05 Vanderbilt Co R T Stabilized solutions of a dithiocarbamate
US3719655A (en) * 1969-12-05 1973-03-06 Lilly Co Eli Process for the crystallization of the ammonium and alkali metal salts in insulin
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DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
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US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
JPH03506023A (ja) * 1988-07-20 1991-12-26 ノボ　ノルデイスク　アクツイエセルスカプ ポリペプチド
HUT56857A (en) * 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
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US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina

Also Published As

Publication number Publication date
FI952930L (fi) 1995-12-17
IL114152A (en) 1999-12-31
PL309099A1 (en) 1995-12-27
FI952930A0 (fi) 1995-06-14
FI952930A7 (fi) 1995-12-17
KR100369951B1 (ko) 2003-03-28
HU9501715D0 (en) 1995-08-28
IL114152A0 (en) 1995-10-31
DE69529708T2 (de) 2003-10-16
AU2168195A (en) 1996-01-04
NO952334L (no) 1995-12-18
CO4410205A1 (es) 1997-01-09
KR960000922A (ko) 1996-01-25
YU39595A (sh) 1997-08-22
ES2188637T3 (es) 2003-07-01
RO113529B1 (ro) 1998-08-28
CN1128271A (zh) 1996-08-07
NZ272358A (en) 1996-12-20
EP0692489A1 (en) 1996-01-17
CA2151563A1 (en) 1995-12-17
CA2151563C (en) 2007-08-07
RU2156257C2 (ru) 2000-09-20
CZ286066B6 (cs) 2000-01-12
HUT73495A (en) 1996-08-28
JP3595607B2 (ja) 2004-12-02
TW379228B (en) 2000-01-11
US5504188A (en) 1996-04-02
ZA954942B (en) 1996-12-17
ATE233278T1 (de) 2003-03-15
IN178919B (https=) 1997-07-19
DE69529708D1 (de) 2003-04-03
PL180968B1 (pl) 2001-05-31
SI0692489T1 (en) 2003-06-30
JPH08169899A (ja) 1996-07-02
AU697794B2 (en) 1998-10-15
RU95110107A (ru) 1997-05-10
CN1184234C (zh) 2005-01-12
BR9502798A (pt) 1996-06-04
EP0692489B1 (en) 2003-02-26
MY130551A (en) 2007-06-29
NO952334D0 (no) 1995-06-13
PE21896A1 (es) 1996-06-15
CZ154195A3 (en) 1996-02-14

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