ES2104358T3 - Inhibidores sililados de acetilcolinesterasa. - Google Patents

Inhibidores sililados de acetilcolinesterasa.

Info

Publication number
ES2104358T3
ES2104358T3 ES94908615T ES94908615T ES2104358T3 ES 2104358 T3 ES2104358 T3 ES 2104358T3 ES 94908615 T ES94908615 T ES 94908615T ES 94908615 T ES94908615 T ES 94908615T ES 2104358 T3 ES2104358 T3 ES 2104358T3
Authority
ES
Spain
Prior art keywords
sililed
acetylcholinesterase inhibitors
compounds
methods
acetylcholinesterase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908615T
Other languages
English (en)
Inventor
Jean-Noel Collard
Jean-Marie Hornsperger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2104358T3 publication Critical patent/ES2104358T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

COMPUESTOS AROMATICOS SILILADOS FLUORADOS QUE POSEEN UNA ACTIVIDAD CONTRA LA COLINESTERASA Y METODOS PARA EL TRATAMIENTO DE DEMENCIAS DEGENERATIVAS MEDIANTE LA UTILIZACION DE ESTOS COMPUESTOS.
ES94908615T 1993-02-16 1994-01-25 Inhibidores sililados de acetilcolinesterasa. Expired - Lifetime ES2104358T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93400385A EP0611769A1 (en) 1993-02-16 1993-02-16 Silylated acetylcholinesterase inhibitors

Publications (1)

Publication Number Publication Date
ES2104358T3 true ES2104358T3 (es) 1997-10-01

Family

ID=8214682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908615T Expired - Lifetime ES2104358T3 (es) 1993-02-16 1994-01-25 Inhibidores sililados de acetilcolinesterasa.

Country Status (19)

Country Link
EP (2) EP0611769A1 (es)
JP (1) JP3516955B2 (es)
KR (1) KR100336547B1 (es)
CN (1) CN1043575C (es)
AT (1) ATE152725T1 (es)
AU (1) AU672885B2 (es)
CA (1) CA2154870C (es)
DE (1) DE69403068T2 (es)
DK (1) DK0684951T3 (es)
ES (1) ES2104358T3 (es)
FI (1) FI111461B (es)
GR (1) GR3024151T3 (es)
HU (1) HUT72736A (es)
IL (1) IL108623A0 (es)
MX (1) MX9401175A (es)
NO (1) NO305517B1 (es)
NZ (1) NZ262247A (es)
WO (1) WO1994019356A1 (es)
ZA (1) ZA94925B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627400A1 (en) * 1993-06-04 1994-12-07 Merrell Dow Pharmaceuticals Inc. Aromatic acetylcholinesterase inhibitors
CN100431539C (zh) * 2004-01-12 2008-11-12 和泓生物技术（上海）有限公司 乙酰胆碱酯酶抑制剂在制备治疗帕金森病药物中的应用
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
SI2091948T1 (sl) 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
DK2142514T3 (da) 2007-04-18 2015-03-23 Probiodrug Ag Thioureaderivater som glutaminylcyclase-inhibitorer
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
EA037187B1 (ru) 2010-02-09 2021-02-17 Дзе Джонс Хопкинс Юниверсити Способ и композиция для лечения когнитивного расстройства
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
JP6050264B2 (ja) 2011-03-16 2016-12-21 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
AU2016268096B2 (en) 2015-05-22 2021-04-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN112047973B (zh) * 2019-06-06 2022-11-18 上海科技大学 一种大麻素类化合物，其制备方法、组合物和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0403713A1 (en) * 1989-06-22 1990-12-27 Merrell Dow Pharmaceuticals Inc. Novel acetylcholinesterase inhibitors

Also Published As

Publication number Publication date
EP0684951B1 (en) 1997-05-07
EP0684951A1 (en) 1995-12-06
NZ262247A (en) 1996-01-26
FI111461B (fi) 2003-07-31
EP0611769A1 (en) 1994-08-24
DE69403068T2 (de) 1997-12-11
GR3024151T3 (en) 1997-10-31
DE69403068D1 (en) 1997-06-12
KR100336547B1 (ko) 2002-11-02
NO305517B1 (no) 1999-06-14
ATE152725T1 (de) 1997-05-15
JPH08507059A (ja) 1996-07-30
NO953201D0 (no) 1995-08-15
JP3516955B2 (ja) 2004-04-05
AU672885B2 (en) 1996-10-17
FI953851A (fi) 1995-08-15
WO1994019356A1 (en) 1994-09-01
CN1043575C (zh) 1999-06-09
NO953201L (no) 1995-08-15
MX9401175A (es) 1994-08-31
DK0684951T3 (da) 1997-05-26
CA2154870C (en) 1998-10-27
KR960701068A (ko) 1996-02-24
CA2154870A1 (en) 1994-09-01
CN1117733A (zh) 1996-02-28
IL108623A0 (en) 1994-05-30
ZA94925B (en) 1994-08-25
FI953851A0 (fi) 1995-08-15
HUT72736A (en) 1996-05-28
AU6164194A (en) 1994-09-14

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