DE69403068D1 - Silylierte acetylcholinesterase inhibitoren - Google Patents
Silylierte acetylcholinesterase inhibitorenInfo
- Publication number
- DE69403068D1 DE69403068D1 DE69403068T DE69403068T DE69403068D1 DE 69403068 D1 DE69403068 D1 DE 69403068D1 DE 69403068 T DE69403068 T DE 69403068T DE 69403068 T DE69403068 T DE 69403068T DE 69403068 D1 DE69403068 D1 DE 69403068D1
- Authority
- DE
- Germany
- Prior art keywords
- silylierte
- inhibitoren
- acetylcholinesterase
- compounds
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000012440 Acetylcholinesterase Human genes 0.000 title 1
- 108010022752 Acetylcholinesterase Proteins 0.000 title 1
- 229940022698 acetylcholinesterase Drugs 0.000 title 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Fluorinated silylated aromatic compounds possessing anticholinesterase activity and methods of treating Degenerative Dementias using these compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93400385A EP0611769A1 (en) | 1993-02-16 | 1993-02-16 | Silylated acetylcholinesterase inhibitors |
| PCT/US1994/000720 WO1994019356A1 (en) | 1993-02-16 | 1994-01-25 | Silylated acetylcholinesterase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69403068D1 true DE69403068D1 (en) | 1997-06-12 |
| DE69403068T2 DE69403068T2 (en) | 1997-12-11 |
Family
ID=8214682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69403068T Expired - Lifetime DE69403068T2 (en) | 1993-02-16 | 1994-01-25 | SILYLATED ACETYL CHOLINESTERASE INHIBITORS |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP0611769A1 (en) |
| JP (1) | JP3516955B2 (en) |
| KR (1) | KR100336547B1 (en) |
| CN (1) | CN1043575C (en) |
| AT (1) | ATE152725T1 (en) |
| AU (1) | AU672885B2 (en) |
| CA (1) | CA2154870C (en) |
| DE (1) | DE69403068T2 (en) |
| DK (1) | DK0684951T3 (en) |
| ES (1) | ES2104358T3 (en) |
| FI (1) | FI111461B (en) |
| GR (1) | GR3024151T3 (en) |
| HU (1) | HUT72736A (en) |
| IL (1) | IL108623A0 (en) |
| MX (1) | MX9401175A (en) |
| NO (1) | NO305517B1 (en) |
| NZ (1) | NZ262247A (en) |
| WO (1) | WO1994019356A1 (en) |
| ZA (1) | ZA94925B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627400A1 (en) * | 1993-06-04 | 1994-12-07 | Merrell Dow Pharmaceuticals Inc. | Aromatic acetylcholinesterase inhibitors |
| CN100431539C (en) * | 2004-01-12 | 2008-11-12 | 和泓生物技术（上海）有限公司 | Use of acetylchloinesterase inhibitor for preparing medicine for treating parkinson's disease |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| MX2009009234A (en) | 2007-03-01 | 2009-12-01 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors. |
| EP2865670B1 (en) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| ES2548913T3 (en) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Heterocyclic derivatives such as glutaminyl cyclase inhibitors |
| CN102905532A (en) | 2010-02-09 | 2013-01-30 | 约翰斯.霍普金斯大学 | Methods and compositions for improving cognitive function |
| ES2586231T3 (en) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Glutaminyl cyclase inhibitors |
| AU2011226074B2 (en) | 2010-03-10 | 2015-01-22 | Vivoryon Therapeutics N.V. | Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
| EA034167B8 (en) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Extended release pharmaceutical compositions of levetiracetam |
| DK3461819T3 (en) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | GLUTAMINYL CYCLASE INHIBITORS |
| CN112047973B (en) * | 2019-06-06 | 2022-11-18 | 上海科技大学 | Cannabinoids compound, preparation method, composition and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0403713A1 (en) * | 1989-06-22 | 1990-12-27 | Merrell Dow Pharmaceuticals Inc. | Novel acetylcholinesterase inhibitors |
-
1993
- 1993-02-16 EP EP93400385A patent/EP0611769A1/en not_active Withdrawn
-
1994
- 1994-01-25 EP EP94908615A patent/EP0684951B1/en not_active Expired - Lifetime
- 1994-01-25 HU HU9502406A patent/HUT72736A/en unknown
- 1994-01-25 AU AU61641/94A patent/AU672885B2/en not_active Ceased
- 1994-01-25 WO PCT/US1994/000720 patent/WO1994019356A1/en active IP Right Grant
- 1994-01-25 DK DK94908615.1T patent/DK0684951T3/en active
- 1994-01-25 CN CN94191196A patent/CN1043575C/en not_active Expired - Fee Related
- 1994-01-25 KR KR1019950703485A patent/KR100336547B1/en not_active IP Right Cessation
- 1994-01-25 CA CA002154870A patent/CA2154870C/en not_active Expired - Fee Related
- 1994-01-25 DE DE69403068T patent/DE69403068T2/en not_active Expired - Lifetime
- 1994-01-25 JP JP51897494A patent/JP3516955B2/en not_active Expired - Fee Related
- 1994-01-25 AT AT94908615T patent/ATE152725T1/en active
- 1994-01-25 NZ NZ262247A patent/NZ262247A/en unknown
- 1994-01-25 ES ES94908615T patent/ES2104358T3/en not_active Expired - Lifetime
- 1994-02-10 ZA ZA94925A patent/ZA94925B/en unknown
- 1994-02-11 IL IL10862394A patent/IL108623A0/en unknown
- 1994-02-15 MX MX9401175A patent/MX9401175A/en not_active Application Discontinuation
-
1995
- 1995-08-15 FI FI953851A patent/FI111461B/en not_active IP Right Cessation
- 1995-08-15 NO NO953201A patent/NO305517B1/en unknown
-
1997
- 1997-07-16 GR GR970401801T patent/GR3024151T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9401175A (en) | 1994-08-31 |
| FI953851A0 (en) | 1995-08-15 |
| NO953201L (en) | 1995-08-15 |
| NO953201D0 (en) | 1995-08-15 |
| IL108623A0 (en) | 1994-05-30 |
| DE69403068T2 (en) | 1997-12-11 |
| KR960701068A (en) | 1996-02-24 |
| DK0684951T3 (en) | 1997-05-26 |
| AU6164194A (en) | 1994-09-14 |
| CN1117733A (en) | 1996-02-28 |
| FI953851A (en) | 1995-08-15 |
| JPH08507059A (en) | 1996-07-30 |
| WO1994019356A1 (en) | 1994-09-01 |
| ES2104358T3 (en) | 1997-10-01 |
| EP0684951B1 (en) | 1997-05-07 |
| GR3024151T3 (en) | 1997-10-31 |
| NO305517B1 (en) | 1999-06-14 |
| ZA94925B (en) | 1994-08-25 |
| CN1043575C (en) | 1999-06-09 |
| JP3516955B2 (en) | 2004-04-05 |
| AU672885B2 (en) | 1996-10-17 |
| EP0611769A1 (en) | 1994-08-24 |
| FI111461B (en) | 2003-07-31 |
| HUT72736A (en) | 1996-05-28 |
| KR100336547B1 (en) | 2002-11-02 |
| CA2154870A1 (en) | 1994-09-01 |
| EP0684951A1 (en) | 1995-12-06 |
| ATE152725T1 (en) | 1997-05-15 |
| NZ262247A (en) | 1996-01-26 |
| CA2154870C (en) | 1998-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: AVENTISUB II INC., GREENVILLE, DEL., US |