DK0684951T3 - Silylerede acetylcholinesterase-inhibitorer - Google Patents
Silylerede acetylcholinesterase-inhibitorerInfo
- Publication number
- DK0684951T3 DK0684951T3 DK94908615.1T DK94908615T DK0684951T3 DK 0684951 T3 DK0684951 T3 DK 0684951T3 DK 94908615 T DK94908615 T DK 94908615T DK 0684951 T3 DK0684951 T3 DK 0684951T3
- Authority
- DK
- Denmark
- Prior art keywords
- silylated
- acetylcholinesterase inhibitors
- compounds
- methods
- acetylcholinesterase
- Prior art date
Links
- 239000000544 cholinesterase inhibitor Substances 0.000 title abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93400385A EP0611769A1 (en) | 1993-02-16 | 1993-02-16 | Silylated acetylcholinesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0684951T3 true DK0684951T3 (da) | 1997-05-26 |
Family
ID=8214682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94908615.1T DK0684951T3 (da) | 1993-02-16 | 1994-01-25 | Silylerede acetylcholinesterase-inhibitorer |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP0611769A1 (sv) |
| JP (1) | JP3516955B2 (sv) |
| KR (1) | KR100336547B1 (sv) |
| CN (1) | CN1043575C (sv) |
| AT (1) | ATE152725T1 (sv) |
| AU (1) | AU672885B2 (sv) |
| CA (1) | CA2154870C (sv) |
| DE (1) | DE69403068T2 (sv) |
| DK (1) | DK0684951T3 (sv) |
| ES (1) | ES2104358T3 (sv) |
| FI (1) | FI111461B (sv) |
| GR (1) | GR3024151T3 (sv) |
| HU (1) | HUT72736A (sv) |
| IL (1) | IL108623A0 (sv) |
| MX (1) | MX9401175A (sv) |
| NO (1) | NO305517B1 (sv) |
| NZ (1) | NZ262247A (sv) |
| WO (1) | WO1994019356A1 (sv) |
| ZA (1) | ZA94925B (sv) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627400A1 (en) * | 1993-06-04 | 1994-12-07 | Merrell Dow Pharmaceuticals Inc. | Aromatic acetylcholinesterase inhibitors |
| CN100431539C (zh) * | 2004-01-12 | 2008-11-12 | 和泓生物技术（上海）有限公司 | 乙酰胆碱酯酶抑制剂在制备治疗帕金森病药物中的应用 |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| JP5523107B2 (ja) | 2006-11-30 | 2014-06-18 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
| ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| ES2533484T3 (es) | 2007-04-18 | 2015-04-10 | Probiodrug Ag | Derivados de tiourea como inhibidores de la glutaminil ciclasa |
| EA022007B1 (ru) | 2009-09-11 | 2015-10-30 | Пробиодруг Аг | Гетероциклические производные в качестве ингибиторов глутаминилциклазы |
| JP6082250B2 (ja) | 2010-02-09 | 2017-02-15 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 認知機能を改善するための方法および組成物 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| KR101790806B1 (ko) | 2010-03-10 | 2017-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제 |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| NZ738682A (en) | 2015-05-22 | 2022-01-28 | Agenebio Inc | Extended release pharmaceutical compositions of levetiracetam |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| CN112047973B (zh) * | 2019-06-06 | 2022-11-18 | 上海科技大学 | 一种大麻素类化合物，其制备方法、组合物和用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0403713A1 (en) * | 1989-06-22 | 1990-12-27 | Merrell Dow Pharmaceuticals Inc. | Novel acetylcholinesterase inhibitors |
-
1993
- 1993-02-16 EP EP93400385A patent/EP0611769A1/en not_active Withdrawn
-
1994
- 1994-01-25 WO PCT/US1994/000720 patent/WO1994019356A1/en active IP Right Grant
- 1994-01-25 ES ES94908615T patent/ES2104358T3/es not_active Expired - Lifetime
- 1994-01-25 EP EP94908615A patent/EP0684951B1/en not_active Expired - Lifetime
- 1994-01-25 HU HU9502406A patent/HUT72736A/hu unknown
- 1994-01-25 KR KR1019950703485A patent/KR100336547B1/ko not_active IP Right Cessation
- 1994-01-25 CN CN94191196A patent/CN1043575C/zh not_active Expired - Fee Related
- 1994-01-25 DE DE69403068T patent/DE69403068T2/de not_active Expired - Lifetime
- 1994-01-25 CA CA002154870A patent/CA2154870C/en not_active Expired - Fee Related
- 1994-01-25 JP JP51897494A patent/JP3516955B2/ja not_active Expired - Fee Related
- 1994-01-25 DK DK94908615.1T patent/DK0684951T3/da active
- 1994-01-25 AT AT94908615T patent/ATE152725T1/de active
- 1994-01-25 NZ NZ262247A patent/NZ262247A/en unknown
- 1994-01-25 AU AU61641/94A patent/AU672885B2/en not_active Ceased
- 1994-02-10 ZA ZA94925A patent/ZA94925B/xx unknown
- 1994-02-11 IL IL10862394A patent/IL108623A0/xx unknown
- 1994-02-15 MX MX9401175A patent/MX9401175A/es not_active Application Discontinuation
-
1995
- 1995-08-15 FI FI953851A patent/FI111461B/sv not_active IP Right Cessation
- 1995-08-15 NO NO953201A patent/NO305517B1/no unknown
-
1997
- 1997-07-16 GR GR970401801T patent/GR3024151T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3024151T3 (en) | 1997-10-31 |
| IL108623A0 (en) | 1994-05-30 |
| WO1994019356A1 (en) | 1994-09-01 |
| CA2154870A1 (en) | 1994-09-01 |
| KR100336547B1 (ko) | 2002-11-02 |
| FI953851A (sv) | 1995-08-15 |
| JP3516955B2 (ja) | 2004-04-05 |
| KR960701068A (ko) | 1996-02-24 |
| CN1043575C (zh) | 1999-06-09 |
| EP0684951B1 (en) | 1997-05-07 |
| ZA94925B (en) | 1994-08-25 |
| NO953201D0 (no) | 1995-08-15 |
| NO305517B1 (no) | 1999-06-14 |
| MX9401175A (es) | 1994-08-31 |
| DE69403068D1 (en) | 1997-06-12 |
| FI953851A0 (sv) | 1995-08-15 |
| ES2104358T3 (es) | 1997-10-01 |
| ATE152725T1 (de) | 1997-05-15 |
| EP0611769A1 (en) | 1994-08-24 |
| HUT72736A (en) | 1996-05-28 |
| JPH08507059A (ja) | 1996-07-30 |
| AU672885B2 (en) | 1996-10-17 |
| CN1117733A (zh) | 1996-02-28 |
| CA2154870C (en) | 1998-10-27 |
| EP0684951A1 (en) | 1995-12-06 |
| DE69403068T2 (de) | 1997-12-11 |
| AU6164194A (en) | 1994-09-14 |
| FI111461B (sv) | 2003-07-31 |
| NO953201L (no) | 1995-08-15 |
| NZ262247A (en) | 1996-01-26 |
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